Strain Name:
C57BL/6J-MtgxR8884Btlr/Mmmh
Stock Number:
068690-MU
Citation ID:
RRID:MMRRC_068690-MU
Other Names:
R8884 (G1)
Major Collection:

Strain Information

B4galt6
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56386
VEGA: 18
HGNC: HGNC:929
Homologene: 3506
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: 5730417K16Rik, Acrb3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Prkd3
Name: protein kinase D3
Synonyms: Prkcn, 5730497N19Rik, PKD3, 4930557O20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Cacng6
Name: calcium channel, voltage-dependent, gamma subunit 6
Synonyms: 2310033H20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54378
Homologene: 15427
Rgs7
Name: regulator of G protein signaling 7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 24012
Homologene: 2193
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: Spar, 4931426N11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Fgr
Name: FGR proto-oncogene, Src family tyrosine kinase
Synonyms: Ali18, Mhdaali18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14191
HGNC: HGNC:3697
Homologene: 3842
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Cdc5l
Name: cell division cycle 5-like
Synonyms: PCDC5RP, 1200002I02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Agfg1
Name: ArfGAP with FG repeats 1
Synonyms: Hrb, D730048C23Rik, C130049H11Rik, Rip
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15463
HGNC: HGNC:5175
Homologene: 37929
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Alx4
Name: aristaless-like homeobox 4
Synonyms: Aristaless-like 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11695
HGNC: HGNC:450
Homologene: 7229
4930522L14Rik
Name: RIKEN cDNA 4930522L14 gene
Synonyms: Gm42152
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041734
Pdcd1lg2
Name: programmed cell death 1 ligand 2
Synonyms: B7-DC, Btdc, PD-L2, F730015O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58205
Homologene: 10973
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, Gm21044, LOC385009
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Zbtb8os
Name: zinc finger and BTB domain containing 8 opposite strand
Synonyms: 2310028N13Rik, Arch, 2010001H09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67106
Homologene: 12083
Ric3
Name: RIC3 acetylcholine receptor chaperone
Synonyms: E130307J04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320360
Homologene: 49772
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Sez6l
Name: seizure related 6 homolog like
Synonyms: Acig1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56747
Homologene: 10895
Zfp354a
Name: zinc finger protein 354A
Synonyms: Tcf17, kid1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21408
Homologene: 55921
Enpep
Name: glutamyl aminopeptidase
Synonyms: 6030431M22Rik, Bp-1/6C3, Ly51, aminopeptidase-A, Ly-51, APA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC382129, 9430076A06Rik, LOC234973
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, ihj, erythroid, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Ttc32
Name: tetratricopeptide repeat domain 32
Synonyms: 1700013G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75516
VEGA: 12
Homologene: 18991
Cdh7
Name: cadherin 7, type 2
Synonyms: 9330156F07Rik, CDH7L1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: mdg, DHPR alpha1s, sj, muscle dysgenesis, Cav1.1, Cchl1a3, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Treh
Name: trehalase (brush-border membrane glycoprotein)
Synonyms: 2210412M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58866
Homologene: 5198
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC5, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Insr
Name: insulin receptor
Synonyms: IR-B, 4932439J01Rik, D630014A15Rik, IR, CD220, IR-A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Tmem175
Name: transmembrane protein 175
Synonyms: 3010001K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72392
Homologene: 12461
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Pfkfb2
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: 4930568D07Rik, PFK-2/FBPase-2 gene B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18640
HGNC: HGNC:8873
Homologene: 88554
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212892
Homologene: 71779
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Kif14
Name: kinesin family member 14
Synonyms: D1Ertd367e, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: A130097D21Rik, enterokinase, enteropeptidase, Prss7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Wsb2
Name: WD repeat and SOCS box-containing 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59043
Homologene: 32417
Epcip
Name: exosomal polycystin 1 interacting protein
Synonyms: 4932438H23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74387
HGNC: HGNC:1305
Homologene: 49594
Vmn2r37
Name: vomeronasal 2, receptor 37
Synonyms: V2r14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22305
Homologene: 113703
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384534
Homologene: 129605
Ssbp2
Name: single-stranded DNA binding protein 2
Synonyms: Hspc116, 1500004K09Rik, A830008M03Rik, 2310079I02Rik, 9330163K02Rik, Ssdp2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66970
Homologene: 22724
Ttc14
Name: tetratricopeptide repeat domain 14
Synonyms: 2700016E08Rik, cI-44, 4930434D01Rik, 4933402I15Rik, 4931403I22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67120
