Strain Name:
C57BL/6J-MtgxR8941Btlr/Mmmh
Stock Number:
068781-MU
Citation ID:
RRID:MMRRC_068781-MU
Other Names:
R8941 (G1)
Major Collection:

Strain Information

Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, Tkrb, C030027L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Chat
Name: choline acetyltransferase
Synonyms: B230380D24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12647
VEGA: 14
HGNC: HGNC:1912
Homologene: 40693
Adora2a
Name: adenosine A2a receptor
Synonyms: A2AAR, ARA2A, AA2AR, A2a, Rs, A2aR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Trdmt1
Name: tRNA aspartic acid methyltransferase 1
Synonyms: Dnmt2, Rnmt2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13434
HGNC: HGNC:2977
Homologene: 3249
Mdm4
Name: transformed mouse 3T3 cell double minute 4
Synonyms: 4933417N07Rik, Mdmx
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17248
HGNC: HGNC:6974
Homologene: 1794
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: 5830450F21Rik, Myst1, 2010203C02Rik, D7Ertd629e, MOF
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67773
Homologene: 41676
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100763
Homologene: 8783
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Afg2a
Name: AFG2 AAA ATPase homolog A
Synonyms: C78064, Spaf, 2510048F20Rik, Spata5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57815
Homologene: 56920
Cog8
Name: component of oligomeric golgi complex 8
Synonyms: C87832
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97484
Homologene: 13018
Rpl4
Name: ribosomal protein L4
Synonyms: 2010004J23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67891
VEGA: 9
Homologene: 748
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, Tce4, 5830477H08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Il15ra
Name: interleukin 15 receptor, alpha chain
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16169
HGNC: HGNC:5978
Homologene: 1650
Rsbn1l
Name: round spermatid basic protein 1-like
Synonyms: C330002G24Rik, 8430412F05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242860
Homologene: 19435
Tle3
Name: transducin-like enhancer of split 3
Synonyms: Grg3b, ESG, Grg3a, 2610103N05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21887
Homologene: 21059
Canx
Name: calnexin
Synonyms: 1110069N15Rik, CNX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: KCC1, K-Cl Co-transporter-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20498
Homologene: 21056
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: Pax3/7bp, 1810007M14Rik, Gcfc1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67367
Homologene: 9604
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69710
Homologene: 12326
Sass6
Name: SAS-6 centriolar assembly protein
Synonyms: 2810453L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72776
Homologene: 45668
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: Nor1, MINOR, NOR-1, TEC
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Tas1r3
Name: taste receptor, type 1, member 3
Synonyms: T1r3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83771
Homologene: 12890
Ramp1
Name: receptor (calcitonin) activity modifying protein 1
Synonyms: 9130218E19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 51801
HGNC: HGNC:9843
Homologene: 4275
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15257
Homologene: 56483
Snrk
Name: SNF related kinase
Synonyms: SNRK, 2010012F07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20623
Homologene: 9797
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Dbt
Name: dihydrolipoamide branched chain transacylase E2
Synonyms: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, D3Wsu60e, BCKAD E2, dihydrolipoyl transacylase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13171
HGNC: HGNC:2698
Homologene: 1444
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Tsbp1
Name: testis expressed basic protein 1
Synonyms: BC051142
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407788
Homologene: 128168
Ptprn
Name: protein tyrosine phosphatase receptor type N
Synonyms: IA-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19275
HGNC: HGNC:9676
Homologene: 48142
Pou6f1
Name: POU domain, class 6, transcription factor 1
Synonyms: 2310038G18Rik, cns-1, Emb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19009
HGNC: HGNC:9224
Homologene: 7703
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78911
Homologene: 12712
Cox15
Name: cytochrome c oxidase assembly protein 15
Synonyms: 2900026G05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226139
HGNC: HGNC:2263
Homologene: 5848
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: Lorsdh, LOR/SDH
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30956
Homologene: 4212
Sdcbp
Name: syndecan binding protein
Synonyms: syntenin-1, MDA-9, syndecan interacting protein, syntenin, Sycl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53378
