Strain Name:
C57BL/6J-MtgxR8787Btlr/Mmmh
Stock Number:
068633-MU
Citation ID:
RRID:MMRRC_068633-MU
Other Names:
R8787 (G1)
Major Collection:

Strain Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Cola-1, Col1a-1, Cola1, Mov-13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Htr4
Name: 5 hydroxytryptamine (serotonin) receptor 4
Synonyms: 5-HT4L, 5-HT4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15562
VEGA: 18
HGNC: HGNC:5299
Homologene: 20243
Lefty1
Name: left right determination factor 1
Synonyms: lefty-1, Lefty, Ebaf, Stra3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13590
HGNC: HGNC:6552
Homologene: 49231
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Oxtr
Name: oxytocin receptor
Synonyms: OTR
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18430
HGNC: HGNC:8529
Homologene: 20255
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: Sfrs11, 0610009J05Rik, 2610019N13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69207
Homologene: 36164
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: Zfp262, 6330503C17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
R3hdm2
Name: R3H domain containing 2
Synonyms: 1300003K24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71750
Homologene: 8954
Pdcd11
Name: programmed cell death 11
Synonyms: 1110021I22Rik, ALG-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Chek1
Name: checkpoint kinase 1
Synonyms: Chk1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12649
HGNC: HGNC:1925
Homologene: 975
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: mVam6, A230065P22Rik, Vam6P, Vam6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269338
Homologene: 41025
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Acp5
Name: acid phosphatase 5, tartrate resistant
Synonyms: TRACP, TRAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11433
VEGA: 9
HGNC: HGNC:124
Homologene: 137203
Clec1a
Name: C-type lectin domain family 1, member a
Synonyms: 5930406N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243653
Homologene: 9549
Hadh
Name: hydroxyacyl-Coenzyme A dehydrogenase
Synonyms: Hadhsc, Schad
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15107
HGNC: HGNC:4799
Homologene: 55888
Tgfbr1
Name: transforming growth factor, beta receptor I
Synonyms: TbetaRI, TbetaR-I, ALK5, Alk-5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21812
Homologene: 3177
Glg1
Name: golgi apparatus protein 1
Synonyms: ESL-1, Selel, CFR, MG-160, MG160, CFR-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20340
HGNC: HGNC:4316
Homologene: 7533
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Fads1
Name: fatty acid desaturase 1
Synonyms: A930006B21Rik, 0710001O03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76267
VEGA: 19
HGNC: HGNC:3574
Homologene: 22753
Wtap
Name: WT1 associating protein
Synonyms: 2810408K05Rik, 9430038B09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 60532
Homologene: 68422
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
L1td1
Name: LINE-1 type transposase domain containing 1
Synonyms: ECAT11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381591
Homologene: 135709
Smpd3
Name: sphingomyelin phosphodiesterase 3, neutral
Synonyms: nSMase2, 4631433G07Rik, fro, Nsm2, neutral sphingomyelinase II
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58994
Homologene: 10260
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Tek
Name: TEK receptor tyrosine kinase
Synonyms: tie-2, Hyk, Cd202b, Tie2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21687
Homologene: 397
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 332221
Homologene: 13122
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Kcnn3
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Synonyms: SK3, small conductance calcium-activated potassium channel 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140493
HGNC: HGNC:6292
Homologene: 20516
Serpinb9h
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9h
Synonyms: Gm11397
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544923
HGNC: HGNC:8955
Homologene: 69093
Efcab7
Name: EF-hand calcium binding domain 7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230500
Homologene: 19952
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Or8k33
Name: olfactory receptor family 8 subfamily K member 33
Synonyms: GA_x6K02T2Q125-48039418-48038477, Olfr1080, MOR192-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258404
Homologene: 104285
Syna
Name: syncytin a
Synonyms: Gm52, syncytin-A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 214292
Homologene: 86751
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: Srcasm, 2310045L10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71943
Homologene: 38055
Vmn1r24
Name: vomeronasal 1 receptor 24
Synonyms: V1rc18
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171191
Homologene: 134024
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624845
Homologene: 83483
Adra2b
Name: adrenergic receptor, alpha 2b
Synonyms: a2b-AR, alpha2B, [a]2B, Adra-2b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11552
HGNC: HGNC:282
Homologene: 553
Vsig10
Name: V-set and immunoglobulin domain containing 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231668
Homologene: 10414
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, PLCeta2, Plcl4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Or2ad1
Name: olfactory receptor family 2 subfamily AD member 1
Synonyms: GA_x6K02T2QHY8-12104556-12105500, MOR256-15, Olfr1368
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258527
