Strain Name:
C57BL/6J-MtgxR8833Btlr/Mmmh
Stock Number:
068661-MU
Citation ID:
RRID:MMRRC_068661-MU
Other Names:
R8833 (G1)
Major Collection:

Strain Information

Ttr
Name: transthyretin
Synonyms: prealbumin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 22139
VEGA: 18
Homologene: 317
Pak1
Name: p21 (RAC1) activated kinase 1
Synonyms: PAK-1, Paka
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18479
HGNC: HGNC:8590
Homologene: 1936
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, SBP2, 2810012K13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70508
Homologene: 10634
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98732
Homologene: 40842
Bzw2
Name: basic leucine zipper and W2 domains 2
Synonyms: HSPC028, 1110001I24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66912
VEGA: 12
Homologene: 8530
Rarb
Name: retinoic acid receptor, beta
Synonyms: RARbeta2, RAR beta 2, Hap
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218772
VEGA: 14
HGNC: HGNC:9865
Homologene: 68100
Sox11
Name: SRY (sex determining region Y)-box 11
Synonyms: end1, 6230403H02Rik, 1110038H03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20666
Homologene: 37733
Zfp980
Name: zinc finger protein 980
Synonyms: Gm13242
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041379
Homologene: 133076
Zfp141
Name: zinc finger protein 141
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434178
C1qtnf6
Name: C1q and tumor necrosis factor related protein 6
Synonyms: 2810036M19Rik, CTRP6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72709
Homologene: 12481
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, Mis6, 9930111A19Rik, Motch A, N1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67419
Homologene: 12127
Gfra2
Name: glial cell line derived neurotrophic factor family receptor alpha 2
Synonyms: GFR alpha 2, GFR alpha-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14586
VEGA: 14
HGNC: HGNC:4244
Homologene: 1145
Tatdn2
Name: TatD DNase domain containing 2
Synonyms: mKIAA0218
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381801
Homologene: 8848
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 2810455B10Rik, PAR3beta, PAR3L, PAR3B, 2010002N16Rik, Als2cr19, 1810008K04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72823
Homologene: 35389
Syt11
Name: synaptotagmin XI
Synonyms: 6530420C11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229521
Homologene: 23120
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 623046
VEGA: 12
Homologene: 136275
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: t2md1, LLGL4, A830015P08Rik, insulin level locus 1, tomosyn-2, T2dm1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207227
Homologene: 18173
Cdh4
Name: cadherin 4
Synonyms: Rcad, R-cadherin, R-Cadh
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Or4k5
Name: olfactory receptor family 4 subfamily K member 5
Synonyms: GA_x6K02T2PMLR-5839874-5838903, MOR246-6, Olfr729
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258275
Homologene: 17167
Or52z13
Name: olfactory receptor family 52 subfamily Z member 13
Synonyms: GA_x6K02T2PBJ9-6320148-6321104, MOR31-9, Olfr618
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259049
Homologene: 72966
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Or5k14
Name: olfactory receptor family 5 subfamily K member 14
Synonyms: GA_x54KRFPKG5P-55091371-55090442, MOR184-7, Olfr177, MOR184-8, GA_x54KRFPKG5P-55043245-55042289, Olfr176
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258998
Homologene: 121500
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93880
HGNC: HGNC:8689
Homologene: 87124
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
Cpne9
Name: copine family member IX
Synonyms: A730016F12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211232
Homologene: 84686
Spata17
Name: spermatogenesis associated 17
Synonyms: 4930504I07Rik, 1700065F16Rik, 4930513F16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74717
Homologene: 12551
Niban1
Name: niban apoptosis regulator 1
Synonyms: Niban, Fam129a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63913
Homologene: 62170
Slc28a3
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms: Cnt3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 114304
Homologene: 32533
Ces4a
Name: carboxylesterase 4A
Synonyms: Ces8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234677
Homologene: 71949
Pkdcc
Name: protein kinase domain containing, cytoplasmic
Synonyms: ESTM17, Vlk, MAd1, Adtk1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106522
Homologene: 18932
Ro60
Name: Ro60, Y RNA binding protein
Synonyms: SS-A/Ro, Ssa, A530054J02Rik, 1810007I17Rik, Ssa2, Trove2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20822
Homologene: 3383
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Fuca1
Name: fucosidase, alpha-L- 1, tissue
