Strain Name:
C57BL/6J-MtgxR8841Btlr/Mmmh
Stock Number:
068732-MU
Citation ID:
RRID:MMRRC_068732-MU
Other Names:
R8841 (G1)
Major Collection:

Strain Information

Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, C430013M08Rik, 5730544L10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Lmna
Name: lamin A
Synonyms: Dhe, lamin A/C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16905
HGNC: HGNC:6636
Homologene: 41321
Washc2
Name: WASH complex subunit 2
Synonyms: Fam21, D6Wsu116e, C530005J20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28006
Homologene: 41686
Klhdc4
Name: kelch domain containing 4
Synonyms: G430025P05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234825
Homologene: 69234
Nomo1
Name: nodal modulator 1
Synonyms: PM5, D7Ertd156e, Nomo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211548
Homologene: 13810
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57258
Homologene: 10733
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Emsy
Name: EMSY, BRCA2-interacting transcriptional repressor
Synonyms: 2210018M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233545
Homologene: 32465
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Zfp691
Name: zinc finger protein 691
Synonyms: 6430544H17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195522
Homologene: 9300
Tfcp2
Name: transcription factor CP2
Synonyms: LBP-1d, UBP-1, CP-2, Tcfcp2, LBP1, CP2, D230015P20Rik, LSF, LBP-1c
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21422
VEGA: 15
Homologene: 4134
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: hsp-E7I, HSP110, hsp110/105, Hsp105
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15505
Homologene: 21322
Slc18a2
Name: solute carrier family 18 (vesicular monoamine), member 2
Synonyms: 1110037L13Rik, Vmat2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 214084
VEGA: 19
Homologene: 2298
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71888
Homologene: 74433
Hpgd
Name: hydroxyprostaglandin dehydrogenase 15 (NAD)
Synonyms: 15-PGDH
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15446
HGNC: HGNC:5154
Homologene: 68095
Gask1b
Name: golgi associated kinase 1B
Synonyms: 2210419I08Rik, 1110032E23Rik, Ened, Fam198b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68659
Homologene: 9590
Phactr4
Name: phosphatase and actin regulator 4
Synonyms: 3110001B12Rik, C330013F19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100169
Homologene: 41537
Slc25a38
Name: solute carrier family 25, member 38
Synonyms: appoptosin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208638
Homologene: 5553
Washc5
Name: WASH complex subunit 5
Synonyms: E430025E21Rik, strumpellin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223593
VEGA: 15
Homologene: 8898
Ush1g
Name: USH1 protein network component sans
Synonyms: Sans, js
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16470
Homologene: 56113
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Fyb1
Name: FYN binding protein 1
Synonyms: Fyb, B630013F22Rik, ADAP, FYB-120/130
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23880
HGNC: HGNC:4036
Homologene: 22664
Ralgps1
Name: Ral GEF with PH domain and SH3 binding motif 1
Synonyms: 5830418G11Rik, RALGPS1A, RALGEF2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241308
Homologene: 65163
Glp2r
Name: glucagon-like peptide 2 receptor
Synonyms: GLP-2, 9530092J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 93896
HGNC: HGNC:4325
Homologene: 3132
Chrd
Name: chordin
Synonyms: Chd
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12667
HGNC: HGNC:1949
Homologene: 2774
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209012
Homologene: 41205
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: Scnn1, ENaC alpha, mENaC
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20276
