Strain Name:
C57BL/6J-MtgxR8957Btlr/Mmmh
Stock Number:
068793-MU
Citation ID:
RRID:MMRRC_068793-MU
Other Names:
R8957 (G1)
Major Collection:

Strain Information

Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Tesk2
Name: testis-specific kinase 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230661
Homologene: 5188
Aco2
Name: aconitase 2, mitochondrial
Synonyms: Aco3, Aco-2, D10Wsu183e, Irp1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11429
HGNC: HGNC:118
Homologene: 856
Pou5f1
Name: POU domain, class 5, transcription factor 1
Synonyms: Oct4, Oct3/4, Oct-3/4, Otf4, Otf3, Oct-3, Otf3g, Otf3-rs7, Otf-4, Otf-3, Oct-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18999
Homologene: 8422
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Af4, Rob, 9630032B01Rik, Mllt2h
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106585
Homologene: 9059
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Sec62
Name: SEC62 homolog, preprotein translocation
Synonyms: HTP1, Dtrp1, SEC62, 3100002M17Rik, Tloc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69276
Homologene: 2449
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Atf7ip
Name: activating transcription factor 7 interacting protein
Synonyms: ATFa-associated Modulator, AM, 2610204M12Rik, Mcaf1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54343
Homologene: 10051
Ankle2
Name: ankyrin repeat and LEM domain containing 2
Synonyms: 1110001J12Rik, D5Ertd585e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71782
Homologene: 35424
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Fnta
Name: farnesyltransferase, CAAX box, alpha
Synonyms: FTA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14272
HGNC: HGNC:3782
Homologene: 1534
Rbm34
Name: RNA binding motif protein 34
Synonyms: 4930547K05Rik, D8Ertd233e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52202
Homologene: 56691
Dis3
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Synonyms: 2810028N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72662
VEGA: 14
Homologene: 6910
Cux2
Name: cut-like homeobox 2
Synonyms: Cux-2, Cux2, ENSMUSG00000072641, Cutl2, 1700051K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Tmub1
Name: transmembrane and ubiquitin-like domain containing 1
Synonyms: Hops, 2010004O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64295
Homologene: 11187
Pgam1
Name: phosphoglycerate mutase 1
Synonyms: Pgam-1, 2310050F24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18648
VEGA: 19
Homologene: 37647
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Firrm
Name: FIGNL1 interacting regulator of recombination and mitosis
Synonyms: BC055324, Flip
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381306
Homologene: 10058
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434179
Homologene: 134004
Apeh
Name: acylpeptide hydrolase
Synonyms: N-acylaminoacyl peptide hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235606
HGNC: HGNC:586
Homologene: 1240
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Lrrc74b
Name: leucine rich repeat containing 74B
Synonyms: 4930451C15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74685
Homologene: 25894
Pcdhb11
Name: protocadherin beta 11
Synonyms: Pcdhb5E, PcdhbK
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93882
HGNC: HGNC:8690
Homologene: 62178
Klra1
Name: killer cell lectin-like receptor, subfamily A, member 1
Synonyms: Ly49A, Ly49o129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16627
Homologene: 110821
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: organic anion-transporting polypeptide, Oatp-5, 4930422F19Rik, Slc21a13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Des
Name: desmin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13346
HGNC: HGNC:2770
Homologene: 56469
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22307
Homologene: 129606
Jmjd4
