Strain Name:
C57BL/6J-MtgxR8739Btlr/Mmmh
Stock Number:
068586-MU
Citation ID:
RRID:MMRRC_068586-MU
Other Names:
R8739 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Synonyms: C030030P04Rik, Acrb-2, [b]2-nAchR, Acrb2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11444
HGNC: HGNC:1962
Homologene: 595
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: Ggta, GALT, glycoprotein alpha galactosyl transferase 1, Ggta-1, Gal, alpha Gal, alpha3GalT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: IkappaB kinase alpha, IKK 1, IKK-alpha, IKK alpha, IKK[a], Chuk1, IKK1, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Morc3
Name: microrchidia 3
Synonyms: Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Agrn
Name: agrin
Synonyms: nmf380, NMF380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66185
Homologene: 41043
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Luzp5, Mtb, 5830426I05Rik, mCAP-G2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: 9430035O09Rik, MmRad24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Ten-m4, l7Rn3, Odz4, l(7)-3Rn, ELM2, Doc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Nrip1
Name: nuclear receptor interacting protein 1
Synonyms: 8430438I05Rik, 6030458L20Rik, RIP140
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268903
HGNC: HGNC:8001
Homologene: 2606
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Synonyms: 2810411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66313
Homologene: 41490
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Inpp4a
Name: inositol polyphosphate-4-phosphatase, type I
Synonyms: 107kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269180
HGNC: HGNC:6074
Homologene: 2871
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Spint1
Name: serine protease inhibitor, Kunitz type 1
Synonyms: HAI-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20732
Homologene: 9653
Kcnj14
Name: potassium inwardly-rectifying channel, subfamily J, member 14
Synonyms: IRK4, A930026G01Rik, Kir2.4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211480
HGNC: HGNC:6260
Homologene: 27086
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Sec31b
Name: SEC31 homolog B, COPII coat complex component
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240667
Homologene: 56708
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Pcdhb11
Name: protocadherin beta 11
Synonyms: PcdhbK, Pcdhb5E
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93882
HGNC: HGNC:8690
Homologene: 62178
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: b2b585Clo, PC6, SPC6, PC5/6A, PC5A, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: Mer3, LOC381663, Sec63d1, A330009G12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Clec4a3
Name: C-type lectin domain family 4, member a3
Synonyms: 3110037K17Rik, mDcir3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73149
Homologene: 9413
Adamts9
Name: ADAM metallopeptidase with thrombospondin type 1 motif 9
Synonyms: 1810011L16Rik, UND3, Mhdaund4, Gsfund3, 8430403M15Rik, Mhdaund3, E030027K14Rik, UND4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101401
Homologene: 18821
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
Arid5a
Name: AT-rich interaction domain 5A
Synonyms: D430024K22Rik, Mrf1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214855
Homologene: 34940
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Spmap2
Name: sperm microtubule associated protein 2
Synonyms: Theg
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21830
Homologene: 7976
Espnl
Name: espin-like
Synonyms: LOC227357
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227357
Homologene: 77795
Tfb1m
Name: transcription factor B1, mitochondrial
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224481
VEGA: 17
Homologene: 9343
Gcnt1
Name: glucosaminyl (N-acetyl) transferase 1, core 2
Synonyms: C2 GlcNAcT, IGnT, 5630400D21Rik, beta-1, 6-N-acetylglucosaminyltransferase
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14537
HGNC: HGNC:4203
Homologene: 37486
Dctd
Name: dCMP deaminase
Synonyms: 6030466N05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320685
HGNC: HGNC:2710
Homologene: 55618
Adam24
Name: ADAM metallopeptidase domain 24
Synonyms: Dtgn5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Tmx2
Name: thioredoxin-related transmembrane protein 2
Synonyms: Txndc14, 2310042M24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66958
Homologene: 9317
Or13a19
Name: olfactory receptor family 13 subfamily A member 19
Synonyms: Olfr525, GA_x6K02T2PBJ9-42472898-42473827, MOR251-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258958
Homologene: 138321
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Rnf215
Name: ring finger protein 215
Synonyms: 0610009J22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71673
Homologene: 12402
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Ttll13
Name: tubulin tyrosine ligase-like family, member 13
Synonyms: 1700111A04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269954
Homologene: 136186
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Trabd
Name: TraB domain containing
