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Strain Name:
C57BL/6J-MtgxR9074Btlr/Mmmh
Stock Number:
068895-MU
Citation ID:
RRID:MMRRC_068895-MU
Other Names:
R9074 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268980
Homologene: 2380
Btc
Name: betacellulin, epidermal growth factor family member
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12223
HGNC: HGNC:1121
Homologene: 1309
Tesk2
Name: testis-specific kinase 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230661
Homologene: 5188
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: E230024D05Rik, 9030416H16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71521
Homologene: 22877
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: 5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Akap9
Name: A kinase anchor protein 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: 5031439A09Rik, Gpr177
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68151
Homologene: 11779
Abcg5
Name: ATP binding cassette subfamily G member 5
Synonyms: Sterolin-1, trac, cmp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27409
Homologene: 31909
Pias1
Name: protein inhibitor of activated STAT 1
Synonyms: GBP, 2900068C24Rik, Ddxbp1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56469
VEGA: 9
HGNC: HGNC:2752
Homologene: 22953
Taf6
Name: TATA-box binding protein associated factor 6
Synonyms: p80, Taf2e, 80kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21343
Homologene: 7561
Ier5
Name: immediate early response 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15939
HGNC: HGNC:5393
Homologene: 7778
Lrrc4
Name: leucine rich repeat containing 4
Synonyms: Nag14, NGL-2, NGL2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192198
Homologene: 36403
Pmm1
Name: phosphomannomutase 1
Synonyms: Secp53 (yeast) homolog
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29858
HGNC: HGNC:9114
Homologene: 90898
Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
Synonyms: Jmjd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216850
Homologene: 18945
Spp1
Name: secreted phosphoprotein 1
Synonyms: 44kDa bone phosphoprotein, bone sialoprotein 1, osteopontin, ETA-1, BNSP, minopontin, Opn, Opnl, Ric, Spp-1, OP, Apl-1, osteopontin-like protein, 2ar
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20750
Homologene: 20156
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Gnb1l
Name: guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Synonyms: Wdvcf, ESTM55, Wdr14, Me49f07
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13972
HGNC: HGNC:4397
Homologene: 41515
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Ghr
Name: growth hormone receptor
Synonyms: GHBP, GHR/BP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Itga9
Name: integrin alpha 9
Synonyms: 2610002H11Rik, D9Ertd428e, 6720458D17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Clcn2
Name: chloride channel, voltage-sensitive 2
Synonyms: Clc2, ClC-2, nmf240
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12724
HGNC: HGNC:2020
Homologene: 3213
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Naip-rs6, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Zfp654
Name: zinc finger protein 654
Synonyms: 1810008K20Rik, 1600021C16Rik, Gm5488
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72020
Homologene: 10114
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Epas1
Name: endothelial PAS domain protein 1
Synonyms: MOP2, HIF-2alpha, Hif like protein, hypoxia inducible transcription factor 2alpha, HLF, HRF, HIF2A, bHLHe73
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13819
VEGA: 17
HGNC: HGNC:3374
Homologene: 1095
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433619
Homologene: 54921
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Rida
Name: reactive intermediate imine deaminase A homolog
Synonyms: HRP12, HR12, Hrsp12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15473
Homologene: 4261
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Cfap52
Name: cilia and flagella associated protein 52
Synonyms: 4933417B11Rik, 1700019F09Rik, Wdr16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71860
Homologene: 12416
Proc
Name: protein C
Synonyms: inactivator of coagulation factors Va, VIII, PC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19123
VEGA: 18
HGNC: HGNC:9451
Homologene: 37288
Slc2a7
Name: solute carrier family 2 (facilitated glucose transporter), member 7
Synonyms: OTTMUSG00000010396
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435818
Homologene: 72470
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69922
Homologene: 55966
Csn1s2a
Name: casein alpha s2-like A
Synonyms: Csn1s2a, Csng
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12993
Homologene: 7284
Adgrf1
Name: adhesion G protein-coupled receptor F1
Synonyms: 5031409J19Rik, Gpr110
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77596
Homologene: 124643
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: TCF-11, NRF1, LCR-F1, TCF11, Lcrf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Map3k21
Name: mitogen-activated protein kinase kinase kinase 21
Synonyms: BC021891
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234878
Homologene: 32778
Or2p2
Name: olfactory receptor family 2 subfamily P member 2
Synonyms: GA_x6K02T2QHY8-12181473-12182423, MOR256-14, Olfr1370
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258528
Homologene: 105231
Zfp956
Name: zinc finger protein 956
Synonyms: AI894139
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101197
Homologene: 128449
Ssrp1
Name: structure specific recognition protein 1
Synonyms: T160, Hmgi-rs3, Hmg1-rs1, Hmgox
