Strain Name:
C57BL/6J-MtgxR8762Btlr/Mmmh
Stock Number:
068622-MU
Citation ID:
RRID:MMRRC_068622-MU
Other Names:
R8762 (G1)
Major Collection:

Strain Information

Arhgef7
Name: Rho guanine nucleotide exchange factor
Synonyms: betaPix-b, betaPix-c, p85SPR, Pak interacting exchange factor, PIX, Cool, cool-1, betaPix
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54126
Homologene: 2895
Cdh1
Name: cadherin 1
Synonyms: UM, L-CAM, E-cad, E-cadherin, Ecad, uvomorulin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12550
HGNC: HGNC:1748
Homologene: 20917
Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Synonyms: Acra-3, Acra3, alpha 3, (a)3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit, A730007P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110834
VEGA: 9
HGNC: HGNC:1957
Homologene: 591
Plk3
Name: polo like kinase 3
Synonyms: Cnk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12795
HGNC: HGNC:2154
Homologene: 20865
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: Baiap1, Gukmi1, WWP3, BAP1, AIP3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Nptn
Name: neuroplastin
Synonyms: Sdfr1, NP65
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20320
Homologene: 105617
Pml
Name: promyelocytic leukemia
Synonyms: 1200009E24Rik, Trim19
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Brd2
Name: bromodomain containing 2
Synonyms: D17H6S113E, Fsrg1, Rnf3, Ring3, Frg-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14312
HGNC: HGNC:1103
Homologene: 74540
Coro7
Name: coronin 7
Synonyms: 0610011B16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78885
Homologene: 11573
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, pet, hypothroid
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: CIF150, TAFII150, 150kDa, 4732460C16Rik, TAF2B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Rif1
Name: replication timing regulatory factor 1
Synonyms: D2Ertd145e, 5730435J01Rik, 6530403D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237339
Homologene: 18226
Acbd6
Name: acyl-Coenzyme A binding domain containing 6
Synonyms: 0610010G04Rik, 2610100E10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72482
Homologene: 12465
Slc18a2
Name: solute carrier family 18 (vesicular monoamine), member 2
Synonyms: 1110037L13Rik, Vmat2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 214084
VEGA: 19
Homologene: 2298
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: Jmjd1b, JHDM2B, 5830462I21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Bicc1
Name: BicC family RNA binding protein 1
Synonyms: jcpk, Bic-C
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83675
Homologene: 12856
Lef1
Name: lymphoid enhancer binding factor 1
Synonyms: lymphoid enhancer factor 1, Lef-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16842
HGNC: HGNC:6551
Homologene: 7813
Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
Synonyms: 2310044P18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69684
Homologene: 6821
Neurod6
Name: neurogenic differentiation 6
Synonyms: Atoh2, Nex1m, Math2, bHLHa2, Nex, Math-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11922
Homologene: 7632
Crmp1
Name: collapsin response mediator protein 1
Synonyms: DRP-1, Ulip3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Sec31a
Name: SEC31 homolog A, COPII coat complex component
Synonyms: Sec31l1, 1810024J13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69162
Homologene: 42056
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Rabgef1
Name: RAB guanine nucleotide exchange factor (GEF) 1
Synonyms: Ras negative regulator Rabex-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56715
Homologene: 8720
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243407
Homologene: 135976
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Flywch1
Name: FLYWCH-type zinc finger 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224613
