Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR9011Btlr/Mmmh
Stock Number:
068841-MU
Citation ID:
RRID:MMRRC_068841-MU
Other Names:
R9011 (G1)
Major Collection:

Strain Information

Rc3h1
Name: RING CCCH (C3H) domains 1
Synonyms: roquin, 5730557L09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381305
Homologene: 19036
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Lefty1
Name: left right determination factor 1
Synonyms: lefty-1, Stra3, Lefty, Ebaf
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13590
HGNC: HGNC:6552
Homologene: 49231
Mrpl14
Name: mitochondrial ribosomal protein L14
Synonyms: MRP-L32, Rpml32, 1110006I11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68463
Homologene: 12268
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: B130005I07Rik, D9Ertd809e, Dopey1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Eif3l
Name: eukaryotic translation initiation factor 3, subunit L
Synonyms: PAF67, 0610011H21Rik, HSP-66Y, Eif3s6ip, Eif3eip, D15N1e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223691
VEGA: 15
Homologene: 9380
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 36,402,520 bp
  • A to G, chromosome 1 at 37,115,686 bp
  • A to T, chromosome 1 at 90,782,335 bp
  • A to G, chromosome 1 at 106,995,789 bp
  • G to A, chromosome 1 at 125,562,313 bp
  • G to A, chromosome 1 at 131,977,976 bp
  • A to C, chromosome 1 at 160,965,103 bp
  • G to C, chromosome 1 at 179,702,419 bp
  • A to T, chromosome 1 at 180,937,676 bp
  • A to T, chromosome 1 at 188,906,479 bp
  • G to A, chromosome 1 at 189,896,636 bp
  • A to C, chromosome 1 at 191,163,061 bp
  • A to G, chromosome 2 at 65,521,826 bp
  • T to C, chromosome 2 at 76,710,162 bp
  • T to A, chromosome 2 at 174,426,924 bp
  • G to A, chromosome 3 at 31,224,196 bp
  • A to T, chromosome 3 at 106,149,715 bp
  • T to C, chromosome 3 at 108,207,440 bp
  • A to T, chromosome 3 at 154,856,549 bp
  • G to A, chromosome 4 at 130,022,318 bp
  • T to C, chromosome 4 at 130,052,859 bp
  • T to C, chromosome 4 at 141,433,033 bp
  • T to G, chromosome 5 at 43,979,285 bp
  • A to G, chromosome 5 at 107,725,559 bp
  • C to G, chromosome 5 at 128,602,305 bp
  • T to A, chromosome 5 at 139,354,559 bp
  • T to A, chromosome 6 at 8,373,931 bp
  • G to A, chromosome 7 at 6,316,628 bp
  • A to T, chromosome 7 at 38,106,660 bp
  • A to G, chromosome 7 at 45,145,527 bp
  • A to G, chromosome 7 at 132,270,517 bp
  • T to A, chromosome 8 at 35,825,672 bp
  • T to C, chromosome 8 at 105,375,652 bp
  • T to C, chromosome 9 at 62,755,627 bp
  • A to T, chromosome 9 at 86,515,343 bp
  • A to G, chromosome 9 at 94,936,440 bp
  • A to C, chromosome 9 at 119,630,094 bp
  • A to T, chromosome 10 at 123,026,308 bp
  • A to G, chromosome 11 at 59,799,407 bp
  • A to T, chromosome 11 at 89,526,618 bp
  • C to T, chromosome 11 at 94,415,837 bp
  • T to C, chromosome 11 at 97,240,931 bp
  • T to A, chromosome 11 at 103,209,851 bp
  • A to T, chromosome 12 at 55,605,529 bp
  • A to T, chromosome 12 at 57,457,079 bp
  • A to G, chromosome 12 at 70,952,960 bp
  • A to G, chromosome 12 at 87,174,164 bp
  • T to A, chromosome 13 at 62,700,466 bp
  • A to G, chromosome 13 at 120,264,210 bp
  • A to G, chromosome 14 at 16,435,140 bp
  • A to G, chromosome 14 at 53,717,147 bp
  • T to G, chromosome 15 at 79,089,525 bp
  • A to G, chromosome 15 at 101,562,800 bp
  • G to A, chromosome 16 at 22,247,190 bp
  • A to G, chromosome 16 at 49,759,414 bp
  • A to G, chromosome 16 at 84,841,321 bp
  • G to A, chromosome 17 at 8,137,928 bp
  • A to G, chromosome 17 at 45,698,404 bp
  • A to G, chromosome 18 at 49,864,173 bp
  • A to T, chromosome 18 at 57,667,304 bp
  • T to C, chromosome 19 at 6,298,078 bp
  • A to T, chromosome 19 at 12,920,115 bp
  • C to T, chromosome Y at 1,316,978 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9011 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068841-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.