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Strain Name:
C57BL/6J-MtgxR8798Btlr/Mmmh
Stock Number:
068724-MU
Citation ID:
RRID:MMRRC_068724-MU
Other Names:
R8798 (G1)
Major Collection:

Strain Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: Hrs, tn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Lrrn3
Name: leucine rich repeat protein 3, neuronal
Synonyms: NLRR-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16981
VEGA: 12
Homologene: 36315
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2b, TRPC2a, mTrp2, trp2, Trrp2, 3010009O07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22064
Homologene: 135989
Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68310
Homologene: 32904
Tnpo3
Name: transportin 3
Synonyms: 5730544L10Rik, C430013M08Rik, D6Ertd313e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Psmd13
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
Synonyms: S11, 26S proteasome subunit p40.5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23997
HGNC: HGNC:9558
Homologene: 2110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 72,314,178 bp
  • A to G, chromosome 1 at 161,820,435 bp
  • A to G, chromosome 1 at 173,225,480 bp
  • C to T, chromosome 2 at 4,919,082 bp
  • A to G, chromosome 2 at 21,212,398 bp
  • T to A, chromosome 2 at 50,188,762 bp
  • T to C, chromosome 2 at 52,043,812 bp
  • A to G, chromosome 2 at 60,323,926 bp
  • C to T, chromosome 2 at 76,826,132 bp
  • G to A, chromosome 2 at 120,704,731 bp
  • G to A, chromosome 2 at 121,302,287 bp
  • T to C, chromosome 2 at 155,822,966 bp
  • T to G, chromosome 3 at 88,436,697 bp
  • T to C, chromosome 4 at 45,051,605 bp
  • A to T, chromosome 4 at 45,285,424 bp
  • C to A, chromosome 4 at 52,970,790 bp
  • A to C, chromosome 4 at 103,266,377 bp
  • A to G, chromosome 4 at 106,379,239 bp
  • A to T, chromosome 4 at 127,049,871 bp
  • A to G, chromosome 4 at 129,596,924 bp
  • G to C, chromosome 4 at 129,930,204 bp
  • T to C, chromosome 5 at 21,271,250 bp
  • T to C, chromosome 5 at 76,325,100 bp
  • T to A, chromosome 5 at 115,969,043 bp
  • T to A, chromosome 5 at 127,360,153 bp
  • T to C, chromosome 6 at 29,572,621 bp
  • A to G, chromosome 6 at 122,081,610 bp
  • A to G, chromosome 6 at 125,307,295 bp
  • A to T, chromosome 7 at 5,327,888 bp
  • A to G, chromosome 7 at 8,161,523 bp
  • A to G, chromosome 7 at 35,529,180 bp
  • T to C, chromosome 7 at 43,995,948 bp
  • C to T, chromosome 7 at 80,238,977 bp
  • C to G, chromosome 7 at 102,084,560 bp
  • T to C, chromosome 7 at 127,589,782 bp
  • T to A, chromosome 7 at 140,897,750 bp
  • T to C, chromosome 7 at 141,987,864 bp
  • T to A, chromosome 8 at 3,364,645 bp
  • G to T, chromosome 8 at 46,807,314 bp
  • G to A, chromosome 8 at 79,189,834 bp
  • G to A, chromosome 8 at 79,210,751 bp
  • C to A, chromosome 8 at 80,716,508 bp
  • T to G, chromosome 8 at 107,347,689 bp
  • A to G, chromosome 8 at 110,719,887 bp
  • G to A, chromosome 8 at 129,219,298 bp
  • G to A, chromosome 9 at 38,848,917 bp
  • G to A, chromosome 9 at 39,950,717 bp
  • A to G, chromosome 9 at 58,913,166 bp
  • G to A, chromosome 9 at 78,443,066 bp
  • G to A, chromosome 9 at 79,820,090 bp
  • A to G, chromosome 9 at 111,023,760 bp
  • T to C, chromosome 10 at 18,647,051 bp
  • T to A, chromosome 10 at 41,382,851 bp
  • T to C, chromosome 10 at 78,409,190 bp
  • T to C, chromosome 11 at 52,260,594 bp
  • T to C, chromosome 11 at 53,400,508 bp
  • A to C, chromosome 11 at 65,905,231 bp
  • A to C, chromosome 11 at 87,106,055 bp
  • G to A, chromosome 11 at 115,863,406 bp
  • T to C, chromosome 11 at 116,174,357 bp
  • T to C, chromosome 11 at 120,480,112 bp
  • A to G, chromosome 12 at 41,453,175 bp
  • A to T, chromosome 12 at 104,217,443 bp
  • C to A, chromosome 14 at 50,893,108 bp
  • A to T, chromosome 15 at 4,948,709 bp
  • A to C, chromosome 15 at 27,851,837 bp
  • A to T, chromosome 15 at 47,731,986 bp
  • G to T, chromosome 16 at 33,982,855 bp
  • G to A, chromosome 16 at 34,899,402 bp
  • A to G, chromosome 16 at 44,220,173 bp
  • A to T, chromosome 16 at 58,915,944 bp
  • A to G, chromosome 17 at 25,124,742 bp
  • T to C, chromosome 17 at 56,199,037 bp
  • A to G, chromosome 19 at 40,962,351 bp
  • C to T, chromosome 19 at 41,585,259 bp
  • A to G, chromosome 19 at 43,808,666 bp
  • A to T, chromosome 19 at 43,986,236 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8798 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068724-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.