Homologene: 105156
Lao1
Name: L-amino acid oxidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100470
Homologene: 44223
Ncf1
Name: neutrophil cytosolic factor 1
Synonyms: NOXO2, p47phox, Ncf-1, p47phox, NADPH oxidase subunit (47kDa)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17969
Homologene: 30964
Ccdc78
Name: coiled-coil domain containing 78
Synonyms: LOC381077, LOC381146
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381077
VEGA: 17
Homologene: 105408
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: Cark, D830019J24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 435766
Homologene: 41084
Angpt1
Name: angiopoietin 1
Synonyms: Ang-1, 1110046O21Rik, Angiopoietin-1, ang1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11600
VEGA: 15
HGNC: HGNC:484
Homologene: 37447
Alox12
Name: arachidonate 12-lipoxygenase
Synonyms: 9930022G08Rik, P-12LO, Alox12p
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11684
HGNC: HGNC:429
Homologene: 560
Mrc2
Name: mannose receptor, C type 2
Synonyms: uPARAP, Endo180, novel lectin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5-LOX, 5LX, 5LO
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: Pycs, 2810433K04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99334
Homologene: 17586
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: experimental autoimmune prostatitis antigen 1, 9530008N10Rik, Eapa1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331046
Homologene: 20689
Stpg1
Name: sperm tail PG rich repeat containing 1
Synonyms: 4930555I21Rik, 4930403G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78806
Homologene: 12705
Or14j7
Name: olfactory receptor family 14 subfamily J member 7
Synonyms: MOR218-13, GA_x6K02T2PSCP-2374126-2375048, Olfr128
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383243
Homologene: 134080
Rassf10
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
Synonyms: 4632411J06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78748
Homologene: 121963
Ubqln5
Name: ubiquilin 5
Synonyms: 4931431F19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70980
Homologene: 78030
Lmx1b
Name: LIM homeobox transcription factor 1 beta
Synonyms: LMX1.2, Icst, GENA 191
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16917
HGNC: HGNC:6654
Homologene: 55648
Rgs13
Name: regulator of G-protein signaling 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246709
HGNC: HGNC:9995
Homologene: 14774
Spata31e1
Name: spermatogenesis associated 31 subfamily E member 1
Synonyms: Gm30302
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102632152
VEGA: 13
Homologene: 141176
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,288,237 bp
  • CTT to CTTTTT, chromosome 1 at 133,701,747 bp
  • T to C, chromosome 1 at 144,140,744 bp
  • C to A, chromosome 1 at 180,936,553 bp
  • T to C, chromosome 2 at 33,639,510 bp
  • A to G, chromosome 2 at 69,552,401 bp
  • G to A, chromosome 2 at 86,553,953 bp
  • T to A, chromosome 2 at 118,631,824 bp
  • A to G, chromosome 2 at 120,342,025 bp
  • A to T, chromosome 2 at 121,166,395 bp
  • A to T, chromosome 2 at 127,364,497 bp
  • T to A, chromosome 3 at 83,046,662 bp
  • A to G, chromosome 3 at 89,645,450 bp
  • T to A, chromosome 3 at 131,234,176 bp
  • T to C, chromosome 3 at 154,940,054 bp
  • A to T, chromosome 3 at 158,012,400 bp
  • A to T, chromosome 4 at 47,405,555 bp
  • T to C, chromosome 4 at 94,849,800 bp
  • G to A, chromosome 4 at 98,737,577 bp
  • A to G, chromosome 4 at 99,900,594 bp
  • A to G, chromosome 4 at 118,968,368 bp
  • T to G, chromosome 4 at 126,923,160 bp
  • T to A, chromosome 4 at 135,533,797 bp
  • C to A, chromosome 4 at 154,986,418 bp
  • C to A, chromosome 5 at 117,334,916 bp
  • A to C, chromosome 5 at 134,225,291 bp
  • C to T, chromosome 5 at 134,559,869 bp
  • G to A, chromosome 6 at 57,955,973 bp
  • T to G, chromosome 6 at 112,489,910 bp
  • G to T, chromosome 6 at 116,413,141 bp
  • A to T, chromosome 6 at 129,451,654 bp
  • T to C, chromosome 7 at 104,129,122 bp
  • T to A, chromosome 7 at 112,955,531 bp
  • G to A, chromosome 8 at 106,255,745 bp
  • C to A, chromosome 8 at 111,161,482 bp
  • G to A, chromosome 9 at 22,127,193 bp
  • A to T, chromosome 9 at 36,713,737 bp
  • G to T, chromosome 9 at 123,061,845 bp
  • C to T, chromosome 10 at 79,378,060 bp
  • T to G, chromosome 10 at 127,457,652 bp
  • C to T, chromosome 11 at 9,275,053 bp
  • C to A, chromosome 11 at 70,253,320 bp
  • A to T, chromosome 11 at 90,671,105 bp
  • T to C, chromosome 11 at 94,942,808 bp
  • A to T, chromosome 11 at 105,347,639 bp
  • T to C, chromosome 12 at 65,042,781 bp
  • A to T, chromosome 13 at 21,142,283 bp
  • G to A, chromosome 13 at 33,404,221 bp
  • T to C, chromosome 13 at 49,785,228 bp
  • G to T, chromosome 15 at 42,512,384 bp
  • A to T, chromosome 15 at 94,286,413 bp
  • T to C, chromosome 17 at 5,986,239 bp
  • G to A, chromosome 17 at 12,967,601 bp
  • G to T, chromosome 17 at 18,597,988 bp
  • A to G, chromosome 17 at 23,610,037 bp
  • A to T, chromosome 17 at 25,787,833 bp
  • T to A, chromosome 17 at 37,924,184 bp
  • C to T, chromosome 18 at 5,059,332 bp
  • T to C, chromosome 18 at 37,091,889 bp
  • A to G, chromosome 18 at 62,437,782 bp
  • T to C, chromosome 19 at 6,847,423 bp
  • T to A, chromosome 19 at 10,192,961 bp
  • T to C, chromosome 19 at 40,557,786 bp
  • T to G, chromosome 19 at 47,108,580 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8787 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068633-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.