Synonyms: Afuc, 0610006A03Rik, 9530055J05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71665
HGNC: HGNC:4006
Homologene: 20078
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78895
Homologene: 12842
Vmn1r32
Name: vomeronasal 1 receptor 32
Synonyms: V1rc15
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171188
Homologene: 115644
Pdpr
Name: pyruvate dehydrogenase phosphatase regulatory subunit
Synonyms: 4930402E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319518
Homologene: 9948
Or4d10c
Name: olfactory receptor family 4 subfamily D member 10C
Synonyms: GA_x6K02T2RE5P-2447610-2446675, MOR239-1, Olfr1426
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258805
Homologene: 128079
Slc26a1
Name: solute carrier family 26 (sulfate transporter), member 1
Synonyms: Sat1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231583
Homologene: 32539
Rom1
Name: rod outer segment membrane protein 1
Synonyms: Rom-1, Tspan23, M101156, Rgsc1156
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19881
VEGA: 19
Homologene: 276
Orm1
Name: orosomucoid 1
Synonyms: Agp-2, Agp-1, Orm-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18405
Homologene: 130632
Akr1c6
Name: aldo-keto reductase family 1, member C6
Synonyms: estradiol 17-beta-dehydrogenase (A-specific), 3alpha-HSD, Akr1c1, Hsd17b5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83702
Homologene: 84695
Vmn1r129
Name: vomeronasal 1 receptor 129
Synonyms: Gm6237
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 621510
Homologene: 104166
Grap2
Name: GRB2-related adaptor protein 2
Synonyms: Gads, Grb2-related adaptor downstream of Sch, GRID, GRAP-2, GrbX, GRB2L, Grf40, P38, Mona, GrpL
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17444
VEGA: 15
HGNC: HGNC:4563
Homologene: 21007
Tor3a
Name: torsin family 3, member A
Synonyms: Adir
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30935
Homologene: 23359
Potefam3c
Name: POTE ankyrin domain family member 3C
Synonyms: Pote3c, Gm9495
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 670593
Homologene: 128726
Speer1a
Name: spermatogenesis associated glutamate (E)-rich protein 1A
Synonyms: SPEER-1, Speer1-ps1, Speer1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70896
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 62,344,999 bp
  • T to A, chromosome 1 at 143,765,779 bp
  • T to A, chromosome 1 at 151,644,930 bp
  • T to C, chromosome 1 at 156,655,803 bp
  • T to A, chromosome 1 at 185,258,525 bp
  • T to C, chromosome 1 at 187,183,239 bp
  • G to A, chromosome 2 at 26,481,603 bp
  • A to G, chromosome 2 at 179,894,035 bp
  • T to C, chromosome 3 at 88,747,842 bp
  • A to T, chromosome 4 at 63,344,701 bp
  • C to A, chromosome 4 at 88,643,920 bp
  • A to G, chromosome 4 at 123,471,341 bp
  • A to G, chromosome 4 at 135,920,895 bp
  • T to A, chromosome 4 at 145,701,026 bp
  • C to A, chromosome 5 at 11,344,238 bp
  • G to T, chromosome 5 at 105,018,802 bp
  • T to C, chromosome 5 at 108,672,316 bp
  • A to G, chromosome 6 at 66,553,639 bp
  • T to C, chromosome 6 at 113,304,512 bp
  • T to G, chromosome 6 at 113,707,387 bp
  • A to T, chromosome 7 at 21,361,280 bp
  • T to C, chromosome 7 at 42,476,263 bp
  • T to A, chromosome 7 at 97,854,632 bp
  • T to G, chromosome 7 at 103,598,237 bp
  • A to G, chromosome 7 at 141,858,368 bp
  • A to T, chromosome 8 at 69,429,330 bp
  • G to A, chromosome 8 at 80,612,772 bp
  • A to G, chromosome 8 at 105,131,982 bp
  • G to A, chromosome 8 at 111,125,680 bp
  • C to A, chromosome 9 at 67,221,411 bp
  • G to A, chromosome 10 at 67,218,383 bp
  • A to G, chromosome 11 at 43,222,159 bp
  • T to A, chromosome 11 at 87,493,052 bp
  • A to G, chromosome 12 at 27,342,314 bp
  • A to T, chromosome 12 at 36,119,070 bp
  • T to A, chromosome 12 at 64,473,223 bp
  • T to A, chromosome 13 at 4,446,378 bp
  • T to A, chromosome 13 at 9,575,483 bp
  • T to C, chromosome 13 at 51,665,316 bp
  • C to T, chromosome 13 at 58,559,263 bp
  • T to A, chromosome 13 at 100,222,934 bp
  • T to A, chromosome 14 at 16,819,015 bp
  • C to T, chromosome 14 at 49,773,861 bp
  • A to T, chromosome 14 at 50,148,366 bp
  • T to C, chromosome 14 at 70,925,897 bp
  • T to C, chromosome 15 at 71,462,934 bp
  • G to T, chromosome 15 at 78,525,374 bp
  • A to G, chromosome 15 at 80,638,483 bp
  • A to T, chromosome 15 at 94,540,262 bp
  • T to C, chromosome 16 at 37,204,452 bp
  • T to A, chromosome 16 at 50,225,266 bp
  • A to T, chromosome 16 at 58,872,596 bp
  • T to C, chromosome 17 at 83,223,926 bp
  • T to G, chromosome 18 at 20,666,493 bp
  • G to T, chromosome 18 at 37,401,415 bp
  • A to T, chromosome 19 at 8,928,107 bp
  • A to G, chromosome 19 at 12,088,279 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8833 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068661-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.