Strain Name:
C57BL/6J-MtgxR8945Btlr/Mmmh
Stock Number:
068713-MU
Citation ID:
RRID:MMRRC_068713-MU
Other Names:
R8945 (G1)
Major Collection:

Strain Information

Med26
Name: mediator complex subunit 26
Synonyms: Crsp7, 5730493L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70625
HGNC: HGNC:2376
Homologene: 68417
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Papola
Name: poly (A) polymerase alpha
Synonyms: Plap, PapIII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18789
Homologene: 23389
Rev1
Name: REV1, DNA directed polymerase
Synonyms: Rev1l, REV1, 1110027I23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56210
Homologene: 32309
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 2900005P22Rik, TRS130, 4632408O18Rik, Nibp, 1810044A24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Dyrk1a
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a
Synonyms: Mnbh, 2310043O08Rik, D16Ertd493e, Dyrk, D16Ertd272e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13548
HGNC: HGNC:3091
Homologene: 55576
Fnbp1
Name: formin binding protein 1
Synonyms: 1110057E06Rik, FBP17, FBP1, 2210010H06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14269
Homologene: 100983
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, hypothroid, pet
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Oprm1
Name: opioid receptor, mu 1
Synonyms: MOR-1, MOP-R, MOP receptor, Oprm, muOR, mor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18390
HGNC: HGNC:8156
Homologene: 37368
G3bp2
Name: G3BP stress granule assembly factor 2
Synonyms: E430034L04Rik, G3BP2, G3BP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23881
Homologene: 137244
Lrrc1
Name: leucine rich repeat containing 1
Synonyms: A430093J20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214345
Homologene: 44445
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Bmp1
Name: bone morphogenetic protein 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12153
VEGA: 14
HGNC: HGNC:1067
Homologene: 55955
Jak1
Name: Janus kinase 1
Synonyms: C130039L05Rik, BAP004
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16451
HGNC: HGNC:6190
Homologene: 1678
Dhx32
Name: DEAH-box helicase 32 (putative)
Synonyms: Ddx32, DEAH (Asp-Glu-Ala-His) box polypeptide 32
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101437
Homologene: 56798
Btnl9
Name: butyrophilin-like 9
Synonyms: D330012D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237754
Homologene: 68540
Clec18a
Name: C-type lectin domain family 18, member A
Synonyms: Mrcl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353287
Homologene: 18755
Nktr
Name: natural killer tumor recognition sequence
Synonyms: 5330401F18Rik, D9Wsu172e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18087
HGNC: HGNC:7833
Homologene: 122148
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Mturn
Name: maturin, neural progenitor differentiation regulator homolog (Xenopus)
Synonyms: B230212L03Rik, 2410066E13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68235
Spmip2
Name: sperm microtubule inner protein 2
Synonyms: Gm17359
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100233207
Homologene: 105634
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: Clc1, SMCC1, Clc-1, nmf355, NMF355
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Hps3
Name: HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Synonyms: Hermansky-Pudlak syndrome 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12807
Homologene: 13019
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211936
Homologene: 52235
Aste1
Name: asteroid homolog 1
Synonyms: 1100001A21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66595
Homologene: 130666
Dusp26
Name: dual specificity phosphatase 26
Synonyms: 2310043K02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66959
Homologene: 11421
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Rp1h, mG145, oxygen-regulated protein 1, Dcdc3, Orp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Myo1h
Name: myosin 1H
Synonyms: 4631401O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231646
Homologene: 82639
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382018
Homologene: 11279
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100322896
Homologene: 123510
Bcl9l
Name: B cell CLL/lymphoma 9-like
Synonyms: DLNB11
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80288
VEGA: 9
Homologene: 65615
Tcaf1
Name: TRPM8 channel-associated factor 1
Synonyms: 3321401G04Rik, 2810407D09Rik, A230020K05Rik, Fam115a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77574
Homologene: 8815
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237711
Homologene: 104282
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: Tj6, TJ6s, ATP6a2, Atp6n2, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21871
Homologene: 56523
