Strain Name:
C57BL/6J-MtgxR8551Btlr/Mmmh
Stock Number:
068516-MU
Citation ID:
RRID:MMRRC_068516-MU
Other Names:
R8551 (G1)
Major Collection:

Strain Information

Twist1
Name: twist basic helix-loop-helix transcription factor 1
Synonyms: charlie chaplin, Skam10Jus, Pluridigite, pdt, Ska10, bHLHa38, M-Twist
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22160
VEGA: 12
Homologene: 402
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Oxtr
Name: oxytocin receptor
Synonyms: OTR
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18430
HGNC: HGNC:8529
Homologene: 20255
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: Zfp403, D330017P12Rik, DIF-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: Ascc3l1, A330064G03Rik, HELIC2, U5-200KD
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71472
Homologene: 41730
Naa50
Name: N(alpha)-acetyltransferase 50, NatE catalytic subunit
Synonyms: San, Nat13, Nat5, Mak3p, 2810441M03Rik, 2600005K24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72117
Homologene: 11851
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: Zak, MLTKbeta, B230120H23Rik, MLTKalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65964
Homologene: 32331
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: VR-OAC, VRL-2, VROAC, Trp12, OTRPC4, 0610033B08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 63873
Homologene: 11003
Galr1
Name: galanin receptor 1
Synonyms: Galnr1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14427
VEGA: 18
HGNC: HGNC:4132
Homologene: 74396
Hbp1
Name: high mobility group box transcription factor 1
Synonyms: C86454, 1700058O05Rik, C330012F01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73389
Homologene: 8171
Stk38
Name: serine/threonine kinase 38
Synonyms: 5830476G13Rik, 9530097A09Rik, Ndr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106504
Homologene: 56033
Lyrm4
Name: LYR motif containing 4
Synonyms: LOC380840
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380840
VEGA: 13
Homologene: 41373
Slc7a5
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Synonyms: TA1, D0H16S474E, LAT1, Gm42049
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20539
Homologene: 55759
Mthfsl
Name: 5, 10-methenyltetrahydrofolate synthetase-like
Synonyms: Gm2382
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100039707
HGNC: HGNC:7437
Homologene: 4702
Gnao1
Name: guanine nucleotide binding protein, alpha O
Synonyms: Galphao, Go alpha, alphaO
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14681
HGNC: HGNC:4389
Homologene: 39203
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Exph5
Name: exophilin 5
Synonyms: AC079869.22gm5, slac2-b, B130009M24Rik, Slac2b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320051
Homologene: 9007
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL19, DLP12, LOC380889, Dnahc7l, 4921531P07Rik, Hdhc3, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Liph
Name: lipase, member H
Synonyms: PLA1B, mPA-PLA1, D16Wsu119e, C130037N08Rik, LPDLR, Lpdlr
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Trim69
Name: tripartite motif-containing 69
Synonyms: Rnf36, Trif, 4921519C19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70928
Homologene: 18827
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: GC-LRR, 4921520L01Rik, Nalp14, Nalp-iota
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76858
Homologene: 18531
Relt
Name: RELT tumor necrosis factor receptor
Synonyms: E430021K24Rik, Tnfrsf19l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320100
Homologene: 13151
Or6d14
Name: olfactory receptor family 6 subfamily D member 14
Synonyms: MOR119-1, GA_x54KRFPKN04-58190962-58191900, Olfr214
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258754
Homologene: 133694
Lrguk
Name: leucine-rich repeats and guanylate kinase domain containing
Synonyms: 4921528H16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74354
Homologene: 34923
Gata3
Name: GATA binding protein 3
Synonyms: jal, Gata-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Eri2
Name: exoribonuclease 2
Synonyms: 4933424N09Rik, Exod1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71151
Homologene: 12383
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230815
Homologene: 69303
Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PRKN, Parkin, Park2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50873
HGNC: HGNC:8607
Homologene: 3355
Tfap2d
Name: transcription factor AP-2, delta
Synonyms: Tcfap2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226896
Homologene: 17700
Or5b119
Name: olfactory receptor family 5 subfamily B member 119
Synonyms: Olfr1475, MOR202-36, GA_x6K02T2RE5P-3812807-3811863
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258298
Homologene: 77370
Tas2r116
Name: taste receptor, type 2, member 116
Synonyms: Tas2r14, TRB1, T2R16, mt2r56, TRB4, Tas2r7, Tas2r16, mGR16
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 112408
Homologene: 130070
Sccpdh
Name: saccharopine dehydrogenase (putative)
Synonyms: C330023F11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109232
Homologene: 9334
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66753
Homologene: 9247
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 19,104,800 bp
  • T to C, chromosome 1 at 46,116,200 bp
  • T to A, chromosome 1 at 179,681,448 bp
  • C to A, chromosome 2 at 9,863,183 bp
  • T to A, chromosome 2 at 22,332,466 bp
  • T to G, chromosome 2 at 72,402,360 bp
  • A to G, chromosome 2 at 122,173,329 bp
  • A to G, chromosome 2 at 127,227,051 bp
  • T to C, chromosome 3 at 51,857,067 bp
  • A to G, chromosome 4 at 11,513,397 bp
  • A to T, chromosome 4 at 134,703,015 bp
  • A to T, chromosome 5 at 114,630,839 bp
  • T to C, chromosome 6 at 34,116,511 bp
  • T to C, chromosome 6 at 112,488,978 bp
  • G to T, chromosome 6 at 116,557,328 bp
  • T to C, chromosome 6 at 132,856,030 bp
  • G to A, chromosome 7 at 82,540,470 bp
  • T to C, chromosome 7 at 100,863,202 bp
  • C to T, chromosome 7 at 107,183,152 bp
  • A to T, chromosome 7 at 119,787,839 bp
  • A to G, chromosome 8 at 93,956,107 bp
  • A to G, chromosome 8 at 121,886,311 bp
  • A to G, chromosome 9 at 53,374,051 bp
  • G to T, chromosome 9 at 88,688,890 bp
  • A to T, chromosome 9 at 108,499,297 bp
  • C to A, chromosome 11 at 30,931,829 bp
  • A to G, chromosome 11 at 73,712,296 bp
  • A to T, chromosome 11 at 84,841,525 bp
  • T to C, chromosome 12 at 31,930,710 bp
  • C to T, chromosome 12 at 33,958,104 bp
  • T to A, chromosome 13 at 11,560,593 bp
  • T to A, chromosome 13 at 13,634,060 bp
  • T to A, chromosome 13 at 35,979,861 bp
  • T to A, chromosome 14 at 26,774,270 bp
  • C to G, chromosome 16 at 21,981,408 bp
  • A to G, chromosome 16 at 44,159,633 bp
  • A to G, chromosome 17 at 11,067,216 bp
  • A to G, chromosome 17 at 28,988,225 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • T to G, chromosome 17 at 74,557,954 bp
  • T to A, chromosome 18 at 82,406,066 bp
  • A to G, chromosome 19 at 13,479,745 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8551 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.