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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR9028Btlr/Mmmh
Stock Number:
068857-MU
Citation ID:
RRID:MMRRC_068857-MU
Other Names:
R9028 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Zdhhc17
Name: zinc finger, DHHC domain containing 17
Synonyms: A230053P19Rik, D130071N24Rik, Hip14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320150
VEGA: 10
Homologene: 56324

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Itk
Name: IL2 inducible T cell kinase
Synonyms: Emt, Tsk, Tcsk
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051

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Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268

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Map2k6
Name: mitogen-activated protein kinase kinase 6
Synonyms: MAP kinase kinase 6, MKK6, SAPKK3, Prkmk6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26399
HGNC: HGNC:6846
Homologene: 55686

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Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351

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IMPC
Google
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Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711

Additional Resources
IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
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KOMP Phenotyping
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Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,152,855 bp
  • G to A, chromosome 1 at 34,588,677 bp
  • T to A, chromosome 1 at 40,726,452 bp
  • T to C, chromosome 1 at 52,853,709 bp
  • T to C, chromosome 1 at 53,521,138 bp
  • A to T, chromosome 1 at 80,606,295 bp
  • T to A, chromosome 2 at 22,600,087 bp
  • T to A, chromosome 2 at 89,282,332 bp
  • A to G, chromosome 2 at 119,947,589 bp
  • A to T, chromosome 3 at 53,453,571 bp
  • T to C, chromosome 3 at 63,915,548 bp
  • A to G, chromosome 3 at 79,074,344 bp
  • G to A, chromosome 3 at 108,463,503 bp
  • T to G, chromosome 4 at 58,145,199 bp
  • T to A, chromosome 4 at 89,691,677 bp
  • C to A, chromosome 4 at 109,890,908 bp
  • T to C, chromosome 4 at 118,436,560 bp
  • T to C, chromosome 4 at 134,233,297 bp
  • A to T, chromosome 5 at 5,646,958 bp
  • A to G, chromosome 5 at 20,794,375 bp
  • G to T, chromosome 5 at 33,752,503 bp
  • A to G, chromosome 5 at 35,079,475 bp
  • A to G, chromosome 5 at 53,649,690 bp
  • A to T, chromosome 5 at 73,098,266 bp
  • A to G, chromosome 5 at 76,876,130 bp
  • A to T, chromosome 6 at 40,444,255 bp
  • G to A, chromosome 6 at 48,496,153 bp
  • C to T, chromosome 6 at 120,439,131 bp
  • C to T, chromosome 6 at 132,312,655 bp
  • A to T, chromosome 7 at 12,772,189 bp
  • T to A, chromosome 7 at 102,460,398 bp
  • T to A, chromosome 7 at 113,547,422 bp
  • T to C, chromosome 8 at 13,026,087 bp
  • T to C, chromosome 8 at 80,714,013 bp
  • A to T, chromosome 8 at 95,369,688 bp
  • T to A, chromosome 8 at 120,671,283 bp
  • T to C, chromosome 9 at 49,507,436 bp
  • T to C, chromosome 9 at 61,921,059 bp
  • A to G, chromosome 9 at 106,651,185 bp
  • T to C, chromosome 10 at 110,961,073 bp
  • T to A, chromosome 10 at 117,683,509 bp
  • A to C, chromosome 10 at 128,353,083 bp
  • C to T, chromosome 11 at 3,922,111 bp
  • T to C, chromosome 11 at 32,499,432 bp
  • T to A, chromosome 11 at 46,344,883 bp
  • C to T, chromosome 11 at 51,048,833 bp
  • C to T, chromosome 11 at 71,122,993 bp
  • T to C, chromosome 11 at 74,346,921 bp
  • A to G, chromosome 11 at 91,577,185 bp
  • T to A, chromosome 11 at 110,298,078 bp
  • T to A, chromosome 11 at 110,497,973 bp
  • G to A, chromosome 11 at 117,836,663 bp
  • T to A, chromosome 11 at 119,270,381 bp
  • T to A, chromosome 13 at 6,605,689 bp
  • T to C, chromosome 13 at 12,300,978 bp
  • G to A, chromosome 13 at 46,798,365 bp
  • T to C, chromosome 13 at 55,159,154 bp
  • C to A, chromosome 14 at 46,853,743 bp
  • C to A, chromosome 14 at 53,763,430 bp
  • T to C, chromosome 14 at 55,628,951 bp
  • T to C, chromosome 14 at 61,005,201 bp
  • A to C, chromosome 15 at 41,103,362 bp
  • T to A, chromosome 15 at 75,947,500 bp
  • A to T, chromosome 15 at 76,003,889 bp
  • A to G, chromosome 15 at 77,423,416 bp
  • T to C, chromosome 15 at 85,816,897 bp
  • C to T, chromosome 16 at 55,919,552 bp
  • T to A, chromosome 17 at 3,665,910 bp
  • T to G, chromosome 17 at 20,419,850 bp
  • T to A, chromosome 17 at 35,144,154 bp
  • T to C, chromosome 17 at 47,733,058 bp
  • T to C, chromosome 18 at 34,942,031 bp
  • G to A, chromosome 19 at 30,089,344 bp
  • T to C, chromosome 19 at 36,969,108 bp
  • T to C, chromosome 19 at 47,170,690 bp
  • T to G, chromosome 19 at 47,620,073 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9028 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
068857-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.