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Strain Name:
C57BL/6J-MtgxR9239Btlr/Mmmh
Stock Number:
069067-MU
Citation ID:
RRID:MMRRC_069067-MU
Other Names:
R9239 (G1)
Major Collection:

Strain Information

Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Runx1
Name: runt related transcription factor 1
Synonyms: AML1, Pebp2a2, runt domain, alpha subunit 2, Cbfa2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12394
Homologene: 1331
Pipox
Name: pipecolic acid oxidase
Synonyms: Pso
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19193
Homologene: 40640
Anxa4
Name: annexin A4
Synonyms: Anx4, Xanx-4, annexin IV, AIV
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11746
HGNC: HGNC:542
Homologene: 68164
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hbo1, Hboa, Myst2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: mTAFI68, 4930408G01Rik, A230108M10Rik, p63
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21340
VEGA: 12
Homologene: 31331
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 57,832,098 bp (GRCm38)
  • T to C, chromosome 1 at 92,511,732 bp (GRCm38)
  • G to A, chromosome 1 at 130,159,716 bp (GRCm38)
  • T to A, chromosome 1 at 153,754,351 bp (GRCm38)
  • A to G, chromosome 1 at 164,065,607 bp (GRCm38)
  • A to G, chromosome 2 at 119,749,542 bp (GRCm38)
  • A to G, chromosome 2 at 125,583,910 bp (GRCm38)
  • C to T, chromosome 2 at 130,691,744 bp (GRCm38)
  • A to G, chromosome 2 at 164,804,688 bp (GRCm38)
  • G to T, chromosome 3 at 64,104,538 bp (GRCm38)
  • T to A, chromosome 3 at 94,266,564 bp (GRCm38)
  • T to C, chromosome 3 at 103,330,137 bp (GRCm38)
  • A to G, chromosome 3 at 152,217,849 bp (GRCm38)
  • C to T, chromosome 4 at 119,419,038 bp (GRCm38)
  • G to A, chromosome 5 at 87,979,526 bp (GRCm38)
  • T to C, chromosome 5 at 107,911,706 bp (GRCm38)
  • T to A, chromosome 6 at 86,757,830 bp (GRCm38)
  • G to A, chromosome 6 at 89,869,895 bp (GRCm38)
  • ACCCC to ACCC, chromosome 7 at 25,628,251 bp (GRCm38)
  • G to T, chromosome 7 at 104,644,539 bp (GRCm38)
  • A to T, chromosome 7 at 141,800,217 bp (GRCm38)
  • T to C, chromosome 8 at 79,269,227 bp (GRCm38)
  • A to T, chromosome 9 at 121,778,571 bp (GRCm38)
  • A to G, chromosome 9 at 123,797,572 bp (GRCm38)
  • T to C, chromosome 10 at 7,774,061 bp (GRCm38)
  • A to G, chromosome 10 at 83,506,632 bp (GRCm38)
  • A to T, chromosome 11 at 61,359,518 bp (GRCm38)
  • A to G, chromosome 11 at 73,776,520 bp (GRCm38)
  • A to G, chromosome 11 at 77,883,939 bp (GRCm38)
  • T to A, chromosome 11 at 95,306,194 bp (GRCm38)
  • T to C, chromosome 11 at 116,007,304 bp (GRCm38)
  • A to G, chromosome 12 at 14,150,184 bp (GRCm38)
  • T to A, chromosome 12 at 24,556,016 bp (GRCm38)
  • A to G, chromosome 12 at 104,218,451 bp (GRCm38)
  • T to C, chromosome 14 at 7,299,352 bp (GRCm38)
  • A to G, chromosome 14 at 21,022,024 bp (GRCm38)
  • T to G, chromosome 14 at 84,533,209 bp (GRCm38)
  • A to G, chromosome 14 at 122,927,666 bp (GRCm38)
  • A to G, chromosome 16 at 92,606,047 bp (GRCm38)
  • T to A, chromosome 17 at 71,949,869 bp (GRCm38)
  • G to T, chromosome 17 at 88,009,094 bp (GRCm38)
  • T to A, chromosome 18 at 20,340,693 bp (GRCm38)
  • A to T, chromosome 18 at 37,638,116 bp (GRCm38)
  • T to C, chromosome 19 at 37,330,499 bp (GRCm38)
  • CT to C, chromosome 19 at 55,192,662 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9239 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069067-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.