Strain Name:
C57BL/6J-MtgxR8759Btlr/Mmmh
Stock Number:
068718-MU
Citation ID:
RRID:MMRRC_068718-MU
Other Names:
R8759 (G1)
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-2, Sema6D-4, Sema6D-5, Sema6D-1, Sema6D-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Nrg1
Name: neuregulin 1
Synonyms: ARIA, HRGalpha, NDF, D230005F13Rik, HGL, Hgl, HRG, GGFII, SMDF, 6030402G23Rik, heregulin, GGF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Mkrn1
Name: makorin, ring finger protein, 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54484
HGNC: HGNC:7112
Homologene: 32175
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2810012K13Rik, 2210413N07Rik, SBP2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Ddx50
Name: DExD box helicase 50
Synonyms: GU2, 4933429B04Rik, 8430408E17Rik, RH-II/Gubeta, DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 94213
VEGA: 10
Homologene: 56986
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Tmem199
Name: transmembrane protein 199
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195040
Homologene: 45125
Rev1
Name: REV1, DNA directed polymerase
Synonyms: 1110027I23Rik, Rev1l, REV1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56210
Homologene: 32309
Cog6
Name: component of oligomeric golgi complex 6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67542
Homologene: 10802
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Psmc5
Name: protease (prosome, macropain) 26S subunit, ATPase 5
Synonyms: mSUG1, Rpt6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19184
HGNC: HGNC:9552
Homologene: 2098
Tigar
Name: Trp53 induced glycolysis regulatory phosphatase
Synonyms: 9630033F20Rik, Tigar
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319801
HGNC: HGNC:1185
Homologene: 32473
2310022B05Rik
Name: RIKEN cDNA 2310022B05 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69551
Homologene: 13120
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Zc3h18
Name: zinc finger CCCH-type containing 18
Synonyms: 5830416A07Rik, 1190001B23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76014
Homologene: 44894
Tnc
Name: tenascin C
Synonyms: hexabrachion, C130033P17Rik, cytotactin, TN-C, tenascin-C, Hxb, TN
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
6030468B19Rik
Name: RIKEN cDNA 6030468B19 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77727
Homologene: 90660
Drg1
Name: developmentally regulated GTP binding protein 1
Synonyms: Nedd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13494
HGNC: HGNC:3029
Homologene: 3060
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: wa3, NFkB interacting protein 1, IASPP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Aqp4
Name: aquaporin 4
Synonyms: aquaporin-4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11829
VEGA: 18
HGNC: HGNC:637
Homologene: 37507
Nr1d1
Name: nuclear receptor subfamily 1, group D, member 1
Synonyms: rev-erbA(alpha), REV-ERBalpha, A530070C09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217166
HGNC: HGNC:7962
Homologene: 23324
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, ihj, erythroid, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: A930038D23Rik, Ae3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Cntn1
Name: contactin 1
Synonyms: CNTN, usl, F3cam
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12805
HGNC: HGNC:2171
Homologene: 7274
Fmo2
Name: flavin containing monooxygenase 2
Synonyms: 2310042I22Rik, 2310008D08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 55990
HGNC: HGNC:3770
Homologene: 86882
Ubqlnl
Name: ubiquilin-like
Synonyms: 4922504M18Rik, LOC244179
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244179
Homologene: 17034
Xab2
Name: XPA binding protein 2
Synonyms: 0610041O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67439
Homologene: 5738
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242341
Homologene: 72090
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217835
Homologene: 11748
Adamts18
Name: ADAM metallopeptidase with thrombospondin type 1 motif 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 208936
Homologene: 65241
Ficd
Name: FIC domain containing
Synonyms: D5Ertd40e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231630
Homologene: 5139
Vmn1r13
Name: vomeronasal 1 receptor 13
Synonyms: V1rc5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113862
Homologene: 74368
Cdh15
Name: cadherin 15
