Strain Name:
C57BL/6J-MtgxR8781Btlr/Mmmh
Stock Number:
068605-MU
Citation ID:
RRID:MMRRC_068605-MU
Other Names:
R8781 (G1)
Major Collection:

Strain Information

Pknox1
Name: Pbx/knotted 1 homeobox
Synonyms: PREP1, D17Wsu76e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18771
HGNC: HGNC:9022
Homologene: 3363
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Pde1b
Name: phosphodiesterase 1B, Ca2+-calmodulin dependent
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18574
VEGA: 15
HGNC: HGNC:8775
Homologene: 37370
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Suco
Name: SUN domain containing ossification factor
Synonyms: osteopotentia, Opt, AI848100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226551
HGNC: HGNC:1240
Homologene: 32212
Ddx54
Name: DEAD box helicase 54
Synonyms: APR-5, DP97, 2410015A15Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71990
Homologene: 5590
Cog5
Name: component of oligomeric golgi complex 5
Synonyms: GOLTC1, GTC90, 5430405C01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238123
VEGA: 12
Homologene: 42221
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Parg
Name: poly (ADP-ribose) glycohydrolase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26430
HGNC: HGNC:8605
Homologene: 50532
Wdr12
Name: WD repeat domain 12
Synonyms: Ytm1, Ytm1p, 4933402C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57750
Homologene: 10098
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: LOC237436, 8430435B07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Cyth1
Name: cytohesin 1
Synonyms: CLM1, CTH-1, Pscd1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19157
HGNC: HGNC:9501
Homologene: 31262
Kri1
Name: KRI1 homolog
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215194
Homologene: 133742
Fam81a
Name: family with sequence similarity 81, member A
Synonyms: 6430514L14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76886
Homologene: 17584
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Tcp1
Name: t-complex protein 1
Synonyms: Ccta, c-cpn, TRic, CCT, Tcp-1, Tp63, p63, Cct1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21454
Homologene: 5656
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Klf6
Name: Kruppel-like transcription factor 6
Synonyms: Zf9, FM6, FM2, BCD1, Ierepo1, Ierepo3, Copeb, CPBP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 23849
VEGA: 13
HGNC: HGNC:2235
Homologene: 996
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, 2010013B10Rik, A230048G03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Tmprss4
Name: transmembrane protease, serine 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214523
Homologene: 80930
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, bob, nmf112, nmf181, nmf252, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Trim29
Name: tripartite motif-containing 29
Synonyms: 2810431N19Rik, 4732461M22Rik, 1110047J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72169
VEGA: 9
Homologene: 8100
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Stk31
Name: serine threonine kinase 31
Synonyms: C330007K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77485
Homologene: 12677
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V3R4, V1rd4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81014
Homologene: 41799
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: LOC380730, Gm884
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Usp12
Name: ubiquitin specific peptidase 12
Synonyms: Ubh1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22217
Homologene: 56137
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233437
Homologene: 115466
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665210
Homologene: 115024
Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Synonyms: 2410127E16Rik, Liprin-alpha3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76787
HGNC: HGNC:9247
Homologene: 37833
Smg8
Name: SMG8 nonsense mediated mRNA decay factor
Synonyms: 1200011M11Rik, smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74133
Homologene: 32393
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: 4933427B05Rik, SYPH1, synphilin-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67847
Homologene: 3987
Pla2g3
Name: phospholipase A2, group III
Synonyms: 9130003P18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237625
Homologene: 9251
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192166
Homologene: 5149
Yipf5
Name: Yip1 domain family, member 5
Synonyms: Yip1a, 2610311I19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67180
VEGA: 18
Homologene: 56969
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627479
Homologene: 129606
Kif28
Name: kinesin family member 28
Synonyms: LOC383592, Gm1305
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383592
Homologene: 130945
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Fbp1
Name: fructose bisphosphatase 1
Synonyms: FBPase brain isoform, FBPase liver, Fbp-2, Fbp3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14121
