Strain Name:
C57BL/6J-MtgxR8715Btlr/Mmmh
Stock Number:
068613-MU
Citation ID:
RRID:MMRRC_068613-MU
Other Names:
R8715 (G1)
Major Collection:

Strain Information

Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Card11
Name: caspase recruitment domain family, member 11
Synonyms: 0610008L17Rik, CARMA1, 2410011D02Rik, BIMP3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, Arhgap7, A730069N07Rik, STARD12
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Rspry1
Name: ring finger and SPRY domain containing 1
Synonyms: 4930470D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67610
Homologene: 12164
Ccdc60
Name: coiled-coil domain containing 60
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269693
Homologene: 18624
Armc10
Name: armadillo repeat containing 10
Synonyms: 2810037C14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67211
Homologene: 12097
Msh6
Name: mutS homolog 6
Synonyms: Gtmbp, GTBP, Msh6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Rab7
Name: RAB7, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19349
HGNC: HGNC:9788
Homologene: 3408
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Shisal1
Name: shisa like 1
Synonyms: 1810041L15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72301
Homologene: 28255
Tm9sf3
Name: transmembrane 9 superfamily member 3
Synonyms: 2810031D16Rik, 1810073M23Rik, Smbp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107358
VEGA: 19
Homologene: 10588
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 5730470G24Rik, CCCAP, 2700048G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76816
Homologene: 4839
Cd209d
Name: CD209d antigen
Synonyms: SIGN-R3, SIGNR3, mSIGNR3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170779
HGNC: HGNC:1641
Homologene: 8603
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: Dpde3, 9630011N22Rik, dunce
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: Ttc40, 9330101J02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Cyp2c66
Name: cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms: 2010301M18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69888
Homologene: 133566
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Gsap
Name: gamma-secretase activating protein
Synonyms: Pion, A530088I07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212167
Homologene: 45504
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14918
Homologene: 71540
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Faap100
Name: Fanconi anemia core complex associated protein 100
Synonyms: 2310003H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71885
Homologene: 69394
Atosb
Name: atos homolog B
Synonyms: B230312A22Rik, Fam214b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230088
Homologene: 32625
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: mdr, Pgy1, Pgy-1, Abcb1, Mdr1b, Mdr1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Gimap6
Name: GTPase, IMAP family member 6
Synonyms: Ian6, 4833419H03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231931
Homologene: 11670
Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 213550
Homologene: 15797
Or5m13
Name: olfactory receptor family 5 subfamily M member 13
Synonyms: MOR196-5P, Olfr1025, MOR196-6_p, GA_x6K02T2Q125-47397266-47398205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258083
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mdga2, 6720489L24Rik, Adp, 9330209L04Rik, Mamdc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Gmpr
Name: guanosine monophosphate reductase
Synonyms: 2310004P21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66355
HGNC: HGNC:4376
Homologene: 5009
Lgals4
Name: lectin, galactose binding, soluble 4
Synonyms: galectin-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16855
HGNC: HGNC:6565
Homologene: 21239
Or2y17
Name: olfactory receptor family 2 subfamily Y member 17
Synonyms: GA_x6K02T2QP88-6094111-6093176, MOR256-2, Olfr1390
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259068
Vmn2r99
Name: vomeronasal 2, receptor 99
Synonyms: EG665376
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665376
Homologene: 115024
Lrrc74a
Name: leucine rich repeat containing 74A
Synonyms: Gm6772, Lrrc74
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 627607
VEGA: 12
Homologene: 19331
Cdhr4
Name: cadherin-related family member 4
Synonyms: D330022A01Rik, 1700021K14Rik, Cdh29
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69398
Homologene: 82362
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: Hgfl, D9H3F15S2, DNF15S2h, D3F15S2h
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15235
