Strain Name:
C57BL/6J-MtgxR8868Btlr/Mmmh
Stock Number:
068683-MU
Citation ID:
RRID:MMRRC_068683-MU
Other Names:
R8868 (G1)
Major Collection:

Strain Information

Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-2, Sema6D-4, Sema6D-5, Sema6D-1, Sema6D-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Sdf2
Name: stromal cell derived factor 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20316
Homologene: 5045
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Wdr47
Name: WD repeat domain 47
Synonyms: nemitin, 1810073M12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99512
Homologene: 8984
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: 5430402I23Rik, LEC3, Lphn3, D130075K09Rik, lectomedin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Kcnc4
Name: potassium voltage gated channel, Shaw-related subfamily, member 4
Synonyms: Kcr2-4, Kv3.4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99738
HGNC: HGNC:6236
Homologene: 68427
E2f3
Name: E2F transcription factor 3
Synonyms: E2f3a, E2F3b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13557
HGNC: HGNC:3115
Homologene: 74413
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: D16Ium21, D16Ium21e, TPRD, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Ints8
Name: integrator complex subunit 8
Synonyms: 2810013E07Rik, D130008D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72656
Homologene: 9888
Lrpprc
Name: leucine-rich PPR-motif containing
Synonyms: Lrp130, 3110001K13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72416
Homologene: 32695
Tbc1d14
Name: TBC1 domain family, member 14
Synonyms: 2810413P16Rik, D5Ertd110e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100855
Homologene: 10809
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: Dcdc2, RU2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195208
Homologene: 9483
Zfp369
Name: zinc finger protein 369
Synonyms: B930030B22Rik, NRIF2, D230020H11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170936
Homologene: 129707
Sec1
Name: secretory blood group 1
Synonyms: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III, Fut3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56546
Homologene: 431
Zbtb18
Name: zinc finger and BTB domain containing 18
Synonyms: RP58, Zfp238
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30928
Homologene: 21276
Fmnl2
Name: formin-like 2
Synonyms: man, 5430425K04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Nav1
Name: neuron navigator 1
Synonyms: unc53H1, POMFIL3, 9930003A20Rik, C230080M11Rik, steerin-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215690
Homologene: 10719
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: D030002L11Rik, LOC382100, Rme8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Hps6
Name: HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
Synonyms: 5330434M19Rik, ru, ruby eye, Hermansky-Pudlak syndrome 6, BLOC-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20170
VEGA: 19
Homologene: 11691
Ifi27
Name: interferon, alpha-inducible protein 27
Synonyms: 2900026P10Rik, 1110013J02Rik, D12Ertd647e, Ifi27l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52668
Homologene: 134610
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 1110021D17Rik, Polydom, D430029O09Rik, 4833413O10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Or7g20
Name: olfactory receptor family 7 subfamily G member 20
Synonyms: MOR150-3, Olfr835, GA_x6K02T2PVTD-12771995-12772930
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257872
HGNC: HGNC:8466
Homologene: 133702
Dclre1b
Name: DNA cross-link repair 1B
Synonyms: Apollo, SNMIB, mSNM1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140917
Homologene: 32553
Ak9
Name: adenylate kinase 9
Synonyms: Akd2, LOC215946, Akd1, Gm7127
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 633979
Homologene: 67934
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cavbeta2, Cchb2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Dmwd
Name: dystrophia myotonica-containing WD repeat motif
Synonyms: Dm9, DMR-N9, 59
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13401
HGNC: HGNC:2936
Homologene: 22559
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Intin2, Itih-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Svop
Name: SV2 related protein
Synonyms: 1110030H18Rik, msvop
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68666
Homologene: 41283
Usp45
Name: ubiquitin specific petidase 45
Synonyms: 3110003C05Rik, Gcap7, 4930550B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77593
Homologene: 17674
Krt23
Name: keratin 23
Synonyms: Krt1-23, K23, CK23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94179
HGNC: HGNC:6438
Homologene: 9172
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Cmya1, mXin alpha, Xin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381411
Homologene: 86007
Ogfod1
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 1
Synonyms: 4930415J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270086
Homologene: 41238
Rnf148
Name: ring finger protein 148
Synonyms: 4933432M07Rik, Greul3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71300
Homologene: 82404
Slc18b1
Name: solute carrier family 18, subfamily B, member 1
Synonyms: 1110021L09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76306
Homologene: 33473
Akr1c19
Name: aldo-keto reductase family 1, member C19
