Strain Name:
C57BL/6J-MtgxR9052Btlr/Mmmh
Stock Number:
068878-MU
Citation ID:
RRID:MMRRC_068878-MU
Other Names:
R9052 (G1)
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: Vdp, transcytosis associated protein p115, TAP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Dlg1
Name: discs large MAGUK scaffold protein 1
Synonyms: Dlgh1, SAP97, B130052P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13383
HGNC: HGNC:2900
Homologene: 20869
Manbal
Name: mannosidase, beta A, lysosomal-like
Synonyms: 1810024K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69161
Homologene: 41466
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Nacc1
Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Synonyms: Btbd14b, 4930511N13Rik, Nac1, 2010001H03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66830
VEGA: 8
Homologene: 12042
2610021A01Rik
Name: RIKEN cDNA 2610021A01 gene
Type: Gene
Species: Mouse
Chromosome: 7
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225432
VEGA: 18
Homologene: 35410
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: 1700121J11Rik, PMR1, D930003G21Rik, ATP2C1A, SPCA
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235574
Homologene: 56672
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, D130071B19Rik, Nirf
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109113
Homologene: 17001
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84585
Homologene: 11112
Mrps5
Name: mitochondrial ribosomal protein S5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77721
Homologene: 32726
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70427
Homologene: 18941
Coch
Name: cochlin
Synonyms: D12H14S564E, Coch-5B2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Itgb3
Name: integrin beta 3
Synonyms: platelet glycoprotein IIIa (GP3A), CD61
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Ttc23
Name: tetratricopeptide repeat domain 23
Synonyms: 1600012K10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67009
Homologene: 11289
Zfp317
Name: zinc finger protein 317
Synonyms: D230022C05Rik, Zfp67, Zfp75, KRAB9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244713
Homologene: 36389
Zfp799
Name: zinc finger protein 799
Synonyms: 6030490I01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240064
Homologene: 107106
1110059G10Rik
Name: RIKEN cDNA 1110059G10 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66202
Homologene: 10791
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: D530031C13Rik, 1110014E10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Rhbdf2
Name: rhomboid 5 homolog 2
Synonyms: Uncv, cub, Rhbdl6, iRhom2, 4732465I17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217344
Homologene: 11612
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: auxilin, 2810027M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: A930008G09Rik, 7530426H14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, D430003I15Rik, Abc10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114875
Homologene: 23815
Siglecl2
Name: Siglec family like 2
Synonyms: 4931406B18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74054
Homologene: 105741
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Gm10226
Name: predicted gene 10226
Type: Gene
Species: Mouse
Chromosome: 17
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Hltf
Name: helicase-like transcription factor
Synonyms: Smarca3, P113, Snf2l3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20585
Homologene: 30136
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329421
Homologene: 51393
Crybg2
Name: crystallin beta-gamma domain containing 2
Synonyms: Aim1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230806
Homologene: 19232
Il18
Name: interleukin 18
Synonyms: Il-18, Igif
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16173
VEGA: 9
HGNC: HGNC:5986
Homologene: 1200
Mfap5
Name: microfibrillar associated protein 5
Synonyms: MAGP-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50530
Homologene: 2599
Stat2
Name: signal transducer and activator of transcription 2
Synonyms: 1600010G07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20847
VEGA: 10
Homologene: 3952
Or1n1b
Name: olfactory receptor family 1 subfamily N member 1B
Synonyms: GA_x6K02T2NLDC-33585366-33584431, Olfr353, MOR127-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258943
HGNC: HGNC:8221
Homologene: 115503
Naaladl1
Name: N-acetylated alpha-linked acidic dipeptidase-like 1
Synonyms: LOC381204
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381204
Homologene: 21124
Masp1
Name: MBL associated serine protease 1
Synonyms: Crarf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17174
VEGA: 16
HGNC: HGNC:6901
Homologene: 88793
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: Fam46c, 4930431B09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74645
Homologene: 56783
Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms: PI3Kgamma, PI3Kgamma, p110gamma, 5830428L06Rik, PI(3)Kgamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30955
HGNC: HGNC:8978
Homologene: 68269
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319807
Homologene: 14974
Zfp955a
Name: zinc finger protein 955A
Synonyms: AI842447
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77652
VEGA: 17
Homologene: 104925
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Tgs1
Name: trimethylguanosine synthase 1
Synonyms: Pimt, D4Ertd800e, Ncoa6ip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 116940
Homologene: 32608
Atp8a1
Name: ATPase phospholipid transporting 8A1
Synonyms: B230107D19Rik, Atp3a2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11980
Homologene: 48402
Isg20
Name: interferon-stimulated protein
Synonyms: DnaQl, 20kDa, 1600023I01Rik, HEM45, 2010107M23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57444
