Strain Name:
C57BL/6J-MtgxR8901Btlr/Mmmh
Stock Number:
068758-MU
Citation ID:
RRID:MMRRC_068758-MU
Other Names:
R8901 (G1)
Major Collection:

Strain Information

Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra-5, Acra5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Sntb2
Name: syntrophin, basic 2
Synonyms: Snt2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20650
Homologene: 4911
Gtf2i
Name: general transcription factor II I
Synonyms: TFII-I, BAP-135, 6030441I21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
Wdr43
Name: WD repeat domain 43
Synonyms: 2610318G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72515
VEGA: 17
Homologene: 38810
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Ehd4
Name: EH-domain containing 4
Synonyms: 2210022F10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98878
HGNC: HGNC:3245
Homologene: 26430
Ankrd27
Name: ankyrin repeat domain 27
Synonyms: D330003H11Rik, Varp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245886
Homologene: 12956
Brat1
Name: BRCA1-associated ATM activator 1
Synonyms: Baat1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231841
Homologene: 16776
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, RPA116, 128kDa, D630020H17Rik, Rpo1-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Mettl13
Name: methyltransferase 13, eEF1A lysine and N-terminal methyltransferase
Synonyms: 5630401D24Rik, Eef1aknmt
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71449
Homologene: 32285
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Ybx1
Name: Y box protein 1
Synonyms: MSY1, DNA binding protein B, Nsep1, dbpB, EF1A, YB-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22608
HGNC: HGNC:8014
Homologene: 88707
Jph3
Name: junctophilin 3
Synonyms: JP-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57340
Homologene: 10762
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: 1110031M08Rik, Hnrpul2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225348
VEGA: 18
Homologene: 6536
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Rap1gds1
Name: RAP1, GTP-GDP dissociation stimulator 1
Synonyms: GDS1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229877
HGNC: HGNC:9859
Homologene: 41422
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, ZFYVE2, A430109M19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229474
Homologene: 18920
Gnao1
Name: guanine nucleotide binding protein, alpha O
Synonyms: Go alpha, alphaO, Galphao
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14681
HGNC: HGNC:4389
Homologene: 39203
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Mdnah5, b2b1537Clo, b2b1565Clo, b2b1154Clo, b2b1134Clo, Dnahc5, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Setd1b
Name: SET domain containing 1B
Synonyms: KMT2G
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208043
Homologene: 134654
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Daw1
Name: dynein assembly factor with WDR repeat domains 1
Synonyms: 4933429D11Rik, 4930563E19Rik, Wdr69, b2b1116Clo, b2b1584Clo
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71227
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
Synonyms: Lhr, Gpcr19-rs1, LH-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16867
VEGA: 17
HGNC: HGNC:6585
Homologene: 37276
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, M-type receptor, Pla2g1br
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: B830017A01Rik, 3110047P20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319807
Homologene: 14974
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54380
Homologene: 8558
Ces1e
Name: carboxylesterase 1E
Synonyms: Eg, Es-22, egasyn, Es22
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13897
HGNC: HGNC:1863
Homologene: 115660
Adprm
Name: ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
Synonyms: 2310004I24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66358
Homologene: 10632
Ppfia3
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Synonyms: 2410127E16Rik, Liprin-alpha3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76787
HGNC: HGNC:9247
Homologene: 37833
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, FXI, Cf11, 1600027G01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Itga2b
Name: integrin alpha 2b
Synonyms: platelet glycoprotein IIb, GpIIb, alphaIIb, CD41, GP IIb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16399
HGNC: HGNC:6138
Homologene: 37304
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: F830032C23Rik, Nlrc2, Card15
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Khnyn
Name: KH and NYN domain containing
