Strain Name:
C57BL/6J-MtgxR8813Btlr/Mmmh
Stock Number:
068648-MU
Citation ID:
RRID:MMRRC_068648-MU
Other Names:
R8813 (G1)
Major Collection:

Strain Information

H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-M alpha, H-2Ma, H2-Ma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Efnb2
Name: ephrin B2
Synonyms: Eplg5, Epl5, Htk-L, ELF-2, LERK-5, NLERK-1, Lerk5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13642
HGNC: HGNC:3227
Homologene: 3019
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2l2, Bat2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Nup133
Name: nucleoporin 133
Synonyms: mermaid, 4832420O05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234865
Homologene: 32402
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Lonp2
Name: lon peptidase 2, peroxisomal
Synonyms: 1300002A08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66887
Homologene: 12050
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Cops7b
Name: COP9 signalosome subunit 7B
Synonyms: COP9 complex S7b, D1Wsu66e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26895
Homologene: 8068
Clmp
Name: CXADR-like membrane protein
Synonyms: 9030425E11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71566
Homologene: 11705
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Sla
Name: src-like adaptor
Synonyms: Slap, Slap-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20491
Homologene: 36206
Marcksl1
Name: MARCKS-like 1
Synonyms: Macs2, Macs3, D4Bc1, Mrp, Macs-3, Macs-2, Mlp, F52, MacMARCKS
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17357
HGNC: HGNC:7142
Homologene: 40748
Rb1
Name: RB transcriptional corepressor 1
Synonyms: pRb, Rb, retinoblastoma 1, Rb-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Amotl2
Name: angiomotin-like 2
Synonyms: Lccp, MASCOT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56332
Homologene: 9420
Trim33
Name: tripartite motif-containing 33
Synonyms: 8030451N04Rik, Tif1g, Ecto, ectodermin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216850
Homologene: 18945
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b3491Clo, Mdnah5, b2b1537Clo, b2b1134Clo, Dnahc5, b2b1154Clo, b2b1565Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, Mlsn1, melastatin, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Pter
Name: phosphotriesterase related
Synonyms: Mpr56-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19212
HGNC: HGNC:9590
Homologene: 7495
Rnasel
Name: ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
Synonyms: E230029I04Rik, 2-5A-dependent RNAase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 24014
Homologene: 8040
Tro
Name: trophinin
Synonyms: Maged3, magphinin-beta 2, necdin and trophinin like, magphinin-gamma, Maged3l, Trol, trophinin-2, magphinin, Tnn, magphinin-alpha
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 56191
Homologene: 75113
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242584
Homologene: 11702
T
Name: brachyury, T-box transcription factor T
Synonyms: T1, Bra, Tbxt
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20997
Homologene: 2393
Pde1a
Name: phosphodiesterase 1A, calmodulin-dependent
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18573
HGNC: HGNC:8774
Homologene: 21043
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277668
Homologene: 129883
Vmn1r56
Name: vomeronasal 1 receptor 56
Synonyms: V3R3, V1rd3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81015
Homologene: 41799
Zfp11
Name: zinc finger protein 11
Synonyms: Zfp-11, Krox-6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22648
Homologene: 87241
Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms: Cyp2c44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226143
Homologene: 115563
Cenpj
Name: centromere protein J
Synonyms: Sas4, 4932437H03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219103
Homologene: 10204
Or13a19
Name: olfactory receptor family 13 subfamily A member 19
Synonyms: Olfr525, GA_x6K02T2PBJ9-42472898-42473827, MOR251-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258958
Homologene: 138321
Zscan4e
Name: zinc finger and SCAN domain containing 4E
Synonyms: EG665848
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665848
Homologene: 85986
Or7g31
Name: olfactory receptor family 7 subfamily G member 31
Synonyms: GA_x6K02T2PVTD-13214162-13213224, Olfr850, MOR147-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258516
HGNC: HGNC:8466
Homologene: 121552
Nxf7
Name: nuclear RNA export factor 7
Synonyms: nfx-a1, nxf-a2
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 170722
Homologene: 134586
Habp2
Name: hyaluronic acid binding protein 2
