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Strain Name:
C57BL/6J-MtgxR8841Btlr/Mmmh
Stock Number:
068732-MU
Citation ID:
RRID:MMRRC_068732-MU
Other Names:
R8841 (G1)
Major Collection:

Strain Information

Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Tnpo3
Name: transportin 3
Synonyms: 5730544L10Rik, C430013M08Rik, D6Ertd313e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Washc2
Name: WASH complex subunit 2
Synonyms: C530005J20Rik, D6Wsu116e, Fam21
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28006
Homologene: 41686
Klhdc4
Name: kelch domain containing 4
Synonyms: G430025P05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234825
Homologene: 69234
Nomo1
Name: nodal modulator 1
Synonyms: PM5, Nomo, D7Ertd156e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211548
Homologene: 13810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 105,557,909 bp
  • A to G, chromosome 1 at 135,827,232 bp
  • A to C, chromosome 2 at 33,155,317 bp
  • G to A, chromosome 2 at 34,822,832 bp
  • T to A, chromosome 2 at 66,326,122 bp
  • T to C, chromosome 3 at 64,406,637 bp
  • A to G, chromosome 3 at 79,887,119 bp
  • A to G, chromosome 3 at 88,484,613 bp
  • A to G, chromosome 3 at 106,486,264 bp
  • C to T, chromosome 4 at 53,143,925 bp
  • A to C, chromosome 4 at 89,691,713 bp
  • A to T, chromosome 4 at 119,170,664 bp
  • A to G, chromosome 4 at 132,365,573 bp
  • A to G, chromosome 4 at 156,232,198 bp
  • T to C, chromosome 5 at 105,480,322 bp
  • T to C, chromosome 5 at 136,123,183 bp
  • T to A, chromosome 5 at 137,456,674 bp
  • C to A, chromosome 5 at 138,065,275 bp
  • T to A, chromosome 5 at 144,844,211 bp
  • T to A, chromosome 5 at 149,627,324 bp
  • T to A, chromosome 6 at 29,589,183 bp
  • A to G, chromosome 6 at 116,258,955 bp
  • T to C, chromosome 6 at 125,343,245 bp
  • T to A, chromosome 7 at 46,058,487 bp
  • G to T, chromosome 7 at 78,356,093 bp
  • A to G, chromosome 7 at 98,615,561 bp
  • T to A, chromosome 7 at 105,070,272 bp
  • G to A, chromosome 7 at 119,848,788 bp
  • C to T, chromosome 8 at 23,156,258 bp
  • G to A, chromosome 8 at 25,986,379 bp
  • T to A, chromosome 8 at 56,307,674 bp
  • T to C, chromosome 8 at 121,085,180 bp
  • T to A, chromosome 8 at 121,796,641 bp
  • A to T, chromosome 9 at 19,808,589 bp
  • A to G, chromosome 9 at 38,994,583 bp
  • A to G, chromosome 9 at 110,858,412 bp
  • A to G, chromosome 9 at 120,120,779 bp
  • A to G, chromosome 9 at 121,204,738 bp
  • A to G, chromosome 10 at 79,622,316 bp
  • A to G, chromosome 10 at 107,382,663 bp
  • A to G, chromosome 10 at 129,034,173 bp
  • A to C, chromosome 11 at 49,113,111 bp
  • G to T, chromosome 11 at 67,762,729 bp
  • G to A, chromosome 11 at 70,724,833 bp
  • G to T, chromosome 11 at 83,704,112 bp
  • A to G, chromosome 11 at 100,014,135 bp
  • A to G, chromosome 11 at 104,310,377 bp
  • G to T, chromosome 11 at 115,319,181 bp
  • A to T, chromosome 12 at 102,369,278 bp
  • T to A, chromosome 14 at 50,127,209 bp
  • T to C, chromosome 14 at 57,597,956 bp
  • T to A, chromosome 14 at 78,947,262 bp
  • T to C, chromosome 15 at 6,652,491 bp
  • G to T, chromosome 15 at 59,335,122 bp
  • A to T, chromosome 15 at 83,581,792 bp
  • A to G, chromosome 15 at 100,513,108 bp
  • C to T, chromosome 16 at 3,710,978 bp
  • T to A, chromosome 16 at 20,735,737 bp
  • C to T, chromosome 16 at 93,905,020 bp
  • A to G, chromosome 17 at 7,773,349 bp
  • A to G, chromosome 17 at 18,063,037 bp
  • T to C, chromosome 18 at 31,964,437 bp
  • A to G, chromosome 18 at 37,355,646 bp
  • C to A, chromosome 19 at 55,078,518 bp
  • C to T, chromosome 19 at 59,273,281 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8841 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068732-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.