Strain Name:
C57BL/6J-MtgxR8773Btlr/Mmmh
Stock Number:
068627-MU
Citation ID:
RRID:MMRRC_068627-MU
Other Names:
R8773 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Lcat
Name: lecithin cholesterol acyltransferase
Synonyms: D8Wsu61e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16816
HGNC: HGNC:6522
Homologene: 68042
Top1
Name: topoisomerase (DNA) I
Synonyms: Top-1, D130064I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Serpinb6a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6a
Synonyms: Spi3, ovalbumin, D330015H01Rik, 4930482L21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20719
HGNC: HGNC:8950
Homologene: 20956
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, 1500001N15Rik, D14Ertd64e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68059
Homologene: 21004
Apbb2
Name: amyloid beta precursor protein binding family B member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75302
Homologene: 10102
Faf1
Name: Fas-associated factor 1
Synonyms: Fam, Dffrx
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14084
HGNC: HGNC:3578
Homologene: 5120
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Tomm22
Name: translocase of outer mitochondrial membrane 22
Synonyms: Tom22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223696
Homologene: 10638
Agk
Name: acylglycerol kinase
Synonyms: MuLK, 2610037M15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69923
Homologene: 41239
Mrtfa
Name: myocardin related transcription factor A
Synonyms: Mal, Bsac, MRTF-A, Mkl1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223701
Homologene: 32487
Ptk7
Name: PTK7 protein tyrosine kinase 7
Synonyms: 8430404F20Rik, mPTK7/CCK4, chz
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71461
VEGA: 17
HGNC: HGNC:9618
Homologene: 43672
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Rufy1
Name: RUN and FYVE domain containing 1
Synonyms: Rabip4, 3000002E04Rik, ZFYVE12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216724
Homologene: 23522
Pcdhb18
Name: protocadherin beta 18
Synonyms: Pcdhb9, PcdhbR
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93889
Homologene: 137649
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Hps6
Name: HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
Synonyms: 5330434M19Rik, ruby eye, ru, BLOC-2, Hermansky-Pudlak syndrome 6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20170
VEGA: 19
Homologene: 11691
Cyb561d2
Name: cytochrome b-561 domain containing 2
Synonyms: 101F6 protein, Tsp10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56368
Homologene: 38261
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232854
Homologene: 119890
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1203Clo, b2b1279Clo, b2b1289Clo, b2b1727Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Mapkapk2
Name: MAP kinase-activated protein kinase 2
Synonyms: MAPKAP kinase 2, Rps6kc1, MK2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17164
HGNC: HGNC:6887
Homologene: 56412
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Pip4p1
Name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Synonyms: Tmem55b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219024
Homologene: 10279
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Abcc6
Name: ATP-binding cassette, sub-family C member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Pcdhga11
Name: protocadherin gamma subfamily A, 11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93723
HGNC: HGNC:8698
Homologene: 110934
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: Gnn, BC030307
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4930415N18Rik, 4933428F06Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, 1110018I21Rik, E030018G17Rik, Tns, E030037J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Shc2
Name: SHC (Src homology 2 domain containing) transforming protein 2
Synonyms: ShcB, Sli
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216148
Homologene: 19127
Bnc1
Name: basonuclin zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Abhd12b
Name: abhydrolase domain containing 12B
Synonyms: LOC328121
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100504285
Homologene: 128243
Mpeg1
Name: macrophage expressed gene 1
Synonyms: Mpg-1, MPS1, Perforin-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17476
VEGA: 19
Homologene: 11216
Tmem268
Name: transmembrane protein 268
Synonyms: 6330416G13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230279
Homologene: 17005
Serpina11
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
Synonyms: LOC380780
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380780
Homologene: 28490
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: 9430008B02Rik, SAST170, SAST
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56527
Homologene: 10543
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23805
Homologene: 4299
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 5830443C21Rik, 9530023M17Rik, 1110054A01Rik, 0610009F02Rik, 5830406C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76073
VEGA: 19
Homologene: 12632
4921509C19Rik
Name: RIKEN cDNA 4921509C19 gene
Synonyms: LOC381389
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381393
Homologene: 72396
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Dnaaf1
Name: dynein, axonemal assembly factor 1
Synonyms: 4930457P18Rik, Lrrc50, m4Bei
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68270
Homologene: 12256