VEGA: 17
Homologene: 72130
Plcd4
Name: phospholipase C, delta 4
Synonyms: 4921507K24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18802
HGNC: HGNC:9062
Homologene: 88782
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Aplnr
Name: apelin receptor
Synonyms: msr/apj, apelin receptor, Agtrl1, APJ
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23796
HGNC: HGNC:339
Homologene: 3784
Oscar
Name: osteoclast associated receptor
Synonyms: mOSCAR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232790
Homologene: 77042
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MHC2A, Myhs-f, Myhsf1, MyHC-IIa, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382090
Homologene: 8930
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cavbeta2, Cchb2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Albfm1
Name: albumin superfamily member 1
Synonyms: 5830473C10Rik, ARG, Gm17754
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622307
Homologene: 129803
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cytosolic phospholipase A2, Type IV PLA2, cPLA2alpha, cPLA2, cytosolic PLA2, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Adam9
Name: ADAM metallopeptidase domain 9
Synonyms: Mltng, MDC9, Mltng, MDC9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Psg20
Name: pregnancy-specific beta-1-glycoprotein 20
Synonyms: EG434540, cea7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434540
Homologene: 110989
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230872
Homologene: 16811
Phgdh
Name: 3-phosphoglycerate dehydrogenase
Synonyms: A10, 3PGDH, PGDH, SERA, PGAD, 3-PGDH, PGD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 236539
HGNC: HGNC:8923
Homologene: 39318
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: TCF11, TCF-11, NRF1, Lcrf1, LCR-F1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Kash5
Name: KASH domain containing 5
Synonyms: Ccdc155, LOC384619
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384619
Homologene: 16973
Sidt1
Name: SID1 transmembrane family, member 1
Synonyms: B830021E24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320007
Homologene: 41189
Fpr1
Name: formyl peptide receptor 1
Synonyms: FPR, fMLF-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14293
HGNC: HGNC:3826
Homologene: 20466
Tctn3
Name: tectonic family member 3
Synonyms: Tect3, 4930521E07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67590
Homologene: 9221
Disc1
Name: disrupted in schizophrenia 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244667
HGNC: HGNC:2888
Homologene: 10257
Themis3
Name: thymocyte selection associated family member 3
Synonyms: 9130404H23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74556
Homologene: 137389
Pltp
Name: phospholipid transfer protein
Synonyms: OD107, Bpife
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18830
HGNC: HGNC:9093
Homologene: 4536
Plppr4
Name: phospholipid phosphatase related 4
Synonyms: D3Bwg0562e, PRG-1, Lppr4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229791
Homologene: 8895
Slc34a3
Name: solute carrier family 34 (sodium phosphate), member 3
Synonyms: Npt2c, NPTIIc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 142681
Homologene: 15444
Cfap161
Name: cilia and flagella associated protein 161
Synonyms: 1700026D08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75556
Homologene: 12605
Fpr-rs7
Name: formyl peptide receptor, related sequence 7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321021
HGNC: HGNC:3827
Mrps11
Name: mitochondrial ribosomal protein S11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67994
Homologene: 32554
Or5g25
Name: olfactory receptor family 5 subfamily G member 25
Synonyms: MOR175-2, GA_x6K02T2Q125-47127746-47126790, Olfr1002
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258566
Homologene: 104131
Actr1b
Name: ARP1 actin-related protein 1B, centractin beta
