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Strain Name:
C57BL/6J-MtgxR9158Btlr/Mmmh
Stock Number:
068942-MU
Citation ID:
RRID:MMRRC_068942-MU
Other Names:
R9158 (G1)
Major Collection:

Strain Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Dap3
Name: death associated protein 3
Synonyms: 4921514D13Rik, DAP-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 65111
HGNC: HGNC:2673
Homologene: 3404
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230793
Homologene: 17144
Prepl
Name: prolyl endopeptidase-like
Synonyms: 9530014L06Rik, 2810457N15Rik, D030028O16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213760
VEGA: 17
Homologene: 15481
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: HMG-CoAR, 3-hydroxy-3-methylglutaryl-CoA reductase, Red
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215351
Homologene: 9196
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,403,471 bp
  • A to T, chromosome 1 at 37,631,361 bp
  • G to A, chromosome 1 at 40,293,231 bp
  • T to C, chromosome 1 at 65,103,039 bp
  • T to A, chromosome 1 at 75,196,376 bp
  • T to C, chromosome 2 at 22,874,939 bp
  • A to G, chromosome 2 at 85,331,004 bp
  • A to G, chromosome 2 at 94,004,737 bp
  • T to A, chromosome 2 at 165,170,707 bp
  • A to G, chromosome 3 at 84,174,948 bp
  • A to G, chromosome 3 at 88,925,330 bp
  • G to A, chromosome 4 at 33,036,711 bp
  • G to T, chromosome 4 at 126,236,685 bp
  • A to G, chromosome 4 at 127,312,673 bp
  • A to G, chromosome 4 at 133,065,194 bp
  • T to C, chromosome 4 at 140,996,801 bp
  • A to G, chromosome 5 at 15,935,041 bp
  • A to G, chromosome 5 at 53,063,875 bp
  • A to T, chromosome 5 at 86,489,307 bp
  • C to A, chromosome 5 at 90,268,716 bp
  • A to T, chromosome 5 at 111,383,010 bp
  • T to C, chromosome 5 at 120,549,923 bp
  • T to C, chromosome 5 at 134,492,397 bp
  • T to A, chromosome 6 at 41,687,971 bp
  • T to C, chromosome 6 at 116,515,830 bp
  • A to G, chromosome 6 at 141,249,888 bp
  • T to C, chromosome 7 at 4,919,154 bp
  • C to A, chromosome 7 at 9,988,908 bp
  • A to G, chromosome 7 at 16,461,408 bp
  • T to G, chromosome 7 at 39,411,062 bp
  • T to C, chromosome 7 at 104,924,879 bp
  • T to C, chromosome 7 at 109,026,755 bp
  • T to C, chromosome 7 at 140,667,634 bp
  • T to A, chromosome 7 at 141,256,553 bp
  • G to A, chromosome 8 at 40,755,608 bp
  • A to T, chromosome 8 at 109,667,575 bp
  • A to T, chromosome 9 at 26,853,709 bp
  • C to A, chromosome 9 at 37,773,504 bp
  • C to T, chromosome 9 at 66,469,118 bp
  • A to G, chromosome 9 at 80,087,450 bp
  • T to A, chromosome 9 at 111,038,935 bp
  • T to G, chromosome 9 at 121,753,088 bp
  • T to A, chromosome 10 at 51,481,733 bp
  • C to T, chromosome 10 at 81,178,859 bp
  • A to G, chromosome 11 at 49,854,268 bp
  • C to T, chromosome 11 at 70,690,550 bp
  • G to A, chromosome 11 at 116,127,224 bp
  • G to A, chromosome 12 at 84,791,090 bp
  • G to A, chromosome 13 at 96,655,662 bp
  • C to T, chromosome 13 at 112,533,860 bp
  • T to C, chromosome 14 at 12,546,356 bp
  • A to G, chromosome 14 at 79,767,742 bp
  • C to T, chromosome 15 at 98,843,139 bp
  • A to C, chromosome 16 at 19,241,262 bp
  • A to T, chromosome 17 at 19,588,899 bp
  • A to G, chromosome 17 at 23,550,974 bp
  • A to G, chromosome 17 at 44,735,621 bp
  • T to C, chromosome 17 at 85,075,951 bp
  • C to T, chromosome 18 at 47,298,263 bp
  • C to G, chromosome 19 at 4,324,687 bp
  • T to A, chromosome 19 at 8,606,063 bp
  • T to A, chromosome 19 at 44,998,407 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9158 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068942-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.