Strain Name:
C57BL/6J-MtgxR8670Btlr/Mmmh
Stock Number:
068525-MU
Citation ID:
RRID:MMRRC_068525-MU
Other Names:
R8670 (G1)
Major Collection:

Strain Information

Gga3
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3
Synonyms: C230037M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 260302
Homologene: 121703
Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: 1500002J22Rik, repro8, G1-419-52, eIF4GII, 4930523M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, Drf3, mDia2, 4930417P13Rik, Diap3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Clcn7
Name: chloride channel, voltage-sensitive 7
Synonyms: ClC-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26373
HGNC: HGNC:2025
Homologene: 56546
Tbl1xr1
Name: transducin (beta)-like 1X-linked receptor 1
Synonyms: DC42, C230089I12Rik, 8030499H02Rik, C21, Ira1, A630076E03Rik, TBLR1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81004
Homologene: 69382
Prom1
Name: prominin 1
Synonyms: Prom-1, Prom, AC133, 4932416E19Rik, CD133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Orc3
Name: origin recognition complex, subunit 3
Synonyms: Orc3l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50793
HGNC: HGNC:8489
Homologene: 8225
Mex3c
Name: mex3 RNA binding family member C
Synonyms: A130001D14Rik, Rkhd2, BM-013
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240396
Homologene: 9601
Slc49a4
Name: solute carrier family 49 member 4
Synonyms: Dirc2, RCC4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224132
Homologene: 13137
Smarce1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms: BAF57, 5830412H02Rik, 9030408N19Rik, 2810417B20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57376
Homologene: 37727
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l7Rn3, Odz4, l(7)-3Rn, ELM2, Doc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Rab8a
Name: RAB8A, member RAS oncogene family
Synonyms: Mel
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17274
HGNC: HGNC:7007
Homologene: 100934
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, Sec3l1, 2810407P21Rik, A730011E05Rik, SEC3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69940
Homologene: 41241
Cd82
Name: CD82 antigen
Synonyms: Tspan27, C33, Kai1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12521
HGNC: HGNC:6210
Homologene: 20512
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: HKalpha2, ATPase H+K+-transporting, alpha 2, Atp1al1, cHKA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: CD169, Siglec-1, Sn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20612
Homologene: 124458
Il1rl1
Name: interleukin 1 receptor-like 1
Synonyms: St2-rs1, T1/ST2, T1 gene, ST2, Fit-1, DER4, ST2L, St2, T1, Ly84
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17082
HGNC: HGNC:5998
Homologene: 2862
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Wdpcp
Name: WD repeat containing planar cell polarity effector
Synonyms: homoloc-13, AV249152
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216560
Homologene: 9299
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Zfp947
Name: zinc finger protein 947
Synonyms: Gm4769
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210853
Homologene: 133253
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 632671
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Ccdc178
Name: coiled coil domain containing 178
Synonyms: 4921528I01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70950
VEGA: 18
Homologene: 12373
Ankrd24
Name: ankyrin repeat domain 24
Synonyms: 4631433D01Rik, 5730519E19Rik, D10Bur2e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70615
Homologene: 49885
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Spty2d1
Name: SPT2 chromatin protein domain containing 1
Synonyms: 5830435K17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101685
Homologene: 45499
Cpvl
Name: carboxypeptidase, vitellogenic-like
Synonyms: 4933436L16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71287
Homologene: 80235
Scnn1b
Name: sodium channel, nonvoltage-gated 1 beta