Synonyms: 2310066K23Rik, Arp1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226977
HGNC: HGNC:168
Homologene: 101541
Zrsr2-ps1
Name: zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1
Synonyms: U2afbp-rs, Zrsr1, SP2, Irlgs2, 35kDa, D11Ncvs75, U2af1-rs1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22183
Homologene: 84793
Bambi
Name: BMP and activin membrane-bound inhibitor
Synonyms: 2610003H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68010
VEGA: 18
Homologene: 8215
Or1e28-ps1
Name: olfactory receptor family 1 subfamily E member 28, pseudogene 1
Synonyms: MOR135-22, Olfr388-ps1, GA_x6K02T2P1NL-3884648-3883708
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258182
Ighv5-16
Name: immunoglobulin heavy variable 5-16
Synonyms: Gm16632
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 633568
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,709,828 bp
  • A to G, chromosome 1 at 74,552,054 bp
  • C to T, chromosome 1 at 149,886,184 bp
  • G to A, chromosome 1 at 155,686,960 bp
  • A to G, chromosome 2 at 14,967,948 bp
  • T to C, chromosome 2 at 25,230,991 bp
  • A to T, chromosome 2 at 52,111,730 bp
  • T to A, chromosome 2 at 76,709,082 bp
  • A to C, chromosome 2 at 76,777,950 bp
  • A to T, chromosome 2 at 85,137,171 bp
  • A to T, chromosome 2 at 85,647,690 bp
  • T to C, chromosome 2 at 164,844,732 bp
  • A to C, chromosome 3 at 98,339,708 bp
  • C to T, chromosome 3 at 104,050,853 bp
  • A to T, chromosome 3 at 113,531,627 bp
  • A to T, chromosome 3 at 117,325,833 bp
  • T to A, chromosome 3 at 131,194,717 bp
  • ACACTCAC to ACAC, chromosome 4 at 117,131,893 bp
  • T to C, chromosome 4 at 141,034,058 bp
  • C to T, chromosome 4 at 141,472,950 bp
  • C to A, chromosome 5 at 37,284,096 bp
  • A to G, chromosome 5 at 90,566,602 bp
  • T to C, chromosome 5 at 100,378,829 bp
  • A to G, chromosome 5 at 130,208,716 bp
  • A to G, chromosome 6 at 41,675,379 bp
  • T to A, chromosome 6 at 55,679,243 bp
  • T to C, chromosome 6 at 65,447,409 bp
  • A to G, chromosome 6 at 73,179,828 bp
  • T to A, chromosome 6 at 93,815,808 bp
  • A to G, chromosome 7 at 3,610,901 bp
  • C to A, chromosome 7 at 18,674,632 bp
  • G to T, chromosome 7 at 45,196,057 bp
  • G to T, chromosome 7 at 78,788,739 bp
  • T to A, chromosome 7 at 83,794,074 bp
  • T to C, chromosome 8 at 11,781,216 bp
  • T to A, chromosome 8 at 24,967,219 bp
  • G to T, chromosome 8 at 106,659,704 bp
  • A to G, chromosome 8 at 125,155,057 bp
  • C to T, chromosome 9 at 36,718,340 bp
  • T to A, chromosome 9 at 55,015,711 bp
  • C to T, chromosome 9 at 58,247,065 bp
  • T to A, chromosome 9 at 58,618,622 bp
  • T to C, chromosome 9 at 87,227,261 bp
  • T to A, chromosome 10 at 26,276,223 bp
  • G to A, chromosome 10 at 70,943,386 bp
  • T to G, chromosome 11 at 3,526,407 bp
  • T to C, chromosome 11 at 22,973,694 bp
  • A to T, chromosome 11 at 67,193,752 bp
  • G to T, chromosome 11 at 73,724,481 bp
  • A to T, chromosome 11 at 96,820,480 bp
  • A to G, chromosome 11 at 101,410,400 bp
  • A to T, chromosome 12 at 21,351,594 bp
  • G to A, chromosome 12 at 91,537,550 bp
  • G to A, chromosome 12 at 113,489,607 bp
  • T to C, chromosome 12 at 113,838,668 bp
  • A to T, chromosome 15 at 55,047,453 bp
  • A to C, chromosome 16 at 4,634,339 bp
  • T to C, chromosome 16 at 44,332,344 bp
  • A to T, chromosome 17 at 17,877,589 bp
  • C to T, chromosome 17 at 20,113,527 bp
  • A to G, chromosome 17 at 23,756,757 bp
  • T to A, chromosome 17 at 34,116,960 bp
  • A to T, chromosome 17 at 66,559,681 bp
  • G to A, chromosome 18 at 3,511,277 bp
  • A to T, chromosome 18 at 24,679,497 bp
  • A to G, chromosome 18 at 34,804,104 bp
  • A to G, chromosome 19 at 40,607,192 bp
  • T to A, chromosome 19 at 59,272,923 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8762 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068622-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.