Homologene: 7360
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: PI5, Spi1-5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Best3
Name: bestrophin 3
Synonyms: mBest4, Vmd2l3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382427
VEGA: 10
Homologene: 33850
Trhr2
Name: thyrotropin releasing hormone receptor 2
Synonyms: TRH-R2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170732
Homologene: 44052
Muc1
Name: mucin 1, transmembrane
Synonyms: CD227, Muc-1, EMA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Zfp663
Name: zinc finger protein 663
Synonyms: Gm1008, LOC381405
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381405
Homologene: 128277
Podnl1
Name: podocan-like 1
Synonyms: 5832418A03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244550
Homologene: 41590
Nphp1
Name: nephronophthisis 1 (juvenile) homolog (human)
Synonyms: nephrocystin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53885
HGNC: HGNC:7905
Homologene: 229
Tdrkh
Name: tudor and KH domain containing protein
Synonyms: 2700091C21Rik, Tdrd2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72634
Homologene: 4999
Pla1a
Name: phospholipase A1 member A
Synonyms: Ps-pla1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 85031
VEGA: 16
Homologene: 9294
Naa11
Name: N(alpha)-acetyltransferase 11, NatA catalytic subunit
Synonyms: Ard1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97243
Homologene: 39206
Pou4f3
Name: POU domain, class 4, transcription factor 3
Synonyms: Brn3.1, Brn3c, Brn-3.1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18998
HGNC: HGNC:9220
Homologene: 2023
Pcdha12
Name: protocadherin alpha 12
Synonyms: Cnr5, Crnr5, Pcdha13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192164
HGNC: HGNC:8667
Homologene: 135870
Trav4-3
Name: T cell receptor alpha variable 4-3
Synonyms: Gm17002
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126471
Or1p4-ps1
Name: olfactory receptor family 1 subfamily P member 4, pseudogene 1
Synonyms: Olfr409-ps1, MOR133-2, GA_x6K02T2P1NL-4449217-4450187
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258131
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 176,946,237 bp
  • G to A, chromosome 2 at 85,917,929 bp
  • G to T, chromosome 2 at 127,763,809 bp
  • C to T, chromosome 2 at 161,530,543 bp
  • T to C, chromosome 2 at 165,352,724 bp
  • G to A, chromosome 3 at 89,231,514 bp
  • T to C, chromosome 3 at 94,424,661 bp
  • A to G, chromosome 4 at 43,033,944 bp
  • A to G, chromosome 4 at 109,102,576 bp
  • T to C, chromosome 4 at 117,111,522 bp
  • A to T, chromosome 5 at 8,812,750 bp
  • A to G, chromosome 5 at 21,226,247 bp
  • T to C, chromosome 5 at 21,653,518 bp
  • A to G, chromosome 5 at 97,392,207 bp
  • A to T, chromosome 5 at 116,190,094 bp
  • G to A, chromosome 5 at 130,269,224 bp
  • A to T, chromosome 5 at 140,885,560 bp
  • A to T, chromosome 6 at 48,702,618 bp
  • T to C, chromosome 6 at 88,012,387 bp
  • C to T, chromosome 7 at 28,841,496 bp
  • C to T, chromosome 7 at 42,613,445 bp
  • C to T, chromosome 7 at 98,444,112 bp
  • T to C, chromosome 7 at 139,605,644 bp
  • CAT to C, chromosome 8 at 3,873,772 bp
  • T to A, chromosome 8 at 36,938,641 bp
  • A to G, chromosome 8 at 40,754,062 bp
  • T to C, chromosome 8 at 84,129,327 bp
  • A to G, chromosome 8 at 94,623,260 bp
  • T to A, chromosome 8 at 122,358,880 bp
  • C to T, chromosome 9 at 64,307,060 bp
  • G to A, chromosome 9 at 107,997,397 bp
  • T to C, chromosome 9 at 108,082,043 bp
  • T to A, chromosome 10 at 116,993,066 bp
  • C to A, chromosome 10 at 127,560,621 bp
  • A to T, chromosome 11 at 49,341,327 bp
  • T to A, chromosome 11 at 74,317,160 bp
  • G to A, chromosome 11 at 113,780,902 bp
  • T to C, chromosome 11 at 120,374,473 bp
  • T to C, chromosome 12 at 66,868,752 bp
  • A to G, chromosome 12 at 86,758,465 bp
  • T to C, chromosome 12 at 103,950,918 bp
  • T to C, chromosome 13 at 45,542,626 bp
  • A to G, chromosome 13 at 109,935,342 bp
  • A to G, chromosome 14 at 53,599,305 bp
  • A to C, chromosome 15 at 84,417,145 bp
  • A to T, chromosome 16 at 38,409,638 bp
  • A to T, chromosome 17 at 19,393,660 bp
  • C to T, chromosome 17 at 87,985,767 bp
  • A to C, chromosome 18 at 37,020,470 bp
  • G to T, chromosome 18 at 42,395,528 bp
  • T to C, chromosome 19 at 6,855,845 bp
  • A to G, chromosome 19 at 39,170,944 bp
  • T to A, chromosome 19 at 41,256,285 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8715 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068613-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.