Strain Name:
C57BL/6J-MtgxR8702Btlr/Mmmh
Stock Number:
068556-MU
Citation ID:
RRID:MMRRC_068556-MU
Other Names:
R8702 (G1)
Major Collection:

Strain Information

Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms: Kir1.2, Kir4.1, BIRK-1, BIR10, Kir4.1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16513
HGNC: HGNC:6256
Homologene: 1689
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: PSGAP-m, PSGAP-s, A930033B01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Sirt3
Name: sirtuin 3
Synonyms: Sir2l3, 2310003L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64384
Homologene: 81827
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: 9530001P15Rik, Ponsin, 2310065E01Rik, Sh3d5, c-Cbl-associated protein, CAP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Serbp1
Name: serpine1 mRNA binding protein 1
Synonyms: 1200009K13Rik, 9330147J08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66870
Homologene: 134277
Nrros
Name: negative regulator of reactive oxygen species
Synonyms: Lrrc33, E430025L02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224109
Homologene: 17134
Dck
Name: deoxycytidine kinase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13178
HGNC: HGNC:2704
Homologene: 616
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Efl1
Name: elongation factor like GTPase 1
Synonyms: D7Ertd791e, 4932434J20Rik, Eftud1, 6030468D11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101592
Homologene: 11599
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: alpha3(IV), tumstatin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, KCP, Crim2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Fyttd1
Name: forty-two-three domain containing 1
Synonyms: 3830411L18Rik, 2010005M05Rik, 4933423A17Rik, 3830421F13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69823
Homologene: 12334
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232748
Homologene: 17147
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Elac1
Name: elaC ribonuclease Z 1
Synonyms: 8430417G19Rik, 2610018O07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 114615
Homologene: 10272
Actn2
Name: actinin alpha 2
Synonyms: 1110008F24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11472
HGNC: HGNC:164
Homologene: 31016
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219149
Homologene: 18287
Lrrtm2
Name: leucine rich repeat transmembrane neuronal 2
Synonyms: C630011A14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107065
VEGA: 18
Homologene: 65342
Palm2
Name: paralemmin 2
Synonyms: 53-H12, pEN70
Type: Gene
Species: Mouse
Chromosome: 4
Or5d35
Name: olfactory receptor family 5 subfamily D member 35
Synonyms: GA_x6K02T2Q125-49516664-49517629, MOR174-2, Olfr1161
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258845
Homologene: 138318
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78774
Oxct1
Name: 3-oxoacid CoA transferase 1
Synonyms: Scot-s, 2610008O03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67041
HGNC: HGNC:8527
Homologene: 377
Or6c65
Name: olfactory receptor family 6 subfamily C member 65
Synonyms: Olfr808, GA_x6K02T2PULF-11446184-11447122, MOR112-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258930
Homologene: 17438
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 111175
Homologene: 69255
Grxcr2
Name: glutaredoxin, cysteine rich 2
Synonyms: LOC332309
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 332309
VEGA: 18
Homologene: 85304
Cfap91
Name: cilia and flagella associated protein 91
Synonyms: Spata26, Maats1, 4932425I24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320214
Homologene: 33470
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 72,267,502 bp
  • A to T, chromosome 1 at 82,710,979 bp
  • A to G, chromosome 1 at 172,369,560 bp
  • T to C, chromosome 2 at 52,195,705 bp
  • T to C, chromosome 2 at 88,025,495 bp
  • T to A, chromosome 2 at 118,638,494 bp
  • T to C, chromosome 2 at 146,200,790 bp
  • C to A, chromosome 2 at 156,019,390 bp
  • A to T, chromosome 2 at 177,387,222 bp
  • C to T, chromosome 2 at 181,501,956 bp
  • C to T, chromosome 4 at 57,709,489 bp
  • T to A, chromosome 5 at 88,778,413 bp
  • A to T, chromosome 6 at 24,461,915 bp
  • A to T, chromosome 6 at 29,482,751 bp
  • A to T, chromosome 6 at 42,642,767 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • G to T, chromosome 6 at 67,267,172 bp
  • A to G, chromosome 7 at 82,750,790 bp
  • A to T, chromosome 7 at 140,878,114 bp
  • C to A, chromosome 8 at 14,942,638 bp
  • A to G, chromosome 8 at 77,259,103 bp
  • T to A, chromosome 10 at 39,838,469 bp
  • A to T, chromosome 10 at 129,768,415 bp
  • T to C, chromosome 13 at 12,282,529 bp
  • G to T, chromosome 14 at 63,819,654 bp
  • T to C, chromosome 15 at 4,153,761 bp
  • T to A, chromosome 16 at 32,147,771 bp
  • A to G, chromosome 16 at 32,884,159 bp
  • A to G, chromosome 16 at 38,332,312 bp
  • G to T, chromosome 18 at 35,212,965 bp
  • T to C, chromosome 18 at 41,998,689 bp
  • G to A, chromosome 18 at 49,859,135 bp
  • G to T, chromosome 18 at 73,739,220 bp
  • G to C, chromosome 19 at 40,376,800 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8702 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068556-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.