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20833
Homologene: 110735
Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Synonyms: Roct, OAT3, mOat3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19879
VEGA: 19
Homologene: 20901
Ackr2
Name: atypical chemokine receptor 2
Synonyms: D6, Ccbp2, chemokine decoy receptor D6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59289
VEGA: 9
HGNC: HGNC:1565
Homologene: 992
Mchr1
Name: melanin-concentrating hormone receptor 1
Synonyms: Gpr24-9, melanin-concentrating hormone receptor 1, MCH-1R, Mch1r, Gpr24
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207911
VEGA: 15
HGNC: HGNC:4479
Homologene: 21097
Mixl1
Name: Mix paired-like homeobox
Synonyms: Mml
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27217
Homologene: 8445
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13631
Homologene: 7299
Creb3l3
Name: cAMP responsive element binding protein 3-like 3
Synonyms: CREB-H, D10Bur1e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208677
Homologene: 13080
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Dedd
Name: death effector domain-containing
Synonyms: Dedpro1, KE05, FLDED1, CASP8IP1, DEFT
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21945
HGNC: HGNC:2755
Homologene: 7980
Pgc
Name: progastricsin (pepsinogen C)
Synonyms: Upg-1, Upg1, 2210410L06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 109820
HGNC: HGNC:8890
Homologene: 55669
Ubl7
Name: ubiquitin-like 7 (bone marrow stromal cell-derived)
Synonyms: 2300004C15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69459
VEGA: 9
Homologene: 12312
Or56b1
Name: olfactory receptor family 56 subfamily B member 1
Synonyms: GA_x6K02T2PBJ9-7263864-7264823, MOR40-13, Olfr657
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258309
Homologene: 17189
Ndufb11b
Name: NADH:ubiquinone oxidoreductase subunit B11B
Synonyms: 1700029P11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66346
Homologene: 32635
Gm5862
Name: predicted gene 5862
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545739
Homologene: 69402
Irf2bp2
Name: interferon regulatory factor 2 binding protein 2
Synonyms: E130305N23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270110
Homologene: 34290
Or51r1
Name: olfactory receptor family 51 subfamily R member 1
Synonyms: GA_x6K02T2PBJ9-5297243-5298193, MOR16-1, Olfr550
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259108
Homologene: 17507
Mup2
Name: major urinary protein 2
Synonyms: Mup-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17841
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 105,628,521 bp
  • C to A, chromosome 1 at 155,098,529 bp
  • G to T, chromosome 1 at 171,340,320 bp
  • C to A, chromosome 1 at 174,608,632 bp
  • T to C, chromosome 1 at 180,694,680 bp
  • G to T, chromosome 2 at 4,603,954 bp
  • T to A, chromosome 2 at 85,045,467 bp
  • A to C, chromosome 3 at 92,824,919 bp
  • T to A, chromosome 3 at 159,909,766 bp
  • T to C, chromosome 4 at 60,139,717 bp
  • A to G, chromosome 4 at 116,801,736 bp
  • A to G, chromosome 4 at 150,158,168 bp
  • T to A, chromosome 5 at 4,077,959 bp
  • A to T, chromosome 5 at 25,284,345 bp
  • T to C, chromosome 5 at 26,021,626 bp
  • A to G, chromosome 5 at 65,647,136 bp
  • A to T, chromosome 5 at 87,786,599 bp
  • A to T, chromosome 5 at 91,360,744 bp
  • A to G, chromosome 5 at 104,440,301 bp
  • A to T, chromosome 5 at 109,943,433 bp
  • A to C, chromosome 5 at 138,182,203 bp
  • T to TCCC, chromosome 6 at 4,756,451 bp
  • C to A, chromosome 6 at 28,831,596 bp
  • C to T, chromosome 6 at 47,962,528 bp
  • T to G, chromosome 6 at 72,425,941 bp
  • C to T, chromosome 6 at 124,308,988 bp
  • T to G, chromosome 7 at 102,579,226 bp
  • C to T, chromosome 7 at 104,636,084 bp
  • C to T, chromosome 7 at 120,891,901 bp
  • T to A, chromosome 7 at 142,512,086 bp
  • G to A, chromosome 8 at 125,937,311 bp
  • A to G, chromosome 8 at 126,591,717 bp
  • A to G, chromosome 9 at 57,919,354 bp
  • T to C, chromosome 9 at 62,980,882 bp
  • A to C, chromosome 9 at 74,218,620 bp
  • T to A, chromosome 9 at 118,807,276 bp
  • T to A, chromosome 9 at 121,908,663 bp
  • T to A, chromosome 10 at 81,088,618 bp
  • T to A, chromosome 10 at 82,288,060 bp
  • T to C, chromosome 10 at 121,792,352 bp
  • T to A, chromosome 11 at 26,593,917 bp
  • G to A, chromosome 11 at 67,931,830 bp
  • A to T, chromosome 11 at 69,402,151 bp
  • G to A, chromosome 11 at 96,819,747 bp
  • C to T, chromosome 13 at 21,072,614 bp
  • T to A, chromosome 13 at 89,691,027 bp
  • C to T, chromosome 13 at 100,154,951 bp
  • T to C, chromosome 13 at 100,154,960 bp
  • T to C, chromosome 13 at 100,221,756 bp
  • G to A, chromosome 15 at 3,340,988 bp
  • T to A, chromosome 15 at 34,488,677 bp
  • T to A, chromosome 15 at 64,702,091 bp
  • T to G, chromosome 15 at 81,235,779 bp
  • C to T, chromosome 15 at 81,955,695 bp
  • T to A, chromosome 15 at 81,980,810 bp
  • G to T, chromosome 15 at 102,224,362 bp
  • T to A, chromosome 16 at 18,540,995 bp
  • A to G, chromosome 16 at 20,712,664 bp
  • A to G, chromosome 16 at 64,791,133 bp
  • A to T, chromosome 16 at 96,023,410 bp
  • A to T, chromosome 17 at 43,290,988 bp
  • T to A, chromosome 17 at 47,732,426 bp
  • C to G, chromosome 17 at 78,736,361 bp
  • A to T, chromosome 17 at 84,664,829 bp
  • A to T, chromosome 17 at 86,827,839 bp
  • A to G, chromosome 18 at 10,532,797 bp
  • T to C, chromosome 18 at 10,558,795 bp
  • A to G, chromosome 18 at 32,135,897 bp
  • A to G, chromosome 19 at 8,609,661 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9074 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068895-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.