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Strain Name:
C57BL/6J-MtgxR8791Btlr/Mmmh
Stock Number:
068609-MU
Citation ID:
RRID:MMRRC_068609-MU
Other Names:
R8791 (G1)
Major Collection:

Strain Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1, NFATp, NFAT1-D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Fgf4
Name: fibroblast growth factor 4
Synonyms: Hst1, kFGF, Fgf-4, Hstf-1, Fgfk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14175
HGNC: HGNC:3682
Homologene: 1522
Pias3
Name: protein inhibitor of activated STAT 3
Synonyms: Pias3L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229615
Homologene: 4447
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Esrrb
Name: estrogen related receptor, beta
Synonyms: Estrrb, ERRb, ERR2, Err2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26380
HGNC: HGNC:3473
Homologene: 69108
Zcchc8
Name: zinc finger, CCHC domain containing 8
Synonyms: 5730565F05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70650
Homologene: 32349
Zfp516
Name: zinc finger protein 516
Synonyms: C330029B10Rik, Zfp26l
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Wdr76
Name: WD repeat domain 76
Synonyms: 5830411K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241627
Homologene: 38573
Cd63
Name: CD63 antigen
Synonyms: ME491, Tspan30
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12512
VEGA: 10
HGNC: HGNC:1692
Homologene: 37526
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Apba3
Name: amyloid beta precursor protein binding family A member 3
Synonyms: Mint-3, neuronal munc18-1-interacting protein 3, neuron-specific X11L2 protein, X11gamma, lin-10, Mint 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57267
VEGA: 10
HGNC: HGNC:580
Homologene: 3591
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, SEC3, A730011E05Rik, 2810407P21Rik, Sec3l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69940
Homologene: 41241
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: ADAR1, mZaADAR, Adar1p150, Adar1p110
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: Nalp-eta, E330028A19Rik, Nalp4a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243880
Homologene: 79696
Trim17
Name: tripartite motif-containing 17
Synonyms: terf, Rnf16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56631
Homologene: 9387
Nkpd1
Name: NTPase, KAP family P-loop domain containing 1
Synonyms: 2310015G09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69547
Homologene: 18876
Slc4a8
Name: solute carrier family 4 (anion exchanger), member 8
Synonyms: sodium bicarbonate cotransporter isoform 3 kNBC-3, KNBC-3, NDCBE
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 59033
Homologene: 68419
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Rint1
Name: RAD50 interactor 1
Synonyms: 2810450M21Rik, 1500019C06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72772
Homologene: 11070
Rnh1
Name: ribonuclease/angiogenin inhibitor 1
Synonyms: RNH
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 107702
Homologene: 2204
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: Agtr-1b, AT1B, Angtr-1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Mmp15
Name: matrix metallopeptidase 15
Synonyms: MT2-MMP, Membrane type 2-MMP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Ildr1
Name: immunoglobulin-like domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106347
Homologene: 15892
Fcgr4
Name: Fc receptor, IgG, low affinity IV
Synonyms: CD16-2, 4833442P21Rik, FcgammaRIV, Fcgr3a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246256
Homologene: 477
Ccdc149
Name: coiled-coil domain containing 149
Synonyms: LOC242997, Gm447
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503884
Homologene: 65264
Tmc1
Name: transmembrane channel-like gene family 1
Synonyms: Bth, Beethoven, 4933416G09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13409
VEGA: 19
Homologene: 23670
