Strain Name:
C57BL/6J-MtgxR8723Btlr/Mmmh
Stock Number:
068615-MU
Citation ID:
RRID:MMRRC_068615-MU
Other Names:
R8723 (G1)
Major Collection:

Strain Information

Figla
Name: folliculogenesis specific basic helix-loop-helix
Synonyms: bHLHc8, FIG alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26910
Homologene: 49294
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Rps6kb1
Name: ribosomal protein S6 kinase, polypeptide 1
Synonyms: 2610318I15Rik, p70s6k, p70/85s6k, p70S6K1, S6K1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72508
Homologene: 81703
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240725
Homologene: 49408
Uqcc1
Name: ubiquinol-cytochrome c reductase complex assembly factor 1
Synonyms: 3110038N19Rik, 2410003P15Rik, Cbp3, Uqcc, 2310079L17Rik, Bfzp, mbFZb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56046
Homologene: 14709
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Trim27
Name: tripartite motif-containing 27
Synonyms: Rfp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19720
HGNC: HGNC:9975
Homologene: 111010
Ctnnd1
Name: catenin delta 1
Synonyms: catenin (cadherin associated protein), delta 1, P120, Catns, p120-catenin, Ctnnd
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Spag5
Name: sperm associated antigen 5
Synonyms: MAP126, D11Bhm180e, Deepest, Astrin, S17, s17, Mastrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54141
Homologene: 4718
Nrip1
Name: nuclear receptor interacting protein 1
Synonyms: 8430438I05Rik, RIP140, 6030458L20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268903
HGNC: HGNC:8001
Homologene: 2606
Strip2
Name: striatin interacting protein 2
Synonyms: D330017J20Rik, Fam40b, Myoscape
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320609
Homologene: 66198
Grhl1
Name: grainyhead like transcription factor 1
Synonyms: Tcfcp2l2, p70 MGR, LBP-32, p61 MGR
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 195733
VEGA: 12
Homologene: 32219
Tubgcp3
Name: tubulin, gamma complex component 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 259279
Homologene: 4609
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Cd13, aminopeptidase N, Apn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Sag
Name: S-antigen, retina and pineal gland (arrestin)
Synonyms: A930001K18Rik, arrestin 1, Arr1, rod arrestin, visual arrestin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20215
Homologene: 455
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Elf3
Name: E74-like factor 3
Synonyms: ESE-1, ESX, jen
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13710
HGNC: HGNC:3318
Homologene: 3265
Fsd1l
Name: fibronectin type III and SPRY domain containing 1-like
Synonyms: Fsd1nl, Csdufd1, A230072O16Rik, Ccdc10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 319636
Homologene: 45825
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Ttc39a
Name: tetratricopeptide repeat domain 39A
Synonyms: 4922503N01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230603
Homologene: 17739
Klc4
Name: kinesin light chain 4
Synonyms: Knsl8, 1200014P03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74764
VEGA: 17
Homologene: 12584
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Ankrd50
Name: ankyrin repeat domain 50
Synonyms: E430012K20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99696
Homologene: 129859
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cav2.2, Cchn1a, alpha(1B)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229595
Homologene: 23141
Vmn2r89
Name: vomeronasal 2, receptor 89
Synonyms: V2r11, V2r10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22301
Rxfp1
Name: relaxin/insulin-like family peptide receptor 1
Synonyms: LOC381489, Lgr7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381489
Homologene: 11007
Ms4a20
Name: membrane-spanning 4-domains, subfamily A, member 20
Synonyms: 1700017D01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69369
P2rx1
Name: purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms: P2x, Pdcd3, P2X1 receptor, RP-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18436
HGNC: HGNC:8533
Homologene: 1921
Stk25
Name: serine/threonine kinase 25 (yeast)
Synonyms: Ste20-like, SOK-1, 1500019J11Rik, Ysk1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59041
Homologene: 48428
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
Tmem237
Name: transmembrane protein 237
Synonyms: Als2cr4, LOC381259
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381259
Homologene: 17570
Vmn2r117
Name: vomeronasal 2, receptor 117
Synonyms: EG619788, V2Rp6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619788
Homologene: 86604
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Itih-3, Intin3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Or8k3
