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Strain Name:
C57BL/6J-MtgxR8783Btlr/Mmmh
Stock Number:
068631-MU
Citation ID:
RRID:MMRRC_068631-MU
Other Names:
R8783 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Nrg1
Name: neuregulin 1
Synonyms: HGL, HRG, Hgl, SMDF, GGF, ARIA, heregulin, D230005F13Rik, HRGalpha, 6030402G23Rik, GGFII, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Trim6
Name: tripartite motif-containing 6
Synonyms: D7Ertd684e, C430046K18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 94088
Homologene: 14381
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 68,040,172 bp
  • A to T, chromosome 1 at 93,812,432 bp
  • A to G, chromosome 1 at 135,373,206 bp
  • A to T, chromosome 1 at 149,864,990 bp
  • A to G, chromosome 1 at 192,513,937 bp
  • A to T, chromosome 2 at 52,258,632 bp
  • A to C, chromosome 2 at 76,743,350 bp
  • T to G, chromosome 2 at 76,789,014 bp
  • T to C, chromosome 2 at 88,412,607 bp
  • C to A, chromosome 2 at 130,395,723 bp
  • T to G, chromosome 2 at 131,191,852 bp
  • G to A, chromosome 2 at 164,605,849 bp
  • G to T, chromosome 2 at 174,438,882 bp
  • G to A, chromosome 2 at 180,614,177 bp
  • G to A, chromosome 3 at 67,384,664 bp
  • A to T, chromosome 3 at 79,098,344 bp
  • A to G, chromosome 3 at 93,074,473 bp
  • T to C, chromosome 3 at 127,052,806 bp
  • T to A, chromosome 3 at 129,989,693 bp
  • T to A, chromosome 4 at 61,673,530 bp
  • T to A, chromosome 4 at 88,644,289 bp
  • C to T, chromosome 4 at 141,909,092 bp
  • T to A, chromosome 4 at 155,755,695 bp
  • T to C, chromosome 5 at 25,692,219 bp
  • T to A, chromosome 5 at 33,879,111 bp
  • T to C, chromosome 5 at 73,068,842 bp
  • C to T, chromosome 5 at 134,559,869 bp
  • A to T, chromosome 5 at 148,083,051 bp
  • T to A, chromosome 5 at 148,342,833 bp
  • A to G, chromosome 6 at 23,002,027 bp
  • A to G, chromosome 6 at 23,302,304 bp
  • A to T, chromosome 6 at 40,656,489 bp
  • C to T, chromosome 6 at 101,155,880 bp
  • A to G, chromosome 6 at 113,491,725 bp
  • A to G, chromosome 6 at 125,123,384 bp
  • A to G, chromosome 6 at 131,686,769 bp
  • T to C, chromosome 6 at 132,777,649 bp
  • T to C, chromosome 6 at 135,310,332 bp
  • A to G, chromosome 7 at 30,232,365 bp
  • T to C, chromosome 7 at 31,132,795 bp
  • A to T, chromosome 7 at 85,858,460 bp
  • A to T, chromosome 7 at 103,937,544 bp
  • G to A, chromosome 7 at 104,225,646 bp
  • G to A, chromosome 7 at 128,238,253 bp
  • A to T, chromosome 7 at 141,063,846 bp
  • A to T, chromosome 8 at 31,958,601 bp
  • G to A, chromosome 8 at 33,336,013 bp
  • A to T, chromosome 8 at 46,987,185 bp
  • A to T, chromosome 8 at 106,099,152 bp
  • A to G, chromosome 8 at 111,049,883 bp
  • A to T, chromosome 8 at 120,576,378 bp
  • T to A, chromosome 9 at 51,816,667 bp
  • T to C, chromosome 9 at 61,927,571 bp
  • T to C, chromosome 9 at 108,069,073 bp
  • A to G, chromosome 10 at 78,451,505 bp
  • T to A, chromosome 10 at 81,179,665 bp
  • T to G, chromosome 10 at 121,417,164 bp
  • T to G, chromosome 10 at 127,457,652 bp
  • T to C, chromosome 11 at 82,036,534 bp
  • A to T, chromosome 11 at 106,263,032 bp
  • A to G, chromosome 11 at 107,131,531 bp
  • T to A, chromosome 11 at 116,126,317 bp
  • T to A, chromosome 12 at 102,788,242 bp
  • T to C, chromosome 12 at 107,917,303 bp
  • T to A, chromosome 12 at 113,288,792 bp
  • T to A, chromosome 13 at 34,990,197 bp
  • T to A, chromosome 13 at 54,552,707 bp
  • A to T, chromosome 13 at 93,089,380 bp
  • A to G, chromosome 14 at 4,743,761 bp
  • A to T, chromosome 14 at 51,414,066 bp
  • C to A, chromosome 14 at 76,007,724 bp
  • C to T, chromosome 15 at 76,853,213 bp
  • A to T, chromosome 16 at 87,410,359 bp
  • T to A, chromosome 17 at 24,974,758 bp
  • T to C, chromosome 17 at 35,619,983 bp
  • T to C, chromosome 17 at 43,478,190 bp
  • T to C, chromosome 17 at 46,655,649 bp
  • T to C, chromosome 18 at 37,695,543 bp
  • A to T, chromosome 19 at 9,011,473 bp
  • A to T, chromosome 19 at 13,654,959 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8783 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068631-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.