Strain Name:
C57BL/6J-MtgxR8816Btlr/Mmmh
Stock Number:
068726-MU
Citation ID:
RRID:MMRRC_068726-MU
Other Names:
R8816 (G1)
Major Collection:

Strain Information

Kifc2
Name: kinesin family member C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16581
VEGA: 15
Homologene: 7800
Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Sod2
Name: superoxide dismutase 2, mitochondrial
Synonyms: manganese superoxide dismutase, manganese SOD, Sod-2, MnSOD
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20656
VEGA: 17
Homologene: 530
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: Tcfap2b, AP-2(beta), E130018K07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21419
Homologene: 20688
Spns1
Name: SPNS lysolipid transporter 1, lysophospholipid
Synonyms: 2210013K02Rik, spinster homolog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73658
Homologene: 41530
Smyd1
Name: SET and MYND domain containing 1
Synonyms: 4632404M21Rik, Bop
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12180
Homologene: 7645
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: D5Bwg1524e, Rutbc2, 2410098H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226409
Homologene: 32770
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: Myhn2, Fltn, Fltn, NMHC II-B, 5730504C04Rik, nonmuscle myosin heavy chain IIB, 9330167F11Rik, myosin IIB, nonmuscle myosin heavy chain II-B, Myhn-2, SMemb, Myosin IIB, NMHC-B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Ywhae
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Synonyms: 14-3-3 epsilon
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22627
Homologene: 100743
Bltp3b
Name: bridge-like lipid transfer protein family member 3B
Synonyms: 4930506D01Rik, E030041M21Rik, Uhrf1bp1l, 2010319N22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Nudcd3
Name: NudC domain containing 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 209586
Homologene: 9097
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: AATYK2, KPI-2, cprk, KPI2, A330101P12Rik, BREK, 2900041G10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231876
Homologene: 8948
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: 5031439A09Rik, Gpr177
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68151
Homologene: 11779
Cyb5r4
Name: cytochrome b5 reductase 4
Synonyms: b5/b5r, B5+B5R, 2810034J18Rik, Ncb5or
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 266690
Homologene: 69207
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: Solo, 6720464I07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: E130018M02Rik, mGluR7, Gpr1g, mGlu7a receptor, 6330570A01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Htr1f
Name: 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms: Htr1eb
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15557
VEGA: 16
HGNC: HGNC:5292
Homologene: 37361
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 5630401D06Rik, 2810040A01Rik, 2810013C04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Ass1
Name: argininosuccinate synthetase 1
Synonyms: Ass-1, fold, ASS
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Rab6a
Name: RAB6A, member RAS oncogene family
Synonyms: 2610028L11Rik, Rab6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19346
HGNC: HGNC:9786
Homologene: 55697
Eif2b3
Name: eukaryotic translation initiation factor 2B, subunit 3
Synonyms: 1190002P15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108067
HGNC: HGNC:3259
Homologene: 7005
Fmnl2
Name: formin-like 2
Synonyms: man, 5430425K04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Csnk1g2
Name: casein kinase 1, gamma 2
Synonyms: 2810429I12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103236
VEGA: 10
HGNC: HGNC:2455
Homologene: 100845
Bicdl1
Name: BICD family like cargo adaptor 1
Synonyms: Ccdc64, BICDR-1, 2210403N09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75665
Homologene: 18013
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, LTRPC3, melastatin 2, MLSN2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, steerin 3, unc53H3, 9630020C08Rik, 4732483H20Rik, POMFIL1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: Rw, LOC384168, Dpp-6, B930011P16Rik, In(5)6H-p, Peplb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Fbxw14
Name: F-box and WD-40 domain protein 14
Synonyms: E330009N23Rik, Fbx12, Fbxo12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50757
Homologene: 110776
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230613
Homologene: 136292
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320207
Homologene: 8627
Cdhr4
Name: cadherin-related family member 4
Synonyms: D330022A01Rik, 1700021K14Rik, Cdh29
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69398
Homologene: 82362
Slc35c2
Name: solute carrier family 35, member C2
Synonyms: Ovcov1, D2Wsu58e, CGI-15
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228875
Homologene: 6581
Usb1
Name: U6 snRNA biogenesis 1
Synonyms: AA960436
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101985