Synonyms: 5730502D15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67976
Homologene: 36427
Ankrd6
Name: ankyrin repeat domain 6
Synonyms: diversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140577
Homologene: 8967
Selenbp1
Name: selenium binding protein 1
Synonyms: Lp56, Lpsb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20341
Homologene: 2930
Or4f52
Name: olfactory receptor family 4 subfamily F member 52
Synonyms: MOR245-18, GA_x6K02T2Q125-72283260-72282322, Olfr1275
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257980
Homologene: 79419
Thrb
Name: thyroid hormone receptor beta
Synonyms: T3Rbeta, c-erbAbeta, T3R[b], Nr1a2, TR beta, Thrb2, Thrb1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21834
Homologene: 36025
Stx5a
Name: syntaxin 5A
Synonyms: syntaxin 5, 0610031F24Rik, D19Ertd627e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56389
Homologene: 2381
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Dhrs13
Name: dehydrogenase/reductase 13
Synonyms: dehydrogenase/reductase (SDR family) member 13, 2610209N15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70451
Homologene: 64807
Or4d5
Name: olfactory receptor family 4 subfamily D member 5
Synonyms: Olfr984, GA_x6K02T2PVTD-33799484-33798540, MOR239-6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258601
VEGA: 9
Homologene: 17314
Marveld3
Name: MARVEL (membrane-associating) domain containing 3
Synonyms: MARVD3, Mrvldc3, 1810006A16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73608
Homologene: 12504
Pdcd4
Name: programmed cell death 4
Synonyms: MA-3, D19Ucla1, TIS
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18569
VEGA: 19
HGNC: HGNC:8763
Homologene: 7879
Mettl17
Name: methyltransferase like 17
Synonyms: Mett11d1, 2310032K15Rik, D14Ertd209e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52535
Homologene: 11226
Rab3c
Name: RAB3C, member RAS oncogene family
Synonyms: 2700062I01Rik, 3110015B08Rik, 3110037E15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67295
VEGA: 13
Homologene: 23420
Try5
Name: trypsin 5
Synonyms: 1810049H19Rik, Tc
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 103964
Homologene: 106639
Pdf
Name: peptide deformylase (mitochondrial)
Synonyms: 2610019N19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68023
Homologene: 69354
Gm49333
Name: predicted gene, 49333
Type: Gene
Species: Mouse
Chromosome: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,319,596 bp
  • A to G, chromosome 1 at 37,383,126 bp
  • T to A, chromosome 1 at 91,344,595 bp
  • A to T, chromosome 1 at 153,144,653 bp
  • T to C, chromosome 2 at 35,402,560 bp
  • T to C, chromosome 2 at 84,675,401 bp
  • C to A, chromosome 2 at 111,231,489 bp
  • T to C, chromosome 2 at 119,248,805 bp
  • T to C, chromosome 2 at 125,620,055 bp
  • T to C, chromosome 3 at 63,870,685 bp
  • A to G, chromosome 3 at 89,762,439 bp
  • A to T, chromosome 3 at 94,937,290 bp
  • T to C, chromosome 4 at 11,540,643 bp
  • A to G, chromosome 4 at 32,806,337 bp
  • C to T, chromosome 4 at 156,172,588 bp
  • A to T, chromosome 5 at 106,898,505 bp
  • A to G, chromosome 5 at 108,591,738 bp
  • T to A, chromosome 6 at 41,311,703 bp
  • T to C, chromosome 6 at 92,854,280 bp
  • T to C, chromosome 6 at 122,967,549 bp
  • A to T, chromosome 7 at 3,825,189 bp
  • C to G, chromosome 7 at 45,819,388 bp
  • T to C, chromosome 7 at 80,253,175 bp
  • C to T, chromosome 7 at 96,905,941 bp
  • T to C, chromosome 7 at 140,322,734 bp
  • T to C, chromosome 8 at 40,680,441 bp
  • T to A, chromosome 8 at 48,138,848 bp
  • T to A, chromosome 8 at 107,047,164 bp
  • T to C, chromosome 8 at 109,961,977 bp
  • C to T, chromosome 9 at 18,637,298 bp
  • G to A, chromosome 9 at 40,101,340 bp
  • T to C, chromosome 9 at 67,258,273 bp
  • A to G, chromosome 9 at 119,967,305 bp
  • G to T, chromosome 10 at 79,583,747 bp
  • T to G, chromosome 11 at 4,135,959 bp
  • A to G, chromosome 11 at 60,477,262 bp
  • G to C, chromosome 11 at 78,032,666 bp
  • G to T, chromosome 11 at 106,852,496 bp
  • T to A, chromosome 12 at 38,228,324 bp
  • T to C, chromosome 12 at 110,614,580 bp
  • T to G, chromosome 12 at 116,415,478 bp
  • T to C, chromosome 13 at 100,629,490 bp
  • T to C, chromosome 13 at 110,260,601 bp
  • A to G, chromosome 14 at 17,963,082 bp
  • T to C, chromosome 14 at 51,891,391 bp
  • T to C, chromosome 15 at 8,303,420 bp
  • G to A, chromosome 15 at 28,345,860 bp
  • T to C, chromosome 15 at 89,084,949 bp
  • T to G, chromosome 16 at 15,808,204 bp
  • G to A, chromosome 16 at 20,630,915 bp
  • A to C, chromosome 16 at 76,291,348 bp
  • T to A, chromosome 16 at 93,860,510 bp
  • T to C, chromosome 17 at 3,519,652 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • T to A, chromosome 18 at 37,422,496 bp
  • A to T, chromosome 19 at 8,748,560 bp
  • A to T, chromosome 19 at 17,330,073 bp
  • G to T, chromosome 19 at 17,454,774 bp
  • A to G, chromosome 19 at 44,088,696 bp
  • G to A, chromosome 19 at 44,519,181 bp
  • T to A, chromosome 19 at 53,910,974 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8739 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068586-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.