Loading...

Strain Detail Sheet

Published:
Revised: 03/02/2024

Strain Name:
C57BL/6J-MtgxR8867Btlr/Mmmh
Stock Number:
068682-MU
Citation ID:
RRID:MMRRC_068682-MU
Other Names:
R8867 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Cnnm2
Name: cyclin M2
Synonyms: Acdp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94219
VEGA: 19
HGNC: HGNC:103
Homologene: 9761

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Syt6
Name: synaptotagmin VI
Synonyms: 3110037A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54524
Homologene: 10301

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 65,244,417 bp
  • C to T, chromosome 1 at 90,787,951 bp
  • T to A, chromosome 1 at 144,753,960 bp
  • T to C, chromosome 1 at 172,244,924 bp
  • A to T, chromosome 1 at 172,894,437 bp
  • T to C, chromosome 1 at 193,175,098 bp
  • T to C, chromosome 2 at 23,080,358 bp
  • A to G, chromosome 2 at 34,838,624 bp
  • T to C, chromosome 2 at 36,997,679 bp
  • T to C, chromosome 2 at 37,352,336 bp
  • A to T, chromosome 2 at 76,810,083 bp
  • G to T, chromosome 2 at 87,033,459 bp
  • T to C, chromosome 2 at 150,589,966 bp
  • G to A, chromosome 2 at 161,021,069 bp
  • A to T, chromosome 2 at 163,469,682 bp
  • T to A, chromosome 3 at 85,604,409 bp
  • A to G, chromosome 3 at 103,627,055 bp
  • T to A, chromosome 3 at 158,161,884 bp
  • A to G, chromosome 4 at 43,028,256 bp
  • G to A, chromosome 4 at 73,942,850 bp
  • C to T, chromosome 4 at 115,635,972 bp
  • A to G, chromosome 4 at 128,557,676 bp
  • C to T, chromosome 4 at 134,058,684 bp
  • T to C, chromosome 4 at 141,929,574 bp
  • A to G, chromosome 4 at 156,009,302 bp
  • T to A, chromosome 5 at 31,550,715 bp
  • T to C, chromosome 5 at 125,102,675 bp
  • A to G, chromosome 5 at 142,477,256 bp
  • A to T, chromosome 6 at 12,338,687 bp
  • G to A, chromosome 6 at 48,589,695 bp
  • A to G, chromosome 6 at 66,553,667 bp
  • A to G, chromosome 6 at 73,021,148 bp
  • T to C, chromosome 6 at 89,333,097 bp
  • T to A, chromosome 6 at 115,880,671 bp
  • A to C, chromosome 6 at 121,771,829 bp
  • G to A, chromosome 6 at 122,628,643 bp
  • T to A, chromosome 6 at 127,629,773 bp
  • A to T, chromosome 7 at 4,238,166 bp
  • A to C, chromosome 7 at 43,970,323 bp
  • T to A, chromosome 7 at 103,321,242 bp
  • G to A, chromosome 7 at 103,754,686 bp
  • A to G, chromosome 7 at 144,669,660 bp
  • A to G, chromosome 8 at 106,079,008 bp
  • C to T, chromosome 8 at 121,555,228 bp
  • G to A, chromosome 9 at 58,618,981 bp
  • G to A, chromosome 9 at 67,330,550 bp
  • A to T, chromosome 9 at 88,957,450 bp
  • A to T, chromosome 9 at 106,627,499 bp
  • T to A, chromosome 10 at 39,048,000 bp
  • C to A, chromosome 10 at 76,470,704 bp
  • T to C, chromosome 10 at 78,037,975 bp
  • A to T, chromosome 10 at 129,669,759 bp
  • A to G, chromosome 11 at 58,566,736 bp
  • A to G, chromosome 11 at 60,742,655 bp
  • G to T, chromosome 11 at 61,493,806 bp
  • A to G, chromosome 12 at 75,942,846 bp
  • T to C, chromosome 13 at 14,247,690 bp
  • T to C, chromosome 13 at 23,184,101 bp
  • T to C, chromosome 13 at 23,855,960 bp
  • C to T, chromosome 13 at 24,638,777 bp
  • C to T, chromosome 13 at 25,202,283 bp
  • A to T, chromosome 13 at 55,282,757 bp
  • C to T, chromosome 13 at 56,860,933 bp
  • T to C, chromosome 13 at 73,628,447 bp
  • C to T, chromosome 13 at 76,131,309 bp
  • C to A, chromosome 14 at 20,546,449 bp
  • C to A, chromosome 15 at 31,581,927 bp
  • T to C, chromosome 15 at 58,315,039 bp
  • G to A, chromosome 15 at 81,772,480 bp
  • A to G, chromosome 15 at 89,370,402 bp
  • A to G, chromosome 15 at 90,968,179 bp
  • A to G, chromosome 17 at 11,237,561 bp
  • A to G, chromosome 17 at 24,573,833 bp
  • G to A, chromosome 17 at 24,735,481 bp
  • A to T, chromosome 17 at 35,637,980 bp
  • T to C, chromosome 17 at 36,870,156 bp
  • C to A, chromosome 18 at 22,516,490 bp
  • T to C, chromosome 18 at 77,475,486 bp
  • T to A, chromosome 19 at 46,762,557 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8867 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
068682-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.