Strain Name:
C57BL/6J-MtgxR8669Btlr/Mmmh
Stock Number:
068524-MU
Citation ID:
RRID:MMRRC_068524-MU
Other Names:
R8669 (G1)
Major Collection:

Strain Information

Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Dgkh
Name: diacylglycerol kinase, eta
Synonyms: 5930402B05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380921
VEGA: 14
HGNC: HGNC:2854
Homologene: 99373
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2900036C23Rik, 2810413I22Rik, 2410152H17Rik, 6030449K19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Zfp462
Name: zinc finger protein 462
Synonyms: 9430078C22Rik, Gt4-2, Zfpip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Dyrk1a
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a
Synonyms: Mnbh, 2310043O08Rik, D16Ertd493e, Dyrk, D16Ertd272e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13548
HGNC: HGNC:3091
Homologene: 55576
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Ift122
Name: intraflagellar transport 122
Synonyms: sopb, Wdr10, C86139
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 81896
Homologene: 12819
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l7Rn3, Odz4, l(7)-3Rn, ELM2, Doc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Thra
Name: thyroid hormone receptor alpha
Synonyms: Thra2, T3Ralpha, TR alpha 2, Thra1, Rvr, Erba, TR alpha 1, 6430529J03Rik, c-erbAalpha, Nr1a1, T3R[a]
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21833
Homologene: 37747
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Krt19
Name: keratin 19
Synonyms: Krt-1.19, cytokeratin-19, Krt1-19, K19, EndoC, cytokeratin 19, cytokeratin19
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16669
HGNC: HGNC:6436
Homologene: 1713
Blzf1
Name: basic leucine zipper nuclear factor 1
Synonyms: 1700030G05Rik, Golgin-45, Blzf1l, Jem-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66352
HGNC: HGNC:1065
Homologene: 31187
Myo6
Name: myosin VI
Synonyms: Myo6rsv, rsv, Tlc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Txnip
Name: thioredoxin interacting protein
Synonyms: VDUP1, THIF, mVDUP1, Hyplip1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56338
Homologene: 38186
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ccdc125
Name: coiled-coil domain containing 125
Synonyms: 5830436D01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76041
VEGA: 13
Homologene: 27932
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL19, DLP12, LOC380889, Dnahc7l, 4921531P07Rik, Hdhc3, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: Xtrp2, XT2, D630001K16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22598
VEGA: 13
Homologene: 40785
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: 2210017P03Rik, NF-ATc, NFATc, NFAT2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Slc22a9, Octn3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56517
Homologene: 137336
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241514
Homologene: 18461
Gm7298
Name: predicted gene 7298
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 640530
HGNC: HGNC:9750
Gpatch1
Name: G patch domain containing 1
Synonyms: Gpatc1, 1300003A17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67471
Homologene: 41217
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233328
Homologene: 23464
Cep89
Name: centrosomal protein 89
Synonyms: Ccdc123, 2610507L03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72140
Homologene: 12444
Ankrd42
Name: ankyrin repeat domain 42
Synonyms: 4933417L02Rik, Ikbn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73845
Homologene: 23652
Lgals4
Name: lectin, galactose binding, soluble 4
Synonyms: galectin-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16855
HGNC: HGNC:6565
Homologene: 21239
Speer4a1
Name: spermatogenesis associated glutamate (E)-rich protein 4A1
Synonyms: SPEER-4A, Speer4a, 1700027N01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75657
Homologene: 69402
Phtf1
Name: putative homeodomain transcription factor 1
Synonyms: Phft
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18685
HGNC: HGNC:8939
Homologene: 4817
Krt87
Name: keratin 87
Synonyms: Krt2-25, Krt83
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Unc5c
Name: unc-5 netrin receptor C
Synonyms: B130051O18Rik, Unc5h3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22253
Homologene: 2765
Gcnt1
Name: glucosaminyl (N-acetyl) transferase 1, core 2
Synonyms: C2 GlcNAcT, IGnT, 5630400D21Rik, beta-1, 6-N-acetylglucosaminyltransferase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14537
HGNC: HGNC:4203
Homologene: 37486
Rhbdl3
Name: rhomboid like 3
Synonyms: Vrho, Rhbdl4, Ventrhoid
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246104
Homologene: 34700
Cdc20b
Name: cell division cycle 20B
Synonyms: EG622422, EG238896
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238896
Homologene: 65056
Osm
Name: oncostatin M
Synonyms: OncoM
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18413