Synonyms: FSAP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226243
HGNC: HGNC:4798
Homologene: 3050
Rragd
Name: Ras-related GTP binding D
Synonyms: C030003H22Rik, 5730543C08Rik, D4Ertd174e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52187
Homologene: 49667
Or4a73
Name: olfactory receptor family 4 subfamily A member 73
Synonyms: GA_x6K02T2Q125-51034790-51033846, MOR231-9, Olfr1246
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258788
Homologene: 74246
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930540C21Rik, 4930517G15Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Or7g34
Name: olfactory receptor family 7 subfamily G member 34
Synonyms: MOR147-3, Olfr854, GA_x6K02T2PVTD-13313295-13312357
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258515
Homologene: 128144
Parp12
Name: poly (ADP-ribose) polymerase family, member 12
Synonyms: Zc3hdc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243771
Homologene: 11236
Vmn1r205
Name: vomeronasal 1 receptor 205
Synonyms: V1rh8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171251
Homologene: 110880
Erich3
Name: glutamate rich 3
Synonyms: 5031409G23Rik, 4922501L14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 209601
Homologene: 27877
Klk5
Name: kallikrein related-peptidase 5
Synonyms: 1110030O19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68668
HGNC: HGNC:6366
Homologene: 75000
Or52e5
Name: olfactory receptor family 52 subfamily E member 5
Synonyms: MOR32-5, Olfr678, GA_x6K02T2PBJ9-7698491-7699432
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258753
Homologene: 27254
Kcnk13
Name: potassium channel, subfamily K, member 13
Synonyms: THIK-1, LOC381712, F730021E22Rik, LOC380778
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217826
HGNC: HGNC:6275
Homologene: 69351
AA467197
Name: expressed sequence AA467197
Synonyms: NMES1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433470
Homologene: 41867
Eif1ad6
Name: eukaryotic translation initiation factor 1A domain containing 6
Synonyms: Gm4027
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100042776
Homologene: 103865
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 86,601,124 bp
  • G to A, chromosome 1 at 87,915,544 bp
  • T to A, chromosome 1 at 153,753,895 bp
  • T to C, chromosome 1 at 162,705,243 bp
  • T to C, chromosome 2 at 12,980,303 bp
  • T to A, chromosome 2 at 59,799,921 bp
  • G to A, chromosome 2 at 80,128,917 bp
  • A to T, chromosome 2 at 89,590,386 bp
  • C to A, chromosome 2 at 118,448,325 bp
  • T to C, chromosome 2 at 122,640,702 bp
  • A to G, chromosome 3 at 103,346,736 bp
  • A to G, chromosome 3 at 154,763,190 bp
  • A to T, chromosome 4 at 33,012,953 bp
  • T to C, chromosome 4 at 103,090,500 bp
  • C to T, chromosome 4 at 129,515,206 bp
  • T to A, chromosome 4 at 143,654,343 bp
  • T to A, chromosome 5 at 30,382,898 bp
  • T to C, chromosome 5 at 129,658,214 bp
  • A to G, chromosome 6 at 39,096,574 bp
  • G to T, chromosome 6 at 73,127,954 bp
  • C to T, chromosome 7 at 5,195,734 bp
  • C to A, chromosome 7 at 11,307,613 bp
  • G to T, chromosome 7 at 43,847,125 bp
  • T to A, chromosome 7 at 64,202,008 bp
  • T to A, chromosome 7 at 105,070,311 bp
  • C to A, chromosome 7 at 140,322,880 bp
  • T to A, chromosome 8 at 8,620,731 bp
  • A to G, chromosome 8 at 86,631,445 bp
  • AAGAGA to AAGA, chromosome 8 at 123,911,888 bp
  • A to G, chromosome 8 at 128,823,461 bp
  • T to G, chromosome 9 at 19,478,181 bp
  • A to T, chromosome 9 at 19,566,599 bp
  • C to T, chromosome 9 at 40,781,253 bp
  • A to G, chromosome 9 at 67,871,284 bp
  • T to G, chromosome 9 at 102,730,092 bp
  • A to T, chromosome 9 at 119,127,430 bp
  • GGGTGGTGGTGGTGGTGG to GGGTGGTGGTGGTGGTGGTGG, chromosome 11 at 69,406,829 bp
  • TGG to TGGGGG, chromosome 11 at 69,406,832 bp
  • A to G, chromosome 12 at 87,621,823 bp
  • G to T, chromosome 12 at 100,061,388 bp
  • A to G, chromosome 13 at 22,592,254 bp
  • C to T, chromosome 14 at 56,552,898 bp
  • A to G, chromosome 14 at 73,262,587 bp
  • G to T, chromosome 15 at 28,229,573 bp
  • G to T, chromosome 15 at 66,792,278 bp
  • A to G, chromosome 17 at 8,434,700 bp
  • T to C, chromosome 17 at 34,135,760 bp
  • T to A, chromosome 17 at 34,719,162 bp
  • T to C, chromosome 18 at 49,957,339 bp
  • A to G, chromosome 19 at 44,013,615 bp
  • G to A, chromosome 19 at 56,306,784 bp
  • G to A, chromosome X at 135,583,766 bp
  • G to A, chromosome X at 150,655,559 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8813 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068648-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.