Strain Name:
C57BL/6J-MtgxR8749Btlr/Mmmh
Stock Number:
068592-MU
Citation ID:
RRID:MMRRC_068592-MU
Other Names:
R8749 (G1)
Major Collection:

Strain Information

Upp1
Name: uridine phosphorylase 1
Synonyms: UdRPase, UPase, Up
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22271
Homologene: 2524
Oxr1
Name: oxidation resistance 1
Synonyms: C7B, C7, 2210416C20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170719
VEGA: 15
Homologene: 24993
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Ggtb3, 2610509D04Rik, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: rim2, recombination induced mutation 2, Hps2, beta3A, AP-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Lpar6
Name: lysophosphatidic acid receptor 6
Synonyms: 2610302I02Rik, P2y5, P2ry5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67168
Homologene: 55925
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, ba, rh, rh-bmh, bldy
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58996
Homologene: 104145
Zfp961
Name: zinc finger protein 961
Synonyms: A230105L22Rik, BC049349
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234413
Homologene: 136286
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Zfp600
Name: zinc finger protein 600
Synonyms: Gm13164
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 667666
Homologene: 133076
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
Pcdhb16
Name: protocadherin beta 16
Synonyms: PcdhbP, Pcdhb8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93887
Homologene: 99843
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Umod
Name: uromodulin
Synonyms: Tamm-Horsfall glycoprotein, uromucoid, urehr4, Urehd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22242
Homologene: 2522
Prf1
Name: perforin 1 (pore forming protein)
Synonyms: perforin, Prf-1, Pfp, Pfn
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18646
VEGA: 10
HGNC: HGNC:9360
Homologene: 3698
Yif1b
Name: Yip1 interacting factor homolog B (S. cerevisiae)
Synonyms: 9430029K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77254
Homologene: 60114
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14789
Homologene: 8401
Fmnl3
Name: formin-like 3
Synonyms: 2700073B04Rik, Wbp3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22379
Homologene: 69101
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
G6pc2
Name: glucose-6-phosphatase, catalytic, 2
Synonyms: IGRP, islet specific glucose-6-phosphatase, G6pc-rs
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14378
Homologene: 41423
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70155
Homologene: 11595
Or4f62
Name: olfactory receptor family 4 subfamily F member 62
Synonyms: GA_x6K02T2Q125-73202172-73203134, MOR245-16, Olfr1318
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258022
Homologene: 134079
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241514
Homologene: 18461
Ciz1
Name: CDKN1A interacting zinc finger protein 1
Synonyms: 0610038H21Rik, 2900056O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68379
Homologene: 8112
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Dmrt3
Name: doublesex and mab-3 related transcription factor 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240590
VEGA: 19
Homologene: 10935
Or4k37
Name: olfactory receptor family 4 subfamily K member 37
Synonyms: GA_x6K02T2Q125-72379864-72380781, MOR248-18, MOR248-14P, Olfr1281
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257979
Homologene: 73992
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Tmem132c
Name: transmembrane protein 132C
Synonyms: 4632425D07Rik, 2810482M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208213
Homologene: 76567
Il12b
Name: interleukin 12b
Synonyms: Il-12p40, IL-12 p40, Il-12b, IL-23 subunit p40
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16160
HGNC: HGNC:5970
Homologene: 1648
Mpeg1
Name: macrophage expressed gene 1
Synonyms: Mpg-1, MPS1, Perforin-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17476
VEGA: 19
Homologene: 11216
Slc29a4
Name: solute carrier family 29 (nucleoside transporters), member 4
Synonyms: ENT4, mPMAT
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243328
Homologene: 71345
Tnfsf18
Name: tumor necrosis factor (ligand) superfamily, member 18
Synonyms: Gitrl, GITR ligand
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240873
Homologene: 3732
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384219
Homologene: 129606
Vmn1r168
Name: vomeronasal 1 receptor 168
Synonyms: Gm10659
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043101
Homologene: 122945
Wdr77
Name: WD repeat domain 77
Synonyms: 2610312E17Rik, p44/MEP50, 2610003I18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70465
Homologene: 11466
Zfp316
Name: zinc finger protein 316
Synonyms: Emzf1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54201
Homologene: 69231
Mtcl3