Synonyms: 9130227C08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219094
VEGA: 14
Homologene: 23611
Txk
Name: TXK tyrosine kinase
Synonyms: Rlk, Btkl, PTK4, A130089B16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22165
Homologene: 2497
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231093
Homologene: 11053
Btbd6
Name: BTB domain containing 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399566
VEGA: 12
Homologene: 41967
Tmem115
Name: transmembrane protein 115
Synonyms: Pl6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56395
Homologene: 135207
Or2y1c
Name: olfactory receptor family 2 subfamily Y member 1C
Synonyms: GA_x6K02T2QP88-5964781-5963852, MOR256-50, Olfr1386
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257888
Homologene: 86692
Slc25a42
Name: solute carrier family 25, member 42
Synonyms: 2900084M01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73095
Homologene: 74852
Ttll8
Name: tubulin tyrosine ligase-like family, member 8
Synonyms: 1700019P01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239591
Homologene: 52766
Lix1l
Name: Lix1-like
Synonyms: D130027M04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 280411
Homologene: 16014
Syt15
Name: synaptotagmin XV
Synonyms: CHR10SYT, sytXV, E230025K04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319508
Homologene: 12901
H2-T3
Name: histocompatibility 2, T region locus 3
Synonyms: H-2T3, TL, H2-Tw3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15043
Homologene: 74884
Ajuba
Name: ajuba LIM protein
Synonyms: Jub
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16475
VEGA: 14
Homologene: 7789
Tas2r114
Name: taste receptor, type 2, member 114
Synonyms: Tas2r14, T2R14, mGR14, mt2r46
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387346
Homologene: 128355
Speer4a3
Name: spermatogenesis associated glutamate (E)-rich protein 4A3
Synonyms: Gm21671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862359
Homologene: 69402
Gm21411
Name: predicted gene, 21411
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 115489953
VEGA: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 72,585,780 bp
  • A to C, chromosome 1 at 83,205,922 bp
  • C to T, chromosome 1 at 162,546,245 bp
  • C to T, chromosome 1 at 189,662,051 bp
  • C to A, chromosome 2 at 60,502,056 bp
  • C to T, chromosome 2 at 65,521,908 bp
  • A to T, chromosome 2 at 120,102,324 bp
  • T to A, chromosome 2 at 129,125,675 bp
  • T to A, chromosome 3 at 84,445,567 bp
  • C to A, chromosome 3 at 96,601,429 bp
  • T to C, chromosome 3 at 138,957,544 bp
  • T to C, chromosome 4 at 119,281,588 bp
  • T to C, chromosome 4 at 121,146,813 bp
  • A to T, chromosome 4 at 143,617,107 bp
  • G to A, chromosome 4 at 146,897,714 bp
  • CTTT to C, chromosome 5 at 25,950,859 bp
  • T to C, chromosome 5 at 30,891,091 bp
  • T to C, chromosome 5 at 63,806,342 bp
  • T to A, chromosome 5 at 72,700,707 bp
  • T to C, chromosome 5 at 123,161,051 bp
  • A to G, chromosome 5 at 134,295,535 bp
  • T to A, chromosome 5 at 140,712,853 bp
  • T to A, chromosome 6 at 131,689,951 bp
  • G to A, chromosome 7 at 35,632,818 bp
  • T to A, chromosome 7 at 45,341,717 bp
  • T to C, chromosome 8 at 45,248,814 bp
  • A to G, chromosome 8 at 70,194,149 bp
  • C to T, chromosome 8 at 88,663,809 bp
  • C to T, chromosome 8 at 93,210,475 bp
  • T to C, chromosome 8 at 93,968,059 bp
  • T to C, chromosome 8 at 107,011,343 bp
  • A to T, chromosome 8 at 121,730,822 bp
  • T to C, chromosome 9 at 55,004,453 bp
  • A to G, chromosome 9 at 107,534,794 bp
  • T to G, chromosome 10 at 95,989,569 bp
  • A to T, chromosome 11 at 49,470,208 bp
  • T to C, chromosome 11 at 67,041,738 bp
  • A to T, chromosome 11 at 102,460,804 bp
  • A to T, chromosome 12 at 104,780,952 bp
  • G to T, chromosome 12 at 112,976,600 bp
  • G to A, chromosome 13 at 38,181,179 bp
  • G to T, chromosome 14 at 34,226,071 bp
  • T to C, chromosome 14 at 54,570,373 bp
  • T to C, chromosome 14 at 55,886,586 bp
  • T to G, chromosome 15 at 28,365,569 bp
  • T to A, chromosome 15 at 66,685,335 bp
  • C to T, chromosome 15 at 88,933,943 bp
  • A to T, chromosome 16 at 56,252,165 bp
  • A to T, chromosome 17 at 34,043,280 bp
  • A to T, chromosome 17 at 36,187,360 bp
  • T to A, chromosome 17 at 58,330,161 bp
  • A to T, chromosome 17 at 71,625,466 bp
  • A to T, chromosome 17 at 88,755,602 bp
  • C to A, chromosome 18 at 32,846,960 bp
  • T to G, chromosome 19 at 8,824,445 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8901 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068758-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.