Strain Name:
C57BL/6J-MtgxR8881Btlr/Mmmh
Stock Number:
068749-MU
Citation ID:
RRID:MMRRC_068749-MU
Other Names:
R8881 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Cdh1
Name: cadherin 1
Synonyms: uvomorulin, L-CAM, E-cadherin, UM, E-cad, Ecad
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12550
HGNC: HGNC:1748
Homologene: 20917
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Il21r
Name: interleukin 21 receptor
Synonyms: NILR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60504
HGNC: HGNC:6006
Homologene: 11040
Nrxn2
Name: neurexin II
Synonyms: 6430591O13Rik, neurexin II beta, neurexin II alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Lgi3
Name: leucine-rich repeat LGI family, member 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213469
VEGA: 14
Homologene: 16406
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Mvd
Name: mevalonate (diphospho) decarboxylase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 192156
HGNC: HGNC:7529
Homologene: 1843
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
Homologene: 1746
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: NuMA, 6720401E04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: KMT4, mDot1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: Ltpr7, 2310022G15Rik, LTRPC7, 5033407O22Rik, TRP-PLIK, CHAK, CHAK1, 4833414K03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Trip13
Name: thyroid hormone receptor interactor 13
Synonyms: D13Ertd328e, 2410002G23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69716
Homologene: 3125
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, 5730481H23Rik, mei2-5, AKAP450, repro12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Dusp5
Name: dual specificity phosphatase 5
Synonyms: LOC240672
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240672
HGNC: HGNC:3071
Homologene: 3256
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71753
VEGA: 15
Homologene: 12408
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Anxa11
Name: annexin A11
Synonyms: Anx11, A830099O17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11744
HGNC: HGNC:535
Homologene: 22759
Grpel1
Name: GrpE-like 1, mitochondrial
Synonyms: mt-GrpE#1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17713
Homologene: 6992
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Nte, Swiss-cheese, MSws
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: wa3, NFkB interacting protein 1, IASPP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Frmd4b
Name: FERM domain containing 4B
Synonyms: GRSP1, 6030440G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Dppa4
Name: developmental pluripotency associated 4
Synonyms: ECAT15-1, 2410091M23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73693
VEGA: 16
Homologene: 130462
Sgtb
Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
Synonyms: C630001O05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218544
Homologene: 10409
Fam151b
Name: family with sequence similarity 151, member B
Synonyms: 4930405M20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73942
VEGA: 13
Homologene: 17853
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1289Clo, b2b1203Clo, Dnahc11, b2b1279Clo, avc4, b2b1727Clo, b2b598Clo, lrd
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: D130026O08Rik, Arhgap14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Taf5l
Name: TATA-box binding protein associated factor 5 like
Synonyms: 1110005N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102162
Homologene: 8676
V1rd19
Name: vomeronasal 1 receptor, D19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404287
Homologene: 104166
Slc4a11
Name: solute carrier family 4, sodium bicarbonate transporter-like, member 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269356
Homologene: 12931
Gzmm
Name: granzyme M (lymphocyte met-ase 1)
Synonyms: Lmet1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16904
HGNC: HGNC:4712
Homologene: 21099
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Itgal
Name: integrin alpha L
Synonyms: Ly-21, Cd11a, LFA-1, Ly-15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Tmem229a
Name: transmembrane protein 229A
Synonyms: 6332401O19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319832
Homologene: 85312
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4930415N18Rik, 4933428F06Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Fam237b
Name: family with sequence similarity 237, member B
Synonyms: Gm8773, Gm29287
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 667705
Speg
Name: SPEG complex locus
Synonyms: SPEGalpha, SPEG, D1Bwg1450e, Apeg1, SPEGbeta, BPEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Or10ak8
Name: olfactory receptor family 10 subfamily AK member 8
Synonyms: Olfr1329, MOR259-2, GA_x6K02T2QD9B-18619941-18620882
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258214
Homologene: 79401
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Or52h7
Name: olfactory receptor family 52 subfamily H member 7
Synonyms: MOR31-8, GA_x6K02T2PBJ9-7191524-7192471, Olfr652
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259050
Homologene: 17477
Or2y10
Name: olfactory receptor family 2 subfamily Y member 10
Synonyms: Olfr1380, GA_x6K02T2QP88-5871967-5871032, MOR256-66_i
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404336
Homologene: 72463
Lcn11
Name: lipocalin 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227630
Homologene: 129702
Nipal4
Name: NIPA-like domain containing 4
Synonyms: 9530066K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214112
Homologene: 133769
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Meis2
Name: Meis homeobox 2
Synonyms: Mrg1, Meis2, Stra10, A430109D20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17536