Name: jumonji domain containing 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 194952
Homologene: 11306
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75172
Homologene: 67159
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242584
Homologene: 11702
Col4a1
Name: collagen, type IV, alpha 1
Synonyms: Col4a-1, Del(8)Bru44H, Del(8)44H, Bru, Svc, Raw, alpha1(IV) collagen
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12826
HGNC: HGNC:2202
Homologene: 20437
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Or5b101
Name: olfactory receptor family 5 subfamily B member 101
Synonyms: GA_x6K02T2RE5P-3357666-3356743, MOR202-6, Olfr1453
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258695
HGNC: HGNC:8324
Homologene: 120159
Cyld
Name: CYLD lysine 63 deubiquitinase
Synonyms: CYLD1, 2010013M14Rik, C130039D01Rik, 2900009M21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74256
HGNC: HGNC:2584
Homologene: 9069
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Cav1
Name: caveolin 1, caveolae protein
Synonyms: Cav-1, caveolin-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12389
HGNC: HGNC:1527
Homologene: 1330
Map9
Name: microtubule-associated protein 9
Synonyms: 5033421J10Rik, 5330427D05Rik, ASAP, Mtap9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213582
Homologene: 41591
Tmem106c
Name: transmembrane protein 106C
Synonyms: D15Ertd405e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380967
VEGA: 15
Homologene: 11440
Fpgs
Name: folylpolyglutamyl synthetase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14287
HGNC: HGNC:3824
Homologene: 6997
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Ccrl2
Name: C-C motif chemokine receptor-like 2
Synonyms: 1810047I05Rik, L-CCR, Cmkbr1l2, CCR11, Ackr5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54199
HGNC: HGNC:1612
Homologene: 2948
Cd1d1
Name: CD1d1 antigen
Synonyms: CD1.1, Cd1a, Cd1d, Ly-38
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12479
HGNC: HGNC:1637
Homologene: 1337
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: LOC381544, LOC381543, Ncrna00082, Gm1661
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Mmp28
Name: matrix metallopeptidase 28 (epilysin)
Synonyms: epilysin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 118453
Homologene: 41559
Or1a1
Name: olfactory receptor family 1 subfamily A member 1
Synonyms: GA_x6K02T2P1NL-4348188-4349129, MOR125-5_p, IA7, Olfr403
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404316
Homologene: 8219
Isyna1
Name: myo-inositol 1-phosphate synthase A1
Synonyms: 1300017C10Rik, inositol-3-phosphate synthase 1, myo-inositol 1-phosphate synthase A1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71780
Homologene: 6222
Tnip3
Name: TNFAIP3 interacting protein 3
Synonyms: 9030611K07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 414084
Homologene: 47979
Myct1
Name: myc target 1
Synonyms: Mtmc1, MT-MC1, 1110020B04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68632
VEGA: 10
Homologene: 11833
Cyp4v3
Name: cytochrome P450, family 4, subfamily v, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102294
Homologene: 133054
Snai2
Name: snail family zinc finger 2
Synonyms: Slugh, Slug, Snail2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20583
VEGA: 16
Homologene: 31127
Or12d13
Name: olfactory receptor family 12 subfamily D member 13
Synonyms: MOR250-3, GA_x6K02T2PSCP-1798423-1797482, MOR250-8_p, Olfr103
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258830
Homologene: 115555
Pate2
Name: prostate and testis expressed 2
Synonyms: LOC330921, mANLP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330921
Homologene: 86016
Ehd1
Name: EH-domain containing 1
Synonyms: Past1, RME-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13660
HGNC: HGNC:3242
Homologene: 81678
Klrb1b
Name: killer cell lectin-like receptor subfamily B member 1B