Synonyms: 1810010N06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432720
HGNC: HGNC:387
Homologene: 134145
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Or8g37
Name: olfactory receptor family 8 subfamily G member 37
Synonyms: GA_x6K02T2PVTD-33517322-33518257, MOR171-16, Olfr970
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258604
VEGA: 9
Homologene: 121532
Catsper4
Name: cation channel, sperm associated 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329954
Homologene: 18638
Cyp4a14
Name: cytochrome P450, family 4, subfamily a, polypeptide 14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13119
Homologene: 134697
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330301
Homologene: 51849
Tex50
Name: testis expressed 50
Synonyms: 4930469G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100502590
Homologene: 130370
Crnn
Name: cornulin
Synonyms: LOC381457
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381457
HGNC: HGNC:1230
Homologene: 9416
Entpd2
Name: ectonucleoside triphosphate diphosphohydrolase 2
Synonyms: Cd39l1, NTPDase2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12496
HGNC: HGNC:3364
Homologene: 20333
Apol11a
Name: apolipoprotein L 11a
Synonyms: EG626615
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626615
VEGA: 15
HGNC: HGNC:618
Homologene: 129975
Alg1
Name: ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
Synonyms: HMAT1, HMT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208211
Homologene: 5387
Acad8
Name: acyl-Coenzyme A dehydrogenase family, member 8
Synonyms: 2310016C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66948
HGNC: HGNC:87
Homologene: 8662
Zfp260
Name: zinc finger protein 260
Synonyms: Zfp63, PEX1, Ozrf1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26466
Homologene: 40802
Or8b55
Name: olfactory receptor family 8 subfamily B member 55
Synonyms: MOR161-3, Olfr922, GA_x6K02T2PVTD-32518237-32519172
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Ikbip
Name: IKBKB interacting protein
Synonyms: 1200009F10Rik, 1700023M03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67454
Homologene: 12138
Tssk1
Name: testis-specific serine kinase 1
Synonyms: TSK-1, Tssk, Stk22a, Tsk1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22114
Homologene: 56448
Cdhr17
Name: cadherin related family member 17
Synonyms: Gm28710
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 102640594
Homologene: 141132
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 135,585,205 bp
  • T to A, chromosome 1 at 161,157,278 bp
  • A to G, chromosome 1 at 177,447,116 bp
  • A to T, chromosome 2 at 10,127,789 bp
  • A to G, chromosome 2 at 14,984,269 bp
  • A to G, chromosome 2 at 25,399,713 bp
  • T to A, chromosome 2 at 48,873,457 bp
  • A to G, chromosome 2 at 53,126,065 bp
  • A to T, chromosome 2 at 76,711,594 bp
  • T to C, chromosome 2 at 76,953,126 bp
  • A to C, chromosome 2 at 93,866,145 bp
  • T to C, chromosome 2 at 124,654,194 bp
  • T to C, chromosome 3 at 93,148,302 bp
  • T to C, chromosome 3 at 103,803,338 bp
  • T to A, chromosome 3 at 107,448,136 bp
  • C to T, chromosome 3 at 108,591,525 bp
  • T to C, chromosome 4 at 11,230,488 bp
  • G to A, chromosome 4 at 21,815,399 bp
  • A to G, chromosome 4 at 58,135,578 bp
  • T to C, chromosome 4 at 103,208,154 bp
  • T to A, chromosome 4 at 115,491,356 bp
  • A to G, chromosome 4 at 134,227,106 bp
  • G to A, chromosome 5 at 16,823,154 bp
  • A to C, chromosome 5 at 36,571,544 bp
  • A to G, chromosome 5 at 81,646,604 bp
  • T to C, chromosome 5 at 114,032,793 bp
  • A to T, chromosome 6 at 14,755,015 bp
  • A to T, chromosome 6 at 23,654,541 bp
  • A to T, chromosome 6 at 47,825,081 bp
  • G to A, chromosome 7 at 16,826,645 bp
  • T to A, chromosome 7 at 19,080,769 bp
  • G to A, chromosome 7 at 19,194,063 bp
  • T to G, chromosome 7 at 30,105,489 bp
  • T to A, chromosome 7 at 45,679,276 bp
  • G to T, chromosome 8 at 94,047,278 bp
  • T to G, chromosome 9 at 19,035,482 bp
  • T to A, chromosome 9 at 26,979,248 bp
  • A to G, chromosome 9 at 37,616,836 bp
  • G to A, chromosome 9 at 38,815,989 bp
  • A to G, chromosome 9 at 39,819,956 bp
  • G to A, chromosome 9 at 104,165,788 bp
  • A to G, chromosome 9 at 120,017,805 bp
  • A to T, chromosome 10 at 23,810,853 bp
  • G to A, chromosome 10 at 41,317,846 bp
  • G to T, chromosome 10 at 41,382,873 bp
  • T to C, chromosome 10 at 91,096,325 bp
  • A to T, chromosome 11 at 78,246,144 bp
  • T to C, chromosome 11 at 99,483,741 bp
  • T to C, chromosome 12 at 103,436,640 bp
  • T to A, chromosome 13 at 4,243,071 bp
  • A to G, chromosome 13 at 9,575,467 bp
  • C to T, chromosome 13 at 25,202,283 bp
  • A to T, chromosome 13 at 29,911,318 bp
  • A to G, chromosome 13 at 42,158,931 bp
  • T to A, chromosome 13 at 65,297,268 bp
  • A to G, chromosome 14 at 7,908,671 bp
  • T to C, chromosome 15 at 9,729,661 bp
  • T to A, chromosome 15 at 77,517,009 bp
  • G to A, chromosome 15 at 81,772,480 bp
  • A to G, chromosome 16 at 5,243,693 bp
  • A to G, chromosome 16 at 17,895,020 bp
  • A to G, chromosome 16 at 94,451,143 bp
  • C to A, chromosome 17 at 84,771,492 bp
  • G to A, chromosome 19 at 46,004,007 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8868 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068683-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.