Strain Name:
C57BL/6J-MtgxR8894Btlr/Mmmh
Stock Number:
068697-MU
Citation ID:
RRID:MMRRC_068697-MU
Other Names:
R8894 (G1)
Major Collection:

Strain Information

Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Sort1
Name: sortilin 1
Synonyms: Ntsr3, sortilin, Ntr3, 2900053A11Rik, neurotensin receptor 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20661
Homologene: 136097
Dst
Name: dystonin
Synonyms: nmf339, athetoid, Bpag, bullous pemphigoid antigen 1, A830042E19Rik, nmf203, Bpag1, ah, 2310001O04Rik, Macf2, BPAG1-n, bullous pemphigoid antigen 1, BPAG1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: AIP3, WWP3, Gukmi1, BAP1, Baiap1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Dhx35
Name: DEAH-box helicase 35
Synonyms: 1200009D07Rik, Ddx35
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71715
Homologene: 6406
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, Zizimin1, D14Wsu89e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Prep
Name: prolyl endopeptidase
Synonyms: Pop, prolyl oligopeptidase, D10Wsu136e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19072
VEGA: 10
HGNC: HGNC:9358
Homologene: 2042
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Mhdadsk9, Nf-1, Dsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Rsrc2
Name: arginine/serine-rich coiled-coil 2
Synonyms: 1500011J06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208606
Homologene: 133892
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24088
Homologene: 20695
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, 5830477H08Rik, Tce4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Adcy1
Name: adenylate cyclase 1
Synonyms: D11Bwg1392e, AC1, I-AC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Psap
Name: prosaposin
Synonyms: SGP-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19156
HGNC: HGNC:9498
Homologene: 37680
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09Rik, Ankrd15, D330024H06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Hapln3
Name: hyaluronan and proteoglycan link protein 3
Synonyms: 4930554N11Rik, Lpr3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67666
Homologene: 18654
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Npat
Name: nuclear protein in the AT region
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244879
HGNC: HGNC:7896
Homologene: 1888
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225348
VEGA: 18
Homologene: 6536
Trim33
Name: tripartite motif-containing 33
Synonyms: 8030451N04Rik, Tif1g, Ecto, ectodermin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: 1110014E10Rik, D530031C13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: Polycystin - L2, TRPP5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: 7530426H14Rik, A930008G09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Trim17
Name: tripartite motif-containing 17
Synonyms: terf, Rnf16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56631
Homologene: 9387
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: D330014H01Rik, Dnhd3, Dnahc2, 2900022L05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Or8c13
Name: olfactory receptor family 8 subfamily C member 13
Synonyms: MOR170-9, Olfr891, GA_x6K02T2PVTD-31862167-31861217
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258471
Homologene: 74210
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Fcrl6
Name: Fc receptor-like 6
Synonyms: FcRH6, mIFGP6, moFcRH6, ENSMUSG00000070504
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 677296
Homologene: 88414
Cyp2d11
Name: cytochrome P450, family 2, subfamily d, polypeptide 11
Synonyms: P450-2D, Cyp2d
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545123
VEGA: 15
Homologene: 86099
Nebl
Name: nebulette
Synonyms: 1200007O21Rik, A630080F05Rik, Lnebl, D830029A09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74103
Homologene: 128431
Krba1
Name: KRAB-A domain containing 1
Synonyms: A930040G15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77827
Homologene: 15880
Lipn
Name: lipase, family member N
Synonyms: Lipl4, 2210418G03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70166
Homologene: 66969
4931429L15Rik
Name: RIKEN cDNA 4931429L15 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74361
Homologene: 86847
Trgv4
Name: T cell receptor gamma, variable 4
Synonyms: Tcrg-V4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21638
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Tnfrsf8
Name: tumor necrosis factor receptor superfamily, member 8
Synonyms: CD30
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21941
Homologene: 949
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: Zfp469, EG381742
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: 4930415K13Rik, Rgsl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Rimbp2
Name: RIMS binding protein 2
Synonyms: A930033C01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231760
Homologene: 14672
Ptprr
Name: protein tyrosine phosphatase receptor type R
Synonyms: PTP-SL, RPTPRR, PTPBR7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Or10g1
Name: olfactory receptor family 10 subfamily G member 1
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6, Olfr1510
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Spata31f1a
Name: spermatogenesis associated 31 subfamily F member 1A
Synonyms: Gm12429, Fam205a1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433698
Homologene: 79022
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216019
Homologene: 128937
Foxc1
Name: forkhead box C1
Synonyms: Mf1, Fkh1, Mf4, fkh-1, fkh1, frkhda, FREAC3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17300
HGNC: HGNC:3800
Homologene: 20373
Cyp3a25
Name: cytochrome P450, family 3, subfamily a, polypeptide 25
