Strain Name:
C57BL/6J-MtgxR8697Btlr/Mmmh
Stock Number:
068551-MU
Citation ID:
RRID:MMRRC_068551-MU
Other Names:
R8697 (G1)
Major Collection:

Strain Information

Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, ne, b2b1562Clo, 6030440P17Rik, my
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Ctnnal1
Name: catenin alpha like 1
Synonyms: catenin (cadherin associated protein), alpha-like 1, Catnal1, ACRP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54366
HGNC: HGNC:2512
Homologene: 2815
Kif20a
Name: kinesin family member 20A
Synonyms: Rabkinesin-6, Rab6kifl
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19348
VEGA: 18
HGNC: HGNC:9787
Homologene: 38093
Morc3
Name: microrchidia 3
Synonyms: Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Washc2
Name: WASH complex subunit 2
Synonyms: Fam21, D6Wsu116e, C530005J20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28006
Homologene: 41686
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: Tarsl1, 2610024N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Skic3
Name: SKI3 subunit of superkiller complex
Synonyms: Ttc37
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218343
VEGA: 13
Homologene: 40966
Gna12
Name: guanine nucleotide binding protein, alpha 12
Synonyms: Galpha12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14673
HGNC: HGNC:4380
Homologene: 22398
Ackr1
Name: atypical chemokine receptor 1 (Duffy blood group)
Synonyms: CCBP1, Dfy, Darc, ESTM35, FY, CD234
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13349
HGNC: HGNC:4035
Homologene: 48067
Alx4
Name: aristaless-like homeobox 4
Synonyms: Aristaless-like 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11695
HGNC: HGNC:450
Homologene: 7229
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2610101O16Rik, 2810409N01Rik, cat eye syndrome chromosome region, candidate 2, Gtl4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Srsf4
Name: serine and arginine-rich splicing factor 4
Synonyms: MNCb-2616, Sfrs4, SRp75, 5730499P16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 57317
Homologene: 25624
Lcn6
Name: lipocalin 6
Synonyms: 9230101D24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 620709
Homologene: 45707
Ctps1
Name: cytidine 5'-triphosphate synthase 1
Synonyms: Ctps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51797
HGNC: HGNC:2519
Homologene: 20446
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930473A06Rik, 4930418J05Rik, A330015D16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320226
Homologene: 27942
Tepsin
Name: TEPSIN, adaptor related protein complex 4 accessory protein
Synonyms: 2410002I01Rik, Enthd2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78777
Homologene: 35359
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227449
Homologene: 9808
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: wmfl, Flk-2, Flk2, Flt-3, CD135
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pcdhb4
Name: protocadherin beta 4
Synonyms: PcdhbD, Pcdhb5A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93875
HGNC: HGNC:8690
Homologene: 62176
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: Mlk2, serine/threonine kinase, MKN28 kinase, mixed lineage kinase 2, MKN28 derived nonreceptor_type
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Mndal
Name: myeloid nuclear differentiation antigen like
Synonyms: Ifi212
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040462
HGNC: HGNC:5395
Homologene: 115929
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Lamp1
Name: lysosomal-associated membrane protein 1
Synonyms: Perk, CD107a, Lamp-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16783
HGNC: HGNC:6499
Homologene: 4061
Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms: Wip1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53892
HGNC: HGNC:9277
Homologene: 31185
Gsdmc
Name: gasdermin C
Synonyms: Gsdmc1, Mlze
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83492
HGNC: HGNC:7151
Homologene: 69487
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Or5m13b
Name: olfactory receptor family 5 subfamily M member 13B
Synonyms: Olfr1026, GA_x6K02T2Q125-47402610-47403533, MOR196-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258577
Homologene: 73971
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Dmwd
Name: dystrophia myotonica-containing WD repeat motif
Synonyms: 59, DMR-N9, Dm9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13401
HGNC: HGNC:2936
Homologene: 22559
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: Grfbeta, CDC25, Grf1, CDC25Mm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Slc52a3
Name: solute carrier protein family 52, member 3
Synonyms: 2310046K01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69698
Homologene: 12324