Name: olfactory receptor family 8 subfamily K member 3
Synonyms: Olfr1047, MOR188-3, GA_x6K02T2Q125-47703682-47702723
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259014
Homologene: 133664
Pif1
Name: PIF1 5'-to-3' DNA helicase
Synonyms: AI449441
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208084
Homologene: 99775
Exoc3l4
Name: exocyst complex component 3-like 4
Synonyms: 1200009I06Rik, 1600013K19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74190
VEGA: 12
Homologene: 41760
Or5w17
Name: olfactory receptor family 5 subfamily W member 17
Synonyms: Olfr1141, GA_x6K02T2Q125-49257818-49256883, MOR177-10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258630
Homologene: 74080
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: Gpr128, 9130020O16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Smoc1
Name: SPARC related modular calcium binding 1
Synonyms: SPARC-related protein, 2600002F22Rik, SRG
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 64075
Homologene: 56943
Alkbh1
Name: alkB homolog 1, histone H2A dioxygenase
Synonyms: Alkbh, alkB, Nrp
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211064
Homologene: 4393
Tacr2
Name: tachykinin receptor 2
Synonyms: Tac2r
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21337
VEGA: 10
Homologene: 55548
Tsen34
Name: tRNA splicing endonuclease subunit 34
Synonyms: Leng5, 0610027F08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66078
Homologene: 44182
Rhobtb1
Name: Rho-related BTB domain containing 1
Synonyms: 1700008H16Rik, 3110048G13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69288
Homologene: 8892
Gtf2h5
Name: general transcription factor IIH, polypeptide 5
Synonyms: 2700017P07Rik, 2810432H05Rik, D17Wsu155e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66467
Homologene: 45635
Zdhhc21
Name: zinc finger, DHHC domain containing 21
Synonyms: 9130404H11Rik, dep, D130004H04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68268
Homologene: 32668
Ear14
Name: eosinophil-associated, ribonuclease A family, member 14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 503847
VEGA: 14
Gm49359
Name: predicted gene, 49359
Type: Gene
Species: Mouse
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 12,786,687 bp
  • A to G, chromosome 1 at 21,505,367 bp
  • A to T, chromosome 1 at 59,106,572 bp
  • A to T, chromosome 1 at 71,321,738 bp
  • G to A, chromosome 1 at 87,823,453 bp
  • C to G, chromosome 1 at 90,767,606 bp
  • A to G, chromosome 1 at 93,625,944 bp
  • A to G, chromosome 1 at 135,257,647 bp
  • A to G, chromosome 2 at 24,658,498 bp
  • T to C, chromosome 2 at 69,486,304 bp
  • G to A, chromosome 2 at 84,620,040 bp
  • A to T, chromosome 2 at 86,228,442 bp
  • T to C, chromosome 2 at 87,753,157 bp
  • C to T, chromosome 2 at 155,887,180 bp
  • A to C, chromosome 3 at 38,457,304 bp
  • T to C, chromosome 3 at 79,650,495 bp
  • C to T, chromosome 3 at 95,677,116 bp
  • A to G, chromosome 4 at 53,647,001 bp
  • A to T, chromosome 4 at 82,844,202 bp
  • T to A, chromosome 4 at 109,443,503 bp
  • G to A, chromosome 4 at 123,455,117 bp
  • A to G, chromosome 5 at 96,838,347 bp
  • A to T, chromosome 5 at 124,814,621 bp
  • T to A, chromosome 6 at 29,941,864 bp
  • A to G, chromosome 6 at 86,020,742 bp
  • A to G, chromosome 7 at 3,695,150 bp
  • G to A, chromosome 7 at 16,857,777 bp
  • G to A, chromosome 7 at 28,987,117 bp
  • A to G, chromosome 7 at 44,622,983 bp
  • A to G, chromosome 7 at 79,838,938 bp
  • A to T, chromosome 8 at 12,621,899 bp
  • T to C, chromosome 8 at 55,871,478 bp
  • A to G, chromosome 8 at 95,736,279 bp
  • T to A, chromosome 9 at 65,594,391 bp
  • A to T, chromosome 10 at 51,615,422 bp
  • A to G, chromosome 10 at 62,258,328 bp
  • A to G, chromosome 10 at 69,270,271 bp
  • C to A, chromosome 11 at 73,008,930 bp
  • T to A, chromosome 11 at 78,321,389 bp
  • T to C, chromosome 11 at 86,519,931 bp
  • G to A, chromosome 12 at 24,612,245 bp
  • G to A, chromosome 12 at 81,135,812 bp
  • A to G, chromosome 12 at 87,438,508 bp
  • T to A, chromosome 12 at 111,430,658 bp
  • A to G, chromosome 13 at 13,712,757 bp
  • T to G, chromosome 13 at 21,000,010 bp
  • A to C, chromosome 13 at 21,190,637 bp
  • A to T, chromosome 13 at 62,454,596 bp
  • T to A, chromosome 14 at 30,908,804 bp
  • C to T, chromosome 14 at 51,204,056 bp
  • T to C, chromosome 14 at 51,456,453 bp
  • T to G, chromosome 16 at 56,761,919 bp
  • T to C, chromosome 16 at 76,292,665 bp
  • C to CA, chromosome 17 at 6,084,558 bp
  • A to T, chromosome 17 at 23,477,369 bp
  • T to G, chromosome 17 at 46,640,700 bp
  • A to G, chromosome 19 at 11,105,691 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8723 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068615-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.