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56388
Homologene: 135775
Mindy4
Name: MINDY lysine 48 deubiquitinase 4
Synonyms: Fam188b, C330043M08Rik, LOC384387
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330323
Homologene: 49991
H2-M10.2
Name: histocompatibility 2, M region locus 10.2
Synonyms: 4.7H
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 333715
Homologene: 117973
Mpp4
Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms: DLG6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227157
Homologene: 23296
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Or10al6
Name: olfactory receptor family 10 subfamily AL member 6
Synonyms: GA_x6K02T2PSCP-2230932-2231897, Olfr122, MOR263-10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258285
Homologene: 122777
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113847
Homologene: 130651
Fibp
Name: fibroblast growth factor (acidic) intracellular binding protein
Synonyms: 2010004G08Rik, 2010005N21Rik, 3010027N18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58249
VEGA: 19
HGNC: HGNC:3705
Homologene: 3106
Or4c11c
Name: olfactory receptor family 4 subfamily C member 11C
Synonyms: Olfr1203, MOR230-3, GA_x6K02T2Q125-50304328-50305251, GA_x6K02T2Q125-50336588-50337313, MOR230-1, Olfr1205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258898
Homologene: 81567
Zfp2
Name: zinc finger protein 2
Synonyms: 9930007F06Rik, mkr-2, Zfp-2, Fnp-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22678
Homologene: 121779
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Ccdc177
Name: coiled-coil domain containing 177
Synonyms: Gm1568, LOC380768
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380768
VEGA: 12
Homologene: 128326
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: A330103J02Rik, Dlgh2, B330007M19Rik, PSD93, LOC382816, Chapsyn-110, B230218P12Rik, Gm21505
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Clpsl2
Name: colipase-like 2
Synonyms: LOC328788, Gm749
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328788
Homologene: 86835
Vmn2r33
Name: vomeronasal 2, receptor 33
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 624512
Homologene: 113703
Nudt21
Name: nudix hydrolase 21
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 21, 5730530J16Rik, Cpsf5, 25kDa, 3110048P04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68219
Homologene: 5090
Vmn2r40
Name: vomeronasal 2, receptor 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042781
Homologene: 113703
Tmppe
Name: transmembrane protein with metallophosphoesterase domain
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100504715
VEGA: 9
Homologene: 62675
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,174,133 bp
  • A to G, chromosome 1 at 59,158,584 bp
  • T to A, chromosome 1 at 139,248,012 bp
  • T to A, chromosome 1 at 153,822,373 bp
  • T to C, chromosome 1 at 172,599,289 bp
  • A to T, chromosome 2 at 17,375,225 bp
  • T to G, chromosome 2 at 88,831,465 bp
  • G to C, chromosome 2 at 158,834,875 bp
  • T to A, chromosome 3 at 83,836,784 bp
  • C to T, chromosome 3 at 103,311,491 bp
  • T to C, chromosome 3 at 108,338,912 bp
  • A to G, chromosome 4 at 42,853,688 bp
  • A to T, chromosome 4 at 103,211,332 bp
  • T to C, chromosome 4 at 145,274,468 bp
  • T to G, chromosome 5 at 94,448,540 bp
  • T to C, chromosome 5 at 96,759,543 bp
  • G to T, chromosome 5 at 123,740,730 bp
  • T to A, chromosome 5 at 128,773,390 bp
  • T to C, chromosome 5 at 142,739,457 bp
  • A to C, chromosome 5 at 145,994,860 bp
  • A to G, chromosome 6 at 48,411,695 bp
  • T to C, chromosome 6 at 55,278,238 bp
  • A to G, chromosome 6 at 89,869,764 bp
  • A to T, chromosome 6 at 93,686,605 bp
  • T to A, chromosome 7 at 7,563,810 bp
  • T to C, chromosome 7 at 8,920,198 bp
  • G to A, chromosome 7 at 79,117,491 bp
  • A to T, chromosome 7 at 91,965,738 bp
  • A to C, chromosome 7 at 120,248,145 bp
  • T to G, chromosome 7 at 141,694,515 bp
  • C to T, chromosome 8 at 57,526,142 bp
  • C to A, chromosome 8 at 94,028,870 bp
  • A to T, chromosome 9 at 38,180,074 bp
  • C to T, chromosome 9 at 46,305,099 bp
  • T to C, chromosome 9 at 53,556,651 bp
  • A to T, chromosome 9 at 114,401,192 bp
  • T to C, chromosome 10 at 45,158,524 bp
  • T to A, chromosome 10 at 50,910,530 bp
  • T to A, chromosome 10 at 60,299,957 bp
  • T to C, chromosome 10 at 62,408,621 bp
  • T to A, chromosome 10 at 116,048,345 bp
  • T to A, chromosome 11 at 7,137,375 bp
  • T to A, chromosome 11 at 50,901,016 bp
  • T to A, chromosome 11 at 58,968,710 bp
  • T to A, chromosome 11 at 69,492,222 bp
  • T to C, chromosome 11 at 79,445,793 bp
  • T to C, chromosome 11 at 100,516,813 bp
  • T to A, chromosome 11 at 103,071,766 bp
  • T to C, chromosome 11 at 103,456,623 bp
  • T to C, chromosome 12 at 5,014,001 bp
  • A to G, chromosome 12 at 80,759,303 bp
  • T to C, chromosome 13 at 19,185,457 bp
  • T to G, chromosome 13 at 31,808,222 bp
  • A to T, chromosome 14 at 52,410,008 bp
  • T to C, chromosome 14 at 121,622,961 bp
  • A to T, chromosome 15 at 82,390,470 bp
  • T to C, chromosome 16 at 5,107,342 bp
  • T to A, chromosome 16 at 59,522,189 bp
  • T to A, chromosome 17 at 5,327,393 bp
  • C to T, chromosome 17 at 24,983,140 bp
  • T to C, chromosome 17 at 28,550,671 bp
  • T to C, chromosome 17 at 36,284,663 bp
  • T to A, chromosome 17 at 37,772,049 bp
  • A to G, chromosome 17 at 64,713,601 bp
  • C to T, chromosome 18 at 32,837,287 bp
  • T to C, chromosome 18 at 34,438,220 bp
  • A to T, chromosome 19 at 5,463,281 bp
  • G to A, chromosome 19 at 25,431,014 bp
  • A to T, chromosome 19 at 34,084,848 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8894 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068697-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.