Homologene: 811
Shc2
Name: SHC (Src homology 2 domain containing) transforming protein 2
Synonyms: ShcB, Sli
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216148
Homologene: 19127
Chaf1b
Name: chromatin assembly factor 1, subunit B
Synonyms: CAF-I 60 kDa subunit, CAF-IP60, CAF1P60, CAF1A, CAF1, 2600017H24Rik, MPHOSPH7, CAF-1 subunit B
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Dmrta1
Name: doublesex and mab-3 related transcription factor like family A1
Synonyms: Dmrt4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242523
Homologene: 18477
Pcdhb8
Name: protocadherin beta 8
Synonyms: PcdhbH, Pcdhb5C
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93879
HGNC: HGNC:8690
Homologene: 89038
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217835
Homologene: 11748
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Nkx6-3
Name: NK6 homeobox 3
Synonyms: 9130417I07Rik, Nkx6.3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74561
Homologene: 46375
Or7e168
Name: olfactory receptor family 7 subfamily E member 168
Synonyms: GA_x6K02T2PVTD-13548326-13549255, MOR146-3, Olfr859, MOR146-10_p
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258519
Homologene: 134093
Dennd2d
Name: DENN domain containing 2D
Synonyms: 2010308M01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72121
Homologene: 11776
Or8g21
Name: olfactory receptor family 8 subfamily G member 21
Synonyms: Olfr935, MOR171-11, GA_x6K02T2PVTD-32691280-32690354
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258741
VEGA: 9
Homologene: 133683
Mefv
Name: Mediterranean fever
Synonyms: FMF, TRIM20, pyrin, marenostrin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637053
Homologene: 129754
Or2v2
Name: olfactory receptor family 2 subfamily V member 2
Synonyms: GA_x6K02T2QP88-6321048-6321995, MOR276-2, Olfr1396
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258334
Homologene: 28537
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Rexo5
Name: RNA exonuclease 5
Synonyms: 2610020H08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434234
Homologene: 12803
Prss50
Name: serine protease 50
Synonyms: Tsp50
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235631
Homologene: 8314
Foxf1
Name: forkhead box F1
Synonyms: Foxf1, Foxf1a, FREAC1, Freac-1, HFH-8, Hfh8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15227
HGNC: HGNC:3809
Homologene: 1114
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Vmn2r-ps113, Gm7196
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 637021
Homologene: 115024
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223723
Homologene: 9036
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14732
Homologene: 7343
Or4k15
Name: olfactory receptor family 4 subfamily K member 15
Synonyms: MOR246-2, Olfr727, GA_x6K02T2PMLR-5817082-5818056
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258316
Homologene: 84571
Kif1c
Name: kinesin family member 1C
Synonyms: N-3 kinsin, D11Bwg1349e, Orch3, B430105J22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16562
HGNC: HGNC:6317
Homologene: 4821
Fbxw2
Name: F-box and WD-40 domain protein 2
Synonyms: Fwd2, MD6, FBW2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30050
Homologene: 8131
Lrwd1
Name: leucine-rich repeats and WD repeat domain containing 1
Synonyms: Orca, 1200011O22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71735
Homologene: 17678
Lrrc8b
Name: leucine rich repeat containing 8 family, member B
Synonyms: R75581, 2210408K08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433926
Homologene: 9103
Lin7a
Name: lin-7 homolog A, crumbs cell polarity complex component
Synonyms: TIP-33, LIN-7A, MALS-1, Veli
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108030
VEGA: 10
Homologene: 20976
Pomk
Name: protein-O-mannose kinase