Synonyms: ENaC beta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20277
Homologene: 133555
Muc21
Name: mucin 21
Synonyms: Gm9573, epiglycanin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 672682
Or8g2
Name: olfactory receptor family 8 subfamily G member 2
Synonyms: GA_x6K02T2PVTD-33608180-33608971, Olfr973, GA_x6K02T02EEW-227-373, Olfr229, MOR171-14
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258606
VEGA: 9
Homologene: 115513
Klhl22
Name: kelch-like 22
Synonyms: Kelchl, 2610318I18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224023
Homologene: 23784
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 9530055J05Rik, 0610006A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Slco1a7
Name: solute carrier organic anion transporter family, member 1a7
Synonyms: Gm5724
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 435927
Zfp322a
Name: zinc finger protein 322A
Synonyms: 9630054P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218100
Homologene: 23460
Or52n2c
Name: olfactory receptor family 52 subfamily N member 2C
Synonyms: MOR34-3, GA_x6K02T2PBJ9-7554614-7553658, Olfr668
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259061
Homologene: 64947
Cym
Name: chymosin
Synonyms: LOC229697, Gm131
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229697
Homologene: 129841
Esp3
Name: exocrine gland secreted peptide 3
Synonyms: Gm21945
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126766
VEGA: 17
Armh2
Name: armadillo-like helical domain containing 2
Synonyms: 1700016G14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 666145
Homologene: 131784
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 40,441,399 bp
  • A to G, chromosome 1 at 178,913,784 bp
  • T to A, chromosome 2 at 93,420,560 bp
  • A to G, chromosome 2 at 131,081,467 bp
  • A to T, chromosome 3 at 22,191,000 bp
  • A to T, chromosome 3 at 93,201,484 bp
  • T to C, chromosome 3 at 107,211,496 bp
  • A to T, chromosome 4 at 34,572,529 bp
  • T to G, chromosome 4 at 118,614,925 bp
  • G to A, chromosome 4 at 135,922,971 bp
  • T to G, chromosome 4 at 138,158,512 bp
  • T to C, chromosome 4 at 152,385,496 bp
  • G to A, chromosome 5 at 14,682,047 bp
  • T to C, chromosome 5 at 15,935,015 bp
  • T to A, chromosome 5 at 44,001,844 bp
  • A to G, chromosome 5 at 76,569,658 bp
  • C to A, chromosome 5 at 151,562,389 bp
  • A to T, chromosome 6 at 53,974,795 bp
  • G to A, chromosome 6 at 141,765,742 bp
  • T to C, chromosome 7 at 46,997,771 bp
  • C to T, chromosome 7 at 96,905,941 bp
  • A to T, chromosome 7 at 104,925,212 bp
  • A to G, chromosome 7 at 121,899,249 bp
  • T to A, chromosome 8 at 33,574,718 bp
  • C to T, chromosome 8 at 43,652,089 bp
  • TA to TAA, chromosome 8 at 72,171,286 bp
  • A to G, chromosome 9 at 39,910,423 bp
  • T to C, chromosome 9 at 107,928,760 bp
  • A to G, chromosome 10 at 50,908,753 bp
  • C to T, chromosome 10 at 81,629,692 bp
  • T to A, chromosome 10 at 86,940,723 bp
  • T to A, chromosome 10 at 93,226,096 bp
  • T to C, chromosome 11 at 21,695,196 bp
  • T to C, chromosome 11 at 99,210,272 bp
  • A to T, chromosome 11 at 110,075,598 bp
  • T to C, chromosome 11 at 115,587,716 bp
  • T to C, chromosome 11 at 119,458,737 bp
  • T to A, chromosome 13 at 23,357,104 bp
  • A to G, chromosome 13 at 24,746,257 bp
  • A to T, chromosome 14 at 56,380,089 bp
  • T to C, chromosome 14 at 86,656,399 bp
  • A to G, chromosome 15 at 76,177,526 bp
  • T to A, chromosome 15 at 99,309,740 bp
  • T to A, chromosome 16 at 17,776,463 bp
  • G to T, chromosome 16 at 35,735,635 bp
  • A to G, chromosome 16 at 94,390,208 bp
  • T to C, chromosome 17 at 22,145,706 bp
  • T to C, chromosome 17 at 25,159,614 bp
  • T to A, chromosome 17 at 35,621,648 bp
  • A to G, chromosome 17 at 40,632,149 bp
  • T to C, chromosome 17 at 84,432,346 bp
  • A to C, chromosome 18 at 6,214,631 bp
  • T to C, chromosome 18 at 22,097,662 bp
  • GC to G, chromosome 18 at 73,589,705 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8670 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068525-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.