Strain Name:
C57BL/6J-MtgxR8730Btlr/Mmmh
Stock Number:
068578-MU
Citation ID:
RRID:MMRRC_068578-MU
Other Names:
R8730 (G1)
Major Collection:

Strain Information

Tnpo1
Name: transportin 1
Synonyms: D13Ertd688e, Kpnb2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238799
HGNC: HGNC:6401
Homologene: 5358
St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: Siat9, GM3 synthase, GM3-specific sialytransferase, mST3Gal V, ST3Gal V, 3S-T, [a]2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20454
Homologene: 2893
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Ccar1
Name: cell division cycle and apoptosis regulator 1
Synonyms: 2610511G16Rik, 9430036H15Rik, Carp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67500
VEGA: 10
Homologene: 10086
Gabpb1
Name: GA repeat binding protein, beta 1
Synonyms: E4Tf1B, GABPB1-2, NRF2B1, E4TF1, NRF2B2, GABPB1-1, BABPB2, E4TF1-53, E4TF1-47
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14391
HGNC: HGNC:4074
Homologene: 7723
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: RIM2, Syt3-rs, 2810036I15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Hey2
Name: hairy/enhancer-of-split related with YRPW motif 2
Synonyms: Hrt2, bHLHb32, Herp1, Hesr2, CHF1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15214
HGNC: HGNC:4881
Homologene: 22705
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19876
Homologene: 2206
Gsx1
Name: GS homeobox 1
Synonyms: Gsh-1, Gsh1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14842
Homologene: 17092
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: SK2, fri, bc, small conductance calcium-activated potassium channel 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Zfp869
Name: zinc finger protein 869
Synonyms: U 2-7-1, 1200003I07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66869
VEGA: 8
Homologene: 134644
Prox1
Name: prospero homeobox 1
Synonyms: A230003G05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19130
HGNC: HGNC:9459
Homologene: 2069
Gm6563
Name: predicted pseudogene 6563
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 625193
VEGA: 19
Muc20
Name: mucin 20
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224116
Homologene: 17135
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, Ugcgl1, 0910001L17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Fem1c
Name: fem 1 homolog c
Synonyms: 2610312A07Rik, 3632443A22Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240263
Homologene: 10606
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Eci3
Name: enoyl-Coenzyme A delta isomerase 3
Synonyms: 1810022C23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69123
Homologene: 74357
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Ets1
Name: E26 avian leukemia oncogene 1, 5' domain
Synonyms: Tpl1, Ets-1, p51Ets-1, p42Ets-1, vs
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23871
HGNC: HGNC:3488
Homologene: 3837
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Kcnma3, Slo3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Urod
Name: uroporphyrinogen decarboxylase
Synonyms: Uro-d
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22275
Homologene: 320
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Angpt4
Name: angiopoietin 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11602
HGNC: HGNC:487
Homologene: 36302
Ugt8a
Name: UDP galactosyltransferase 8A
Synonyms: Cgt, mCerGT, Ugt8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22239
Homologene: 20715
Dcst2
Name: DC-STAMP domain containing 2
Synonyms: LOC329702
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329702
Homologene: 16951
Igsf3
Name: immunoglobulin superfamily, member 3
Synonyms: 4833439O17Rik, 2810035F16Rik, 1700016K10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78908
HGNC: HGNC:5950
Homologene: 1182
Or4c105
Name: olfactory receptor family 4 subfamily C member 105
Synonyms: Olfr1202, MOR232-7, GA_x6K02T2Q125-50290367-50291296
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258454
Homologene: 133021
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Gpr97, A030001G24Rik, Pb99
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54672
Homologene: 18129
Dhrs1
Name: dehydrogenase/reductase 1
Synonyms: 1110029G07Rik, dehydrogenase/reductase (SDR family) member 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52585
Homologene: 41696
Prss39
Name: serine protease 39
Synonyms: Tesp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21755
Homologene: 84781
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: MDC2, 2900022I03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
Nrm
Name: nurim (nuclear envelope membrane protein)
Synonyms: 2610307M02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106582
HGNC: HGNC:8003
Homologene: 38294
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216188
Homologene: 51942
Pfpl
Name: pore forming protein-like
Synonyms: Epcs5, Epcs50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56093
VEGA: 19
Homologene: 130704
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Itgax
Name: integrin alpha X
