Strain Name:
C57BL/6J-MtgxR8748Btlr/Mmmh
Stock Number:
068591-MU
Citation ID:
RRID:MMRRC_068591-MU
Other Names:
R8748 (G1)
Major Collection:

Strain Information

Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SW1/SNF, Brg1, b2b508.1Clo, b2b692Clo, SNF2beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Rpl3
Name: ribosomal protein L3
Synonyms: F2, J1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27367
Homologene: 747
Ccdc91
Name: coiled-coil domain containing 91
Synonyms: 1700086G08Rik, 1810060J02Rik, p56
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67015
Homologene: 10131
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Pgr
Name: progesterone receptor
Synonyms: PR-A, 9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Phrf1
Name: PHD and ring finger domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101471
Homologene: 16377
Chpf2
Name: chondroitin polymerizing factor 2
Synonyms: 2010209O12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100910
Homologene: 14763
Eif4ebp2
Name: eukaryotic translation initiation factor 4E binding protein 2
Synonyms: 4E-BP2, PHAS-II, 2810011I19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13688
VEGA: 10
HGNC: HGNC:3289
Homologene: 3022
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Sh3d1B, Eh domain, SH3 domain regulator of endocytosis 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Fam13c
Name: family with sequence similarity 13, member C
Synonyms: C030038O19Rik, 1200015N20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71721
Homologene: 11490
Cyp20a1
Name: cytochrome P450, family 20, subfamily a, polypeptide 1
Synonyms: A930011N14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77951
Homologene: 18584
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E21Rik, Myospryn, 2310076E16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277978
Homologene: 18629
Dmrt3
Name: doublesex and mab-3 related transcription factor 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240590
VEGA: 19
Homologene: 10935
Abca8b
Name: ATP-binding cassette, sub-family A member 8b
Synonyms: Abca8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Hycc1
Name: hyccin PI4KA lipid kinase complex subunit 1
Synonyms: hyccin, Fam126a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 84652
Homologene: 57175
Unc5d
Name: unc-5 netrin receptor D
Synonyms: D930029E11Rik, Unc5h4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210801
Homologene: 15450
Tmem144
Name: transmembrane protein 144
Synonyms: 5730537D05Rik, 1110057I03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70652
Homologene: 41250
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Postn
Name: periostin, osteoblast specific factor
Synonyms: Periostin, Osf2, A630052E07Rik, OSF-2, peri
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50706
Homologene: 4730
Cts8
Name: cathepsin 8
Synonyms: CTS2, Epcs68, Epcs70
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56094
VEGA: 13
Homologene: 129897
Acte1
Name: actin, epsilon 1
Synonyms: Gm498, LOC244239
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93880
HGNC: HGNC:8689
Homologene: 87124
Mtnr1a
Name: melatonin receptor 1A
Synonyms: Mel1a receptor, MelR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17773
HGNC: HGNC:7463
Homologene: 21207
Ildr1
Name: immunoglobulin-like domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106347
Homologene: 15892
Bscl2
Name: BSCL2 lipid droplet biogenesis associated, seipin
Synonyms: seipin, Gng3lg
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14705
Homologene: 32032
Six5
Name: sine oculis-related homeobox 5
Synonyms: TrexBF, Dmahp, MDMAHP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20475
Homologene: 72248
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Vmn1r74
Name: vomeronasal 1 receptor 74
Synonyms: V1rg5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171240
Homologene: 110796
Zfp184
Name: zinc finger protein 184 (Kruppel-like)
Synonyms: 4930500C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193452
Homologene: 113602
Or10d3
Name: olfactory receptor family 10 subfamily D member 3
Synonyms: MOR224-9, Olfr958, GA_x6K02T2PVTD-33247839-33246901
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258327
VEGA: 9
HGNC: HGNC:8168
Homologene: 27128
Or11h6
Name: olfactory receptor family 11 subfamily H member 6
Synonyms: MOR106-11, GA_x6K02T2PMLR-6361495-6362481, Olfr745
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258296
Homologene: 27116
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233893
Homologene: 62158
Or10v5
Name: olfactory receptor family 10 subfamily V member 5
Synonyms: Olfr1417, MOR266-2, GA_x6K02T2RE5P-2172809-2171862
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258938
Homologene: 27304
Casd1
Name: CAS1 domain containing 1
Synonyms: Cast1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213819
Homologene: 11287
Zfp583
Name: zinc finger protein 583
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213011
Homologene: 65048
Pate13
Name: prostate and testis expressed 13
Synonyms: 9230113P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77908
Tex46
Name: testis expressed 46
Synonyms: 4930549C01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67663
Homologene: 136495
Gm37240
Name: predicted gene, 37240
Type: Gene
Species: Mouse
Chromosome: 3
Rbmyf9
Name: RNA binding motif protein Y-linked family member 9
Synonyms: Gm3376
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 100041505
Homologene: 136626
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,353,022 bp
  • A to G, chromosome 3 at 54,389,339 bp
  • A to G, chromosome 3 at 79,836,232 bp
  • A to G, chromosome 3 at 84,497,738 bp
  • A to G, chromosome 3 at 95,064,384 bp
  • A to G, chromosome 3 at 148,826,390 bp
  • T to C, chromosome 4 at 123,474,275 bp
  • C to T, chromosome 4 at 136,610,497 bp
  • T to A, chromosome 5 at 23,965,322 bp
  • T to C, chromosome 5 at 24,591,823 bp
  • T to A, chromosome 6 at 4,608,634 bp
  • T to C, chromosome 6 at 147,562,696 bp
  • C to T, chromosome 7 at 6,316,420 bp
  • T to A, chromosome 7 at 11,846,976 bp
  • A to G, chromosome 7 at 19,095,124 bp
  • T to C, chromosome 7 at 127,404,690 bp
  • T to C, chromosome 7 at 141,258,235 bp
  • T to C, chromosome 7 at 143,891,819 bp
  • T to C, chromosome 8 at 28,696,425 bp
  • T to C, chromosome 8 at 45,085,638 bp
  • T to C, chromosome 8 at 105,290,145 bp
  • C to A, chromosome 9 at 8,958,448 bp
  • A to T, chromosome 9 at 15,922,865 bp
  • A to G, chromosome 9 at 21,634,868 bp
  • A to C, chromosome 9 at 35,909,055 bp
  • C to G, chromosome 9 at 39,550,415 bp
  • C to A, chromosome 9 at 39,550,416 bp
  • A to G, chromosome 9 at 95,932,423 bp
  • A to T, chromosome 10 at 61,435,027 bp
  • T to A, chromosome 10 at 70,542,686 bp
  • A to T, chromosome 11 at 109,945,771 bp
  • A to G, chromosome 12 at 4,701,337 bp
  • A to T, chromosome 12 at 109,595,058 bp
  • G to A, chromosome 13 at 21,960,047 bp
  • A to T, chromosome 13 at 61,249,272 bp
  • T to A, chromosome 13 at 93,089,721 bp
  • G to T, chromosome 14 at 50,642,754 bp
  • G to A, chromosome 14 at 97,828,334 bp
  • T to C, chromosome 15 at 80,079,701 bp
  • A to C, chromosome 16 at 36,722,372 bp
  • G to A, chromosome 16 at 87,719,291 bp
  • A to G, chromosome 17 at 33,912,164 bp
  • G to A, chromosome 18 at 37,402,848 bp
  • A to G, chromosome 19 at 8,847,947 bp
  • A to G, chromosome 19 at 11,828,232 bp
  • G to A, chromosome 19 at 25,611,186 bp
  • T to A, chromosome Y at 3,774,915 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8748 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068591-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.