Strain Name:
C57BL/6J-MtgxR8721Btlr/Mmmh
Stock Number:
068717-MU
Citation ID:
RRID:MMRRC_068717-MU
Other Names:
R8721 (G1)
Major Collection:

Strain Information

Csnk1e
Name: casein kinase 1, epsilon
Synonyms: tau, KC1epsilon, CK1epsilon, CKI epsilon, CKIepsilon
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 27373
Homologene: 121695
Suclg1
Name: succinate-CoA ligase, GDP-forming, alpha subunit
Synonyms: Sucla1, 1500000I01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56451
Homologene: 55785
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Ascc1
Name: activating signal cointegrator 1 complex subunit 1
Synonyms: CGI-18, ASC1p50, 1810015P09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69090
VEGA: 10
Homologene: 41079
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Frs2
Name: fibroblast growth factor receptor substrate 2
Synonyms: SNT1, C330018A15Rik, Frs2alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327826
VEGA: 10
Homologene: 4846
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, 2600013A04Rik, D230004I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Rmdn3
Name: regulator of microtubule dynamics 3
Synonyms: Fam82a2, 1200015F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67809
Homologene: 34926
Zfp346
Name: zinc finger protein 346
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26919
Homologene: 8073
Hspa12b
Name: heat shock protein 12B
Synonyms: 2700081N06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72630
Homologene: 41749
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: 68kDa, bIG-h3, Beta-ig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21810
VEGA: 13
Homologene: 37294
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Zfp429
Name: zinc finger protein 429
Synonyms: 2810487A22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72807
Homologene: 110878
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 668758
Homologene: 110776
Tril
Name: TLR4 interactor with leucine-rich repeats
Synonyms: 1200009O22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66873
Homologene: 69404
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: teashirt2, Sdccag33l, 2900073F20Rik, Zfp218, Mtsh2, Tsh2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228911
Homologene: 35258
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: ADAM-TS1, ADAMTS-1, METH1, METH-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Or8g19
Name: olfactory receptor family 8 subfamily G member 19
Synonyms: MTPCR56, Olfr242, GA_x6K02T2PVTD-32841223-32842158, Olfr27, MOR171-6, GA_x6K02T2KYVW-1037-120
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258826
VEGA: 9
HGNC: HGNC:8484
Homologene: 110610
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, nmMlck, A930019C19Rik, 9530072E15Rik, MLCK108
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Or4a74
Name: olfactory receptor family 4 subfamily A member 74
Synonyms: MOR231-6, GA_x6K02T2Q125-51051555-51050611, Olfr1247
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258968
Homologene: 121536
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Intin2, Itih-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12549
Homologene: 10644
Fam83d
Name: family with sequence similarity 83, member D
Synonyms: 2310007D09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71878
Homologene: 23715
Gbp2b
Name: guanylate binding protein 2b
Synonyms: LIMIT, Mag-1, Mpa1, Gbp-1, Gbp1, Mpa-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14468
Homologene: 137233
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223723
Homologene: 9036
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
Arhgap24
Name: Rho GTPase activating protein 24
Synonyms: 0610025G21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231532
Homologene: 32754
Mtmr6
Name: myotubularin related protein 6
Synonyms: Gm38641, 4022440C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Hand1
Name: heart and neural crest derivatives expressed 1
Synonyms: Th1, eHAND, Thing1, Ehand1, bHLHa27, Hxt
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15110
HGNC: HGNC:4807
Homologene: 3545
Abhd16a
Name: abhydrolase domain containing 16A
Synonyms: NG26, Bat5, D17H6S82E
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193742
Homologene: 10904
Tas2r134
Name: taste receptor, type 2, member 134
Synonyms: T2R134, Tas2r34
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 387511
Homologene: 66001
Morn4
Name: MORN repeat containing 4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226123
VEGA: 19
Homologene: 16635
Gm8267
Name: predicted gene 8267
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666744
Homologene: 115686
Cfap73
Name: cilia and flagella associated protein 73
Synonyms: Ccdc42b, Gm5988
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 546886
Homologene: 53205
Zscan4-ps2
Name: zinc finger and SCAN domain containing 4, pseudogene 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665913
Traj35
Name: T cell receptor alpha joining 35
Synonyms: Gm16664
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100124354
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 10,106,808 bp
  • C to T, chromosome 2 at 31,425,177 bp
  • T to C, chromosome 2 at 51,627,559 bp
  • T to C, chromosome 2 at 89,609,842 bp
  • T to A, chromosome 2 at 119,139,365 bp
  • A to G, chromosome 2 at 131,141,002 bp
  • G to T, chromosome 2 at 158,785,602 bp
  • T to A, chromosome 2 at 169,885,358 bp
  • A to T, chromosome 3 at 142,606,944 bp
  • G to T, chromosome 4 at 6,268,273 bp
  • A to T, chromosome 5 at 102,875,699 bp
  • T to C, chromosome 5 at 120,630,024 bp
  • A to G, chromosome 6 at 53,820,198 bp
  • G to T, chromosome 6 at 73,269,379 bp
  • A to T, chromosome 7 at 11,517,595 bp
  • T to C, chromosome 7 at 131,277,606 bp
  • T to A, chromosome 8 at 104,833,895 bp
  • T to G, chromosome 9 at 39,144,090 bp
  • C to T, chromosome 9 at 109,328,314 bp
  • T to C, chromosome 10 at 60,098,106 bp
  • T to G, chromosome 10 at 117,074,030 bp
  • A to G, chromosome 11 at 57,831,779 bp
  • G to T, chromosome 11 at 66,095,298 bp
  • A to T, chromosome 11 at 100,521,980 bp
  • T to C, chromosome 11 at 110,144,289 bp
  • T to C, chromosome 12 at 9,025,044 bp
  • T to C, chromosome 12 at 112,036,455 bp
  • A to G, chromosome 13 at 55,113,678 bp
  • A to G, chromosome 13 at 56,625,786 bp
  • T to A, chromosome 13 at 67,390,212 bp
  • A to T, chromosome 14 at 44,722,050 bp
  • C to T, chromosome 14 at 54,183,815 bp
  • T to G, chromosome 14 at 60,289,679 bp
  • T to C, chromosome 15 at 79,429,815 bp
  • A to G, chromosome 15 at 83,580,583 bp
  • A to T, chromosome 16 at 34,996,806 bp
  • A to G, chromosome 16 at 38,606,696 bp
  • A to G, chromosome 16 at 73,906,910 bp
  • G to T, chromosome 16 at 85,797,887 bp
  • T to C, chromosome 17 at 35,091,595 bp
  • A to G, chromosome 18 at 32,007,011 bp
  • A to T, chromosome 19 at 42,078,000 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8721 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068717-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.