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Strain Name:
C57BL/6J-MtgxR8850Btlr/Mmmh
Stock Number:
068673-MU
Citation ID:
RRID:MMRRC_068673-MU
Other Names:
R8850 (G1)
Major Collection:

Strain Information

Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Neurl4
Name: neuralized E3 ubiquitin protein ligase 4
Synonyms: 0610025P10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216860
Homologene: 13029
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: Af10, D630001B22Rik, B130021D15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17354
Homologene: 20973
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, CHAK1, CHAK, TRP-PLIK, Ltpr7, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Tut7
Name: terminal uridylyl transferase 7
Synonyms: 6030448M23Rik, Tent3b, Zcchc6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Eefsec
Name: eukaryotic elongation factor, selenocysteine-tRNA-specific
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 65967
Homologene: 11073
Ppp1r10
Name: protein phosphatase 1, regulatory subunit 10
Synonyms: 2610025H06Rik, D17Ertd808e, PNUTS
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52040
HGNC: HGNC:9284
Homologene: 2033
Nop14
Name: NOP14 nucleolar protein
Synonyms: 2610033H07Rik, Nol14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75416
Homologene: 41773
Trp53bp2
Name: transformation related protein 53 binding protein 2
Synonyms: ASPP2, 53BP2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 209456
Homologene: 3959
Actr10
Name: ARP10 actin-related protein 10
Synonyms: Arp11
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56444
VEGA: 12
Homologene: 10220
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Dtymk
Name: deoxythymidylate kinase
Synonyms: mtmk, D10Ertd203e, CDC8, TYPK, Tmk
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21915
HGNC: HGNC:3061
Homologene: 6285
Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Synonyms: 4430401P03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20662
VEGA: 17
Homologene: 4117
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, ba, rh, rh-bmh, bldy
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Dtl
Name: denticleless E3 ubiquitin protein ligase
Synonyms: 5730564G15Rik, 2810047L02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76843
Homologene: 32313
Aktip
Name: AKT interacting protein
Synonyms: Ft1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14339
Homologene: 7721
Themis
Name: thymocyte selection associated
Synonyms: E430004N04Rik, Tsepa, Gasp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210757
Homologene: 72287
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Poc5
Name: POC5 centriolar protein
Synonyms: 1200014M14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67463
VEGA: 13
Homologene: 12141
Trmt44
Name: tRNA methyltransferase 44
Synonyms: 2310079F23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78890
Homologene: 12708
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, 2010013B10Rik, A230048G03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Adgrd1
Name: adhesion G protein-coupled receptor D1
Synonyms: E230012M21Rik, Gpr133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243277
Homologene: 34616
Pink1
Name: PTEN induced putative kinase 1
Synonyms: 1190006F07Rik, brpk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68943
Homologene: 32672
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242505
Homologene: 28424
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Klk1
Name: kallikrein 1
Synonyms: mGk-6, 0610007D04Rik, Klk6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16612
Homologene: 68141
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75196
Homologene: 35506
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Pla2g10
Name: phospholipase A2, group X
Synonyms: PLA2GX, mGXsPLA2, GX sPLA2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26565
HGNC: HGNC:9029
Homologene: 2636
Steap1
Name: six transmembrane epithelial antigen of the prostate 1
Synonyms: Prss24, 2410007B19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70358
Homologene: 8256
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627743
Homologene: 129680
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78911
Homologene: 12712
Fam171a1
Name: family with sequence similarity 171, member A1
Synonyms: 9630050M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269233
Homologene: 19521
Bag6
Name: BCL2-associated athanogene 6
Synonyms: D17H6S52E, 2410045D21Rik, G3, Scythe, Bat3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224727
Homologene: 3409
Vmn2r22
Name: vomeronasal 2, receptor 22
Synonyms: EG546913
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546913
Homologene: 84037
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Trabd
Name: TraB domain containing
Synonyms: 5730502D15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67976
Homologene: 36427
Mfrp
Name: membrane frizzled-related protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 259172
Homologene: 12866
Rpl13a-ps1