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: Idh-1, Id-1, E030024J03Rik, IDPc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Or5p50
Name: olfactory receptor family 5 subfamily P member 50
Synonyms: GA_x6K02T2PBJ9-10152980-10152036, MOR204-21, Olfr469
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258418
Homologene: 44979
Dgki
Name: diacylglycerol kinase, iota
Synonyms: C130010K08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320127
HGNC: HGNC:2855
Homologene: 37956
Rnf148
Name: ring finger protein 148
Synonyms: Greul3, 4933432M07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71300
Homologene: 82404
Tpi1
Name: triosephosphate isomerase 1
Synonyms: Tpi-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21991
Homologene: 128432
Clvs1
Name: clavesin 1
Synonyms: 4933402J24Rik, Rlbp1l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74438
Homologene: 65267
Vmn1r199
Name: vomeronasal 1 receptor 199
Synonyms: V1rh4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171247
Homologene: 110880
Snx31
Name: sorting nexin 31
Synonyms: 4631426E05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66696
Homologene: 23551
Akr1c6
Name: aldo-keto reductase family 1, member C6
Synonyms: estradiol 17-beta-dehydrogenase (A-specific), 3alpha-HSD, Akr1c1, Hsd17b5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83702
Homologene: 84695
Lrfn1
Name: leucine rich repeat and fibronectin type III domain containing 1
Synonyms: SALM2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80749
Homologene: 12729
Gm20939
Name: predicted gene, 20939
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100044193
VEGA: 17
Nme9
Name: NME/NM23 family member 9
Synonyms: Txndc6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 623534
Homologene: 52255
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 62,749,197 bp
  • CA to CAA, chromosome 1 at 65,165,188 bp
  • C to A, chromosome 1 at 171,019,908 bp
  • G to T, chromosome 2 at 103,992,677 bp
  • C to T, chromosome 2 at 121,527,003 bp
  • T to C, chromosome 2 at 168,536,294 bp
  • T to A, chromosome 3 at 20,316,116 bp
  • A to G, chromosome 3 at 55,121,679 bp
  • T to C, chromosome 3 at 87,779,683 bp
  • G to A, chromosome 3 at 89,736,138 bp
  • C to A, chromosome 3 at 96,704,885 bp
  • A to G, chromosome 4 at 9,429,807 bp
  • T to C, chromosome 5 at 23,800,596 bp
  • C to T, chromosome 5 at 52,439,210 bp
  • C to T, chromosome 5 at 76,535,565 bp
  • T to C, chromosome 5 at 123,707,299 bp
  • T to A, chromosome 5 at 150,542,596 bp
  • A to T, chromosome 6 at 23,654,994 bp
  • A to T, chromosome 6 at 37,019,940 bp
  • A to G, chromosome 6 at 124,812,520 bp
  • G to C, chromosome 7 at 19,524,170 bp
  • C to A, chromosome 7 at 26,444,136 bp
  • A to G, chromosome 7 at 28,459,919 bp
  • C to T, chromosome 7 at 107,823,350 bp
  • C to T, chromosome 7 at 141,162,433 bp
  • T to C, chromosome 7 at 144,861,671 bp
  • C to T, chromosome 8 at 95,369,660 bp
  • T to A, chromosome 9 at 99,468,248 bp
  • T to A, chromosome 10 at 81,269,270 bp
  • C to T, chromosome 10 at 83,550,884 bp
  • C to A, chromosome 10 at 128,912,202 bp
  • A to G, chromosome 11 at 49,823,216 bp
  • T to A, chromosome 11 at 54,568,469 bp
  • A to G, chromosome 11 at 58,971,176 bp
  • A to T, chromosome 11 at 97,351,913 bp
  • A to G, chromosome 12 at 86,470,282 bp
  • T to A, chromosome 13 at 4,449,374 bp
  • T to A, chromosome 13 at 22,383,517 bp
  • T to G, chromosome 14 at 50,963,416 bp
  • C to T, chromosome 14 at 60,691,826 bp
  • A to G, chromosome 15 at 8,187,260 bp
  • A to T, chromosome 15 at 36,537,532 bp
  • T to C, chromosome 15 at 100,807,253 bp
  • T to C, chromosome 16 at 36,708,400 bp
  • A to C, chromosome 17 at 94,877,220 bp
  • A to T, chromosome 18 at 65,305,526 bp
  • T to C, chromosome 18 at 82,957,335 bp
  • T to C, chromosome 19 at 20,789,845 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8791 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068609-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.