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Strain Name:
C57BL/6J-MtgxR9053Btlr/Mmmh
Stock Number:
068879-MU
Citation ID:
RRID:MMRRC_068879-MU
Other Names:
R9053 (G1)
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Pmel
Name: premelanosome protein
Synonyms: Pmel17, gp100, gp87, D12S53Eh, D10H12S53E, Si
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20431
VEGA: 10
Homologene: 5048
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Ociad1
Name: OCIA domain containing 1
Synonyms: expressed during mesenchymal induction 2, Emi2, B230209J16Rik, 6030432N09Rik, TPA018, Asrij, Imi2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68095
Homologene: 9866
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 68,250,620 bp
  • TTTTTTTTTTTTT to TTTTTTTTTTTTTTTTTT, chromosome 1 at 85,644,569 bp
  • T to C, chromosome 1 at 121,561,406 bp
  • G to A, chromosome 1 at 165,306,597 bp
  • A to T, chromosome 2 at 37,399,616 bp
  • A to G, chromosome 2 at 40,858,489 bp
  • A to G, chromosome 2 at 89,630,817 bp
  • A to T, chromosome 3 at 25,434,443 bp
  • T to A, chromosome 3 at 38,887,175 bp
  • T to A, chromosome 3 at 88,689,275 bp
  • T to C, chromosome 3 at 121,527,190 bp
  • T to C, chromosome 3 at 138,422,284 bp
  • C to A, chromosome 4 at 113,238,150 bp
  • A to T, chromosome 4 at 113,546,487 bp
  • T to C, chromosome 4 at 141,783,060 bp
  • A to G, chromosome 5 at 23,979,581 bp
  • T to A, chromosome 5 at 73,303,608 bp
  • A to T, chromosome 5 at 114,715,855 bp
  • A to G, chromosome 5 at 139,762,067 bp
  • T to C, chromosome 6 at 57,071,528 bp
  • T to A, chromosome 6 at 73,084,657 bp
  • A to G, chromosome 7 at 28,617,191 bp
  • A to C, chromosome 7 at 35,505,043 bp
  • T to A, chromosome 7 at 42,764,496 bp
  • A to T, chromosome 7 at 49,780,356 bp
  • A to T, chromosome 7 at 120,019,764 bp
  • A to G, chromosome 8 at 94,490,385 bp
  • G to T, chromosome 9 at 21,959,359 bp
  • T to A, chromosome 9 at 44,821,419 bp
  • C to T, chromosome 9 at 89,215,401 bp
  • T to G, chromosome 9 at 109,688,423 bp
  • T to A, chromosome 9 at 112,155,515 bp
  • T to C, chromosome 10 at 11,154,702 bp
  • T to C, chromosome 10 at 69,986,559 bp
  • T to C, chromosome 10 at 80,834,987 bp
  • G to T, chromosome 10 at 128,716,049 bp
  • A to G, chromosome 11 at 17,945,798 bp
  • T to C, chromosome 11 at 23,493,314 bp
  • C to T, chromosome 11 at 59,081,810 bp
  • G to T, chromosome 11 at 72,922,476 bp
  • A to T, chromosome 11 at 78,321,749 bp
  • C to A, chromosome 11 at 107,672,935 bp
  • T to C, chromosome 12 at 8,008,954 bp
  • T to C, chromosome 14 at 8,518,768 bp
  • G to T, chromosome 14 at 70,440,713 bp
  • A to T, chromosome 14 at 75,032,277 bp
  • T to C, chromosome 15 at 76,241,764 bp
  • A to T, chromosome 15 at 100,498,211 bp
  • T to A, chromosome 16 at 29,586,018 bp
  • A to G, chromosome 17 at 12,928,515 bp
  • G to T, chromosome 17 at 20,570,932 bp
  • T to A, chromosome 17 at 35,829,967 bp
  • G to A, chromosome 18 at 37,498,090 bp
  • A to G, chromosome 18 at 61,508,689 bp
  • G to A, chromosome 19 at 10,269,251 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9053 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068879-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.