Synonyms: Cd11c, CD11C (p150) alpha polypeptide, CR4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: Desc4, 9930032O22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320454
Homologene: 82239
Klhdc9
Name: kelch domain containing 9
Synonyms: 1190002J23Rik, ESTM31
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68874
Homologene: 66637
Slc34a3
Name: solute carrier family 34 (sodium phosphate), member 3
Synonyms: NPTIIc, Npt2c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 142681
Homologene: 15444
Cd177
Name: CD177 antigen
Synonyms: 1190003K14Rik, Pdp3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68891
Homologene: 49628
Or2y3
Name: olfactory receptor family 2 subfamily Y member 3
Synonyms: Olfr131, MOR256-4, GA_x6K02T2PSCP-2531299-2530355
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258867
Homologene: 105889
Or51f23
Name: olfactory receptor family 51 subfamily F member 23
Synonyms: GA_x6K02T2PBJ9-5513635-5514627, MOR14-10, Olfr564
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258356
Homologene: 121507
Dcun1d4
Name: defective in cullin neddylation 1 domain containing 4
Synonyms: DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100737
Homologene: 22867
Or14c41
Name: olfactory receptor family 14 subfamily C member 41
Synonyms: Olfr295, MOR220-1, GA_x6K02T2NHDJ-9539243-9538314
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258850
Homologene: 115526
Pxt1
Name: peroxisomal, testis specific 1
Synonyms: 1700001G18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69307
Vmn1r211
Name: vomeronasal 1 receptor 211
Synonyms: V1rh20
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171277
Homologene: 110880
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237886
Homologene: 45432
Grap2
Name: GRB2-related adaptor protein 2
Synonyms: Grf40, GRB2L, Grb2-related adaptor downstream of Sch, Mona, GrpL, GrbX, Gads, P38, GRID, GRAP-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17444
VEGA: 15
HGNC: HGNC:4563
Homologene: 21007
Or4g7
Name: olfactory receptor family 4 subfamily G member 7
Synonyms: MOR245-9, Olfr1288, GA_x6K02T2Q125-72530279-72531217
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258395
Homologene: 88360
Hand2
Name: heart and neural crest derivatives expressed 2
Synonyms: Hed, bHLHa26, Thing2, Ehand2, dHAND
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15111
HGNC: HGNC:4808
Homologene: 32092
Or13a23-ps1
Name: olfactory receptor family 13 subfamily A member 23, pseudogene 1
Synonyms: MOR253-15_p, Olfr537-ps1, MOR253-11P, GA_x6K02T2PBJ9-42687904-42688835
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258200
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,500,117 bp
  • C to A, chromosome 1 at 36,197,543 bp
  • C to T, chromosome 1 at 171,358,920 bp
  • A to G, chromosome 1 at 190,162,041 bp
  • A to T, chromosome 2 at 25,232,045 bp
  • A to G, chromosome 2 at 59,771,246 bp
  • A to T, chromosome 2 at 76,058,990 bp
  • T to A, chromosome 2 at 88,817,699 bp
  • T to A, chromosome 2 at 111,479,589 bp
  • T to C, chromosome 2 at 126,650,564 bp
  • A to G, chromosome 2 at 151,929,547 bp
  • C to T, chromosome 3 at 89,373,246 bp
  • T to C, chromosome 3 at 101,427,216 bp
  • T to A, chromosome 3 at 103,085,360 bp
  • G to A, chromosome 3 at 125,938,456 bp
  • T to C, chromosome 4 at 103,173,754 bp
  • T to C, chromosome 4 at 116,993,532 bp
  • A to C, chromosome 5 at 8,158,830 bp
  • T to A, chromosome 5 at 73,531,489 bp
  • C to T, chromosome 5 at 86,490,978 bp
  • T to C, chromosome 5 at 147,189,841 bp
  • T to A, chromosome 6 at 72,153,477 bp
  • A to T, chromosome 7 at 24,758,076 bp
  • A to G, chromosome 7 at 86,586,051 bp
  • T to C, chromosome 7 at 102,804,141 bp
  • T to A, chromosome 7 at 120,782,687 bp
  • G to A, chromosome 7 at 128,139,894 bp
  • T to C, chromosome 7 at 128,716,014 bp
  • T to C, chromosome 7 at 140,539,284 bp
  • G to T, chromosome 8 at 25,913,680 bp
  • T to A, chromosome 8 at 57,322,433 bp
  • A to T, chromosome 8 at 69,706,527 bp
  • G to A, chromosome 8 at 95,039,928 bp
  • A to T, chromosome 9 at 32,738,318 bp
  • G to T, chromosome 10 at 30,842,626 bp
  • T to C, chromosome 10 at 62,765,412 bp
  • C to T, chromosome 10 at 83,506,642 bp
  • A to G, chromosome 11 at 69,493,261 bp
  • T to C, chromosome 11 at 82,987,368 bp
  • A to T, chromosome 13 at 22,851,668 bp
  • A to T, chromosome 13 at 34,960,422 bp
  • A to T, chromosome 13 at 98,853,408 bp
  • A to G, chromosome 14 at 33,955,838 bp
  • T to A, chromosome 14 at 55,743,521 bp
  • A to G, chromosome 15 at 39,517,843 bp
  • A to G, chromosome 15 at 45,109,401 bp
  • A to G, chromosome 15 at 80,647,939 bp
  • G to T, chromosome 16 at 32,779,116 bp
  • G to A, chromosome 16 at 72,989,607 bp
  • A to T, chromosome 17 at 28,934,728 bp
  • A to G, chromosome 17 at 35,864,531 bp
  • A to T, chromosome 17 at 38,082,034 bp
  • A to G, chromosome 18 at 45,592,072 bp
  • T to C, chromosome 18 at 46,505,601 bp
  • T to C, chromosome 19 at 12,428,580 bp
  • A to T, chromosome 19 at 23,676,065 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8730 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068578-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.