Synonyms: Nkrp1-b, NKR-P1D, Ly55d, Ly55b, Nkrp1d, NKR-P1B, Klrb1d
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 80782
HGNC: HGNC:6373
Homologene: 84369
Smok2b
Name: sperm motility kinase 2B
Synonyms: LOC236574
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 236574
Homologene: 128738
Fcrlb
Name: Fc receptor-like B
Synonyms: FREB-2, FREB2, FcRL2, Fcry, mFCRL2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435653
Homologene: 83202
Hdhd5
Name: haloacid dehalogenase like hydrolase domain containing 5
Synonyms: A930002G03Rik, Cecr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214932
HGNC: HGNC:1843
Homologene: 32816
Krtap19-3
Name: keratin associated protein 19-3
Synonyms: A030006N06Rik, Krtap16-5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77918
VEGA: 16
1500011B03Rik
Name: RIKEN cDNA 1500011B03 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66236
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 71,321,625 bp
  • A to T, chromosome 1 at 75,363,651 bp
  • T to C, chromosome 1 at 91,946,035 bp
  • C to T, chromosome 1 at 163,964,766 bp
  • G to A, chromosome 1 at 170,907,967 bp
  • T to C, chromosome 2 at 32,685,342 bp
  • A to G, chromosome 2 at 37,399,648 bp
  • T to A, chromosome 3 at 30,810,522 bp
  • A to G, chromosome 3 at 82,371,380 bp
  • G to A, chromosome 3 at 83,282,266 bp
  • T to C, chromosome 3 at 86,998,833 bp
  • A to T, chromosome 4 at 81,332,979 bp
  • T to C, chromosome 4 at 103,096,753 bp
  • T to A, chromosome 4 at 116,802,713 bp
  • T to C, chromosome 4 at 117,229,907 bp
  • G to A, chromosome 4 at 155,436,730 bp
  • A to G, chromosome 5 at 21,309,587 bp
  • G to T, chromosome 5 at 24,446,777 bp
  • A to G, chromosome 5 at 103,833,768 bp
  • T to G, chromosome 5 at 109,001,914 bp
  • G to A, chromosome 5 at 110,231,255 bp
  • A to G, chromosome 5 at 114,813,830 bp
  • C to T, chromosome 5 at 121,860,948 bp
  • T to A, chromosome 6 at 17,339,236 bp
  • A to G, chromosome 6 at 65,605,859 bp
  • C to T, chromosome 6 at 120,518,443 bp
  • T to A, chromosome 6 at 128,818,559 bp
  • A to G, chromosome 6 at 130,380,646 bp
  • A to G, chromosome 6 at 136,566,703 bp
  • T to C, chromosome 6 at 142,145,767 bp
  • A to T, chromosome 7 at 42,661,733 bp
  • T to G, chromosome 7 at 49,571,216 bp
  • T to A, chromosome 8 at 11,245,906 bp
  • T to C, chromosome 8 at 25,999,513 bp
  • A to T, chromosome 8 at 45,306,981 bp
  • T to G, chromosome 8 at 70,596,722 bp
  • G to T, chromosome 8 at 88,705,782 bp
  • A to C, chromosome 8 at 126,965,458 bp
  • T to C, chromosome 9 at 35,685,615 bp
  • A to T, chromosome 9 at 108,092,373 bp
  • T to C, chromosome 9 at 111,055,489 bp
  • C to T, chromosome 10 at 5,604,208 bp
  • C to A, chromosome 10 at 50,700,112 bp
  • A to G, chromosome 10 at 82,289,074 bp
  • C to T, chromosome 11 at 59,450,058 bp
  • A to G, chromosome 11 at 67,250,954 bp
  • T to A, chromosome 11 at 74,195,946 bp
  • T to C, chromosome 11 at 83,443,810 bp
  • A to G, chromosome 11 at 120,886,035 bp
  • G to A, chromosome 13 at 95,635,646 bp
  • T to C, chromosome 14 at 99,099,591 bp
  • A to T, chromosome 15 at 81,889,500 bp
  • A to T, chromosome 15 at 97,969,600 bp
  • T to C, chromosome 16 at 14,708,249 bp
  • T to C, chromosome 16 at 17,561,112 bp
  • T to C, chromosome 16 at 88,877,945 bp
  • T to A, chromosome 17 at 13,234,986 bp
  • T to G, chromosome 17 at 35,510,469 bp
  • A to G, chromosome 17 at 37,336,491 bp
  • T to C, chromosome 17 at 65,984,496 bp
  • A to C, chromosome 18 at 37,421,639 bp
  • A to G, chromosome 18 at 37,422,819 bp
  • A to G, chromosome 19 at 6,294,409 bp
  • T to A, chromosome 19 at 13,027,517 bp
  • T to A, chromosome 19 at 41,916,776 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8957 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068793-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.