HGNC: HGNC:8506
Homologene: 10741
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23805
Homologene: 4299
Slc16a14
Name: solute carrier family 16 (monocarboxylic acid transporters), member 14
Synonyms: 1110004H10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71781
Homologene: 34318
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235612
Homologene: 110776
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Klhl40
Name: kelch-like 40
Synonyms: 2310024D23Rik, Kbtbd5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72330
VEGA: 9
Homologene: 17571
Tc2n
Name: tandem C2 domains, nuclear
Synonyms: Mtac2d1, Tac2-N, 4933406D09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74413
Homologene: 12560
Or52ab7
Name: olfactory receptor family 52 subfamily AB member 7
Synonyms: GA_x6K02T2PBJ9-6037823-6038782, MOR23-4P, MOR23-5, Olfr598
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257975
Homologene: 132401
Gal3st2b
Name: galactose-3-O-sulfotransferase 2B
Synonyms: Gm9994
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100041596
Homologene: 41471
Dhrs13
Name: dehydrogenase/reductase 13
Synonyms: dehydrogenase/reductase (SDR family) member 13, 2610209N15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70451
Homologene: 64807
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6as, Six6os1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75801
Homologene: 49922
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: D1Mgi1, 9230107O05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Crnn
Name: cornulin
Synonyms: LOC381457
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381457
HGNC: HGNC:1230
Homologene: 9416
Defb8
Name: defensin beta 8
Synonyms: Defr1, mBD8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244334
Gulp1
Name: GULP, engulfment adaptor PTB domain containing 1
Synonyms: CED-6, 3110030A04Rik, Ced6, GULP, 5730529O06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70676
Homologene: 9467
Tcstv7b
Name: Tcstv family member 7B
Synonyms: Gm21731
Type: Gene
Species: Mouse
Chromosome: 13
Defb5
Name: defensin beta 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 81007
Tmem218
Name: transmembrane protein 218
Synonyms: 1810021J13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66279
VEGA: 9
Homologene: 11941
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 21,405,826 bp
  • T to A, chromosome 1 at 44,766,110 bp
  • A to G, chromosome 1 at 84,922,884 bp
  • A to T, chromosome 1 at 93,941,042 bp
  • T to A, chromosome 1 at 164,302,544 bp
  • A to G, chromosome 2 at 41,282,035 bp
  • A to T, chromosome 2 at 82,257,762 bp
  • A to T, chromosome 3 at 93,148,989 bp
  • T to C, chromosome 3 at 96,558,936 bp
  • T to A, chromosome 3 at 104,003,476 bp
  • A to G, chromosome 3 at 141,803,943 bp
  • T to A, chromosome 4 at 55,051,313 bp
  • T to A, chromosome 4 at 58,070,119 bp
  • A to G, chromosome 4 at 148,051,477 bp
  • T to C, chromosome 5 at 15,935,015 bp
  • T to G, chromosome 5 at 26,038,238 bp
  • T to A, chromosome 6 at 108,393,967 bp
  • C to A, chromosome 6 at 115,923,291 bp
  • T to C, chromosome 6 at 121,765,043 bp
  • C to T, chromosome 7 at 28,841,496 bp
  • C to A, chromosome 7 at 35,291,779 bp
  • A to G, chromosome 7 at 35,429,177 bp
  • G to A, chromosome 7 at 66,262,596 bp
  • A to G, chromosome 7 at 92,619,673 bp
  • C to T, chromosome 7 at 96,905,941 bp
  • A to T, chromosome 7 at 103,329,074 bp
  • A to G, chromosome 8 at 19,250,745 bp
  • A to G, chromosome 8 at 19,445,957 bp
  • C to T, chromosome 9 at 37,222,519 bp
  • T to G, chromosome 9 at 80,266,249 bp
  • G to T, chromosome 9 at 109,484,414 bp
  • T to A, chromosome 9 at 121,778,022 bp
  • T to C, chromosome 10 at 41,552,356 bp
  • C to T, chromosome 10 at 80,313,657 bp
  • A to T, chromosome 11 at 4,239,665 bp
  • C to T, chromosome 11 at 53,979,817 bp
  • G to C, chromosome 11 at 78,032,666 bp
  • G to A, chromosome 11 at 80,353,513 bp
  • T to C, chromosome 11 at 98,763,650 bp
  • T to C, chromosome 11 at 100,141,167 bp
  • A to T, chromosome 12 at 72,902,460 bp
  • T to C, chromosome 12 at 101,694,592 bp
  • T to A, chromosome 13 at 73,664,311 bp
  • A to T, chromosome 13 at 84,272,169 bp
  • T to C, chromosome 13 at 100,188,969 bp
  • T to C, chromosome 13 at 100,696,175 bp
  • C to T, chromosome 13 at 113,071,926 bp
  • C to A, chromosome 13 at 120,240,802 bp
  • A to T, chromosome 14 at 26,830,625 bp
  • A to G, chromosome 14 at 78,725,019 bp
  • T to A, chromosome 15 at 99,303,347 bp
  • C to A, chromosome 15 at 101,487,896 bp
  • T to C, chromosome 16 at 56,165,952 bp
  • G to T, chromosome 16 at 94,663,791 bp
  • A to G, chromosome 18 at 20,590,075 bp
  • T to C, chromosome 18 at 80,682,191 bp
  • T to G, chromosome 19 at 17,329,779 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8669 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068524-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.