Homologene: 12085
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216188
Homologene: 51942
Fbxw13
Name: F-box and WD-40 domain protein 13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211305
Homologene: 110776
Mindy4
Name: MINDY lysine 48 deubiquitinase 4
Synonyms: C330043M08Rik, LOC384387, Fam188b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330323
Homologene: 49991
Clca1
Name: chloride channel accessory 1
Synonyms: gob5, Clca3, gob-5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, Facl6, A330035H04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Or13a18
Name: olfactory receptor family 13 subfamily A member 18
Synonyms: MOR253-8, IF5, ID12, Olfr46, IB7, GA_x6K02T2PBJ9-42759973-42760905
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18345
Homologene: 110491
Or13a24
Name: olfactory receptor family 13 subfamily A member 24
Synonyms: Olfr538, MOR253-13P, MOR253-12P, Olfr1523-ps1, Olfr1553-ps1, MOR253-12P, GA_x6K02T2PBJ9-42723314-42724246, MOR253-10P, MOR253-13P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258201
Homologene: 110491
Pimreg
Name: PICALM interacting mitotic regulator
Synonyms: Fam64a, CATS, 2610008F03Rik, 6720460F02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 109212
Homologene: 10378
Vmn1r44
Name: vomeronasal 1 receptor 44
Synonyms: V1rb4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113854
Homologene: 113975
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgfb-2, Tgf-beta2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21808
Homologene: 2432
Dctn6
Name: dynactin 6
Synonyms: p27, WS-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22428
Homologene: 4792
Cpn1
Name: carboxypeptidase N, polypeptide 1
Synonyms: 0610011F20Rik, CPN, 50 kDa
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 93721
HGNC: HGNC:2312
Homologene: 1002
Commd8
Name: COMM domain containing 8
Synonyms: IMAGE:1958590, D5Buc26e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27784
Homologene: 9873
Larp6
Name: La ribonucleoprotein 6, translational regulator
Synonyms: 5430431G03Rik, acheron, Achn
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67557
Homologene: 32408
Krtap5-24
Name: keratin associated protein 5-24
Synonyms: Gm40460
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 105244938
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 82,882,389 bp
  • A to T, chromosome 1 at 110,100,130 bp
  • A to G, chromosome 1 at 130,706,476 bp
  • G to A, chromosome 1 at 136,115,243 bp
  • G to A, chromosome 1 at 136,486,351 bp
  • G to T, chromosome 1 at 174,217,688 bp
  • A to G, chromosome 1 at 175,153,164 bp
  • G to A, chromosome 1 at 186,632,710 bp
  • A to G, chromosome 2 at 93,643,010 bp
  • G to A, chromosome 3 at 19,227,694 bp
  • A to G, chromosome 3 at 33,800,547 bp
  • A to T, chromosome 3 at 55,805,299 bp
  • A to T, chromosome 3 at 129,321,403 bp
  • A to T, chromosome 3 at 145,013,996 bp
  • T to C, chromosome 4 at 129,343,131 bp
  • C to T, chromosome 4 at 132,986,298 bp
  • G to A, chromosome 5 at 72,168,171 bp
  • A to G, chromosome 5 at 76,891,794 bp
  • A to G, chromosome 5 at 108,646,461 bp
  • A to T, chromosome 5 at 109,737,488 bp
  • T to C, chromosome 5 at 112,475,044 bp
  • T to A, chromosome 5 at 117,370,704 bp
  • T to C, chromosome 6 at 55,278,238 bp
  • T to C, chromosome 6 at 89,893,476 bp
  • C to T, chromosome 7 at 3,430,468 bp
  • T to G, chromosome 7 at 9,215,917 bp
  • T to A, chromosome 7 at 10,158,807 bp
  • C to T, chromosome 7 at 109,038,481 bp
  • A to T, chromosome 7 at 140,574,311 bp
  • C to T, chromosome 7 at 140,610,703 bp
  • T to C, chromosome 7 at 141,849,419 bp
  • A to T, chromosome 7 at 142,240,818 bp
  • T to C, chromosome 8 at 3,155,679 bp
  • T to C, chromosome 8 at 27,393,918 bp
  • T to C, chromosome 8 at 34,090,779 bp
  • A to G, chromosome 8 at 61,994,519 bp
  • TG to TGG, chromosome 9 at 7,465,083 bp
  • G to A, chromosome 9 at 16,029,984 bp
  • G to A, chromosome 9 at 18,644,200 bp
  • C to G, chromosome 9 at 44,684,503 bp
  • C to T, chromosome 9 at 58,853,422 bp
  • G to A, chromosome 9 at 60,713,399 bp
  • T to A, chromosome 9 at 109,181,401 bp
  • T to G, chromosome 10 at 5,231,822 bp
  • T to C, chromosome 10 at 33,905,844 bp
  • T to A, chromosome 10 at 82,283,652 bp
  • T to C, chromosome 10 at 83,508,677 bp
  • A to T, chromosome 11 at 51,059,978 bp
  • T to A, chromosome 11 at 54,345,902 bp
  • A to G, chromosome 11 at 72,045,687 bp
  • T to C, chromosome 11 at 110,074,115 bp
  • T to A, chromosome 12 at 9,038,083 bp
  • T to A, chromosome 12 at 40,806,885 bp
  • T to G, chromosome 12 at 82,363,097 bp
  • G to A, chromosome 13 at 11,779,266 bp
  • A to G, chromosome 13 at 91,688,870 bp
  • G to A, chromosome 13 at 119,438,017 bp
  • A to G, chromosome 16 at 79,024,769 bp
  • T to C, chromosome 16 at 91,055,849 bp
  • T to C, chromosome 16 at 93,759,662 bp
  • G to A, chromosome 17 at 27,118,677 bp
  • C to A, chromosome 17 at 45,433,541 bp
  • T to C, chromosome 17 at 78,974,764 bp
  • A to T, chromosome 18 at 20,689,015 bp
  • T to A, chromosome 18 at 24,267,584 bp
  • T to A, chromosome 18 at 80,795,347 bp
  • G to T, chromosome 19 at 29,445,918 bp
  • T to A, chromosome 19 at 43,966,176 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8884 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068690-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.