Name: MTCL family member 3
Synonyms: 6330407J23Rik, Soga3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67412
VEGA: 10
Homologene: 28227
Dusp15
Name: dual specificity phosphatase-like 15
Synonyms: T-DSP10, LMW-DSP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 252864
Homologene: 33586
Prr30
Name: proline rich 30
Synonyms: 1700110M21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76627
Homologene: 130773
Uck1
Name: uridine-cytidine kinase 1
Synonyms: URK1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22245
Homologene: 7990
Akr1c12
Name: aldo-keto reductase family 1, member C12
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 622402
HGNC: HGNC:387
Homologene: 121208
Vmn1r180
Name: vomeronasal 1 receptor 180
Synonyms: LOC232962, V1rd16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232962
Homologene: 104166
Creb3l4
Name: cAMP responsive element binding protein 3-like 4
Synonyms: 5330432F22Rik, ATCE1, 1700012K17Rik, mJAL, JAL, Tisp40beta, Tisp40alpha, Tisp40
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78284
Homologene: 12693
Prkra
Name: protein kinase, interferon inducible double stranded RNA dependent activator
Synonyms: RAX, Pact, PRK, lear
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23992
HGNC: HGNC:9438
Homologene: 2738
Galk1
Name: galactokinase 1
Synonyms: Glk1, Glk
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14635
HGNC: HGNC:4118
Homologene: 125
H3c3
Name: H3 clustered histone 3
Synonyms: H3-143, Hist1h3c
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319148
Homologene: 134489
Tmem100
Name: transmembrane protein 100
Synonyms: 1810057C19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67888
Homologene: 10110
Or4x12-ps1
Name: olfactory receptor family 4 subfamily X member 12, pseudogene 1
Synonyms: GA_x6K02T2Q125-51518604-51517675, MOR228-1, Olfr1267-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258204
Pet117
Name: PET117 homolog
Synonyms: Gm20571
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100048644
Homologene: 130056
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 23,370,318 bp
  • T to A, chromosome 1 at 110,099,279 bp
  • A to G, chromosome 1 at 161,503,478 bp
  • T to C, chromosome 2 at 32,256,512 bp
  • A to T, chromosome 2 at 32,365,836 bp
  • T to C, chromosome 2 at 52,290,851 bp
  • A to G, chromosome 2 at 69,226,796 bp
  • A to G, chromosome 2 at 76,630,535 bp
  • T to C, chromosome 2 at 82,257,575 bp
  • T to C, chromosome 2 at 90,086,287 bp
  • T to C, chromosome 2 at 111,328,472 bp
  • A to G, chromosome 2 at 112,156,524 bp
  • C to A, chromosome 2 at 144,373,202 bp
  • T to A, chromosome 2 at 152,946,289 bp
  • T to C, chromosome 3 at 90,237,892 bp
  • T to A, chromosome 3 at 105,959,659 bp
  • C to T, chromosome 4 at 139,402,624 bp
  • T to A, chromosome 4 at 145,138,613 bp
  • T to A, chromosome 4 at 145,537,586 bp
  • T to A, chromosome 4 at 146,196,581 bp
  • C to T, chromosome 5 at 101,882,580 bp
  • A to G, chromosome 5 at 109,047,453 bp
  • A to G, chromosome 5 at 127,359,939 bp
  • A to G, chromosome 5 at 142,715,064 bp
  • A to G, chromosome 5 at 143,262,810 bp
  • G to A, chromosome 6 at 124,845,977 bp
  • T to A, chromosome 7 at 12,651,869 bp
  • A to T, chromosome 7 at 23,541,003 bp
  • G to T, chromosome 7 at 23,952,990 bp
  • C to T, chromosome 7 at 29,247,265 bp
  • A to G, chromosome 7 at 86,954,305 bp
  • T to A, chromosome 7 at 119,471,416 bp
  • A to G, chromosome 8 at 22,028,318 bp
  • T to C, chromosome 8 at 71,965,842 bp
  • T to C, chromosome 9 at 7,035,063 bp
  • C to T, chromosome 9 at 53,499,197 bp
  • T to C, chromosome 9 at 123,189,962 bp
  • T to C, chromosome 10 at 29,196,725 bp
  • T to C, chromosome 10 at 61,303,169 bp
  • A to T, chromosome 11 at 9,129,561 bp
  • A to T, chromosome 11 at 44,404,037 bp
  • G to A, chromosome 11 at 90,035,748 bp
  • T to A, chromosome 11 at 97,500,815 bp
  • A to T, chromosome 11 at 116,008,936 bp
  • A to G, chromosome 11 at 116,229,406 bp
  • C to T, chromosome 13 at 4,270,156 bp
  • T to C, chromosome 13 at 23,745,125 bp
  • T to A, chromosome 13 at 94,528,217 bp
  • G to A, chromosome 14 at 70,558,070 bp
  • A to T, chromosome 14 at 73,239,510 bp
  • T to A, chromosome 14 at 101,198,929 bp
  • A to G, chromosome 15 at 41,710,864 bp
  • A to T, chromosome 15 at 99,321,441 bp
  • G to A, chromosome 16 at 15,783,165 bp
  • G to A, chromosome 16 at 87,719,291 bp
  • C to T, chromosome 17 at 24,504,800 bp
  • A to T, chromosome 18 at 37,479,339 bp
  • A to T, chromosome 18 at 43,989,358 bp
  • A to T, chromosome 18 at 49,955,870 bp
  • G to C, chromosome 18 at 60,829,051 bp
  • G to A, chromosome 19 at 12,461,927 bp
  • G to A, chromosome 19 at 25,611,186 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8749 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068592-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.