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Strain Name:
C57BL/6J-MtgxR8880Btlr/Mmmh
Stock Number:
068748-MU
Citation ID:
RRID:MMRRC_068748-MU
Other Names:
R8880 (G1)
Major Collection:

Strain Information

Vps33a
Name: VPS33A CORVET/HOPS core subunit
Synonyms: bf, 3830421M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77573
Homologene: 11294
Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191
Prdm16
Name: PR domain containing 16
Synonyms: Mel1, 5730557K01Rik, line 27, csp1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70673
Homologene: 11139
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: 4930506N09Rik, C2pa, PDZ-RGS3, RGS3S, C2PA-RGS3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Smc2
Name: structural maintenance of chromosomes 2
Synonyms: 5730502P04Rik, CAP-E, Fin16, Smc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14211
Homologene: 4705
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22241
Homologene: 2640
Dnajc2
Name: DnaJ heat shock protein family (Hsp40) member C2
Synonyms: MIDA1, Mida1, Zrf1, Zrf2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22791
Homologene: 31656
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,795,395 bp
  • T to C, chromosome 1 at 105,664,495 bp
  • A to T, chromosome 1 at 139,237,148 bp
  • A to G, chromosome 1 at 188,728,536 bp
  • G to A, chromosome 1 at 193,321,055 bp
  • A to G, chromosome 2 at 6,026,172 bp
  • A to T, chromosome 2 at 25,229,255 bp
  • A to T, chromosome 2 at 77,015,212 bp
  • C to T, chromosome 2 at 117,284,944 bp
  • T to C, chromosome 2 at 118,790,758 bp
  • A to G, chromosome 2 at 126,748,309 bp
  • A to T, chromosome 2 at 130,284,084 bp
  • T to C, chromosome 2 at 145,848,852 bp
  • C to T, chromosome 3 at 10,197,171 bp
  • A to C, chromosome 3 at 10,419,133 bp
  • C to T, chromosome 3 at 108,703,019 bp
  • A to G, chromosome 3 at 145,314,037 bp
  • C to T, chromosome 3 at 158,161,744 bp
  • A to T, chromosome 4 at 52,462,856 bp
  • C to T, chromosome 4 at 58,064,204 bp
  • T to A, chromosome 4 at 62,314,365 bp
  • C to A, chromosome 4 at 62,625,136 bp
  • A to T, chromosome 4 at 131,967,793 bp
  • T to C, chromosome 4 at 143,846,570 bp
  • T to C, chromosome 4 at 147,613,379 bp
  • T to C, chromosome 4 at 154,528,913 bp
  • T to C, chromosome 5 at 21,768,672 bp
  • G to A, chromosome 5 at 110,786,422 bp
  • A to G, chromosome 5 at 121,810,910 bp
  • T to C, chromosome 5 at 123,569,443 bp
  • C to T, chromosome 6 at 37,034,717 bp
  • A to G, chromosome 6 at 38,311,277 bp
  • G to T, chromosome 6 at 68,736,510 bp
  • A to T, chromosome 6 at 78,467,805 bp
  • T to C, chromosome 6 at 142,456,387 bp
  • C to T, chromosome 7 at 4,338,337 bp
  • C to T, chromosome 7 at 19,758,746 bp
  • A to T, chromosome 7 at 41,044,487 bp
  • T to C, chromosome 7 at 43,694,035 bp
  • A to C, chromosome 7 at 45,178,360 bp
  • C to T, chromosome 7 at 67,736,708 bp
  • T to A, chromosome 7 at 79,698,902 bp
  • G to A, chromosome 7 at 86,562,341 bp
  • T to C, chromosome 7 at 105,901,913 bp
  • T to A, chromosome 7 at 120,143,612 bp
  • A to T, chromosome 7 at 130,716,834 bp
  • C to A, chromosome 7 at 140,504,259 bp
  • G to T, chromosome 8 at 126,471,305 bp
  • T to C, chromosome 9 at 31,353,446 bp
  • T to A, chromosome 9 at 39,144,603 bp
  • G to A, chromosome 9 at 45,264,333 bp
  • A to T, chromosome 9 at 50,550,662 bp
  • C to T, chromosome 9 at 65,181,268 bp
  • T to C, chromosome 9 at 83,869,251 bp
  • A to T, chromosome 9 at 107,557,541 bp
  • A to G, chromosome 9 at 110,814,195 bp
  • A to G, chromosome 10 at 21,309,969 bp
  • T to G, chromosome 10 at 112,194,919 bp
  • A to G, chromosome 11 at 36,051,961 bp
  • C to T, chromosome 11 at 43,215,984 bp
  • T to A, chromosome 11 at 70,007,935 bp
  • A to G, chromosome 12 at 69,252,043 bp
  • T to A, chromosome 12 at 113,491,144 bp
  • C to T, chromosome 12 at 114,253,915 bp
  • T to C, chromosome 13 at 23,878,749 bp
  • A to T, chromosome 13 at 55,666,220 bp
  • T to A, chromosome 13 at 112,914,500 bp
  • G to T, chromosome 14 at 23,367,650 bp
  • C to T, chromosome 14 at 32,660,880 bp
  • A to C, chromosome 14 at 33,073,535 bp
  • A to C, chromosome 14 at 33,956,839 bp
  • G to A, chromosome 14 at 45,608,973 bp
  • A to T, chromosome 14 at 72,453,880 bp
  • T to C, chromosome 15 at 7,237,768 bp
  • T to A, chromosome 15 at 84,955,666 bp
  • A to T, chromosome 15 at 95,231,448 bp
  • A to T, chromosome 16 at 5,214,721 bp
  • A to T, chromosome 16 at 19,407,646 bp
  • A to G, chromosome 16 at 34,217,935 bp
  • T to C, chromosome 16 at 52,166,005 bp
  • T to A, chromosome 17 at 20,208,967 bp
  • T to G, chromosome 17 at 25,170,155 bp
  • A to C, chromosome 17 at 28,879,464 bp
  • A to G, chromosome 17 at 43,497,917 bp
  • A to G, chromosome 19 at 43,704,407 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8880 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068748-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.