Strain Name:
C57BL/6J-MtgxR8837Btlr/Mmmh
Stock Number:
068665-MU
Citation ID:
RRID:MMRRC_068665-MU
Other Names:
R8837 (G1)
Major Collection:

Strain Information

Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22173
Homologene: 30969
Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: myosin IIA, E030044M24Rik, NMHC II-A, Fltn, Myhn-1, Myhn1, D0Jmb2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Gga3
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3
Synonyms: C230037M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 260302
Homologene: 121703
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Spns1
Name: SPNS lysolipid transporter 1, lysophospholipid
Synonyms: 2210013K02Rik, spinster homolog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73658
Homologene: 41530
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: p110beta, 1110001J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Mga
Name: MAX gene associated
Synonyms: Mga, D030062C11Rik, C130042M01Rik, Mad5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Rpa1
Name: replication protein A1
Synonyms: RF-A, 5031405K23Rik, 70kDa, RP-A, Rpa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68275
Homologene: 2208
Clybl
Name: citrate lyase beta like
Synonyms: 2310014M14Rik, Clb, 0610033J05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69634
VEGA: 14
Homologene: 49925
Uck2
Name: uridine-cytidine kinase 2
Synonyms: TSA903, Umpk
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 80914
Homologene: 40850
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Rob, Mllt2h, 9630032B01Rik, Af4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Dbnl
Name: drebrin-like
Synonyms: mAbp1, SH3P7, ABP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13169
HGNC: HGNC:2696
Homologene: 8468
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Cog4
Name: component of oligomeric golgi complex 4
Synonyms: D8Ertd515e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102339
Homologene: 7155
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Fas
Name: Fas cell surface death receptor
Synonyms: Tnfrsf6, APO-1, TNFR6, CD95
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14102
VEGA: 19
Homologene: 27
Soat1
Name: sterol O-acyltransferase 1
Synonyms: hid, Acact, 8430426K15Rik, ACAT-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20652
Homologene: 2333
Ttc23
Name: tetratricopeptide repeat domain 23
Synonyms: 1600012K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67009
Homologene: 11289
Dgcr2
Name: DiGeorge syndrome critical region gene 2
Synonyms: DGS-C, Dgsc, Lan, 9930034O06Rik, Sez12, Idd, Dgcr2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13356
HGNC: HGNC:2845
Homologene: 31292
Fabp4
Name: fatty acid binding protein 4, adipocyte
Synonyms: ALBP/Ap2, Ap2, 422/aP2, Lbpl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11770
HGNC: HGNC:3559
Homologene: 36067
Btbd10
Name: BTB domain containing 10
Synonyms: Gmrp1, 1110056N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68815
Homologene: 13009
Dync2i2
Name: dynein 2 intermediate chain 2
Synonyms: Wdr34, 3200002I06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71820
Homologene: 14156
Scfd2
Name: Sec1 family domain containing 2
Synonyms: STXBP1L1, E430013M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212986
Homologene: 77411
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Sec31b
Name: SEC31 homolog B, COPII coat complex component
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240667
Homologene: 56708
Abcb4
Name: ATP-binding cassette, sub-family B member 4
Synonyms: Mdr2, Pgy-2, mdr-2, Pgy2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Catsper1
Name: cation channel, sperm associated 1
Synonyms: KSper
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225865
VEGA: 19
Homologene: 14207
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms: Atpa-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232975
HGNC: HGNC:801
Homologene: 113729
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Lcn10
Name: lipocalin 10
Synonyms: 9230112J07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 332578
Homologene: 52253
Atosb
Name: atos homolog B
Synonyms: B230312A22Rik, Fam214b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230088
Homologene: 32625
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: 4931420C21Rik, EFA6D
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234353
Homologene: 87257
Capn8
Name: calpain 8
Synonyms: nCL-2', nCL-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170725
HGNC: HGNC:1485
Homologene: 15643
Krt18
Name: keratin 18
Synonyms: K18, CK18, Krt1-18, Endo B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16668
VEGA: 15
HGNC: HGNC:6430
Homologene: 55448
Or1j15
Name: olfactory receptor family 1 subfamily J member 15
Synonyms: Olfr344, MOR136-12, GA_x6K02T2NLDC-33262744-33263673
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258621
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: 9030624O13Rik, NHE3, NHE-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105243
