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Strain Name:
C57BL/6J-MtgxR8762Btlr/Mmmh
Stock Number:
068622-MU
Citation ID:
RRID:MMRRC_068622-MU
Other Names:
R8762 (G1)
Major Collection:

Strain Information

Arhgef7
Name: Rho guanine nucleotide exchange factor
Synonyms: Cool, PIX, Pak interacting exchange factor, p85SPR, betaPix-c, betaPix-b, cool-1, betaPix
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54126
Homologene: 2895
Cdh1
Name: cadherin 1
Synonyms: E-cadherin, Ecad, UM, uvomorulin, L-CAM, E-cad
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12550
HGNC: HGNC:1748
Homologene: 20917
Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Synonyms: (a)3, alpha 3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit, Acra-3, Acra3, A730007P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110834
VEGA: 9
HGNC: HGNC:1957
Homologene: 591
Plk3
Name: polo like kinase 3
Synonyms: Cnk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12795
HGNC: HGNC:2154
Homologene: 20865
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, Gukmi1, AIP3, BAP1, Baiap1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Nptn
Name: neuroplastin
Synonyms: Sdfr1, NP65
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20320
Homologene: 105617
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,709,828 bp
  • A to G, chromosome 1 at 74,552,054 bp
  • C to T, chromosome 1 at 149,886,184 bp
  • G to A, chromosome 1 at 155,686,960 bp
  • A to G, chromosome 2 at 14,967,948 bp
  • T to C, chromosome 2 at 25,230,991 bp
  • A to T, chromosome 2 at 52,111,730 bp
  • T to A, chromosome 2 at 76,709,082 bp
  • A to C, chromosome 2 at 76,777,950 bp
  • A to T, chromosome 2 at 85,137,171 bp
  • A to T, chromosome 2 at 85,647,690 bp
  • T to C, chromosome 2 at 164,844,732 bp
  • A to C, chromosome 3 at 98,339,708 bp
  • C to T, chromosome 3 at 104,050,853 bp
  • A to T, chromosome 3 at 113,531,627 bp
  • A to T, chromosome 3 at 117,325,833 bp
  • T to A, chromosome 3 at 131,194,717 bp
  • ACACTCAC to ACAC, chromosome 4 at 117,131,893 bp
  • T to C, chromosome 4 at 141,034,058 bp
  • C to T, chromosome 4 at 141,472,950 bp
  • C to A, chromosome 5 at 37,284,096 bp
  • A to G, chromosome 5 at 90,566,602 bp
  • T to C, chromosome 5 at 100,378,829 bp
  • A to G, chromosome 5 at 130,208,716 bp
  • A to G, chromosome 6 at 41,675,379 bp
  • T to A, chromosome 6 at 55,679,243 bp
  • T to C, chromosome 6 at 65,447,409 bp
  • A to G, chromosome 6 at 73,179,828 bp
  • T to A, chromosome 6 at 93,815,808 bp
  • A to G, chromosome 7 at 3,610,901 bp
  • C to A, chromosome 7 at 18,674,632 bp
  • G to T, chromosome 7 at 45,196,057 bp
  • G to T, chromosome 7 at 78,788,739 bp
  • T to A, chromosome 7 at 83,794,074 bp
  • T to C, chromosome 8 at 11,781,216 bp
  • T to A, chromosome 8 at 24,967,219 bp
  • G to T, chromosome 8 at 106,659,704 bp
  • A to G, chromosome 8 at 125,155,057 bp
  • C to T, chromosome 9 at 36,718,340 bp
  • T to A, chromosome 9 at 55,015,711 bp
  • C to T, chromosome 9 at 58,247,065 bp
  • T to A, chromosome 9 at 58,618,622 bp
  • T to C, chromosome 9 at 87,227,261 bp
  • T to A, chromosome 10 at 26,276,223 bp
  • G to A, chromosome 10 at 70,943,386 bp
  • T to G, chromosome 11 at 3,526,407 bp
  • T to C, chromosome 11 at 22,973,694 bp
  • A to T, chromosome 11 at 67,193,752 bp
  • G to T, chromosome 11 at 73,724,481 bp
  • A to T, chromosome 11 at 96,820,480 bp
  • A to G, chromosome 11 at 101,410,400 bp
  • A to T, chromosome 12 at 21,351,594 bp
  • G to A, chromosome 12 at 91,537,550 bp
  • G to A, chromosome 12 at 113,489,607 bp
  • T to C, chromosome 12 at 113,838,668 bp
  • A to T, chromosome 15 at 55,047,453 bp
  • A to C, chromosome 16 at 4,634,339 bp
  • T to C, chromosome 16 at 44,332,344 bp
  • A to T, chromosome 17 at 17,877,589 bp
  • C to T, chromosome 17 at 20,113,527 bp
  • A to G, chromosome 17 at 23,756,757 bp
  • T to A, chromosome 17 at 34,116,960 bp
  • A to T, chromosome 17 at 66,559,681 bp
  • G to A, chromosome 18 at 3,511,277 bp
  • A to T, chromosome 18 at 24,679,497 bp
  • A to G, chromosome 18 at 34,804,104 bp
  • A to G, chromosome 19 at 40,607,192 bp
  • T to A, chromosome 19 at 59,272,923 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8762 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068622-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.