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Strain Name:
C57BL/6J-MtgxR8810Btlr/Mmmh
Stock Number:
068725-MU
Citation ID:
RRID:MMRRC_068725-MU
Other Names:
R8810 (G1)
Major Collection:

Strain Information

Fgg
Name: fibrinogen gamma chain
Synonyms: gamma-fibrinogen, 3010002H13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99571
HGNC: HGNC:3694
Homologene: 429
Zdhhc17
Name: zinc finger, DHHC domain containing 17
Synonyms: A230053P19Rik, D130071N24Rik, Hip14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320150
VEGA: 10
Homologene: 56324
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Ints6
Name: integrator complex subunit 6
Synonyms: Notch2l, 2900075H24Rik, DICE1, Ddx26
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Pmepa1
Name: prostate transmembrane protein, androgen induced 1
Synonyms: N4wbp4, 2210418I02Rik, PMEPA1, STAG1, Tmepai
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65112
Homologene: 10608
Lrrc41
Name: leucine rich repeat containing 41
Synonyms: D730026A16Rik, MUF1, D630045E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230654
Homologene: 4645
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 133,378,494 bp
  • T to C, chromosome 1 at 155,928,116 bp
  • G to A, chromosome 1 at 178,077,482 bp
  • A to G, chromosome 1 at 181,162,212 bp
  • T to C, chromosome 2 at 25,568,489 bp
  • T to C, chromosome 2 at 35,019,523 bp
  • T to C, chromosome 2 at 66,501,666 bp
  • T to A, chromosome 2 at 76,895,672 bp
  • T to C, chromosome 2 at 87,656,247 bp
  • T to G, chromosome 2 at 92,379,021 bp
  • T to C, chromosome 2 at 104,688,418 bp
  • T to G, chromosome 2 at 122,070,944 bp
  • T to C, chromosome 2 at 125,775,676 bp
  • C to A, chromosome 2 at 173,227,835 bp
  • G to T, chromosome 3 at 83,013,015 bp
  • C to A, chromosome 3 at 106,201,805 bp
  • A to G, chromosome 3 at 135,329,769 bp
  • G to A, chromosome 4 at 96,056,916 bp
  • C to T, chromosome 4 at 116,075,291 bp
  • T to C, chromosome 4 at 155,905,712 bp
  • T to G, chromosome 6 at 41,152,038 bp
  • T to C, chromosome 6 at 50,351,872 bp
  • C to T, chromosome 6 at 55,336,621 bp
  • C to T, chromosome 6 at 85,229,200 bp
  • T to A, chromosome 6 at 113,304,545 bp
  • T to A, chromosome 6 at 123,181,310 bp
  • C to T, chromosome 6 at 125,193,381 bp
  • T to C, chromosome 7 at 6,460,764 bp
  • A to G, chromosome 7 at 15,957,678 bp
  • T to C, chromosome 7 at 79,099,704 bp
  • T to A, chromosome 7 at 84,916,418 bp
  • C to T, chromosome 7 at 85,137,138 bp
  • T to C, chromosome 7 at 101,404,378 bp
  • T to A, chromosome 7 at 104,688,180 bp
  • C to A, chromosome 7 at 138,209,797 bp
  • T to C, chromosome 8 at 3,169,714 bp
  • G to A, chromosome 8 at 4,235,070 bp
  • A to T, chromosome 8 at 95,321,255 bp
  • A to G, chromosome 8 at 104,614,504 bp
  • T to C, chromosome 8 at 105,686,315 bp
  • A to T, chromosome 8 at 123,200,025 bp
  • C to A, chromosome 9 at 13,621,622 bp
  • A to T, chromosome 9 at 18,385,934 bp
  • G to T, chromosome 9 at 39,600,011 bp
  • T to A, chromosome 9 at 50,701,965 bp
  • C to A, chromosome 9 at 113,899,581 bp
  • T to C, chromosome 10 at 23,993,381 bp
  • C to T, chromosome 10 at 41,666,741 bp
  • T to A, chromosome 10 at 59,467,713 bp
  • G to A, chromosome 10 at 78,520,450 bp
  • G to T, chromosome 10 at 110,948,260 bp
  • A to T, chromosome 10 at 123,009,611 bp
  • T to C, chromosome 11 at 6,602,853 bp
  • T to C, chromosome 11 at 58,455,110 bp
  • T to C, chromosome 11 at 59,697,025 bp
  • C to A, chromosome 11 at 80,674,932 bp
  • T to A, chromosome 11 at 80,676,932 bp
  • T to C, chromosome 11 at 103,227,672 bp
  • A to T, chromosome 11 at 104,914,895 bp
  • A to G, chromosome 11 at 111,024,851 bp
  • C to A, chromosome 11 at 120,273,761 bp
  • G to T, chromosome 12 at 21,317,387 bp
  • A to G, chromosome 12 at 36,317,230 bp
  • A to T, chromosome 12 at 36,390,482 bp
  • A to G, chromosome 12 at 103,693,981 bp
  • T to C, chromosome 13 at 23,034,912 bp
  • C to A, chromosome 13 at 33,029,469 bp
  • T to A, chromosome 13 at 61,161,825 bp
  • T to A, chromosome 13 at 93,063,540 bp
  • A to T, chromosome 14 at 56,558,619 bp
  • A to C, chromosome 14 at 62,702,453 bp
  • T to A, chromosome 16 at 8,485,928 bp
  • C to T, chromosome 16 at 35,953,611 bp
  • T to C, chromosome 16 at 45,443,836 bp
  • T to C, chromosome 17 at 22,006,329 bp
  • T to C, chromosome 17 at 32,306,530 bp
  • A to G, chromosome 17 at 40,933,136 bp
  • A to T, chromosome 17 at 56,399,771 bp
  • A to G, chromosome 17 at 56,603,579 bp
  • T to C, chromosome 18 at 15,717,926 bp
  • C to A, chromosome 18 at 34,609,949 bp
  • A to G, chromosome 18 at 37,490,321 bp
  • T to A, chromosome 18 at 63,114,963 bp
  • T to G, chromosome 19 at 6,250,621 bp
  • T to A, chromosome 19 at 56,364,411 bp
  • T to G, chromosome 19 at 61,089,994 bp
  • T to C, chromosome Y at 828,818 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8810 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068725-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.