VEGA: 13
Homologene: 55804
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll4, C430014K11Rik, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: Zfp469, EG381742
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Pde7b
Name: phosphodiesterase 7B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 29863
HGNC: HGNC:8792
Homologene: 32194
Tbxas1
Name: thromboxane A synthase 1, platelet
Synonyms: TXAS, TXS, CYP5A1, CYP5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21391
Homologene: 130979
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, SKIP, A930009L15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Scn11a
Name: sodium channel, voltage-gated, type XI, alpha
Synonyms: NaN, NSS2, SNS2, NaT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24046
VEGA: 9
Homologene: 8041
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, Fars1, 6720478K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Yrdc
Name: yrdC domain containing (E.coli)
Synonyms: IRIP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230734
Homologene: 11635
Or1o3
Name: olfactory receptor family 1 subfamily O member 3
Synonyms: MOR156-4, GA_x6K02T2PSCP-1703582-1702653, Olfr98
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258503
Homologene: 133051
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Kank3
Name: KN motif and ankyrin repeat domains 3
Synonyms: 0610013D04Rik, Ankrd47, D17Ertd288e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80880
Homologene: 12749
Or8b1
Name: olfactory receptor family 8 subfamily B member 1
Synonyms: Olfr906, GA_x6K02T2PVTD-32194085-32195020, MOR167-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258799
VEGA: 9
Homologene: 132439
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: MMCM2, MMSpi2, D12Rp54, contrapsin, Spi2, RP54, 1300001I07Rik, Spi-2, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Prl3d2
Name: prolactin family 3, subfamily d, member 1
Synonyms: Plib, PL-Ib
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 215028
Homologene: 137215
Zfp612
Name: zinc finger protein 612
Synonyms: B230354B21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234725
Homologene: 27083
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: 1700013B16Rik, Fam75d3, Fam75d1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 83,275,663 bp
  • A to G, chromosome 1 at 155,861,772 bp
  • A to G, chromosome 1 at 156,434,202 bp
  • A to G, chromosome 1 at 167,243,146 bp
  • G to T, chromosome 1 at 182,628,634 bp
  • G to A, chromosome 1 at 188,753,650 bp
  • T to A, chromosome 2 at 25,685,286 bp
  • T to C, chromosome 2 at 30,038,362 bp
  • T to C, chromosome 2 at 36,568,691 bp
  • G to A, chromosome 2 at 119,938,791 bp
  • T to C, chromosome 3 at 10,206,045 bp
  • A to G, chromosome 4 at 43,034,531 bp
  • A to G, chromosome 4 at 88,154,668 bp
  • G to A, chromosome 4 at 121,188,235 bp
  • A to G, chromosome 4 at 124,853,884 bp
  • T to G, chromosome 5 at 8,936,873 bp
  • T to C, chromosome 5 at 74,530,995 bp
  • A to G, chromosome 5 at 103,834,212 bp
  • T to C, chromosome 5 at 142,793,056 bp
  • G to T, chromosome 6 at 39,071,430 bp
  • A to G, chromosome 6 at 70,607,958 bp
  • T to C, chromosome 7 at 24,978,555 bp
  • T to C, chromosome 7 at 67,669,746 bp
  • T to A, chromosome 7 at 87,438,015 bp
  • T to C, chromosome 7 at 113,329,926 bp
  • G to A, chromosome 7 at 126,372,421 bp
  • A to G, chromosome 8 at 67,719,944 bp
  • C to A, chromosome 8 at 110,088,971 bp
  • T to A, chromosome 8 at 110,852,372 bp
  • A to T, chromosome 9 at 38,488,301 bp
  • A to T, chromosome 9 at 67,250,584 bp
  • A to T, chromosome 9 at 99,054,064 bp
  • A to G, chromosome 9 at 106,897,340 bp
  • A to G, chromosome 9 at 119,792,344 bp
  • A to G, chromosome 10 at 20,438,723 bp
  • A to C, chromosome 10 at 60,324,976 bp
  • A to G, chromosome 10 at 119,930,035 bp
  • G to A, chromosome 11 at 5,791,839 bp
  • T to A, chromosome 11 at 65,855,234 bp
  • T to C, chromosome 11 at 75,313,341 bp
  • G to T, chromosome 11 at 103,503,969 bp
  • G to A, chromosome 11 at 115,588,479 bp
  • G to T, chromosome 12 at 104,343,033 bp
  • T to A, chromosome 13 at 13,677,963 bp
  • A to T, chromosome 13 at 27,123,943 bp
  • T to A, chromosome 13 at 36,246,426 bp
  • A to T, chromosome 13 at 59,702,782 bp
  • T to A, chromosome 13 at 74,157,704 bp
  • G to A, chromosome 14 at 122,181,782 bp
  • G to A, chromosome 15 at 77,776,937 bp
  • A to T, chromosome 15 at 98,864,167 bp
  • A to G, chromosome 15 at 102,029,830 bp
  • C to G, chromosome 16 at 5,088,990 bp
  • A to T, chromosome 16 at 17,849,766 bp
  • A to G, chromosome 17 at 18,582,626 bp
  • G to C, chromosome 17 at 33,817,653 bp
  • G to T, chromosome 17 at 37,262,916 bp
  • A to C, chromosome 19 at 5,336,042 bp
  • A to T, chromosome 19 at 34,318,649 bp
  • A to T, chromosome 19 at 44,517,667 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8837 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068665-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.