Synonyms: Cdh14, M cadherin, Mcad
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Cers3
Name: ceramide synthase 3
Synonyms: CerS3, T3L, LOC233330, Lass3, 4930550L11Rik, related to TRH3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545975
Homologene: 18719
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: G6pd1, Gpd1, Gpd-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Lyz3
Name: lysozyme 3
Synonyms: 9530003J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77397
HGNC: HGNC:6740
Homologene: 49931
Ces3a
Name: carboxylesterase 3A
Synonyms: Es-male carboxylesterase, Es31
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382053
HGNC: HGNC:1865
Homologene: 84407
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666348
VEGA: 15
HGNC: HGNC:619
Homologene: 40940
Or52e8
Name: olfactory receptor family 52 subfamily E member 8
Synonyms: GA_x6K02T2PBJ9-7604826-7603885, Olfr671, MOR32-12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257910
Homologene: 133595
Epn3
Name: epsin 3
Synonyms: 2310022G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71889
Homologene: 56791
Slc37a4
Name: solute carrier family 37 (glucose-6-phosphate transporter), member 4
Synonyms: G6pt1, G6PT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14385
VEGA: 9
HGNC: HGNC:4061
Homologene: 37482
Lipt2
Name: lipoyl(octanoyl) transferase 2 (putative)
Synonyms: 2610209A20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67164
Homologene: 41659
Ighg1
Name: immunoglobulin heavy constant gamma 1 (G1m marker)
Synonyms: IgG1, Igh-4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16017
Ppihl
Name: peptidyl prolyl isomerase H like
Synonyms: Gm7879
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665989
Gm17027
Name: predicted gene 17027
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102637812
Homologene: 128452
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 38,059,272 bp
  • T to C, chromosome 1 at 75,554,638 bp
  • A to G, chromosome 1 at 162,880,436 bp
  • A to G, chromosome 1 at 172,119,514 bp
  • C to T, chromosome 1 at 174,213,374 bp
  • T to C, chromosome 2 at 12,262,129 bp
  • G to T, chromosome 2 at 22,558,307 bp
  • T to C, chromosome 2 at 91,945,577 bp
  • G to A, chromosome 2 at 124,655,214 bp
  • A to G, chromosome 2 at 174,646,081 bp
  • A to G, chromosome 3 at 52,990,044 bp
  • T to A, chromosome 4 at 19,910,649 bp
  • G to A, chromosome 4 at 64,006,264 bp
  • A to T, chromosome 4 at 116,435,560 bp
  • T to C, chromosome 4 at 117,110,433 bp
  • C to T, chromosome 4 at 149,982,301 bp
  • A to T, chromosome 5 at 43,913,657 bp
  • G to T, chromosome 5 at 113,738,514 bp
  • T to A, chromosome 6 at 32,192,341 bp
  • C to A, chromosome 6 at 39,399,410 bp
  • A to G, chromosome 6 at 57,210,539 bp
  • A to T, chromosome 6 at 127,091,257 bp
  • G to T, chromosome 7 at 19,370,056 bp
  • G to A, chromosome 7 at 66,786,102 bp
  • GGCGCCCGCGCGCG to GGCG, chromosome 7 at 100,159,681 bp
  • T to A, chromosome 7 at 104,149,999 bp
  • T to C, chromosome 7 at 104,975,118 bp
  • G to A, chromosome 7 at 120,407,408 bp
  • T to C, chromosome 8 at 3,611,672 bp
  • C to A, chromosome 8 at 31,818,075 bp
  • A to G, chromosome 8 at 105,057,497 bp
  • G to A, chromosome 8 at 113,706,992 bp
  • A to G, chromosome 8 at 122,411,385 bp
  • A to G, chromosome 8 at 122,860,889 bp
  • T to C, chromosome 8 at 124,639,177 bp
  • C to T, chromosome 9 at 44,402,335 bp
  • T to C, chromosome 9 at 67,367,218 bp
  • T to G, chromosome 10 at 11,157,164 bp
  • T to C, chromosome 10 at 62,616,242 bp
  • T to A, chromosome 10 at 117,234,435 bp
  • T to C, chromosome 11 at 3,254,633 bp
  • A to T, chromosome 11 at 34,695,240 bp
  • T to A, chromosome 11 at 78,507,807 bp
  • C to A, chromosome 11 at 94,496,022 bp
  • G to C, chromosome 11 at 98,769,247 bp
  • A to G, chromosome 11 at 103,457,940 bp
  • A to G, chromosome 11 at 106,262,861 bp
  • T to C, chromosome 11 at 117,806,286 bp
  • G to A, chromosome 12 at 102,373,602 bp
  • A to T, chromosome 12 at 113,329,037 bp
  • G to A, chromosome 13 at 51,679,833 bp
  • T to C, chromosome 14 at 42,159,294 bp
  • T to C, chromosome 15 at 77,717,865 bp
  • T to G, chromosome 15 at 92,255,920 bp
  • T to G, chromosome 18 at 15,399,991 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8759 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068718-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.