Strain Name:
C57BL/6J-MtgxR8774Btlr/Mmmh
Stock Number:
068628-MU
Citation ID:
RRID:MMRRC_068628-MU
Other Names:
R8774 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Whi, GENA 60, GENA 47, Gena 52, Cyn, Cycn, Dz, WBE1, Edy, Flo, Lda, Mt, Obt, Todo, A730019I05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Sod1
Name: superoxide dismutase 1, soluble
Synonyms: Ipo-1, CuZnSOD, SODC, Cu/Zn-SOD, B430204E11Rik, Ipo1, Cu(2+)-Zn2+ superoxide dismutase, Sod-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20655
VEGA: 16
Homologene: 392
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Utp20
Name: UTP20 small subunit processome component
Synonyms: 3830408P06Rik, DRIM, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100763
Homologene: 8783
Ppard
Name: peroxisome proliferator activator receptor delta
Synonyms: PPAR-delta, PPARdelta/beta, Nr1c2, Peroxisome proliferator-activated receptor beta, Pparb/d, NUC1, Pparb
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19015
HGNC: HGNC:9235
Homologene: 4544
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: 2810481F14Rik, 4921509N21Rik, Gm40556, E430034L06Rik, SCAN1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104884
Homologene: 5424
Plcg2
Name: phospholipase C, gamma 2
Synonyms: PLCgamma2, Plcg-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785
Ncbp3
Name: nuclear cap binding subunit 3
Synonyms: 1200014J11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66874
Homologene: 10231
Acy1
Name: aminoacylase 1
Synonyms: Acy-1, 1110014J22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109652
HGNC: HGNC:177
Homologene: 110440
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19876
Homologene: 2206
Gabbr1
Name: gamma-aminobutyric acid type B receptor subunit 1
Synonyms: GABAB1, GABAbR1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54393
HGNC: HGNC:4070
Homologene: 1132
Pygo1
Name: pygopus 1
Synonyms: 2600014C22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72135
Homologene: 41050
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: D930045G19Rik, E130202I16Rik, GAT4, Gat3, Gabt4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243616
Homologene: 129935
Pirb
Name: paired Ig-like receptor B
Synonyms: Lilrb3, Gp91
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18733
Homologene: 134028
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 4930413O22Rik, 2310020J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211660
Homologene: 23487
Map3k2
Name: mitogen-activated protein kinase kinase kinase 2
Synonyms: Mekk2, 9630061B06Rik, MEK kinase 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26405
VEGA: 18
HGNC: HGNC:6854
Homologene: 74576
Fmnl2
Name: formin-like 2
Synonyms: man, 5430425K04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Zswim1
Name: zinc finger SWIM-type containing 1
Synonyms: 2410003H12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71971
Homologene: 12429
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: 9830169D19Rik, Vdu1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170822
Homologene: 8996
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: D930044O18Rik, D430002O22Rik, C230079D11Rik, LOC381127
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211961
Homologene: 19371
Ift172
Name: intraflagellar transport 172
Synonyms: wim, 4930553F24Rik, avc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67661
Homologene: 15202
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Klrg1
Name: killer cell lectin-like receptor subfamily G, member 1
Synonyms: 2F1-Ag
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50928
HGNC: HGNC:6380
Homologene: 4244
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: Nalp-theta, Nalp9a, D7Ertd565e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233001
Homologene: 116072
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170571
Homologene: 24912
Spata31g1
Name: SPATA31 subfamily G member 1
Synonyms: 1700022I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67317
Homologene: 52406
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: Tent6, Papd1, 0610027A18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67440
VEGA: 18
Homologene: 10008
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Zfp867
Name: zinc finger protein 867
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237775
Homologene: 64827
Atg9b
Name: autophagy related 9B
Synonyms: eONE, LOC213948, Apg9l2, Nos3as
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213948
Homologene: 72638
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC5, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: 5730407I04Rik, D18Bwg1409e, Mtsh1, Tsh1, Sdccag33, NY-CO-33, teashirt1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: Abp1, 1600012D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Fhl2
Name: four and a half LIM domains 2
Synonyms: SLIM3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14200
HGNC: HGNC:3703
Homologene: 20372
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cebpa-rs1, Cbf, CBF2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12607
VEGA: 17
Homologene: 4210
Vmn1r222
Name: vomeronasal 1 receptor 222
Synonyms: V1rh16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171274
Homologene: 110880
Vmn1r217
Name: vomeronasal 1 receptor 217
Synonyms: V1rh14
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171273
Homologene: 110880
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: Mrp2, multidrug resistance protein 2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330450
Homologene: 69247
Gzmg
Name: granzyme G
Synonyms: Ctla-7, Ctla7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14944
