Strain Name:
C57BL/6J-MtgxR8777Btlr/Mmmh
Stock Number:
068720-MU
Citation ID:
RRID:MMRRC_068720-MU
Other Names:
R8777 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Neurog2
Name: neurogenin 2
Synonyms: Math4A, ngn2, Atoh4, bHLHa8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11924
Homologene: 7633
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Mib1
Name: MIB E3 ubiquitin protein ligase 1
Synonyms: Mib, E430019M12Rik, skeletrophin, mind bomb-1, mindbomb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225164
Homologene: 10810
Tut7
Name: terminal uridylyl transferase 7
Synonyms: 6030448M23Rik, Tent3b, Zcchc6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Lrpprc
Name: leucine-rich PPR-motif containing
Synonyms: Lrp130, 3110001K13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72416
Homologene: 32695
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Alf4, Laf4l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 93736
Homologene: 8683
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Clec1b
Name: C-type lectin domain family 1, member b
Synonyms: Clec-2, 1810061I13Rik, Clec2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56760
Homologene: 49468
Diablo
Name: diablo, IAP-binding mitochondrial protein
Synonyms: 0610041G12Rik, Smac, 1700006L01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66593
Homologene: 10532
Tubb6
Name: tubulin, beta 6 class V
Synonyms: 2310057H16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67951
VEGA: 18
Homologene: 69414
Aimp2
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Synonyms: Jtv1, Aimp2(p38)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231872
Homologene: 4594
A830010M20Rik
Name: RIKEN cDNA A830010M20 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231570
VEGA: 5
Homologene: 128318
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Tea, Atrc2, Cat2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11988
Homologene: 20659
Abcb4
Name: ATP-binding cassette, sub-family B member 4
Synonyms: mdr-2, Mdr2, Pgy-2, Pgy2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Tent4a
Name: terminal nucleotidyltransferase 4A
Synonyms: LAK-1, TRF4, TRF4-1, Pols, Papd7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210106
Homologene: 5089
Cdh13
Name: cadherin 13
Synonyms: T-cadherin, Tcad, 4932416G01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12554
HGNC: HGNC:1753
Homologene: 20335
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Hephl1
Name: hephaestin-like 1
Synonyms: LOC244698, Zp, zyklopen, thd, cw
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244698
Homologene: 9112
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Kmt5c
Name: lysine methyltransferase 5C
Synonyms: Suv4-20h2, Suv420h2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232811
Homologene: 32792
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227644
Homologene: 2321
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MyHC-IIa, MHC2A, Myhs-f, Myhs-f1, Myhsf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Atp1a4
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27222
Homologene: 113769
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: LOC232313, Glt8d4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232313
Homologene: 16823
Rufy2
Name: RUN and FYVE domain-containing 2
Synonyms: LZ-FYVE, 2610111M19Rik, Denn, ZFYVE13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70432
Homologene: 23064
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, neurexin III beta, neurexin III alpha, 9330112C09Rik, D12Bwg0831e, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Oas1h
Name: 2'-5' oligoadenylate synthetase 1H
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246729
HGNC: HGNC:8086
Homologene: 77345
Mcrs1
Name: microspherule protein 1
Synonyms: P78, ICP22BP, MSP58, C78274
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 51812
VEGA: 15
HGNC: HGNC:6960
Homologene: 4622
Tmem268
Name: transmembrane protein 268
Synonyms: 6330416G13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230279
Homologene: 17005
Tufm
Name: Tu translation elongation factor, mitochondrial
Synonyms: EF-TuMT, 2300002G02Rik, C76308
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233870
Homologene: 2490
Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Synonyms: NIS
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114479
Homologene: 37311
Rft1
Name: RFT1 homolog
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328370
Homologene: 5343
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Timd4
Name: T cell immunoglobulin and mucin domain containing 4
Synonyms: B430010N18Rik, Tim4, TIM-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276891
Homologene: 51381
Ccdc186
Name: coiled-coil domain containing 186
Synonyms: Otg1, 1810028B20Rik, A630007B06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 213993
Homologene: 9963
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216019
Homologene: 128937
Or10x4
Name: olfactory receptor family 10 subfamily X member 4