HGNC: HGNC:3606
Homologene: 55467
Erp27
Name: endoplasmic reticulum protein 27
Synonyms: 1810047B09Rik, 1810033M07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69187
Homologene: 12303
Tmem19
Name: transmembrane protein 19
Synonyms: 2810428F02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67226
VEGA: 10
Homologene: 10107
Fhit
Name: fragile histidine triad gene
Synonyms: Fra14A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14198
HGNC: HGNC:3701
Homologene: 21661
Hsf2bp
Name: heat shock transcription factor 2 binding protein
Synonyms: 4932437G14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74377
HGNC: HGNC:5226
Homologene: 38263
Tas2r138
Name: taste receptor, type 2, member 138
Synonyms: mt2r31, Tas2r38, T2R138
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387513
HGNC: HGNC:9584
Homologene: 47976
Ccdc183
Name: coiled-coil domain containing 183
Synonyms: Cccd183, 4921530D09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77058
Homologene: 50023
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74772
Homologene: 56940
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
1810055G02Rik
Name: RIKEN cDNA 1810055G02 gene
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72056
VEGA: 19
HGNC: HGNC:1174
Homologene: 11174
Or52j3
Name: olfactory receptor family 52 subfamily J member 3
Synonyms: GA_x6K02T2PBJ9-5902266-5903204, MOR0-3P, MOR0-3P, MOR32-13, Olfr1525-ps1, Olfr592
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404317
Homologene: 66215
Zfp768
Name: zinc finger protein 768
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233890
Homologene: 11650
Or2b2b
Name: olfactory receptor family 2 subfamily B member 2B
Synonyms: GA_x6K02T2QHY8-11561962-11562903, MOR256-35, MOR256-10, Olfr1360
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258536
Homologene: 11056
Vmn2r31
Name: vomeronasal 2, receptor 31
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042591
Homologene: 113703
Or8c14-ps1
Name: olfactory receptor family 8 subfamily C member 14, pseudogene 1
Synonyms: GA_x6K02T2PVTD-31869885-31870831, MOR170-12, Olfr892-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257911
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,087,141 bp
  • G to A, chromosome 1 at 75,407,021 bp
  • A to G, chromosome 1 at 128,287,524 bp
  • A to G, chromosome 1 at 161,818,382 bp
  • G to T, chromosome 1 at 179,697,916 bp
  • T to A, chromosome 2 at 25,612,196 bp
  • T to A, chromosome 2 at 27,196,703 bp
  • T to A, chromosome 2 at 34,720,686 bp
  • T to C, chromosome 2 at 66,737,431 bp
  • T to A, chromosome 4 at 140,996,380 bp
  • A to G, chromosome 5 at 108,797,731 bp
  • G to T, chromosome 5 at 120,613,152 bp
  • C to A, chromosome 5 at 146,763,362 bp
  • A to G, chromosome 6 at 40,612,916 bp
  • A to T, chromosome 6 at 49,406,775 bp
  • G to A, chromosome 6 at 136,909,460 bp
  • T to G, chromosome 7 at 5,410,483 bp
  • C to T, chromosome 7 at 7,384,401 bp
  • C to T, chromosome 7 at 45,348,529 bp
  • C to T, chromosome 7 at 84,995,147 bp
  • T to A, chromosome 7 at 103,186,875 bp
  • A to G, chromosome 7 at 127,343,304 bp
  • CTGCTGTGAAATG to C, chromosome 8 at 48,342,449 bp
  • C to T, chromosome 8 at 70,769,402 bp
  • A to T, chromosome 9 at 21,280,452 bp
  • T to G, chromosome 9 at 38,190,089 bp
  • T to A, chromosome 9 at 43,311,318 bp
  • T to C, chromosome 9 at 45,176,442 bp
  • C to A, chromosome 9 at 67,255,951 bp
  • T to A, chromosome 9 at 70,125,099 bp
  • C to T, chromosome 9 at 78,636,647 bp
  • C to T, chromosome 10 at 60,331,788 bp
  • T to C, chromosome 10 at 89,430,979 bp
  • T to C, chromosome 10 at 115,359,658 bp
  • C to A, chromosome 11 at 3,488,530 bp
  • G to A, chromosome 11 at 87,080,321 bp
  • T to A, chromosome 11 at 103,618,132 bp
  • C to T, chromosome 11 at 118,182,243 bp
  • T to A, chromosome 12 at 31,833,250 bp
  • T to A, chromosome 13 at 5,865,072 bp
  • A to G, chromosome 13 at 21,674,843 bp
  • T to G, chromosome 13 at 62,869,017 bp
  • T to A, chromosome 13 at 100,219,830 bp
  • A to G, chromosome 14 at 10,421,503 bp
  • T to A, chromosome 14 at 32,214,443 bp
  • A to T, chromosome 14 at 54,759,539 bp
  • G to A, chromosome 15 at 103,525,300 bp
  • C to T, chromosome 16 at 5,097,936 bp
  • C to T, chromosome 16 at 56,606,149 bp
  • T to C, chromosome 17 at 12,924,376 bp
  • T to A, chromosome 17 at 18,085,061 bp
  • T to A, chromosome 17 at 30,725,104 bp
  • G to A, chromosome 17 at 31,602,863 bp
  • C to G, chromosome 17 at 32,033,267 bp
  • C to T, chromosome 17 at 57,255,313 bp
  • A to T, chromosome 17 at 78,795,309 bp
  • A to T, chromosome 18 at 40,207,699 bp
  • T to C, chromosome 18 at 52,906,542 bp
  • T to C, chromosome 18 at 54,898,729 bp
  • A to G, chromosome 18 at 58,061,647 bp
  • A to G, chromosome 19 at 3,717,538 bp
  • G to A, chromosome 19 at 4,620,952 bp
  • C to T, chromosome 19 at 41,585,259 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8781 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068605-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.