VEGA: 14
Homologene: 133275
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Ankub1
Name: ankyrin repeat and ubiquitin domain containing 1
Synonyms: LOC242037, Gm410
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242037
Homologene: 54680
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: Fam55d, D930028F11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
Or4k38
Name: olfactory receptor family 4 subfamily K member 38
Synonyms: MOR248-2, MOR248-16, Olfr1282, Olfr1557, GA_x6K02T2Q125-72387537-72386620
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258909
Homologene: 73992
Or51aa2
Name: olfactory receptor family 51 subfamily AA member 2
Synonyms: EG545985, Olfr612, MOR15-3, GA_x6K02T2PBJ9-6251685-6250741
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545985
Homologene: 79675
Lsmem1
Name: leucine-rich single-pass membrane protein 1
Synonyms: LOC380755, Gm889
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380755
VEGA: 12
Homologene: 18800
C2cd6
Name: C2 calcium dependent domain containing 6
Synonyms: 1700052H20Rik, Gm33589, 4930408G06Rik, Als2cr11b, C2cd6b, Als2cr11
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73463
Homologene: 134310
Slc15a1
Name: solute carrier family 15 (oligopeptide transporter), member 1
Synonyms: PECT1, PEPT1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56643
VEGA: 14
Homologene: 38006
Nmi
Name: N-myc (and STAT) interactor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64685
HGNC: HGNC:7854
Homologene: 3441
Unc93a
Name: unc-93 homolog A
Synonyms: Unc93l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381058
Homologene: 10356
Or6c213
Name: olfactory receptor family 6 subfamily C member 213
Synonyms: GA_x6K02T2PULF-11417610-11416669, Olfr806, MOR110-5, MOR110-12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258546
Homologene: 73936
Epn3
Name: epsin 3
Synonyms: 2310022G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71889
Homologene: 56791
Sprr2f
Name: small proline-rich protein 2F
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20760
Ptcd1
Name: pentatricopeptide repeat domain 1
Synonyms: 1110069M14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71799
Homologene: 33161
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: neuferricin, 9330151E16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192986
Homologene: 14701
Or8c19-ps1
Name: olfactory receptor family 8 subfamily C member 19, pseudogene1
Synonyms: MOR170-7, GA_x6K02T2PVTD-31999710-32000653, Olfr897-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258473
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 10,112,914 bp
  • A to G, chromosome 1 at 43,123,591 bp
  • A to T, chromosome 1 at 59,060,666 bp
  • C to G, chromosome 2 at 12,182,684 bp
  • T to C, chromosome 2 at 51,958,962 bp
  • T to A, chromosome 2 at 53,042,309 bp
  • A to G, chromosome 2 at 91,477,698 bp
  • C to A, chromosome 2 at 103,731,407 bp
  • T to C, chromosome 2 at 111,335,973 bp
  • C to T, chromosome 2 at 164,826,142 bp
  • A to G, chromosome 3 at 57,690,381 bp
  • G to C, chromosome 3 at 85,672,790 bp
  • T to A, chromosome 3 at 92,366,016 bp
  • T to A, chromosome 3 at 94,773,500 bp
  • T to A, chromosome 3 at 152,379,576 bp
  • T to A, chromosome 4 at 8,854,692 bp
  • T to C, chromosome 4 at 42,971,087 bp
  • A to G, chromosome 4 at 53,090,358 bp
  • T to C, chromosome 5 at 24,390,573 bp
  • C to T, chromosome 5 at 29,607,031 bp
  • A to G, chromosome 5 at 31,257,863 bp
  • C to T, chromosome 5 at 109,340,365 bp
  • A to T, chromosome 5 at 145,155,365 bp
  • T to A, chromosome 6 at 48,908,595 bp
  • C to A, chromosome 6 at 114,230,034 bp
  • T to C, chromosome 6 at 122,278,234 bp
  • T to A, chromosome 6 at 148,146,131 bp
  • G to T, chromosome 7 at 3,717,729 bp
  • T to C, chromosome 7 at 26,558,559 bp
  • C to A, chromosome 7 at 103,538,758 bp
  • T to A, chromosome 7 at 141,865,094 bp
  • A to G, chromosome 8 at 112,803,188 bp
  • A to T, chromosome 8 at 117,579,846 bp
  • G to A, chromosome 9 at 38,309,304 bp
  • A to G, chromosome 9 at 48,393,392 bp
  • A to G, chromosome 9 at 72,945,154 bp
  • A to T, chromosome 9 at 106,436,714 bp
  • A to G, chromosome 10 at 88,752,901 bp
  • T to A, chromosome 10 at 129,738,057 bp
  • A to G, chromosome 11 at 59,464,011 bp
  • A to C, chromosome 11 at 72,789,075 bp
  • T to C, chromosome 11 at 73,047,982 bp
  • G to T, chromosome 11 at 94,492,394 bp
  • T to C, chromosome 11 at 113,839,343 bp
  • G to T, chromosome 12 at 40,177,146 bp
  • T to C, chromosome 12 at 99,911,658 bp
  • T to A, chromosome 13 at 23,113,938 bp
  • A to T, chromosome 13 at 23,232,248 bp
  • G to T, chromosome 13 at 48,818,402 bp
  • G to A, chromosome 13 at 51,461,439 bp
  • A to T, chromosome 13 at 52,839,595 bp
  • A to T, chromosome 13 at 92,761,522 bp
  • C to T, chromosome 14 at 56,156,736 bp
  • G to T, chromosome 14 at 121,487,011 bp
  • T to G, chromosome 16 at 73,035,831 bp
  • T to G, chromosome 16 at 90,226,151 bp
  • A to T, chromosome 17 at 13,122,950 bp
  • G to A, chromosome 17 at 28,298,890 bp
  • T to C, chromosome 17 at 37,071,857 bp
  • A to G, chromosome 17 at 78,921,644 bp
  • C to T, chromosome 18 at 4,387,032 bp
  • A to T, chromosome 18 at 5,049,068 bp
  • C to A, chromosome 18 at 22,524,044 bp
  • G to A, chromosome 18 at 32,212,064 bp
  • T to A, chromosome 18 at 84,014,976 bp
  • A to T, chromosome 19 at 6,847,722 bp
  • T to A, chromosome 19 at 43,799,138 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8774 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068628-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.