HGNC: HGNC:7001
Homologene: 7846
Epha1
Name: Eph receptor A1
Synonyms: Eph, Esk, 5730453L17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13835
HGNC: HGNC:3385
Homologene: 3835
Or3a1d
Name: olfactory receptor family 3 subfamily A member 1D
Synonyms: Olfr411, MOR255-3, GA_x6K02T2P1NL-4481525-4480578
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258704
Homologene: 74999
Mrgpra9
Name: MAS-related GPR, member A9
Synonyms: EG668725, MrgA9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668725
Homologene: 79615
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Fez2
Name: fasciculation and elongation protein zeta 2
Synonyms: zygin 2, D17Ertd315e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225020
HGNC: HGNC:3660
Homologene: 3742
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13631
Homologene: 7299
Or12j3
Name: olfactory receptor family 12 subfamily J member 3
Synonyms: MOR252-2, Olfr530, GA_x6K02T2PBJ9-42523824-42522901
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258512
Homologene: 128384
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: HRR1, Rxrip14, Fxr, FXR, RIP14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Galnt17
Name: polypeptide N-acetylgalactosaminyltransferase 17
Synonyms: Galnt19, Wbscr17, Gcap8, E330012B09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212996
Homologene: 49707
Pate7
Name: prostate and testis expressed 7
Synonyms: Gm17727
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312986
Homologene: 129804
Spns3
Name: SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)
Synonyms: 9830002I17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77577
Homologene: 45648
Mrgprf
Name: MAS-related GPR, member F
Synonyms: MrgF
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 211577
Homologene: 17023
Crisp4
Name: cysteine-rich secretory protein 4
Synonyms: 9230112K08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78081
HGNC: HGNC:304
Homologene: 81683
Dmrtb1
Name: DMRT-like family B with proline-rich C-terminal, 1
Synonyms: Dmrt6, Prp13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56296
Homologene: 13207
Capza3
Name: capping actin protein of muscle Z-line subunit alpha 3
Synonyms: cp alpha3, Cappa3, Tex8, repro32, Gsg3, 510-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12344
Homologene: 7253
Kdf1
Name: keratinocyte differentiation factor 1
Synonyms: 1810019J16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69073
Homologene: 17563
Pcdha6
Name: protocadherin alpha 6
Synonyms: Crnr2, Cnr2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12937
Homologene: 75098
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 18,115,678 bp
  • A to C, chromosome 1 at 68,343,838 bp
  • G to T, chromosome 1 at 75,401,151 bp
  • C to A, chromosome 1 at 150,649,972 bp
  • G to T, chromosome 2 at 25,779,284 bp
  • T to C, chromosome 2 at 52,206,987 bp
  • T to C, chromosome 2 at 116,058,635 bp
  • A to T, chromosome 2 at 126,819,963 bp
  • T to C, chromosome 2 at 130,685,537 bp
  • T to C, chromosome 4 at 107,680,725 bp
  • T to C, chromosome 4 at 112,815,519 bp
  • A to G, chromosome 4 at 118,917,374 bp
  • G to A, chromosome 4 at 133,530,343 bp
  • T to C, chromosome 5 at 3,961,279 bp
  • A to C, chromosome 5 at 5,575,379 bp
  • C to A, chromosome 5 at 36,469,472 bp
  • C to T, chromosome 5 at 123,324,375 bp
  • T to C, chromosome 5 at 130,877,797 bp
  • A to T, chromosome 6 at 22,119,579 bp
  • G to C, chromosome 6 at 24,955,588 bp
  • T to C, chromosome 6 at 42,361,027 bp
  • G to T, chromosome 6 at 97,295,774 bp
  • A to G, chromosome 6 at 112,723,137 bp
  • A to C, chromosome 6 at 140,041,795 bp
  • G to A, chromosome 7 at 19,371,269 bp
  • T to A, chromosome 7 at 24,003,656 bp
  • C to A, chromosome 7 at 41,837,185 bp
  • A to G, chromosome 7 at 47,235,494 bp
  • T to C, chromosome 7 at 102,001,477 bp
  • A to G, chromosome 7 at 104,564,412 bp
  • G to A, chromosome 7 at 120,475,571 bp
  • C to T, chromosome 7 at 120,873,325 bp
  • A to T, chromosome 7 at 125,632,326 bp
  • G to A, chromosome 7 at 127,330,369 bp
  • A to G, chromosome 7 at 140,372,785 bp
  • A to G, chromosome 7 at 145,308,262 bp
  • G to A, chromosome 8 at 3,531,489 bp
  • A to C, chromosome 8 at 62,021,309 bp
  • T to C, chromosome 8 at 106,666,272 bp
  • A to G, chromosome 8 at 122,437,825 bp
  • T to C, chromosome 8 at 124,003,362 bp
  • T to A, chromosome 9 at 35,778,088 bp
  • A to T, chromosome 10 at 5,273,639 bp
  • A to G, chromosome 10 at 12,547,993 bp
  • A to C, chromosome 10 at 79,694,985 bp
  • A to G, chromosome 10 at 80,785,595 bp
  • A to G, chromosome 10 at 89,483,489 bp
  • A to T, chromosome 11 at 46,151,350 bp
  • G to A, chromosome 11 at 49,564,382 bp
  • T to G, chromosome 11 at 72,539,086 bp
  • T to C, chromosome 11 at 74,346,645 bp
  • A to G, chromosome 11 at 115,853,040 bp
  • T to C, chromosome 12 at 81,559,876 bp
  • T to C, chromosome 12 at 118,113,912 bp
  • C to T, chromosome 12 at 118,126,815 bp
  • T to C, chromosome 13 at 67,474,022 bp
  • C to A, chromosome 13 at 73,929,676 bp
  • T to A, chromosome 13 at 92,468,122 bp
  • T to C, chromosome 13 at 104,121,538 bp
  • C to T, chromosome 14 at 25,874,263 bp
  • T to A, chromosome 14 at 70,532,842 bp
  • A to C, chromosome 15 at 78,443,787 bp
  • C to A, chromosome 16 at 48,287,936 bp
  • C to A, chromosome 17 at 24,499,299 bp
  • T to C, chromosome 17 at 78,381,622 bp
  • G to T, chromosome 18 at 36,968,431 bp
  • A to T, chromosome 19 at 3,591,015 bp
  • T to C, chromosome 19 at 6,504,890 bp
  • T to A, chromosome 19 at 53,541,314 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8881 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068749-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.