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Strain Name:
C57BL/6J-MtgxR9129Btlr/Mmmh
Stock Number:
069009-MU
Citation ID:
RRID:MMRRC_069009-MU
Other Names:
R9129 (G1)
Major Collection:

Strain Information

Vps41
Name: VPS41 HOPS complex subunit
Synonyms: Vam2, mVam2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218035
VEGA: 13
Homologene: 69165
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, C030027L06Rik, Tkrb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Hspa4
Name: heat shock protein 4
Synonyms: APG-2, Hsp70RY, Hsp110, 70kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: Af10, B130021D15Rik, D630001B22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17354
Homologene: 20973
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21, 2610202A04Rik, D16Ium21e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 56,636,593 bp (GRCm38)
  • A to T, chromosome 1 at 75,469,825 bp (GRCm38)
  • T to C, chromosome 1 at 91,982,207 bp (GRCm38)
  • A to G, chromosome 1 at 174,231,345 bp (GRCm38)
  • C to T, chromosome 2 at 18,162,593 bp (GRCm38)
  • G to A, chromosome 2 at 77,896,315 bp (GRCm38)
  • A to T, chromosome 2 at 86,008,012 bp (GRCm38)
  • A to T, chromosome 2 at 87,753,704 bp (GRCm38)
  • A to G, chromosome 2 at 89,667,586 bp (GRCm38)
  • T to G, chromosome 2 at 121,046,789 bp (GRCm38)
  • A to T, chromosome 2 at 130,634,945 bp (GRCm38)
  • C to T, chromosome 2 at 132,078,412 bp (GRCm38)
  • A to G, chromosome 2 at 168,675,285 bp (GRCm38)
  • T to A, chromosome 3 at 65,684,005 bp (GRCm38)
  • A to G, chromosome 3 at 93,323,970 bp (GRCm38)
  • T to A, chromosome 4 at 32,676,812 bp (GRCm38)
  • A to T, chromosome 4 at 108,181,812 bp (GRCm38)
  • A to G, chromosome 4 at 118,364,669 bp (GRCm38)
  • A to T, chromosome 4 at 118,431,959 bp (GRCm38)
  • G to A, chromosome 4 at 124,805,120 bp (GRCm38)
  • A to T, chromosome 4 at 144,453,193 bp (GRCm38)
  • G to A, chromosome 4 at 145,171,679 bp (GRCm38)
  • G to T, chromosome 4 at 150,158,544 bp (GRCm38)
  • T to C, chromosome 5 at 4,069,089 bp (GRCm38)
  • G to T, chromosome 5 at 41,818,877 bp (GRCm38)
  • T to C, chromosome 6 at 58,008,388 bp (GRCm38)
  • A to G, chromosome 6 at 85,340,910 bp (GRCm38)
  • T to C, chromosome 6 at 119,336,454 bp (GRCm38)
  • A to G, chromosome 6 at 128,546,260 bp (GRCm38)
  • T to C, chromosome 6 at 148,798,627 bp (GRCm38)
  • C to A, chromosome 7 at 3,895,501 bp (GRCm38)
  • G to T, chromosome 7 at 11,880,586 bp (GRCm38)
  • A to G, chromosome 7 at 24,713,745 bp (GRCm38)
  • G to A, chromosome 7 at 25,068,004 bp (GRCm38)
  • A to G, chromosome 7 at 25,314,840 bp (GRCm38)
  • T to C, chromosome 7 at 26,314,711 bp (GRCm38)
  • A to T, chromosome 7 at 26,378,003 bp (GRCm38)
  • A to T, chromosome 7 at 26,681,764 bp (GRCm38)
  • A to G, chromosome 7 at 46,205,205 bp (GRCm38)
  • G to A, chromosome 7 at 105,122,016 bp (GRCm38)
  • A to C, chromosome 7 at 112,271,382 bp (GRCm38)
  • T to C, chromosome 8 at 15,104,068 bp (GRCm38)
  • T to A, chromosome 8 at 69,038,881 bp (GRCm38)
  • A to T, chromosome 8 at 120,010,749 bp (GRCm38)
  • C to T, chromosome 9 at 44,297,765 bp (GRCm38)
  • A to C, chromosome 9 at 66,779,313 bp (GRCm38)
  • T to A, chromosome 10 at 39,056,891 bp (GRCm38)
  • T to C, chromosome 10 at 80,532,578 bp (GRCm38)
  • T to A, chromosome 10 at 81,719,890 bp (GRCm38)
  • G to A, chromosome 11 at 53,283,636 bp (GRCm38)
  • A to G, chromosome 11 at 66,220,027 bp (GRCm38)
  • G to C, chromosome 11 at 89,301,776 bp (GRCm38)
  • A to G, chromosome 11 at 89,421,216 bp (GRCm38)
  • T to C, chromosome 11 at 102,605,639 bp (GRCm38)
  • T to C, chromosome 11 at 106,410,120 bp (GRCm38)
  • A to C, chromosome 11 at 116,968,522 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • T to A, chromosome 12 at 85,057,278 bp (GRCm38)
  • A to G, chromosome 13 at 18,827,605 bp (GRCm38)
  • T to A, chromosome 13 at 23,114,706 bp (GRCm38)
  • A to T, chromosome 13 at 27,318,081 bp (GRCm38)
  • TTGTTTCTGT to TTGT, chromosome 13 at 32,978,156 bp (GRCm38)
  • T to A, chromosome 13 at 38,193,150 bp (GRCm38)
  • A to G, chromosome 13 at 59,128,270 bp (GRCm38)
  • T to C, chromosome 14 at 70,671,673 bp (GRCm38)
  • C to A, chromosome 15 at 35,448,647 bp (GRCm38)
  • T to A, chromosome 16 at 89,487,748 bp (GRCm38)
  • A to T, chromosome 16 at 94,384,349 bp (GRCm38)
  • G to A, chromosome 17 at 7,326,536 bp (GRCm38)
  • T to A, chromosome 17 at 23,459,944 bp (GRCm38)
  • T to C, chromosome 19 at 5,070,112 bp (GRCm38)
  • C to A, chromosome 19 at 5,340,374 bp (GRCm38)
  • T to G, chromosome 19 at 8,169,305 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9129 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069009-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.