Strain Name:
C57BL/6J-MtgxR9191Btlr/Mmmh
Stock Number:
068952-MU
Citation ID:
RRID:MMRRC_068952-MU
Other Names:
R9191 (G1)
Major Collection:

Strain Information

Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Tpx2
Name: TPX2, microtubule-associated
Synonyms: REPP86, 2610005B21Rik, DIL2, p100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: Larp5, D13Wsu64e, A130023E24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217980
Homologene: 18195
Serbp1
Name: serpine1 mRNA binding protein 1
Synonyms: 9330147J08Rik, 1200009K13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66870
Homologene: 134277
Brap
Name: BRCA1 associated protein
Synonyms: 3010002G07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72399
HGNC: HGNC:1099
Homologene: 4926
Ccdc34
Name: coiled-coil domain containing 34
Synonyms: 2810027O19Rik, 4930522P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68201
Homologene: 12245
Trh
Name: thyrotropin releasing hormone
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22044
Homologene: 5163
Tap1
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: Ham1, Ham-1, Tap-1, RING4, Abcb2, PSF-1, MTP1, TAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21354
HGNC: HGNC:43
Homologene: 495
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: 3830613O22Rik, Tem5-like, Gpr125
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Ercc8
Name: excision repaiross-complementing rodent repair deficiency, complementation group 8
Synonyms: Csa, B130065P18Rik, 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, Ckn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71991
HGNC: HGNC:3439
Homologene: 62
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: LOC231620, Gm449
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243219
Homologene: 129566
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229055
Homologene: 11395
Zfp668
Name: zinc finger protein 668
Synonyms: E130018B19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244219
Homologene: 11667
Acta2
Name: actin alpha 2, smooth muscle, aorta
Synonyms: SMAalpha, SMalphaA, Actvs, 0610041G09Rik, alphaSMA, a-SMA
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11475
VEGA: 19
HGNC: HGNC:130
Homologene: 133938
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, spermNHE, Slc9a10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Intu
Name: inturned planar cell polarity protein
Synonyms: Pdzk6, 9230116I04Rik, 9430087H23Rik, Pdzd6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 380614
Homologene: 41059
Aknad1
Name: AKNA domain containing 1
Synonyms: 4921525H12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329738
Homologene: 51892
Nt5e
Name: 5' nucleotidase, ecto
Synonyms: ecto-5'-nucleotidase, Nt5, 2210401F01Rik, CD73
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23959
HGNC: HGNC:8021
Homologene: 1895
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma protein-E, pregnancy-associated plasma preproprotein-A2, placenta-specific 3, PLAC3, PAPP-A2, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246317
VEGA: 18
Homologene: 16367
Bmp3
Name: bone morphogenetic protein 3
Synonyms: 9530029I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 110075
HGNC: HGNC:1070
Homologene: 927
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16565
Homologene: 56868
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: Grfbeta, CDC25, Grf1, CDC25Mm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 4933432P15Rik, 2610010G17Rik, 1810044B20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71302
Homologene: 36349
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 260305
Homologene: 9024
Msantd5f6
Name: Myb/SANT DNA binding domain containing 5 family member 6
Synonyms: Gm11487
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433719
Homologene: 128423
Tmem198
Name: transmembrane protein 198
Synonyms: Tmem198-1, Tmem198a, A230078I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319998
Homologene: 44245
Slc27a5
Name: solute carrier family 27 (fatty acid transporter), member 5
Synonyms: FACVL3, VLCSH2, FATP5, VLCS-H2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26459
Homologene: 7596
Slc23a4
Name: solute carrier family 23 member 4
Synonyms: LOC243753, 2010107G12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243753
Homologene: 134124
Crybb1
Name: crystallin, beta B1
Synonyms: 3110006K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12960
HGNC: HGNC:2397
Homologene: 1423
Pcdhga7
Name: protocadherin gamma subfamily A, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93715
HGNC: HGNC:8705
Homologene: 36377
Trav7-5
Name: T cell receptor alpha variable 7-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 630061
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 75,479,782 bp
  • A to T, chromosome 1 at 136,172,821 bp
  • A to G, chromosome 1 at 158,857,418 bp
  • A to T, chromosome 2 at 22,579,829 bp
  • T to A, chromosome 2 at 110,021,956 bp
  • A to G, chromosome 2 at 152,885,204 bp
  • T to C, chromosome 3 at 9,265,235 bp
  • T to A, chromosome 3 at 40,692,511 bp
  • C to T, chromosome 3 at 108,756,777 bp
  • A to T, chromosome 4 at 73,401,433 bp
  • A to T, chromosome 4 at 152,556,230 bp
  • A to C, chromosome 5 at 49,987,664 bp
  • A to T, chromosome 5 at 98,872,087 bp
  • T to A, chromosome 5 at 112,269,333 bp
  • G to A, chromosome 5 at 113,182,698 bp
  • A to G, chromosome 5 at 121,685,287 bp
  • A to G, chromosome 6 at 34,948,461 bp
  • A to G, chromosome 6 at 67,272,854 bp
  • G to A, chromosome 6 at 84,068,066 bp
  • G to A, chromosome 6 at 92,242,621 bp
  • T to G, chromosome 7 at 12,991,320 bp
  • T to C, chromosome 7 at 127,866,486 bp
  • T to C, chromosome 9 at 18,644,810 bp
  • T to C, chromosome 9 at 53,527,290 bp
  • T to C, chromosome 9 at 88,364,821 bp
  • G to A, chromosome 9 at 90,001,870 bp
  • T to C, chromosome 10 at 74,326,149 bp
  • T to A, chromosome 13 at 9,170,794 bp
  • T to A, chromosome 13 at 108,169,380 bp
  • C to G, chromosome 14 at 53,531,158 bp
  • A to T, chromosome 15 at 99,304,183 bp
  • C to A, chromosome 16 at 45,599,781 bp
  • T to C, chromosome 17 at 34,194,982 bp
  • A to G, chromosome 18 at 37,715,879 bp
  • G to A, chromosome 18 at 39,306,840 bp
  • A to G, chromosome 18 at 86,498,656 bp
  • T to A, chromosome 19 at 34,245,080 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9191 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068952-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.