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Ilvbl
Name: ilvB (bacterial acetolactate synthase)-like
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216136
VEGA: 10
HGNC: HGNC:6041
Homologene: 68532
Padi4
Name: peptidyl arginine deiminase, type IV
Synonyms: PAD type IV, Pad4, Pdi4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18602
Homologene: 7883
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700024K14Rik, 1700074B05Rik, 4833417L20Rik, 5830409B12Rik, Rsnl2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Utp14b
Name: UTP14B small subunit processome component
Synonyms: 4932411L21Rik, jsd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 195434
Homologene: 78703
Aqp7
Name: aquaporin 7
Synonyms: AQPap, AQP7L
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11832
Homologene: 48000
Or10ac1
Name: olfactory receptor family 10 subfamily AC member 1
Synonyms: EG546896, Olfr455-ps1, Olfr455, MORO-2, GA_x6K02T2P3E9-5021913-5022918, MOR0-2P, MOR0-17_p
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546896
Homologene: 67366
Eepd1
Name: endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms: 2310005P05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67484
Homologene: 12144
Ssr1
Name: signal sequence receptor, alpha
Synonyms: TRAPalpha, SSR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107513
VEGA: 13
Homologene: 2368
Hoxd11
Name: homeobox D11
Synonyms: Hox-5.5, Hox-4.6, Hox-5.4, E230017H14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15431
HGNC: HGNC:5134
Homologene: 7368
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 278279
Homologene: 25521
Trgc2
Name: T cell receptor gamma, constant 2
Synonyms: Trgc2, Gm16603, Tcrg-C2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107574
4930558K02Rik
Name: RIKEN cDNA 4930558K02 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75368
Homologene: 51403
Xcl1
Name: chemokine (C motif) ligand 1
Synonyms: lymphotactin, Lptn, SCM-1, SCM-1a, LTN, ATAC, Scyc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16963
Homologene: 2250
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,076,380 bp
  • T to C, chromosome 1 at 78,666,527 bp
  • A to T, chromosome 1 at 87,489,737 bp
  • C to A, chromosome 1 at 106,030,764 bp
  • C to T, chromosome 1 at 161,967,996 bp
  • C to T, chromosome 1 at 164,935,439 bp
  • A to G, chromosome 1 at 173,332,208 bp
  • C to A, chromosome 1 at 173,872,992 bp
  • A to G, chromosome 2 at 25,677,154 bp
  • G to A, chromosome 2 at 74,682,669 bp
  • A to G, chromosome 2 at 76,744,776 bp
  • A to T, chromosome 2 at 85,923,856 bp
  • G to A, chromosome 2 at 93,675,312 bp
  • A to G, chromosome 2 at 152,004,476 bp
  • T to A, chromosome 3 at 53,525,828 bp
  • A to G, chromosome 3 at 59,318,887 bp
  • C to T, chromosome 3 at 95,746,062 bp
  • T to C, chromosome 4 at 41,045,305 bp
  • T to A, chromosome 4 at 56,838,986 bp
  • A to T, chromosome 4 at 62,321,058 bp
  • T to C, chromosome 4 at 83,682,340 bp
  • T to C, chromosome 4 at 120,542,750 bp
  • C to T, chromosome 4 at 131,900,731 bp
  • GGAGCTCCTGA to GGA, chromosome 4 at 140,757,919 bp
  • T to A, chromosome 5 at 16,365,867 bp
  • T to C, chromosome 5 at 31,074,601 bp
  • T to C, chromosome 5 at 114,213,380 bp
  • T to A, chromosome 5 at 140,785,445 bp
  • T to C, chromosome 5 at 147,358,001 bp
  • C to T, chromosome 6 at 41,614,223 bp
  • A to G, chromosome 6 at 42,538,695 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • A to G, chromosome 6 at 108,523,366 bp
  • A to G, chromosome 6 at 116,229,259 bp
  • T to C, chromosome 6 at 120,733,818 bp
  • A to C, chromosome 7 at 19,078,188 bp
  • A to G, chromosome 7 at 27,663,359 bp
  • T to C, chromosome 7 at 81,473,035 bp
  • A to T, chromosome 8 at 13,174,448 bp
  • A to G, chromosome 8 at 110,532,883 bp
  • T to C, chromosome 8 at 125,482,116 bp
  • A to G, chromosome 9 at 25,586,702 bp
  • A to G, chromosome 9 at 89,995,002 bp
  • A to T, chromosome 10 at 78,583,362 bp
  • A to G, chromosome 10 at 105,369,970 bp
  • T to C, chromosome 11 at 85,337,160 bp
  • T to C, chromosome 11 at 94,416,698 bp
  • A to G, chromosome 11 at 118,086,159 bp
  • G to T, chromosome 11 at 120,097,528 bp
  • A to G, chromosome 12 at 51,772,537 bp
  • A to T, chromosome 13 at 19,307,344 bp
  • G to T, chromosome 13 at 37,983,449 bp
  • A to G, chromosome 13 at 76,180,155 bp
  • A to T, chromosome 15 at 63,780,034 bp
  • T to C, chromosome 16 at 93,871,020 bp
  • T to C, chromosome 17 at 29,846,641 bp
  • G to T, chromosome 17 at 71,856,275 bp
  • C to G, chromosome 18 at 34,628,531 bp
  • G to A, chromosome 18 at 37,308,779 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8697 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068551-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.