Strain Name:
C57BL/6J-MtgxR9048Btlr/Mmmh
Stock Number:
068874-MU
Citation ID:
RRID:MMRRC_068874-MU
Other Names:
R9048 (G1)
Major Collection:

Strain Information

Stx8
Name: syntaxin 8
Synonyms: 1110002H11Rik, 0610007H08Rik, 4930571E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55943
Homologene: 37973
Bmp6
Name: bone morphogenetic protein 6
Synonyms: Vgr1, D13Wsu115e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12161
VEGA: 13
HGNC: HGNC:1073
Homologene: 1300
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27388
Homologene: 8462
Mapk14
Name: mitogen-activated protein kinase 14
Synonyms: p38-alpha, p38, p38 MAP Kinase, Mxi2, CSBP2, Crk1, Csbp1, p38MAPK, p38a, p38 alpha, p38alpha, p38 MAP kinase alpha, p38 MAPK
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26416
HGNC: HGNC:6876
Homologene: 31777
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: t8219b25, 1110012J17Rik, Soga2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68617
Homologene: 41017
Pip5k1c
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
Synonyms: PIP5KIgamma
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18717
HGNC: HGNC:8996
Homologene: 69032
Epb41l3
Name: erythrocyte membrane protein band 4.1 like 3
Synonyms: NBL3, 4.1B, DAL1P, Epb4.1l3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13823
HGNC: HGNC:3380
Homologene: 49308
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: Sin3, mSin3A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20466
Homologene: 32124
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Als2cr6, 3222402C23Rik, 9430073A21Rik, Alsin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Fact140, Spt16, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Stxbp3
Name: syntaxin binding protein 3
Synonyms: Munc-18c, Stxbp3, Stxbp3a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20912
Homologene: 5260
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, CAMDI, 2610301F02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Leng8
Name: leukocyte receptor cluster (LRC) member 8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232798
Homologene: 13612
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74369
Homologene: 46535
Enpp7
Name: ectonucleotide pyrophosphatase/phosphodiesterase 7
Synonyms: Alk-SMase, LOC238011
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 238011
Homologene: 110852
Mfsd2a
Name: MFSD2 lysolipid transporter A, lysophospholipid
Synonyms: major facilitator superfamily domain containing 2A, 1700018O18Rik, Mfsd2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76574
Homologene: 19229
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242608
Homologene: 17803
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: mSiglec-G, A630096C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243958
Homologene: 13228
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Stxbp2
Name: syntaxin binding protein 2
Synonyms: Munc-18b, Munc-18-2, C79054, Sxtp2, Munc18b, muSec1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20911
Homologene: 55530
Exph5
Name: exophilin 5
Synonyms: slac2-b, B130009M24Rik, AC079869.22gm5, Slac2b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320051
Homologene: 9007
Glce
Name: glucuronyl C5-epimerase
Synonyms: heparan sulfate-glucuronic acid C5-epimerase, Hsepi, C130034A12Rik, 1110017N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93683
Homologene: 14111
Il1a
Name: interleukin 1 alpha
Synonyms: Il-1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16175
HGNC: HGNC:5991
Homologene: 480
Or55b3
Name: olfactory receptor family 55 subfamily B member 3
Synonyms: GA_x6K02T2PBJ9-5199377-5198367, MOR42-2, Olfr543
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257947
Homologene: 81631
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Ces1f
Name: carboxylesterase 1F
Synonyms: TGH-2, CesML1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234564
HGNC: HGNC:1863
Homologene: 134311
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Or2t26
Name: olfactory receptor family 2 subfamily T member 26
Synonyms: GA_x6K02T2QP88-6286247-6285294, MOR277-1, Olfr1395
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258877
Homologene: 105890
Zkscan3
Name: zinc finger with KRAB and SCAN domains 3
Synonyms: 2810435N07Rik, Skz1, Zfp307, Zfp306
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72739
Homologene: 130732
Or5h18
Name: olfactory receptor family 5 subfamily H member 18
Synonyms: GA_x54KRFPKG5P-55257214-55256285, MOR183-9, Olfr186
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258318
Homologene: 133671
Col4a1
Name: collagen, type IV, alpha 1
Synonyms: Col4a-1, Del(8)Bru44H, Del(8)44H, Bru, Svc, Raw, alpha1(IV) collagen
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12826
HGNC: HGNC:2202
Homologene: 20437
Cldn10
Name: claudin 10
Synonyms: 6720456I16Rik, D14Ertd728e, Cldn10a, Cldn10b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58187
HGNC: HGNC:2033
Homologene: 5076
Pkn1
Name: protein kinase N1
Synonyms: Pkn, PRK1, PAK1, Stk3, Prkcl1, F730027O18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Cyria
Name: CYFIP related Rac1 interactor A