HGNC: HGNC:6130
Homologene: 31081
Or1x6
Name: olfactory receptor family 1 subfamily X member 6
Synonyms: Olfr1375, GA_x6K02T2QP88-4389999-4389056, MOR126-2, Olfr1375-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258509
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72046
Homologene: 69243
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21934
Homologene: 2848
Rigi
Name: RNA sensor RIG-I
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I, Ddx58, 6430573D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230073
Homologene: 32215
Dhcr7
Name: 7-dehydrocholesterol reductase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13360
HGNC: HGNC:2860
Homologene: 1042
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16552
Homologene: 7796
Ms4a1
Name: membrane-spanning 4-domains, subfamily A, member 1
Synonyms: Cd20, Ly-44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12482
HGNC: HGNC:7315
Homologene: 7259
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: A330035H04Rik, Facl6, Lacsl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Or6c214
Name: olfactory receptor family 6 subfamily C member 214
Synonyms: MOR117-1, Olfr807, GA_x6K02T2PULF-11434134-11433199
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258931
Homologene: 27300
Sh3bp2
Name: SH3-domain binding protein 2
Synonyms: 3BP2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24055
Homologene: 2276
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240726
Homologene: 57135
Or5k16
Name: olfactory receptor family 5 subfamily K member 16
Synonyms: Olfr1563-ps1, MOR184-11P, MOR184-11P, Olfr180, GA_x54KRFPKG5P-55134972-55134019, MOR184-9
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258178
Homologene: 79337
Slc7a9
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
Synonyms: CSNU3, bo, + amino acid transporter, bo, +AT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30962
Homologene: 56668
Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106648
Homologene: 80199
Rasl11a
Name: RAS-like, family 11, member A
Synonyms: 1110065D03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68895
Homologene: 45783
Rfxap
Name: regulatory factor X-associated protein
Synonyms: 5730495K23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170767
HGNC: HGNC:9988
Homologene: 452
Vta1
Name: vesicle (multivesicular body) trafficking 1
Synonyms: 1110001D18Rik, 1110059P08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66201
Homologene: 6473
Ighv1-24
Name: immunoglobulin heavy variable V1-24
Synonyms: Ighv1-24, immunoglobulin heavy variable V1-24
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780885
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 12,990,173 bp
  • A to G, chromosome 1 at 34,166,964 bp
  • C to T, chromosome 1 at 34,197,330 bp
  • G to A, chromosome 1 at 105,827,129 bp
  • C to T, chromosome 1 at 139,243,423 bp
  • T to C, chromosome 2 at 36,890,093 bp
  • A to G, chromosome 2 at 38,021,451 bp
  • A to G, chromosome 2 at 70,232,403 bp
  • G to A, chromosome 2 at 127,591,956 bp
  • T to C, chromosome 2 at 157,379,187 bp
  • T to C, chromosome 2 at 181,240,175 bp
  • A to G, chromosome 3 at 20,098,082 bp
  • G to A, chromosome 3 at 54,807,734 bp
  • A to T, chromosome 3 at 100,473,302 bp
  • G to T, chromosome 3 at 122,147,259 bp
  • T to A, chromosome 4 at 3,585,166 bp
  • C to A, chromosome 4 at 40,208,459 bp
  • C to T, chromosome 4 at 63,171,831 bp
  • T to C, chromosome 4 at 101,639,420 bp
  • T to C, chromosome 4 at 134,075,724 bp
  • A to T, chromosome 5 at 32,830,134 bp
  • A to G, chromosome 5 at 34,551,820 bp
  • A to T, chromosome 5 at 63,804,430 bp
  • A to G, chromosome 5 at 67,778,958 bp
  • G to T, chromosome 5 at 92,180,563 bp
  • C to A, chromosome 5 at 146,845,297 bp
  • G to T, chromosome 6 at 38,177,609 bp
  • A to G, chromosome 6 at 122,524,504 bp
  • G to A, chromosome 6 at 140,023,179 bp
  • G to A, chromosome 7 at 19,087,689 bp
  • A to G, chromosome 7 at 35,453,592 bp
  • G to T, chromosome 7 at 41,626,025 bp
  • T to A, chromosome 7 at 43,498,207 bp
  • C to A, chromosome 7 at 67,692,939 bp
  • A to G, chromosome 7 at 78,916,642 bp
  • C to A, chromosome 7 at 143,841,323 bp
  • A to C, chromosome 8 at 84,676,748 bp
  • A to G, chromosome 9 at 19,645,272 bp
  • C to A, chromosome 9 at 20,799,437 bp
  • C to T, chromosome 9 at 50,577,790 bp
  • A to T, chromosome 9 at 105,452,833 bp
  • A to T, chromosome 9 at 108,059,731 bp
  • T to C, chromosome 9 at 122,948,966 bp
  • A to C, chromosome 10 at 14,675,948 bp
  • G to A, chromosome 10 at 79,548,440 bp
  • A to G, chromosome 10 at 128,281,669 bp
  • C to G, chromosome 10 at 129,755,225 bp
  • A to G, chromosome 11 at 5,723,153 bp
  • G to A, chromosome 11 at 51,048,111 bp
  • A to T, chromosome 11 at 54,341,789 bp
  • A to T, chromosome 11 at 104,633,587 bp
  • A to C, chromosome 11 at 116,603,932 bp
  • C to A, chromosome 12 at 4,965,982 bp
  • T to C, chromosome 12 at 32,195,709 bp
  • T to C, chromosome 12 at 51,593,625 bp
  • C to T, chromosome 12 at 114,772,935 bp
  • C to T, chromosome 15 at 64,920,915 bp
  • T to A, chromosome 16 at 15,690,296 bp
  • T to A, chromosome 16 at 23,520,600 bp
  • T to A, chromosome 16 at 31,838,124 bp
  • T to C, chromosome 16 at 58,916,198 bp
  • A to T, chromosome 16 at 90,938,840 bp
  • T to A, chromosome 17 at 21,692,052 bp
  • C to T, chromosome 17 at 32,692,615 bp
  • G to A, chromosome 17 at 32,820,812 bp
  • G to T, chromosome 17 at 33,242,305 bp
  • T to C, chromosome 18 at 42,332,828 bp
  • T to G, chromosome 19 at 6,108,686 bp
  • T to A, chromosome 19 at 11,256,590 bp
  • T to C, chromosome 19 at 30,092,836 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9052 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068878-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.