Name: ribosomal protein 13A, pseudogene 1
Synonyms: Gm5520
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 433251
VEGA: 19
Or2a54
Name: olfactory receptor family 2 subfamily A member 54
Synonyms: GA_x6K02T2P3E9-4442577-4441645, MOR261-3, Olfr441
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258649
Homologene: 88438
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Or2ak5
Name: olfactory receptor family 2 subfamily AK member 5
Synonyms: GA_x6K02T2NKPP-692816-693736, MOR285-1, Olfr318
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258494
Homologene: 133825
Cyp2j13
Name: cytochrome P450, family 2, subfamily j, polypeptide 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230459
HGNC: HGNC:2634
Homologene: 138297
Lpcat2b
Name: lysophosphatidylcholine acyltransferase 2B
Synonyms: 4921521K07Rik, Aytl1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70902
Homologene: 86793
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
Or7g30
Name: olfactory receptor family 7 subfamily G member 30
Synonyms: GA_x6K02T2PVTD-13176842-13177780, MOR151-1, Olfr849
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258520
HGNC: HGNC:8466
Homologene: 74179
Camk2b
Name: calcium/calmodulin-dependent protein kinase II, beta
Synonyms: CaMK II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12323
HGNC: HGNC:1461
Homologene: 111050
Or8k39
Name: olfactory receptor family 8 subfamily K member 39
Synonyms: GA_x6K02T2Q125-48226321-48225386, MOR193-1, Olfr1089
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257933
Homologene: 79354
Gm17728
Name: predicted gene, 17728
Type: Gene
Species: Mouse
Chromosome: 17
Ifit3
Name: interferon-induced protein with tetratricopeptide repeats 3
Synonyms: Ifi49
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15959
HGNC: HGNC:5411
Homologene: 1189
Pate10
Name: prostate and testis expressed 10
Synonyms: Gm17677
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312949
Homologene: 130079
Igkv4-55
Name: immunoglobulin kappa variable 4-55
Synonyms: LOC385253, Gm1524
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 385253
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,431,331 bp
  • A to C, chromosome 1 at 93,801,821 bp
  • A to G, chromosome 1 at 160,110,244 bp
  • A to G, chromosome 1 at 182,428,910 bp
  • A to T, chromosome 1 at 191,553,063 bp
  • C to T, chromosome 2 at 3,220,307 bp
  • T to A, chromosome 2 at 18,196,658 bp
  • T to A, chromosome 2 at 30,327,564 bp
  • A to G, chromosome 2 at 65,688,386 bp
  • C to A, chromosome 2 at 76,873,864 bp
  • T to C, chromosome 2 at 86,732,958 bp
  • G to T, chromosome 2 at 94,406,658 bp
  • T to A, chromosome 2 at 126,810,180 bp
  • A to T, chromosome 2 at 153,674,013 bp
  • C to A, chromosome 2 at 157,241,753 bp
  • A to G, chromosome 3 at 28,112,290 bp
  • T to A, chromosome 3 at 135,225,016 bp
  • A to G, chromosome 4 at 73,727,603 bp
  • A to G, chromosome 4 at 88,827,985 bp
  • A to T, chromosome 4 at 96,068,191 bp
  • G to T, chromosome 4 at 138,320,022 bp
  • T to A, chromosome 5 at 5,740,838 bp
  • A to C, chromosome 5 at 34,660,008 bp
  • G to A, chromosome 5 at 35,564,329 bp
  • A to T, chromosome 5 at 77,315,914 bp
  • A to G, chromosome 5 at 107,432,826 bp
  • A to G, chromosome 5 at 129,142,510 bp
  • A to G, chromosome 6 at 18,870,007 bp
  • T to A, chromosome 6 at 43,115,971 bp
  • A to T, chromosome 6 at 69,607,331 bp
  • G to A, chromosome 6 at 88,446,271 bp
  • A to G, chromosome 6 at 123,637,495 bp
  • T to A, chromosome 7 at 44,227,632 bp
  • G to A, chromosome 7 at 131,090,404 bp
  • A to T, chromosome 8 at 91,126,774 bp
  • T to A, chromosome 9 at 13,289,352 bp
  • T to C, chromosome 9 at 19,441,521 bp
  • A to G, chromosome 9 at 35,741,095 bp
  • C to T, chromosome 9 at 44,102,510 bp
  • A to G, chromosome 9 at 96,038,679 bp
  • T to A, chromosome 9 at 97,365,994 bp
  • G to T, chromosome 10 at 28,797,496 bp
  • T to A, chromosome 11 at 5,972,838 bp
  • T to A, chromosome 11 at 58,720,746 bp
  • A to G, chromosome 11 at 69,903,962 bp
  • G to A, chromosome 11 at 103,502,655 bp
  • G to A, chromosome 12 at 70,942,258 bp
  • T to A, chromosome 13 at 51,480,212 bp
  • T to A, chromosome 13 at 59,789,197 bp
  • A to T, chromosome 13 at 95,090,285 bp
  • G to T, chromosome 13 at 96,398,720 bp
  • G to T, chromosome 13 at 102,758,666 bp
  • T to A, chromosome 14 at 56,485,201 bp
  • C to T, chromosome 14 at 70,561,865 bp
  • G to T, chromosome 15 at 89,085,464 bp
  • A to T, chromosome 16 at 13,728,050 bp
  • T to C, chromosome 17 at 9,422,327 bp
  • G to A, chromosome 17 at 18,929,345 bp
  • T to A, chromosome 17 at 20,208,610 bp
  • T to C, chromosome 17 at 35,142,065 bp
  • C to T, chromosome 17 at 35,928,798 bp
  • T to C, chromosome 17 at 78,801,759 bp
  • T to C, chromosome 17 at 80,433,976 bp
  • T to C, chromosome 19 at 34,587,588 bp
  • G to A, chromosome 19 at 38,524,367 bp
  • C to T, chromosome 19 at 50,030,300 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8850 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068673-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.