Strain Name:
C57BL/6J-MtgxR8898Btlr/Mmmh
Stock Number:
068755-MU
Citation ID:
RRID:MMRRC_068755-MU
Other Names:
R8898 (G1)
Major Collection:

Strain Information

Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, 4432415E19Rik, GCKR, KHS
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Pde1c
Name: phosphodiesterase 1C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18575
HGNC: HGNC:8776
Homologene: 3682
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: Ltpr7, 2310022G15Rik, LTRPC7, 5033407O22Rik, TRP-PLIK, CHAK, CHAK1, 4833414K03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Spast
Name: spastin
Synonyms: Spg4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50850
VEGA: 17
Homologene: 8970
Chek2
Name: checkpoint kinase 2
Synonyms: CHK2, Rad53
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50883
Homologene: 38289
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2210012C09Rik, 1300004K21Rik, 2310058O11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67867
Homologene: 16944
Dmxl2
Name: Dmx-like 2
Synonyms: 6430411K14Rik, E130119P06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Ambn
Name: ameloblastin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11698
HGNC: HGNC:452
Homologene: 7625
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Tnfrsf17
Name: tumor necrosis factor receptor superfamily, member 17
Synonyms: Tnfrsf13, BCMA, Tnfrsf13a, BCM
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21935
Homologene: 920
Grhl1
Name: grainyhead like transcription factor 1
Synonyms: Tcfcp2l2, p70 MGR, LBP-32, p61 MGR
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 195733
VEGA: 12
Homologene: 32219
Htt
Name: huntingtin
Synonyms: Hdh, huntingtin, htt, HD, IT15, C430023I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Nop2
Name: NOP2 nucleolar protein
Synonyms: Nol1, 120kDa
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110109
HGNC: HGNC:7867
Homologene: 135865
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: 2900010L19Rik, mSorLA, LR11, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Klf5
Name: Kruppel-like transcription factor 5
Synonyms: IKLF, 4930520J07Rik, CKLF, Bteb2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12224
VEGA: 14
HGNC: HGNC:6349
Homologene: 37520
Pde12
Name: phosphodiesterase 12
Synonyms: E430028B21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211948
Homologene: 14272
Raver2
Name: ribonucleoprotein, PTB-binding 2
Synonyms: A430091O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242570
Homologene: 18829
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244049
Homologene: 69254
Cd209a
Name: CD209a antigen
Synonyms: DC-SIGN, CIRE, CD209, SIGNR5, Dcsign, DC-SIGN1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170786
Homologene: 129771
Jag1
Name: jagged 1
Synonyms: Gsfabe2, Headturner, ABE2, Ozz, Serrate-1, Htu
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Cyp7b1
Name: cytochrome P450, family 7, subfamily b, polypeptide 1
Synonyms: hct-1, D3Ertd552e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13123
HGNC: HGNC:2652
Homologene: 3544
Ndufs7
Name: NADH:ubiquinone oxidoreductase core subunit S7
Synonyms: 1010001M04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75406
HGNC: HGNC:7714
Homologene: 11535
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC382129, 9430076A06Rik, LOC234973
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69239
Homologene: 130756
Zfp790
Name: zinc finger protein 790
Synonyms: 6330581L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233056
Homologene: 51695
Ephb6
Name: Eph receptor B6
Synonyms: Cekl, Mep
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Syt11
Name: synaptotagmin XI
Synonyms: 6530420C11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229521
Homologene: 23120
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546983
Homologene: 115466
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: T2dm1, insulin level locus 1, A830015P08Rik, LLGL4, t2md1, tomosyn-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207227
Homologene: 18173
Gtf2ird2
Name: GTF2I repeat domain containing 2
Synonyms: 1700012P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114674
Homologene: 24941
Atg2a
Name: autophagy related 2A
Synonyms: 1810013C15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329015
Homologene: 86985
Sla2
Name: Src-like-adaptor 2
Synonyms: SLAP2, A930009E21Rik, SLAP-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77799
Homologene: 49989
Speg
Name: SPEG complex locus
Synonyms: SPEGalpha, SPEG, D1Bwg1450e, Apeg1, SPEGbeta, BPEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
Ankrd24
Name: ankyrin repeat domain 24
Synonyms: 4631433D01Rik, D10Bur2e, 5730519E19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70615
Homologene: 49885
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, 2610209L14Rik, Snf2l2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Acan
Name: aggrecan
Synonyms: Cspg1, Agc1, b2b183Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243085
Homologene: 128251
Nexn
Name: nexilin
Synonyms: 1110046H09Rik, nF actin binding protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68810
Homologene: 44892
Tex26
Name: testis expressed 26
Synonyms: 4930588N13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75860