Homologene: 4110
Hmgcl
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15356
HGNC: HGNC:5005
Homologene: 159
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Lrrc39
Name: leucine rich repeat containing 39
Synonyms: 2010005E21Rik, 9430028I06Rik, Myomasp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109245
Homologene: 13668
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms: A230054F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 212627
HGNC: HGNC:9467
Homologene: 2073
Tuba4a
Name: tubulin, alpha 4A
Synonyms: Tuba4, M[a]4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22145
Homologene: 68496
Asic5
Name: acid-sensing ion channel family member 5
Synonyms: Accn5, BLINaC, brain-liver-intestine amiloride-sensitive sodium channel
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58170
Homologene: 41171
Sephs2
Name: selenophosphate synthetase 2
Synonyms: Sps2, Ysg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20768
Homologene: 7550
Gm6309
Name: predicted gene 6309
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622306
Homologene: 86127
Rapgefl1
Name: Rap guanine nucleotide exchange factor (GEF)-like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268480
Homologene: 41126
Dio1
Name: deiodinase, iodothyronine, type I
Synonyms: D1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13370
HGNC: HGNC:2883
Homologene: 620
Or5b95
Name: olfactory receptor family 5 subfamily B member 95
Synonyms: Olfr1443, GA_x6K02T2RE5P-3006492-3007430, MOR202-8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258693
HGNC: HGNC:8324
Homologene: 115496
Aadacl2fm3
Name: AADACL2 family member 3
Synonyms: Gm8298
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 666803
Homologene: 86204
2010315B03Rik
Name: RIKEN cDNA 2010315B03 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 630836
Homologene: 136499
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Or10n7-ps1
Name: olfactory receptor family 10 subfamily N member 7, pseudogene 1
Synonyms: GA_x6K02T2PVTD-33383715-33382802, Olfr964-ps1, MOR224-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258855
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 25,094,154 bp
  • T to C, chromosome 1 at 75,217,301 bp
  • A to T, chromosome 1 at 75,251,763 bp
  • C to G, chromosome 1 at 91,206,415 bp
  • T to C, chromosome 1 at 132,991,933 bp
  • C to A, chromosome 1 at 164,198,871 bp
  • A to T, chromosome 2 at 11,733,184 bp
  • A to G, chromosome 2 at 13,522,107 bp
  • T to A, chromosome 3 at 37,431,993 bp
  • A to G, chromosome 3 at 59,876,979 bp
  • A to T, chromosome 3 at 82,006,608 bp
  • A to G, chromosome 3 at 103,753,427 bp
  • T to C, chromosome 3 at 116,546,049 bp
  • G to T, chromosome 3 at 116,565,847 bp
  • T to C, chromosome 3 at 116,614,060 bp
  • T to C, chromosome 3 at 158,163,956 bp
  • T to C, chromosome 4 at 6,393,661 bp
  • C to A, chromosome 4 at 48,051,756 bp
  • C to A, chromosome 4 at 107,306,950 bp
  • A to T, chromosome 4 at 118,569,602 bp
  • G to A, chromosome 4 at 135,955,704 bp
  • G to A, chromosome 4 at 152,378,848 bp
  • C to T, chromosome 4 at 155,863,143 bp
  • A to G, chromosome 5 at 20,905,843 bp
  • G to A, chromosome 5 at 29,637,771 bp
  • G to A, chromosome 5 at 112,874,929 bp
  • A to G, chromosome 5 at 146,170,345 bp
  • A to T, chromosome 6 at 23,075,262 bp
  • A to G, chromosome 7 at 3,822,381 bp
  • G to A, chromosome 7 at 101,408,117 bp
  • A to G, chromosome 7 at 120,776,088 bp
  • A to G, chromosome 7 at 127,273,034 bp
  • T to C, chromosome 7 at 127,925,228 bp
  • C to T, chromosome 8 at 105,946,690 bp
  • T to C, chromosome 8 at 107,056,570 bp
  • A to T, chromosome 9 at 39,686,516 bp
  • T to A, chromosome 9 at 61,412,913 bp
  • A to G, chromosome 9 at 64,174,963 bp
  • T to C, chromosome 9 at 97,363,047 bp
  • G to A, chromosome 9 at 122,160,531 bp
  • T to A, chromosome 9 at 124,294,049 bp
  • G to A, chromosome 10 at 75,333,725 bp
  • T to C, chromosome 11 at 50,304,443 bp
  • C to A, chromosome 11 at 61,737,044 bp
  • A to G, chromosome 11 at 98,840,275 bp
  • C to A, chromosome 11 at 119,414,424 bp
  • A to G, chromosome 13 at 59,060,295 bp
  • A to G, chromosome 13 at 67,593,099 bp
  • C to T, chromosome 14 at 32,409,006 bp
  • T to A, chromosome 14 at 33,956,529 bp
  • A to G, chromosome 14 at 61,192,573 bp
  • A to T, chromosome 15 at 4,962,124 bp
  • T to A, chromosome 15 at 100,591,861 bp
  • G to T, chromosome 16 at 17,296,943 bp
  • T to C, chromosome 16 at 91,035,927 bp
  • C to T, chromosome 17 at 24,983,140 bp
  • A to C, chromosome 17 at 34,459,999 bp
  • T to C, chromosome 17 at 71,752,142 bp
  • G to A, chromosome 19 at 12,680,107 bp
  • A to G, chromosome 19 at 43,743,733 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8941 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068781-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.