Synonyms: 2410157M17Rik, D12Ertd553e, Fam49a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76820
VEGA: 12
Homologene: 12657
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665210
Homologene: 115024
Mup5
Name: major urinary protein 5
Synonyms: Mup V
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17844
Homologene: 74304
Ahcyl
Name: adenosylhomocysteinase like
Synonyms: Gm4737
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11615
VEGA: 16
HGNC: HGNC:343
Dmac2l
Name: distal membrane arm assembly component 2 like
Synonyms: facyor B, 1110015E18Rik, Atp5s
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68055
VEGA: 12
Homologene: 12232
Or10j5
Name: olfactory receptor family 10 subfamily J member 5
Synonyms: MOR23, MOR267-13, GA_x6K02T2R7CC-893157-892228, Olfr16
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18313
Homologene: 7460
Pgap6
Name: post-glycosylphosphatidylinositol attachment to proteins 6
Synonyms: M83, Tmem8, Rxylt1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 60455
Homologene: 10944
Phyh
Name: phytanoyl-CoA hydroxylase
Synonyms: Lnap1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16922
HGNC: HGNC:8940
Homologene: 4530
Ryk
Name: receptor-like tyrosine kinase
Synonyms: Vik, ERK-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20187
Homologene: 68287
Entrep3
Name: endosomal transmembrane epsin interactor 3
Synonyms: 1110013L07Rik, Fam189b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68521
HGNC: HGNC:1233
Homologene: 4805
Or2y1c
Name: olfactory receptor family 2 subfamily Y member 1C
Synonyms: GA_x6K02T2QP88-5964781-5963852, MOR256-50, Olfr1386
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257888
Homologene: 86692
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: Aytl1, lysoPAFAT/LPCAT2, LPCAT2, Aytl1a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270084
Homologene: 41201
Sec61g
Name: SEC61 translocon subunit gamma
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20335
Homologene: 40767
Or13c7b
Name: olfactory receptor family 13 subfamily C member 7B
Synonyms: OR37B, mOR37b, Olfr37b, GA_x6K02T2N78B-16125144-16126100, MOR262-6, Olfr156
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29846
Homologene: 133652
Igf2
Name: insulin-like growth factor 2
Synonyms: Igf-2, Igf-II, Peg2, M6pr, Mpr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16002
HGNC: HGNC:5466
Homologene: 510
Nkx6-2
Name: NK6 homeobox 2
Synonyms: Gtx, Nkx6.2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14912
Homologene: 18580
Krtap10-27
Name: keratin associated protein 10-27
Synonyms: Gm9507
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 670880
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 59,186,511 bp
  • T to C, chromosome 1 at 172,957,362 bp
  • A to T, chromosome 2 at 4,927,438 bp
  • T to C, chromosome 2 at 77,023,528 bp
  • T to A, chromosome 2 at 120,677,934 bp
  • T to C, chromosome 2 at 129,306,521 bp
  • T to C, chromosome 3 at 37,011,777 bp
  • T to C, chromosome 3 at 89,185,741 bp
  • A to T, chromosome 3 at 108,816,388 bp
  • T to C, chromosome 4 at 43,820,584 bp
  • T to A, chromosome 4 at 61,832,375 bp
  • G to C, chromosome 4 at 108,021,399 bp
  • A to G, chromosome 4 at 122,960,975 bp
  • A to G, chromosome 7 at 4,143,932 bp
  • T to C, chromosome 7 at 43,408,579 bp
  • A to T, chromosome 7 at 102,477,477 bp
  • A to G, chromosome 7 at 139,581,960 bp
  • G to T, chromosome 7 at 139,627,343 bp
  • A to G, chromosome 7 at 141,152,884 bp
  • A to T, chromosome 7 at 142,654,022 bp
  • A to G, chromosome 8 at 3,637,218 bp
  • T to A, chromosome 8 at 11,231,944 bp
  • G to A, chromosome 8 at 83,698,034 bp
  • G to T, chromosome 8 at 92,909,250 bp
  • T to C, chromosome 8 at 93,263,067 bp
  • G to A, chromosome 8 at 125,447,726 bp
  • A to G, chromosome 9 at 53,373,635 bp
  • A to G, chromosome 9 at 57,125,336 bp
  • A to T, chromosome 9 at 62,060,131 bp
  • A to T, chromosome 9 at 102,897,269 bp
  • G to A, chromosome 10 at 77,811,411 bp
  • C to A, chromosome 10 at 81,316,876 bp
  • A to G, chromosome 11 at 16,508,129 bp
  • G to A, chromosome 11 at 49,149,003 bp
  • T to A, chromosome 11 at 49,471,053 bp
  • A to G, chromosome 11 at 53,536,703 bp
  • A to G, chromosome 11 at 68,011,385 bp
  • A to G, chromosome 11 at 118,990,629 bp
  • G to A, chromosome 12 at 12,362,285 bp
  • C to T, chromosome 12 at 69,740,978 bp
  • T to C, chromosome 13 at 21,396,516 bp
  • C to T, chromosome 13 at 38,498,802 bp
  • T to A, chromosome 14 at 52,181,056 bp
  • G to A, chromosome 14 at 118,788,244 bp
  • C to A, chromosome 15 at 82,084,835 bp
  • G to A, chromosome 16 at 22,987,772 bp
  • A to G, chromosome 16 at 34,034,484 bp
  • A to T, chromosome 16 at 46,154,195 bp
  • G to A, chromosome 16 at 59,027,235 bp
  • A to T, chromosome 17 at 18,135,860 bp
  • T to C, chromosome 17 at 26,121,541 bp
  • A to G, chromosome 17 at 28,728,384 bp
  • T to C, chromosome 17 at 66,371,336 bp
  • C to T, chromosome 17 at 69,210,223 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9048 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068874-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.