Synonyms: GA_x6K02T2P20D-20771141-20770212, GA_x6K02T2MFC0-1145-1312, MOR267-7, Olfr415, Olfr248
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258709
Piwil4
Name: piwi-like RNA-mediated gene silencing 4
Synonyms: 9230101H05Rik, Miwi2, MIWI2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330890
Homologene: 45122
Grin3b
Name: glutamate receptor, ionotropic, NMDA3B
Synonyms: NR3B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170483
Homologene: 15606
Or2z2
Name: olfactory receptor family 2 subfamily Z member 2
Synonyms: MTPCR07, MOR281-1, GA_x6K02T2NKPP-957001-957948, Olfr30
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18329
Homologene: 131139
Pcsk4
Name: proprotein convertase subtilisin/kexin type 4
Synonyms: PC4, SPC5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18551
HGNC: HGNC:8746
Homologene: 22495
Mylk4
Name: myosin light chain kinase family, member 4
Synonyms: EG238564
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238564
Homologene: 66243
Arl6ip4
Name: ADP-ribosylation factor-like 6 interacting protein 4
Synonyms: Aip-4, Srp25
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 65105
Homologene: 9606
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Ube2r2
Name: ubiquitin-conjugating enzyme E2R 2
Synonyms: Cdc34b, Ubc3b, 1200003M11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67615
Homologene: 3210
Cplx1
Name: complexin 1
Synonyms: 921-S
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12889
HGNC: HGNC:2309
Homologene: 21324
Or6c3
Name: olfactory receptor family 6 subfamily C member 3
Synonyms: GA_x6K02T2PULF-11151514-11152449, MOR111-4, Olfr788
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258544
Homologene: 74200
Esp31
Name: exocrine gland secreted peptide 31
Synonyms: Gm20516
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126768
Vmn2r42
Name: vomeronasal 2, receptor 42
Synonyms: V2r4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22310
Homologene: 113703
Ccdc169
Name: coiled-coil domain containing 169
Synonyms: A730037C10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320604
Homologene: 77607
Gm49336
Name: predicted gene, 49336
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 172,232,302 bp
  • A to T, chromosome 1 at 174,391,282 bp
  • T to A, chromosome 2 at 25,408,117 bp
  • A to G, chromosome 2 at 26,369,363 bp
  • G to A, chromosome 3 at 33,839,133 bp
  • T to C, chromosome 3 at 55,150,913 bp
  • G to T, chromosome 3 at 127,634,093 bp
  • C to T, chromosome 4 at 41,190,715 bp
  • T to A, chromosome 4 at 63,577,839 bp
  • A to T, chromosome 5 at 8,939,894 bp
  • A to G, chromosome 5 at 94,317,168 bp
  • T to G, chromosome 5 at 107,510,427 bp
  • T to A, chromosome 5 at 108,525,569 bp
  • C to T, chromosome 5 at 109,340,365 bp
  • T to C, chromosome 5 at 120,867,044 bp
  • T to A, chromosome 5 at 123,517,927 bp
  • T to G, chromosome 5 at 124,116,548 bp
  • G to A, chromosome 5 at 143,903,007 bp
  • T to A, chromosome 5 at 144,837,139 bp
  • A to G, chromosome 6 at 40,655,251 bp
  • A to G, chromosome 6 at 100,750,471 bp
  • A to T, chromosome 6 at 129,403,574 bp
  • T to C, chromosome 7 at 4,742,713 bp
  • A to G, chromosome 7 at 8,192,693 bp
  • T to C, chromosome 7 at 16,816,608 bp
  • A to G, chromosome 7 at 96,896,037 bp
  • C to A, chromosome 7 at 97,485,020 bp
  • A to G, chromosome 7 at 126,488,862 bp
  • A to T, chromosome 7 at 128,707,131 bp
  • T to G, chromosome 8 at 40,898,954 bp
  • T to C, chromosome 8 at 70,891,290 bp
  • G to T, chromosome 8 at 119,236,967 bp
  • A to C, chromosome 9 at 14,739,389 bp
  • T to G, chromosome 9 at 15,060,794 bp
  • A to G, chromosome 10 at 62,398,833 bp
  • T to G, chromosome 10 at 62,997,881 bp
  • A to T, chromosome 10 at 79,973,138 bp
  • G to T, chromosome 10 at 80,323,723 bp
  • T to A, chromosome 10 at 111,293,113 bp
  • T to A, chromosome 10 at 129,473,505 bp
  • C to A, chromosome 11 at 46,815,482 bp
  • G to A, chromosome 11 at 53,399,956 bp
  • C to T, chromosome 11 at 58,455,931 bp
  • T to A, chromosome 11 at 62,433,666 bp
  • T to A, chromosome 11 at 62,433,668 bp
  • A to G, chromosome 11 at 67,192,572 bp
  • A to T, chromosome 11 at 67,361,335 bp
  • A to G, chromosome 12 at 89,260,464 bp
  • C to T, chromosome 13 at 32,729,106 bp
  • T to C, chromosome 13 at 59,785,783 bp
  • T to A, chromosome 13 at 69,510,705 bp
  • T to C, chromosome 13 at 99,430,796 bp
  • T to C, chromosome 14 at 30,660,199 bp
  • T to C, chromosome 14 at 55,871,663 bp
  • G to A, chromosome 14 at 60,228,736 bp
  • T to C, chromosome 15 at 44,498,571 bp
  • C to T, chromosome 15 at 99,243,356 bp
  • T to C, chromosome 17 at 38,644,691 bp
  • T to A, chromosome 17 at 84,751,229 bp
  • G to A, chromosome 18 at 10,747,422 bp
  • A to T, chromosome 18 at 67,401,528 bp
  • G to T, chromosome 19 at 27,240,546 bp
  • A to G, chromosome 19 at 37,980,393 bp
  • G to A, chromosome 19 at 56,813,361 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8777 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068720-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.