Homologene: 11611
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Trmt10c
Name: tRNA methyltransferase 10C, mitochondrial RNase P subunit
Synonyms: Rg9mtd1, D16Ertd454e, 1300018J16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52575
Homologene: 9858
Ino80b
Name: INO80 complex subunit B
Synonyms: Hmga1l4, HMG1YL4, Znhit4, 2510009I23Rik, Papa1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70020
Homologene: 32566
Phyhip
Name: phytanoyl-CoA hydroxylase interacting protein
Synonyms: C630010D02Rik, PAHX-AP1, PAHX-AP#1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105653
Homologene: 8847
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: 2810471M23Rik, Veph
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72789
Homologene: 11624
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2510025K24Rik, 2810422M04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: very-kind, VKIND, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71481
Homologene: 11849
Smyd4
Name: SET and MYND domain containing 4
Synonyms: G430029E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319822
Homologene: 35098
P2ry2
Name: purinergic receptor P2Y, G-protein coupled 2
Synonyms: P2Y2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18442
HGNC: HGNC:8541
Homologene: 1927
Klk1b3
Name: kallikrein 1-related peptidase b3
Synonyms: Ngfg, mGk-3, Ngfg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18050
Homologene: 68141
Cyp4a30b
Name: cytochrome P450, family 4, subfamily a, polypeptide 30b
Synonyms: Cyp4a30b-ps, OTTMUSG00000008626
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435802
Haus4
Name: HAUS augmin-like complex, subunit 4
Synonyms: 9430093H08Rik, D14Ertd500e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219072
VEGA: 14
Homologene: 9854
Or9s15
Name: olfactory receptor family 9 subfamily S member 15
Synonyms: Olfr1411, GA_x6K02T2R7CC-81157497-81156526, MOR208-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258483
Homologene: 115530
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Gpr119
Name: G-protein coupled receptor 119
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 236781
Homologene: 18670
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 19,214,113 bp
  • T to A, chromosome 1 at 92,597,046 bp
  • C to T, chromosome 1 at 128,036,610 bp
  • T to C, chromosome 2 at 31,493,177 bp
  • T to A, chromosome 2 at 49,694,787 bp
  • T to G, chromosome 2 at 53,114,202 bp
  • T to C, chromosome 2 at 76,291,233 bp
  • C to T, chromosome 2 at 126,372,164 bp
  • C to A, chromosome 2 at 130,906,878 bp
  • T to C, chromosome 2 at 131,004,574 bp
  • A to G, chromosome 2 at 165,277,458 bp
  • G to T, chromosome 3 at 66,158,225 bp
  • A to T, chromosome 3 at 127,684,375 bp
  • A to G, chromosome 3 at 159,934,292 bp
  • A to T, chromosome 4 at 112,746,695 bp
  • G to A, chromosome 4 at 115,452,637 bp
  • C to A, chromosome 4 at 117,070,855 bp
  • C to T, chromosome 5 at 27,725,713 bp
  • T to C, chromosome 5 at 113,287,231 bp
  • T to A, chromosome 5 at 115,724,745 bp
  • T to A, chromosome 5 at 144,175,975 bp
  • A to G, chromosome 6 at 46,856,142 bp
  • T to A, chromosome 6 at 71,215,884 bp
  • T to C, chromosome 6 at 83,121,880 bp
  • C to T, chromosome 6 at 111,254,005 bp
  • A to G, chromosome 6 at 146,241,212 bp
  • T to G, chromosome 7 at 28,084,987 bp
  • T to C, chromosome 7 at 44,202,244 bp
  • C to T, chromosome 7 at 46,301,481 bp
  • T to C, chromosome 7 at 73,490,497 bp
  • T to C, chromosome 7 at 100,629,938 bp
  • T to A, chromosome 7 at 100,998,556 bp
  • G to A, chromosome 7 at 126,372,421 bp
  • C to A, chromosome 7 at 128,198,370 bp
  • T to C, chromosome 7 at 139,937,996 bp
  • G to T, chromosome 8 at 95,345,356 bp
  • C to A, chromosome 9 at 67,221,411 bp
  • A to G, chromosome 9 at 67,221,517 bp
  • T to C, chromosome 9 at 87,022,233 bp
  • T to C, chromosome 9 at 107,995,592 bp
  • G to A, chromosome 9 at 109,276,237 bp
  • T to C, chromosome 10 at 80,638,259 bp
  • T to C, chromosome 10 at 89,790,735 bp
  • C to T, chromosome 10 at 92,878,592 bp
  • T to A, chromosome 10 at 109,863,860 bp
  • C to T, chromosome 11 at 6,150,587 bp
  • A to T, chromosome 11 at 68,494,234 bp
  • A to G, chromosome 11 at 68,802,952 bp
  • T to C, chromosome 11 at 75,390,406 bp
  • T to C, chromosome 11 at 75,733,052 bp
  • T to A, chromosome 11 at 110,236,687 bp
  • G to A, chromosome 14 at 54,542,253 bp
  • A to C, chromosome 14 at 70,466,935 bp
  • T to C, chromosome 14 at 118,922,373 bp
  • G to T, chromosome 15 at 27,741,271 bp
  • A to G, chromosome 15 at 76,664,171 bp
  • A to T, chromosome 16 at 56,034,159 bp
  • A to G, chromosome 16 at 64,926,174 bp
  • A to G, chromosome 17 at 13,008,366 bp
  • T to C, chromosome 19 at 22,988,216 bp
  • C to T, chromosome X at 48,673,399 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8816 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068726-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.