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Spsb1
Name: splA/ryanodine receptor domain and SOCS box containing 1
Synonyms: 1110014L01Rik, 4930422J18Rik, SSB1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74646
Homologene: 11832
Pdcl2
Name: phosducin-like 2
Synonyms: Mgcphlp, 1700016K07Rik, 1700010B22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79455
Homologene: 74832
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Elmo1
Name: engulfment and cell motility 1
Synonyms: C230095H21Rik, 6330578D22Rik, CED-12
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
Nectin1
Name: nectin cell adhesion molecule 1
Synonyms: HveC, PRR1, nectin-1, PRR, Cd111, Pvrl1, HIgR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58235
VEGA: 9
HGNC: HGNC:9706
Homologene: 2138
Tspyl4
Name: TSPY-like 4
Synonyms: 2610102M01Rik, B230210I21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72480
Homologene: 15872
Tmem38a
Name: transmembrane protein 38A
Synonyms: 1110001E17Rik, TRIC-A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74166
Homologene: 11449
Ifnlr1
Name: interferon lambda receptor 1
Synonyms: IFNLR1, CRF2-12, Il28ra
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242700
Homologene: 52086
Fam162b
Name: family with sequence similarity 162, member B
Synonyms: 9430073N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77296
VEGA: 10
Homologene: 82459
Spz1
Name: spermatogenic leucine zipper 1
Synonyms: 1700027M20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 79401
VEGA: 13
Homologene: 49934
Zfp40
Name: zinc finger protein 40
Synonyms: NTfin12, Zfp-40
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22700
Homologene: 136312
Samd14
Name: sterile alpha motif domain containing 14
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217125
Homologene: 17130
Fzd4
Name: frizzled class receptor 4
Synonyms: Fz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14366
HGNC: HGNC:4042
Homologene: 7325
Cavin1
Name: caveolae associated 1
Synonyms: 2310075E07Rik, Cavin, cavin-1, Ptrf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19285
HGNC: HGNC:9688
Homologene: 7499
Gm13283
Name: predicted gene 13283
Synonyms: EG545645
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545645
Homologene: 45671
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 4,349,594 bp
  • A to T, chromosome 1 at 38,083,743 bp
  • T to A, chromosome 2 at 31,105,334 bp
  • A to G, chromosome 2 at 104,991,367 bp
  • T to A, chromosome 3 at 20,014,060 bp
  • T to C, chromosome 3 at 63,731,618 bp
  • A to G, chromosome 3 at 79,345,505 bp
  • C to T, chromosome 4 at 88,760,886 bp
  • A to T, chromosome 4 at 101,162,912 bp
  • T to G, chromosome 4 at 135,704,298 bp
  • T to C, chromosome 4 at 149,907,018 bp
  • A to T, chromosome 5 at 62,849,753 bp
  • A to T, chromosome 5 at 76,317,828 bp
  • G to A, chromosome 5 at 92,068,422 bp
  • A to C, chromosome 5 at 114,332,723 bp
  • G to T, chromosome 5 at 124,646,649 bp
  • A to C, chromosome 5 at 124,813,942 bp
  • G to T, chromosome 5 at 141,613,180 bp
  • A to T, chromosome 6 at 42,286,767 bp
  • C to T, chromosome 6 at 42,686,373 bp
  • C to A, chromosome 6 at 54,689,032 bp
  • A to T, chromosome 7 at 89,407,584 bp
  • A to T, chromosome 7 at 100,391,079 bp
  • A to G, chromosome 7 at 133,722,147 bp
  • G to A, chromosome 8 at 31,096,339 bp
  • A to G, chromosome 8 at 33,574,696 bp
  • T to A, chromosome 8 at 71,647,953 bp
  • T to C, chromosome 8 at 72,497,090 bp
  • C to T, chromosome 8 at 72,584,726 bp
  • A to T, chromosome 8 at 111,081,569 bp
  • A to G, chromosome 9 at 43,791,940 bp
  • G to T, chromosome 9 at 44,500,941 bp
  • G to A, chromosome 9 at 77,435,091 bp
  • G to A, chromosome 9 at 105,396,681 bp
  • T to A, chromosome 9 at 121,746,492 bp
  • A to T, chromosome 10 at 6,832,644 bp
  • T to A, chromosome 10 at 34,297,465 bp
  • T to C, chromosome 10 at 51,590,373 bp
  • G to A, chromosome 10 at 88,792,670 bp
  • T to A, chromosome 11 at 29,753,110 bp
  • T to C, chromosome 11 at 49,174,834 bp
  • A to C, chromosome 11 at 95,021,201 bp
  • T to C, chromosome 11 at 100,958,833 bp
  • T to C, chromosome 12 at 91,538,223 bp
  • T to A, chromosome 12 at 105,809,687 bp
  • G to T, chromosome 12 at 118,023,983 bp
  • T to A, chromosome 13 at 20,582,268 bp
  • G to T, chromosome 13 at 63,240,331 bp
  • T to C, chromosome 13 at 92,574,991 bp
  • T to C, chromosome 14 at 70,490,190 bp
  • T to C, chromosome 15 at 73,058,096 bp
  • A to G, chromosome 16 at 94,666,007 bp
  • A to G, chromosome 17 at 23,182,227 bp
  • G to T, chromosome 17 at 29,839,985 bp
  • C to G, chromosome 18 at 49,939,572 bp
  • A to T, chromosome 19 at 16,664,750 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8945 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068713-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.