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Strain Name:
C57BL/6J-MtgxR8777Btlr/Mmmh
Stock Number:
068720-MU
Citation ID:
RRID:MMRRC_068720-MU
Other Names:
R8777 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Neurog2
Name: neurogenin 2
Synonyms: Math4A, ngn2, Atoh4, bHLHa8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11924
Homologene: 7633
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Mib1
Name: MIB E3 ubiquitin protein ligase 1
Synonyms: E430019M12Rik, Mib, skeletrophin, mind bomb-1, mindbomb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225164
Homologene: 10810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 172,232,302 bp
  • A to T, chromosome 1 at 174,391,282 bp
  • T to A, chromosome 2 at 25,408,117 bp
  • A to G, chromosome 2 at 26,369,363 bp
  • G to A, chromosome 3 at 33,839,133 bp
  • T to C, chromosome 3 at 55,150,913 bp
  • G to T, chromosome 3 at 127,634,093 bp
  • C to T, chromosome 4 at 41,190,715 bp
  • T to A, chromosome 4 at 63,577,839 bp
  • A to T, chromosome 5 at 8,939,894 bp
  • A to G, chromosome 5 at 94,317,168 bp
  • T to G, chromosome 5 at 107,510,427 bp
  • T to A, chromosome 5 at 108,525,569 bp
  • C to T, chromosome 5 at 109,340,365 bp
  • T to C, chromosome 5 at 120,867,044 bp
  • T to A, chromosome 5 at 123,517,927 bp
  • T to G, chromosome 5 at 124,116,548 bp
  • G to A, chromosome 5 at 143,903,007 bp
  • T to A, chromosome 5 at 144,837,139 bp
  • A to G, chromosome 6 at 40,655,251 bp
  • A to G, chromosome 6 at 100,750,471 bp
  • A to T, chromosome 6 at 129,403,574 bp
  • T to C, chromosome 7 at 4,742,713 bp
  • A to G, chromosome 7 at 8,192,693 bp
  • T to C, chromosome 7 at 16,816,608 bp
  • A to G, chromosome 7 at 96,896,037 bp
  • C to A, chromosome 7 at 97,485,020 bp
  • A to G, chromosome 7 at 126,488,862 bp
  • A to T, chromosome 7 at 128,707,131 bp
  • T to G, chromosome 8 at 40,898,954 bp
  • T to C, chromosome 8 at 70,891,290 bp
  • G to T, chromosome 8 at 119,236,967 bp
  • A to C, chromosome 9 at 14,739,389 bp
  • T to G, chromosome 9 at 15,060,794 bp
  • A to G, chromosome 10 at 62,398,833 bp
  • T to G, chromosome 10 at 62,997,881 bp
  • A to T, chromosome 10 at 79,973,138 bp
  • G to T, chromosome 10 at 80,323,723 bp
  • T to A, chromosome 10 at 111,293,113 bp
  • T to A, chromosome 10 at 129,473,505 bp
  • C to A, chromosome 11 at 46,815,482 bp
  • G to A, chromosome 11 at 53,399,956 bp
  • C to T, chromosome 11 at 58,455,931 bp
  • T to A, chromosome 11 at 62,433,666 bp
  • T to A, chromosome 11 at 62,433,668 bp
  • A to G, chromosome 11 at 67,192,572 bp
  • A to T, chromosome 11 at 67,361,335 bp
  • A to G, chromosome 12 at 89,260,464 bp
  • C to T, chromosome 13 at 32,729,106 bp
  • T to C, chromosome 13 at 59,785,783 bp
  • T to A, chromosome 13 at 69,510,705 bp
  • T to C, chromosome 13 at 99,430,796 bp
  • T to C, chromosome 14 at 30,660,199 bp
  • T to C, chromosome 14 at 55,871,663 bp
  • G to A, chromosome 14 at 60,228,736 bp
  • T to C, chromosome 15 at 44,498,571 bp
  • C to T, chromosome 15 at 99,243,356 bp
  • T to C, chromosome 17 at 38,644,691 bp
  • T to A, chromosome 17 at 84,751,229 bp
  • G to A, chromosome 18 at 10,747,422 bp
  • A to T, chromosome 18 at 67,401,528 bp
  • G to T, chromosome 19 at 27,240,546 bp
  • A to G, chromosome 19 at 37,980,393 bp
  • G to A, chromosome 19 at 56,813,361 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8777 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068720-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.