Homologene: 51841
Prl3c1
Name: prolactin family 3, subfamily c, member 1
Synonyms: PLP-J, PLP I, Prlpj
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27372
Homologene: 49353
Rpl13a-ps1
Name: ribosomal protein 13A, pseudogene 1
Synonyms: Gm5520
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 433251
VEGA: 19
Or4n4
Name: olfactory receptor family 4 subfamily N member 4
Synonyms: MOR241-1, Olfr732, GA_x6K02T2PMLR-5975274-5974348
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258659
Homologene: 72012
Trem1
Name: triggering receptor expressed on myeloid cells 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58217
Homologene: 10243
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Septin14
Name: septin 14
Synonyms: Sept14, 1700016K13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74222
Homologene: 87501
Or4a15
Name: olfactory receptor family 4 subfamily A member 15
Synonyms: MOR231-2, GA_x6K02T2Q125-50805620-50804676, Olfr1234
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258975
Homologene: 128156
4930546C10Rik
Name: RIKEN cDNA 4930546C10 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78931
VEGA: 18
N4bp3
Name: NEDD4 binding protein 3
Synonyms: C330016O10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 212706
Homologene: 17124
Nanos2
Name: nanos C2HC-type zinc finger 2
Synonyms: nos2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 378430
Homologene: 35364
Arl4d
Name: ADP-ribosylation factor-like 4D
Synonyms: Arl5, Arfl4, Arf4l, 1110036H21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80981
HGNC: HGNC:656
Homologene: 1255
Foxd1
Name: forkhead box D1
Synonyms: BF-2, Hfh10, Hfhbf2, FREAC4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15229
HGNC: HGNC:3802
Homologene: 3290
Mill2
Name: MHC I like leukocyte 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243864
Homologene: 88329
Gja10
Name: gap junction protein, alpha 10
Synonyms: Cx-57, connexin-57, Cx59, Cx57
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14610
Homologene: 7733
Mbd3l2
Name: methyl-CpG binding domain protein 3-like 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234988
VEGA: 9
Homologene: 44896
Gm17019
Name: predicted gene 17019
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66773
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 75,388,873 bp
  • T to C, chromosome 2 at 12,140,395 bp
  • A to G, chromosome 2 at 89,362,613 bp
  • A to T, chromosome 2 at 126,822,741 bp
  • A to T, chromosome 2 at 137,093,255 bp
  • A to G, chromosome 2 at 142,712,979 bp
  • T to G, chromosome 2 at 156,493,949 bp
  • T to A, chromosome 2 at 156,875,965 bp
  • C to T, chromosome 3 at 18,096,624 bp
  • T to C, chromosome 3 at 87,988,388 bp
  • T to C, chromosome 3 at 88,762,028 bp
  • T to C, chromosome 3 at 152,242,669 bp
  • T to C, chromosome 4 at 32,601,058 bp
  • G to A, chromosome 4 at 101,107,202 bp
  • A to C, chromosome 5 at 15,031,784 bp
  • C to T, chromosome 5 at 34,819,032 bp
  • T to A, chromosome 5 at 87,011,330 bp
  • T to C, chromosome 5 at 88,465,192 bp
  • A to T, chromosome 5 at 110,863,309 bp
  • A to T, chromosome 5 at 129,683,578 bp
  • A to T, chromosome 5 at 134,197,265 bp
  • C to A, chromosome 5 at 149,456,904 bp
  • T to A, chromosome 5 at 150,569,033 bp
  • C to T, chromosome 6 at 41,613,359 bp
  • A to T, chromosome 6 at 56,137,386 bp
  • A to T, chromosome 6 at 82,738,398 bp
  • C to A, chromosome 6 at 125,137,155 bp
  • A to T, chromosome 7 at 18,856,564 bp
  • A to T, chromosome 7 at 18,987,624 bp
  • C to T, chromosome 7 at 29,823,100 bp
  • C to A, chromosome 7 at 67,628,294 bp
  • T to C, chromosome 7 at 72,103,156 bp
  • C to A, chromosome 7 at 79,100,353 bp
  • T to A, chromosome 7 at 86,795,222 bp
  • T to A, chromosome 8 at 3,748,739 bp
  • G to A, chromosome 9 at 15,947,526 bp
  • A to T, chromosome 9 at 18,444,618 bp
  • A to G, chromosome 9 at 42,000,271 bp
  • A to G, chromosome 9 at 54,401,657 bp
  • C to T, chromosome 9 at 79,692,295 bp
  • A to G, chromosome 10 at 45,700,670 bp
  • T to A, chromosome 10 at 80,253,785 bp
  • T to C, chromosome 10 at 81,642,518 bp
  • T to C, chromosome 11 at 51,644,429 bp
  • T to G, chromosome 11 at 71,182,462 bp
  • C to A, chromosome 11 at 97,351,503 bp
  • C to T, chromosome 11 at 101,667,001 bp
  • G to A, chromosome 12 at 24,584,946 bp
  • T to C, chromosome 12 at 69,813,157 bp
  • A to T, chromosome 13 at 27,203,595 bp
  • T to A, chromosome 13 at 98,355,088 bp
  • G to A, chromosome 14 at 26,669,422 bp
  • A to T, chromosome 14 at 32,661,044 bp
  • G to A, chromosome 14 at 50,281,495 bp
  • T to A, chromosome 14 at 99,301,486 bp
  • T to C, chromosome 16 at 11,314,046 bp
  • ATTTT to ATTTTT, chromosome 16 at 37,216,052 bp
  • T to A, chromosome 17 at 48,237,346 bp
  • A to T, chromosome 17 at 58,974,339 bp
  • A to T, chromosome 17 at 67,821,615 bp
  • G to A, chromosome 17 at 74,388,278 bp
  • C to A, chromosome 18 at 13,846,080 bp
  • A to G, chromosome 18 at 68,950,035 bp
  • A to G, chromosome 19 at 6,256,691 bp
  • TGCAGCAGCAGCAGCAGCA to TGCAGCAGCAGCAGCA, chromosome 19 at 26,630,958 bp
  • T to A, chromosome 19 at 50,030,308 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8898 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068755-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.