Cr2
Name: complement receptor 2
Synonyms: CD21, CD35, Cr-1, Cr-2, Cr1, C3DR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Tspyl5
Name: testis-specific protein, Y-encoded-like 5
Synonyms: E130308C19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239364
VEGA: 15
Homologene: 14134
Nlrx1
Name: NLR family member X1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270151
VEGA: 9
Homologene: 11623
Irx1
Name: Iroquois homeobox 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16371
Homologene: 19065
Sirt7
Name: sirtuin 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 209011
Homologene: 56152
Ccdc121rt2
Name: coiled-coil domain containing 121, retrogene 2
Synonyms: Gm6588
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 625464
Homologene: 116059
Gimap8
Name: GTPase, IMAP family member 8
Synonyms: LOC243374, IAN9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243374
Homologene: 69703
Btbd7
Name: BTB domain containing 7
Synonyms: FUP1, 5730507E09Rik, E130118E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238386
VEGA: 12
Homologene: 34300
Cdca7l
Name: cell division cycle associated 7 like
Synonyms: JPO2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217946
Homologene: 10285
Stra8
Name: stimulated by retinoic acid gene 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20899
Homologene: 49197
Vmn1r128
Name: vomeronasal 1 receptor 128
Synonyms: Gm8509
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667199
Homologene: 104166
Ciao2a
Name: cytosolic iron-sulfur assembly component 2A
Synonyms: 5730536A07Rik, Fam96a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68250
Homologene: 12252
Trav3-1
Name: T cell receptor alpha variable 3-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667441
Pcdhga5
Name: protocadherin gamma subfamily A, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93713
HGNC: HGNC:8703
Homologene: 69263
Pdf
Name: peptide deformylase (mitochondrial)
Synonyms: 2610019N19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68023
Homologene: 69354
Or8c19-ps1
Name: olfactory receptor family 8 subfamily C member 19, pseudogene1
Synonyms: GA_x6K02T2PVTD-31999710-32000653, MOR170-7, Olfr897-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258473
VEGA: 9
Or1j8
Name: olfactory receptor family 1 subfamily J member 8
Synonyms: GA_x6K02T2NLDC-33001193-33002131, MOR137-2, Olfr335-ps
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 666118
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 24,185,127 bp
  • T to A, chromosome 1 at 43,970,392 bp
  • T to C, chromosome 1 at 73,937,248 bp
  • T to A, chromosome 1 at 90,768,449 bp
  • T to C, chromosome 1 at 131,055,942 bp
  • A to G, chromosome 1 at 195,158,605 bp
  • C to G, chromosome 2 at 12,182,684 bp
  • T to C, chromosome 2 at 19,288,856 bp
  • A to G, chromosome 2 at 36,302,375 bp
  • T to A, chromosome 2 at 67,525,183 bp
  • A to T, chromosome 2 at 151,472,142 bp
  • A to G, chromosome 2 at 160,714,238 bp
  • T to C, chromosome 4 at 63,580,293 bp
  • T to A, chromosome 4 at 109,842,310 bp
  • A to G, chromosome 5 at 66,451,909 bp
  • T to C, chromosome 5 at 112,449,815 bp
  • A to G, chromosome 5 at 123,273,850 bp
  • T to A, chromosome 6 at 34,935,646 bp
  • T to G, chromosome 6 at 40,357,116 bp
  • C to A, chromosome 6 at 48,656,611 bp
  • A to T, chromosome 7 at 7,182,798 bp
  • A to T, chromosome 7 at 21,349,997 bp
  • C to T, chromosome 7 at 45,985,145 bp
  • C to T, chromosome 7 at 81,973,971 bp
  • A to G, chromosome 7 at 110,348,995 bp
  • A to T, chromosome 8 at 84,916,324 bp
  • T to C, chromosome 8 at 105,940,078 bp
  • A to G, chromosome 8 at 107,048,468 bp
  • A to G, chromosome 8 at 119,575,455 bp
  • G to T, chromosome 9 at 38,309,220 bp
  • A to T, chromosome 9 at 44,256,415 bp
  • A to T, chromosome 9 at 66,138,385 bp
  • A to T, chromosome 9 at 72,912,301 bp
  • A to G, chromosome 9 at 107,540,384 bp
  • C to A, chromosome 9 at 108,110,505 bp
  • A to T, chromosome 9 at 119,230,224 bp
  • T to C, chromosome 10 at 79,621,090 bp
  • T to C, chromosome 10 at 80,306,212 bp
  • A to G, chromosome 10 at 86,729,815 bp
  • T to C, chromosome 11 at 50,430,969 bp
  • T to A, chromosome 11 at 120,624,062 bp
  • A to G, chromosome 12 at 3,457,200 bp
  • A to C, chromosome 12 at 70,166,934 bp
  • A to T, chromosome 12 at 102,837,982 bp
  • A to G, chromosome 12 at 103,986,463 bp
  • G to A, chromosome 12 at 117,875,611 bp
  • T to A, chromosome 12 at 117,995,215 bp
  • T to A, chromosome 13 at 33,931,560 bp
  • C to T, chromosome 13 at 71,959,516 bp
  • C to A, chromosome 14 at 33,962,535 bp
  • T to C, chromosome 14 at 50,929,046 bp
  • T to C, chromosome 14 at 52,580,971 bp
  • A to G, chromosome 14 at 122,143,471 bp
  • T to C, chromosome 15 at 33,687,092 bp
  • C to T, chromosome 15 at 79,671,110 bp
  • T to C, chromosome 15 at 81,018,073 bp
  • A to G, chromosome 16 at 29,441,580 bp
  • T to C, chromosome 16 at 49,195,537 bp
  • A to G, chromosome 17 at 46,566,267 bp
  • T to A, chromosome 18 at 20,582,999 bp
  • A to T, chromosome 18 at 37,491,509 bp
  • T to C, chromosome 18 at 37,696,770 bp
  • C to A, chromosome 18 at 37,757,311 bp
  • A to T, chromosome 19 at 12,463,055 bp
  • G to A, chromosome 19 at 36,411,948 bp
  • C to G, chromosome 19 at 46,005,702 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8773 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068627-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.