Synonyms: 4930444A02Rik, Sgk196
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74653
Homologene: 12580
Or52e5
Name: olfactory receptor family 52 subfamily E member 5
Synonyms: MOR32-5, Olfr678, GA_x6K02T2PBJ9-7698491-7699432
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258753
Homologene: 27254
Lad1
Name: ladinin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Wfdc17
Name: WAP four-disulfide core domain 17
Synonyms: Amwap, Gm11428
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100034251
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Or6c200-ps1
Name: olfactory receptor family 6 subfamily C member 200, pseudogene 1
Synonyms: GA_x6K02T00F4V-833-1750, GA_x6K02T2PULF-10720146-10719487, Olfr764-ps1, MOR115-6_p, Olfr764, Olfr227, Gm6349
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 622733
Homologene: 67771
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 105,557,909 bp
  • A to G, chromosome 1 at 135,827,232 bp
  • A to C, chromosome 2 at 33,155,317 bp
  • G to A, chromosome 2 at 34,822,832 bp
  • T to A, chromosome 2 at 66,326,122 bp
  • T to C, chromosome 3 at 64,406,637 bp
  • A to G, chromosome 3 at 79,887,119 bp
  • A to G, chromosome 3 at 88,484,613 bp
  • A to G, chromosome 3 at 106,486,264 bp
  • C to T, chromosome 4 at 53,143,925 bp
  • A to C, chromosome 4 at 89,691,713 bp
  • A to T, chromosome 4 at 119,170,664 bp
  • A to G, chromosome 4 at 132,365,573 bp
  • A to G, chromosome 4 at 156,232,198 bp
  • T to C, chromosome 5 at 105,480,322 bp
  • T to C, chromosome 5 at 136,123,183 bp
  • T to A, chromosome 5 at 137,456,674 bp
  • C to A, chromosome 5 at 138,065,275 bp
  • T to A, chromosome 5 at 144,844,211 bp
  • T to A, chromosome 5 at 149,627,324 bp
  • T to A, chromosome 6 at 29,589,183 bp
  • A to G, chromosome 6 at 116,258,955 bp
  • T to C, chromosome 6 at 125,343,245 bp
  • T to A, chromosome 7 at 46,058,487 bp
  • G to T, chromosome 7 at 78,356,093 bp
  • A to G, chromosome 7 at 98,615,561 bp
  • T to A, chromosome 7 at 105,070,272 bp
  • G to A, chromosome 7 at 119,848,788 bp
  • C to T, chromosome 8 at 23,156,258 bp
  • G to A, chromosome 8 at 25,986,379 bp
  • T to A, chromosome 8 at 56,307,674 bp
  • T to C, chromosome 8 at 121,085,180 bp
  • T to A, chromosome 8 at 121,796,641 bp
  • A to T, chromosome 9 at 19,808,589 bp
  • A to G, chromosome 9 at 38,994,583 bp
  • A to G, chromosome 9 at 110,858,412 bp
  • A to G, chromosome 9 at 120,120,779 bp
  • A to G, chromosome 9 at 121,204,738 bp
  • A to G, chromosome 10 at 79,622,316 bp
  • A to G, chromosome 10 at 107,382,663 bp
  • A to G, chromosome 10 at 129,034,173 bp
  • A to C, chromosome 11 at 49,113,111 bp
  • G to T, chromosome 11 at 67,762,729 bp
  • G to A, chromosome 11 at 70,724,833 bp
  • G to T, chromosome 11 at 83,704,112 bp
  • A to G, chromosome 11 at 100,014,135 bp
  • A to G, chromosome 11 at 104,310,377 bp
  • G to T, chromosome 11 at 115,319,181 bp
  • A to T, chromosome 12 at 102,369,278 bp
  • T to A, chromosome 14 at 50,127,209 bp
  • T to C, chromosome 14 at 57,597,956 bp
  • T to A, chromosome 14 at 78,947,262 bp
  • T to C, chromosome 15 at 6,652,491 bp
  • G to T, chromosome 15 at 59,335,122 bp
  • A to T, chromosome 15 at 83,581,792 bp
  • A to G, chromosome 15 at 100,513,108 bp
  • C to T, chromosome 16 at 3,710,978 bp
  • T to A, chromosome 16 at 20,735,737 bp
  • C to T, chromosome 16 at 93,905,020 bp
  • A to G, chromosome 17 at 7,773,349 bp
  • A to G, chromosome 17 at 18,063,037 bp
  • T to C, chromosome 18 at 31,964,437 bp
  • A to G, chromosome 18 at 37,355,646 bp
  • C to A, chromosome 19 at 55,078,518 bp
  • C to T, chromosome 19 at 59,273,281 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8841 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068732-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.